FI894911A0 - En terapeutiskt vaerdefull foerening. - Google Patents

En terapeutiskt vaerdefull foerening.

Info

Publication number
FI894911A0
FI894911A0 FI894911A FI894911A FI894911A0 FI 894911 A0 FI894911 A0 FI 894911A0 FI 894911 A FI894911 A FI 894911A FI 894911 A FI894911 A FI 894911A FI 894911 A0 FI894911 A0 FI 894911A0
Authority
FI
Finland
Prior art keywords
imidazole
vaerdefull
foerening
terapeutiskt
dimethylphenyl
Prior art date
Application number
FI894911A
Other languages
English (en)
Finnish (fi)
Inventor
Eija Kalso
Risto Lammintausta
Original Assignee
Farmos Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Publication of FI894911A0 publication Critical patent/FI894911A0/fi
Priority to FI894911A priority Critical patent/FI894911A0/fi
Application filed by Farmos Oy filed Critical Farmos Oy
Priority to JP2275142A priority patent/JP2950597B2/ja
Priority to DK90311245.6T priority patent/DK0424059T3/da
Priority to EP90311245A priority patent/EP0424059B1/en
Priority to DE9090311245T priority patent/DE69001006T2/de
Priority to AU64642/90A priority patent/AU624028B2/en
Priority to AT90311245T priority patent/ATE86109T1/de
Priority to IE371090A priority patent/IE64062B1/en
Priority to NZ245002A priority patent/NZ245002A/en
Priority to HU906460A priority patent/HU207796B/hu
Priority to NZ235716A priority patent/NZ235716A/en
Priority to ZA908301A priority patent/ZA908301B/xx
Priority to CA002027876A priority patent/CA2027876C/en
Priority to US07/599,189 priority patent/US5091402A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Dental Preparations (AREA)
  • Stringed Musical Instruments (AREA)
  • Golf Clubs (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cephalosporin Compounds (AREA)
FI894911A 1989-10-17 1989-10-17 En terapeutiskt vaerdefull foerening. FI894911A0 (fi)

Priority Applications (14)

Application Number Priority Date Filing Date Title
FI894911A FI894911A0 (fi) 1989-10-17 1989-10-17 En terapeutiskt vaerdefull foerening.
JP2275142A JP2950597B2 (ja) 1989-10-17 1990-10-11 硬膜外もしくは髄腔内局所投与用鎮痛剤
DK90311245.6T DK0424059T3 (da) 1989-10-17 1990-10-15 Anvendelse af substituerede imidazoler
EP90311245A EP0424059B1 (en) 1989-10-17 1990-10-15 Use of sustituted imidazoles for the manufacture of an analgesic
DE9090311245T DE69001006T2 (de) 1989-10-17 1990-10-15 Verwendung von substituierten imidazolen zur herstellung eines analgetikums.
AU64642/90A AU624028B2 (en) 1989-10-17 1990-10-15 Use of substituted imidazoles
AT90311245T ATE86109T1 (de) 1989-10-17 1990-10-15 Verwendung von substituierten imidazolen zur herstellung eines analgetikums.
IE371090A IE64062B1 (en) 1989-10-17 1990-10-16 Use of substituted imidazoles
NZ235716A NZ235716A (en) 1989-10-17 1990-10-16 Pharmaceutical compositions containing 4-benzyl- or 4-(1-phenethyl) imidazole derivatives
NZ245002A NZ245002A (en) 1989-10-17 1990-10-16 Pharmaceutical compositions containing 4-benzyl- or 4-(1-phenethyl) imidazole derivatives
HU906460A HU207796B (en) 1989-10-17 1990-10-16 Process for producing pharmaceutical compositions containing imidazol derivatives of antinociceptive activity
ZA908301A ZA908301B (en) 1989-10-17 1990-10-17 Use of substituted imidazolas
CA002027876A CA2027876C (en) 1989-10-17 1990-10-17 Use of substituted imidazoles
US07/599,189 US5091402A (en) 1989-10-17 1990-10-17 Use of substituted imidazoles

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FI894911A FI894911A0 (fi) 1989-10-17 1989-10-17 En terapeutiskt vaerdefull foerening.

Publications (1)

Publication Number Publication Date
FI894911A0 true FI894911A0 (fi) 1989-10-17

Family

ID=8529172

Family Applications (1)

Application Number Title Priority Date Filing Date
FI894911A FI894911A0 (fi) 1989-10-17 1989-10-17 En terapeutiskt vaerdefull foerening.

