FI891689A - Som antiinflammatoriska och antidegenerativa medel anvaendbara nya substituerade azetidinoner. - Google Patents
Som antiinflammatoriska och antidegenerativa medel anvaendbara nya substituerade azetidinoner. Download PDFInfo
- Publication number
- FI891689A FI891689A FI891689A FI891689A FI891689A FI 891689 A FI891689 A FI 891689A FI 891689 A FI891689 A FI 891689A FI 891689 A FI891689 A FI 891689A FI 891689 A FI891689 A FI 891689A
- Authority
- FI
- Finland
- Prior art keywords
- azetidinoner
- antiinflammatoriska
- antidegenerativa
- substituerade
- anvaendbara
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Reinforced Plastic Materials (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17968888A | 1988-04-11 | 1988-04-11 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FI891689A0 FI891689A0 (fi) | 1989-04-10 |
| FI891689A true FI891689A (fi) | 1989-10-12 |
Family
ID=22657566
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI891689A FI891689A (fi) | 1988-04-11 | 1989-04-10 | Som antiinflammatoriska och antidegenerativa medel anvaendbara nya substituerade azetidinoner. |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0337549B1 (fi) |
| JP (1) | JP2736113B2 (fi) |
| KR (1) | KR930008223B1 (fi) |
| CN (1) | CN1037144A (fi) |
| AT (1) | ATE128704T1 (fi) |
| AU (1) | AU621865B2 (fi) |
| CA (1) | CA1337990C (fi) |
| DE (1) | DE68924439T2 (fi) |
| DK (1) | DK169329B1 (fi) |
| ES (1) | ES2079373T3 (fi) |
| FI (1) | FI891689A (fi) |
| GR (1) | GR3017656T3 (fi) |
| HU (1) | HUT50761A (fi) |
| IE (1) | IE891140L (fi) |
| IL (1) | IL89835A0 (fi) |
| LV (1) | LV11459B (fi) |
| NO (1) | NO891470L (fi) |
| NZ (1) | NZ228600A (fi) |
| PT (1) | PT90222B (fi) |
| YU (1) | YU71489A (fi) |
| ZA (1) | ZA892549B (fi) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5229381A (en) * | 1983-12-01 | 1993-07-20 | Merck & Co., Inc. | Substituted azetidinones as anti-inflammatory and antidegenerative agents |
| US5229510A (en) * | 1983-12-01 | 1993-07-20 | Merck & Co., Inc. | β-lactams useful in determining the amount of elastase in a clinical sample |
| IL99658A0 (en) * | 1990-10-15 | 1992-08-18 | Merck & Co Inc | Substituted azetidinones and pharmaceutical compositions containing them |
| GB9103654D0 (en) * | 1991-02-21 | 1991-04-10 | Merck Sharp & Dohme | Chemical process |
| US5104862A (en) * | 1991-03-20 | 1992-04-14 | Merck & Co., Inc. | Bethalactam elastase inhibitors containing phosphorous acid derivatives at the 4-position of the 2-azetidinone |
| US5100880A (en) * | 1991-03-20 | 1992-03-31 | Merck & Co., Inc. | Novel betalactam elastase inhibitors containing phosphorous acid derivatives at the 4-position of the 2-azetidinone |
| US5332734A (en) * | 1991-04-10 | 1994-07-26 | Japan Tobacco, Incorporated | Oxazinone derivative |
| US5348953A (en) * | 1991-06-25 | 1994-09-20 | Merck & Co., Inc. | Substituted azetidinones as anti-inflammatory and antidegenerative agents |
| WO1993000332A1 (en) | 1991-06-25 | 1993-01-07 | Merck & Co., Inc. | Substituted azetidinones as anti-inflammatory and antidegenerative agents |