Country Status (13)

Country Link
US (1) US5091402A (da)
EP (1) EP0424059B1 (da)
JP (1) JP2950597B2 (da)
AT (1) ATE86109T1 (da)
AU (1) AU624028B2 (da)
CA (1) CA2027876C (da)
DE (1) DE69001006T2 (da)
DK (1) DK0424059T3 (da)
FI (1) FI894911A0 (da)
HU (1) HU207796B (da)
IE (1) IE64062B1 (da)
NZ (2) NZ235716A (da)
ZA (1) ZA908301B (da)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2256135B (en) * 1991-05-31 1995-01-18 Orion Yhtymae Oy Transdermal administration of 4-substituted imidazoles
US7091181B2 (en) 1994-12-12 2006-08-15 Omeros Corporation Method of inhibition of pain and inflammation during surgery comprising administration of soluble TNF receptors
US5750720A (en) * 1996-03-28 1998-05-12 Ortho Pharmaceutical Corporation 4- (thien-3-yl)methyl!-imidazole analgesics
US5621113A (en) * 1996-03-28 1997-04-15 Ortho Pharmaceutical Corporation 4-[(thien-2-yl)methyl]-imidazole analgesics
US6716867B1 (en) 1998-04-01 2004-04-06 Orion Corporation Use of dexmedetomidine for ICU sedation
AR015744A1 (es) * 1998-04-01 2001-05-16 Orion Corp Uso de dexmedetomidina para sedacion en terapia intensiva
KR100646811B1 (ko) * 1998-09-28 2006-11-17 오리온 코포레이션 척추내, 척수강내, 또는 경막외 투여용 약물 제조에서3-(1에이치-이미다졸-4-일메틸)-인단-5-올의 용도
ATE291907T1 (de) * 1998-10-20 2005-04-15 Omeros Corp Spülende lösung und methoden zur hemmung von schmerzen und entzündungen
EP1563838A3 (en) * 1998-10-20 2009-11-04 Omeros Corporation Irrigation solution and method for inhibition of pain and inflammation
US7973068B2 (en) 1998-10-20 2011-07-05 Omeros Corporation Arthroscopic irrigation solution and method for peripheral vasoconstriction and inhibition of pain and inflammation
US20030087962A1 (en) 1998-10-20 2003-05-08 Omeros Corporation Arthroscopic irrigation solution and method for peripheral vasoconstriction and inhibition of pain and inflammation
AU5537800A (en) * 1999-06-25 2001-01-31 Orion Corporation Method of admistering an imidazole derivative to obtain analgesia
WO2001030347A1 (en) 1999-10-29 2001-05-03 Orion Corporation Treatment or prevention of hypotension and shock
EP1981880B1 (en) * 2006-01-27 2010-02-24 F.Hoffmann-La Roche Ag Use of 4-imidazole derivatives for cns disorders
ATE546437T1 (de) 2006-10-19 2012-03-15 Hoffmann La Roche Aminomethyl-4-imidazole
KR101176700B1 (ko) 2006-11-02 2012-08-23 에프. 호프만-라 로슈 아게 미량 아민 결합된 수용체의 조절자로서 치환된 2-이미다졸
CA2669112A1 (en) * 2006-11-16 2008-05-22 F. Hoffmann-La Roche Ag Substituted 4-imidazoles
JP2010513238A (ja) 2006-12-13 2010-04-30 エフ．ホフマン−ラ ロシュ アーゲー 微量アミン関連受容体（ｔａａｒ）に対するリガンドとしての新規２−イミダゾール
US20080146523A1 (en) 2006-12-18 2008-06-19 Guido Galley Imidazole derivatives
KR101275405B1 (ko) 2007-02-02 2013-06-17 에프. 호프만-라 로슈 아게 중추 신경계 장애의 치료용 ｔａａｒ1 리간드로서 2-아미노옥사졸린
KR101335845B1 (ko) 2007-02-15 2013-12-02 에프. 호프만-라 로슈 아게 Ｔａａｒ1 리간드로서의 2-아미노옥사졸린
WO2009003868A2 (en) 2007-07-02 2009-01-08 F. Hoffmann-La Roche Ag 2 -imidazolines having a good affinity to the trace amine associated receptors (taars)
AU2008270444A1 (en) 2007-07-03 2009-01-08 F. Hoffmann-La Roche Ag 4-imidazolines and their use as antidepressants
EP2183216A1 (en) 2007-07-27 2010-05-12 F. Hoffmann-Roche AG 2-azetidinemethaneamines and 2-pyrrolidinemethaneamines as taar-ligands