| HUT67341A (en) * | 1991-07-23 | 1995-03-28 | Schering Corp | Substituted beta-lactam compounds useful as hypocholesterolemic agents, pharmaceutical compositions containing the same and process for the production thereof |
| US5688787A (en) * | 1991-07-23 | 1997-11-18 | Schering Corporation | Substituted β-lactam compounds useful as hypochlesterolemic agents and processes for the preparation thereof |
| US5688785A (en) * | 1991-07-23 | 1997-11-18 | Schering Corporation | Substituted azetidinone compounds useful as hypocholesterolemic agents |
| EP0529719A1 (en) * | 1991-08-26 | 1993-03-03 | Merck & Co. Inc. | Assay for evaluating inhibition of PMN elastase by N-Substituted Azetidinones |
| US5274080A (en) * | 1991-08-26 | 1993-12-28 | Merck & Co., Inc. | Monospecific antibodies useful in evaluating inhibition of polymorphonuclear leukocyte elastase by N-substituted azetidinones |
| US5276139A (en) * | 1991-08-26 | 1994-01-04 | Merck & Co., Inc. | Haptens useful in evaluating inhibition of PNN elastase by N-substituted azetidinones |
| US5229267A (en) * | 1991-08-26 | 1993-07-20 | Merck & Co., Inc. | Assay for evaluating inhibition of PMN elastase by N-substituted azetidinones |
| US5149838A (en) * | 1991-09-20 | 1992-09-22 | Merck & Co., Inc. | Intermediates for substituted azetidinones useful as anti-inflammatory and antidegenerative agents |
| GB2266527A (en) * | 1992-03-17 | 1993-11-03 | Merck & Co Inc | Substituted azetidinones useful in the treatment of leukemia |
| US5250676A (en) * | 1992-03-23 | 1993-10-05 | University Of Notre Dame Du Lac | Process for the preparation of 3-substituted-2-azetidinones |
| CA2147129A1 (en) * | 1992-10-27 | 1994-05-11 | James B. Doherty | New substituted azetidinones as anti-inflammatory and antidegenerative agents |
| CA2108584C (en) * | 1992-10-27 | 1998-11-24 | James B. Doherty | Substituted azetidinones as anti-inflammatory and antidegenerative agents |
| US5591737A (en) * | 1992-12-17 | 1997-01-07 | Merck & Co., Inc. | Substituted azetidinones as anti-inflammatory and antidegenerative agents |
| AU5802894A (en) * | 1992-12-17 | 1994-07-04 | Merck & Co., Inc. | New substituted azetidinones as anti-inflammatory and antidegenerative agents |
| LT3595B (en) * | 1993-01-21 | 1995-12-27 | Schering Corp | Spirocycloalkyl-substituted azetidinones useful as hypocholesterolemic agents |
| GB9314350D0 (en) * | 1993-07-12 | 1993-08-25 | Zeneca Ltd | Armide derivatives |
| US5420010A (en) * | 1993-07-30 | 1995-05-30 | Merck & Co., Inc. | Assay for evaluating inhibition of polymorphonuclear leukocyte elastase by N-substituted azetidinones |
| US5631365A (en) | 1993-09-21 | 1997-05-20 | Schering Corporation | Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents |
| US5403952A (en) * | 1993-10-08 | 1995-04-04 | Merck & Co., Inc. | Substituted cyclic derivatives as novel antidegenerative agents |
| WO1995024207A1 (en) * | 1994-03-11 | 1995-09-14 | Merck & Co., Inc. | Composition for the treatment of lung disease |