CA2695331A1 (en) 2007-08-03 2009-02-12 F. Hoffmann-La Roche Ag Pyridinecarboxamide and benzamide derivatives as taar1 ligands
US8242153B2 (en) 2008-07-24 2012-08-14 Hoffmann-La Roche Inc. 4,5-dihydro-oxazol-2YL derivatives
DK3566703T3 (da) 2009-02-13 2021-07-05 Allergan Inc Farmaceutiske sammensætninger omfattende (3-(1-(1h-imidazol-4-yl)ethyl)-2-methylphenyl)methanol
KR101859486B1 (ko) * 2009-05-15 2018-06-28 레크로파마, 인코포레이티드 설하용 덱스메데토미딘 조성물과 그의 사용 방법
US8354441B2 (en) 2009-11-11 2013-01-15 Hoffmann-La Roche Inc. Oxazoline derivatives
US9452980B2 (en) 2009-12-22 2016-09-27 Hoffmann-La Roche Inc. Substituted benzamides
AU2011204315A1 (en) * 2010-01-08 2012-08-02 Recro Pharma, Inc. Topical transdermal dexmedetomidine compositions and methods of use thereof
US20130096170A1 (en) 2011-10-14 2013-04-18 Hospira, Inc. Methods of treating pediatric patients using dexmedetomidine
US9095576B2 (en) 2011-11-21 2015-08-04 Allergan, Inc. Pharmaceutical compositions comprising 4-[1-(2,3-dimethylphenyl)ethyl]-3H-imidazole derivatives for treating retinal diseases
EP2787970B1 (en) 2011-12-11 2018-04-11 Recro Pharma, Inc. Intranasal dexmedetomidine compositions and methods of use thereof
US8242158B1 (en) 2012-01-04 2012-08-14 Hospira, Inc. Dexmedetomidine premix formulation
RU2648449C2 (ru) 2013-10-07 2018-03-26 ТЕЙКОКУ ФАРМА ЮЭсЭй, ИНК. Способы и композиции для трансдермальной доставки неседативного количества дексмедетомидина
EP3054935B1 (en) 2013-10-07 2020-12-09 Teikoku Pharma USA, Inc. Methods and compositions for treating attention deficit hyperactivity disorder, anxiety and insomnia using dexmedetomidine transdermal compositions
KR101827980B1 (ko) 2013-10-07 2018-02-13 테이코쿠 팔마 유에스에이, 인코포레이티드 덱스메데토미딘 경피 전달 장치 및 이의 사용 방법
CN104814966B (zh) * 2015-04-20 2017-12-29 宋兴荣 一种椎管内麻醉剂及其制备方法和应用
HUE050986T2 (hu) 2016-03-17 2021-01-28 Hoffmann La Roche 5-etil-4-metil-pirazol-3-karboxamid származék, amely TAAR-agonista aktivitású
US9717796B1 (en) 2016-04-20 2017-08-01 Slypharma, Llc Heat sterilizeable, premixed, ready to use dexmedetomidine solution packaged in a flexible plastic container
US11160791B2 (en) 2018-11-01 2021-11-02 Medefil, Inc. Dexmedetomidine injection premix formulation in ready to use (RTU) bags

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2215206B (en) * 1988-02-29 1991-07-03 Farmos Oy 4-substituted imidazole derivatives useful in perioperative care

Also Published As

Publication number Publication date
AU624028B2 (en) 1992-05-28
DE69001006T2 (de) 1993-07-08
AU6464290A (en) 1991-04-26
JPH03133921A (ja) 1991-06-07
IE64062B1 (en) 1995-07-12
IE903710A1 (en) 1991-04-24
DK0424059T3 (da) 1993-04-05
ZA908301B (en) 1991-09-25
NZ245002A (en) 1997-07-27
CA2027876A1 (en) 1991-04-18
HUT55228A (en) 1991-05-28
EP0424059A1 (en) 1991-04-24
EP0424059B1 (en) 1993-03-03
CA2027876C (en) 2002-01-22
HU906460D0 (en) 1991-04-29
NZ235716A (en) 1997-04-24
DE69001006D1 (de) 1993-04-08
HU207796B (en) 1993-06-28
JP2950597B2 (ja) 1999-09-20
ATE86109T1 (de) 1993-03-15
US5091402A (en) 1992-02-25

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Legal Events

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Owner name: FARMOS-YHTYMAE OY