| US5627176A (en) * | 1994-03-25 | 1997-05-06 | Schering Corporation | Substituted azetidinone compounds useful as hypocholesterolemic agents |
| US5633246A (en) * | 1994-11-18 | 1997-05-27 | Schering Corporation | Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents |
| US5624920A (en) * | 1994-11-18 | 1997-04-29 | Schering Corporation | Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents |
| US5656624A (en) * | 1994-12-21 | 1997-08-12 | Schering Corporation | 4-[(heterocycloalkyl or heteroaromatic)-substituted phenyl]-2-azetidinones useful as hypolipidemic agents |
| AU5014496A (en) * | 1995-03-23 | 1996-10-08 | Japan Tobacco Inc. | Diphenylmethyl-azetidinone compounds and elastase inhibitor |
| US5747485A (en) * | 1995-04-13 | 1998-05-05 | Merck & Co., Inc. | Substituted azetidiones as anti-inflammatory and antidegenerative agents |
| US5523233A (en) * | 1995-05-03 | 1996-06-04 | Merck & Co., Inc. | Enzymatic hydrolysis of 3,3-diethyl-4-[(4-carboxy)phenoxy]-2-azetidinone esters |
| CN1197452A (zh) * | 1995-07-01 | 1998-10-28 | 史密丝克莱恩比彻姆有限公司 | 用于治疗动脉粥样硬化的氮杂环丁烷酮衍生物 |
| WO1997013750A1 (en) * | 1995-10-09 | 1997-04-17 | Chiroscience Limited | Azetidinones and their therapeutic use as cytokine inhibitors |
| EP0869943A1 (en) * | 1995-12-08 | 1998-10-14 | Smithkline Beecham Plc | Monocyclic beta-lactame derivatives for treatment of atherosclerosis |
| TR199802160T2 (xx) * | 1996-04-26 | 1999-04-21 | Smithkline Beecham Plc | Ateroskleroz tedavisi i�in azetidinon t�revleri. |
| US5756470A (en) * | 1996-10-29 | 1998-05-26 | Schering Corporation | Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents |
| US6903075B1 (en) | 1997-05-29 | 2005-06-07 | Merck & Co., Inc. | Heterocyclic amide compounds as cell adhesion inhibitors |
| AU9426098A (en) * | 1997-10-07 | 1999-04-27 | Boehringer Ingelheim (Canada) Ltd. | Azetidinone derivatives for the treatment of hcmv infections |
| US6211170B1 (en) * | 1997-10-07 | 2001-04-03 | Boehringer Ingelheim (Canada) Ltd. | Azetidinone derivatives for the treatment of HCMV infections |
| CA2301548C (en) * | 1997-10-07 | 2005-05-17 | Boehringer Ingelheim (Canada) Ltd. | Azetidinone derivatives for the treatment of hcmv infections |
| AU8059598A (en) * | 1998-06-11 | 1999-12-30 | Merck & Co., Inc. | Heterocyclic amide compounds as cell adhesion inhibitors |
| US6335324B1 (en) | 1998-06-25 | 2002-01-01 | Bristol-Myers Squibb Co. | Beta lactam compounds and their use as inhibitors of tryptase |
| WO2000005204A1 (fr) * | 1998-07-23 | 2000-02-03 | Shionogi & Co., Ltd. | COMPOSES DE β-LACTAME MONOCYCLIQUES ET INHIBITEURS DE LA CHYMASE LES RENFERMANT |
| US6593078B1 (en) | 1999-04-16 | 2003-07-15 | Schering Corporation | Use of azetidinone compounds |
| EE05453B1 (et) | 2001-03-28 | 2011-08-15 | Schering Corporation | Protsess asetidinoonvahehendite valmistamiseks |
| US7056906B2 (en) | 2001-09-21 | 2006-06-06 | Schering Corporation | Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women |
| ATE406364T1 (de) | 2003-03-07 | 2008-09-15 | Schering Corp | Substituierte azetidinon-derivate, deren pharmazeutische formulierungen und deren verwendung zur behandlung von hypercholesterolemia |
| JP4589919B2 (ja) | 2003-03-07 | 2010-12-01 | シェーリング コーポレイション | 高コレステロール血症の処置のための、置換アゼチジノン化合物、これらの処方物および使用 |
| US8440819B2 (en) | 2008-02-22 | 2013-05-14 | Allergan, Inc. | Therapeutic substituted beta-lactams |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4680391A (en) * | 1983-12-01 | 1987-07-14 | Merck & Co., Inc. | Substituted azetidinones as anti-inflammatory and antidegenerative agents |
-
1989
- 1989-04-04 NZ NZ228600A patent/NZ228600A/en unknown
- 1989-04-04 IL IL89835A patent/IL89835A0/xx unknown
- 1989-04-06 AT AT89200864T patent/ATE128704T1/de not_active IP Right Cessation
- 1989-04-06 EP EP89200864A patent/EP0337549B1/en not_active Expired - Lifetime
- 1989-04-06 ES ES89200864T patent/ES2079373T3/es not_active Expired - Lifetime
- 1989-04-06 DE DE68924439T patent/DE68924439T2/de not_active Expired - Fee Related
- 1989-04-07 CA CA000595997A patent/CA1337990C/en not_active Expired - Fee Related
- 1989-04-07 PT PT90222A patent/PT90222B/pt not_active IP Right Cessation
- 1989-04-07 ZA ZA892549A patent/ZA892549B/xx unknown
- 1989-04-10 CN CN89103271A patent/CN1037144A/zh active Pending
- 1989-04-10 HU HU891708A patent/HUT50761A/hu unknown
- 1989-04-10 YU YU00714/89A patent/YU71489A/xx unknown
- 1989-04-10 FI FI891689A patent/FI891689A/fi not_active Application Discontinuation
- 1989-04-10 NO NO89891470A patent/NO891470L/no unknown
- 1989-04-10 AU AU32630/89A patent/AU621865B2/en not_active Ceased
- 1989-04-10 IE IE891140A patent/IE891140L/xx not_active IP Right Cessation
- 1989-04-10 DK DK170589A patent/DK169329B1/da not_active IP Right Cessation
- 1989-04-10 KR KR1019890004702A patent/KR930008223B1/ko active IP Right Grant
- 1989-04-11 JP JP1091723A patent/JP2736113B2/ja not_active Expired - Fee Related
-
1995
- 1995-10-05 GR GR950402512T patent/GR3017656T3/el unknown
-
1996
- 1996-02-01 LV LVP-96-24A patent/LV11459B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPH026471A (ja) | 1990-01-10 |
| DK170589D0 (da) | 1989-04-10 |
| CN1037144A (zh) | 1989-11-15 |
| ATE128704T1 (de) | 1995-10-15 |
| LV11459A (lv) | 1996-08-20 |
| JP2736113B2 (ja) | 1998-04-02 |
| CA1337990C (en) | 1996-01-23 |
| NZ228600A (en) | 1992-02-25 |
| PT90222B (pt) | 1994-07-29 |
| NO891470D0 (no) | 1989-04-10 |
| EP0337549B1 (en) | 1995-10-04 |
| DK169329B1 (da) | 1994-10-10 |
| HUT50761A (en) | 1990-03-28 |
| DE68924439D1 (de) | 1995-11-09 |
| KR930008223B1 (ko) | 1993-08-27 |
| GR3017656T3 (en) | 1996-01-31 |
| DE68924439T2 (de) | 1996-05-09 |
| KR900016121A (ko) | 1990-11-12 |
| IL89835A0 (en) | 1989-12-15 |
| EP0337549A1 (en) | 1989-10-18 |
| IE891140L (en) | 1989-10-11 |
| ZA892549B (en) | 1989-11-29 |
| YU71489A (en) | 1991-10-31 |
| LV11459B (en) | 1996-12-20 |
| FI891689A0 (fi) | 1989-04-10 |
| PT90222A (pt) | 1989-11-10 |
| NO891470L (no) | 1989-10-12 |
| AU621865B2 (en) | 1992-03-26 |
| DK170589A (da) | 1989-10-12 |
| ES2079373T3 (es) | 1996-01-16 |
| AU3263089A (en) | 1989-10-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Application withdrawn |
Owner name: MERCK & CO., INC. |