FI88503B - Foerfarande foer framstaellning av nya, farmakologiskt vaerdefulla 1,2-ditiol-3-tion-s-oxidfoereningar - Google Patents
Foerfarande foer framstaellning av nya, farmakologiskt vaerdefulla 1,2-ditiol-3-tion-s-oxidfoereningar Download PDFInfo
- Publication number
- FI88503B FI88503B FI892571A FI892571A FI88503B FI 88503 B FI88503 B FI 88503B FI 892571 A FI892571 A FI 892571A FI 892571 A FI892571 A FI 892571A FI 88503 B FI88503 B FI 88503B
- Authority
- FI
- Finland
- Prior art keywords
- dithiol
- compounds
- thione
- alempaa
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/02—Five-membered rings
- C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Claims (2)
1. Menetelmä yleisen kaavan I mukaisten, lääkitsevästi vaikuttavien 1,2-ditioli-3-tioni-S-oksidiyhdisteiden valmistamiseksi r! X)—===«* R L 1, i w=s-> ° missä kaavassa R1 tarkoittaa alempaa alkyyliä, alempaa alkoksia, hydroksia, halogeenia, trifluorimetyyliä tai nitroa, ja R2 tarkoittaa vetyä, halogeenia tai alempaa alkoksia, tai R1 ja R2 ovat sitoutuneet vierekkäisiin hiiliatomeihin ja tarkoittavat yhdessä alempaa alkyleenidioksia, tunnettu siitä, että yleisen kaavan II r! jQ— pr U— missä Rl ja R2 ovat edellä esitettyjen määritelmien mukaisia, mukaiset 1, 2-ditioli-3-tioniyhdisteet hapetetaan. 20 58503
1. Förfarande för framställning av medicinalt verkaamme 1, 2-ditiol-3-tion-S-oxidföreningar med den allmänna formeln I 'X)~ 1ΓΎ RZ ' L I I w=s^° där R1 betecknar lägre alkyl, lägre alkoxi, hydroxi, halogen, trifluormetyl eller nitro, och Ra betecknar väte, halogen eller lägre alkoxi, eller Rl och Ra är bundna tili närliggande kolatomer och betecknar tillsammans lägre alkylendioxi, kännetecknatav att man oxiderar 1, 2-ditiol-3-tion-föreningar med den allmänna formeln II R1 Χ>-ρτ U— där R1 och Ra betecknar samma som ovan definierats.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP88401304A EP0343303A1 (de) | 1988-05-27 | 1988-05-27 | Neue 1,2-Dithiol-3-thion-S-oxid-Verbindungen enthaltende Arzneimittel |
| EP88401304 | 1988-05-27 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI892571A0 FI892571A0 (fi) | 1989-05-26 |
| FI892571A FI892571A (fi) | 1989-11-28 |
| FI88503B true FI88503B (fi) | 1993-02-15 |
| FI88503C FI88503C (sv) | 1993-05-25 |
Family
ID=8200390
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI892571A FI88503C (sv) | 1988-05-27 | 1989-05-26 | Förfarande för framställning av nya, farmakologiskt värdefulla 1,2-dit iol-3-tion-S-oxidföreningar |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5096920A (sv) |
| EP (2) | EP0343303A1 (sv) |
| JP (1) | JP2718429B2 (sv) |
| KR (1) | KR970011289B1 (sv) |
| CN (2) | CN1027893C (sv) |
| AR (1) | AR247207A1 (sv) |
| AU (1) | AU624141B2 (sv) |
| CA (1) | CA1332609C (sv) |
| DD (1) | DD283820A5 (sv) |
| DE (1) | DE58905106D1 (sv) |
| DK (1) | DK175286B1 (sv) |
| DZ (1) | DZ1340A1 (sv) |
| ES (1) | ES2058386T3 (sv) |
| FI (1) | FI88503C (sv) |
| GR (1) | GR3009107T3 (sv) |
| HU (1) | HU203745B (sv) |
| IE (1) | IE63291B1 (sv) |
| IL (1) | IL90407A0 (sv) |
| NO (1) | NO172579C (sv) |
| NZ (1) | NZ229274A (sv) |
| PT (1) | PT90521B (sv) |
| ZA (1) | ZA893037B (sv) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6437092B1 (en) * | 1998-11-06 | 2002-08-20 | Conjuchem, Inc. | Conjugates of opioids and endogenous carriers |
| KR100484526B1 (ko) * | 2002-11-13 | 2005-04-20 | 씨제이 주식회사 | 티온 유도체, 그 제조방법 및 약제학적 조성물 |
| CN101463030B (zh) * | 2009-01-09 | 2012-03-21 | 福建深纳生物工程有限公司 | 茴三硫的制备方法 |
| CN103012394B (zh) * | 2012-11-19 | 2015-03-25 | 苏州大学 | 一种罗丹宁衍生物及其制备方法 |
| CN102993166B (zh) * | 2012-12-13 | 2015-05-13 | 苏州大学 | 一种3h-1,2-二硫环戊烯-3-硫酮类化合物的制备方法与应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE874447C (de) * | 1944-08-22 | 1953-04-23 | Bruno Dr Boettcher | Verfahren zur Herstellung von 5-Thion-1, 2-dithiolen |
| US2556963A (en) * | 1946-07-15 | 1951-06-12 | Gaudin Olivier | Benzenes containing sulfur in their allylic or propenylic side chains and process of preparing them |
| US2662899A (en) * | 1950-07-29 | 1953-12-15 | Stauffer Chemical Co | Chlorinated cyclic organic trithiocarbonate and process for preparing same |
| US2688620A (en) * | 1951-05-04 | 1954-09-07 | Gaudin Olivier | Trisulfureted heterocyclic compounds |
| US2816116A (en) * | 1954-06-01 | 1957-12-10 | Standard Oil Co | 2-para-t-butyl phenyl trithione |
| US3225062A (en) * | 1963-02-11 | 1965-12-21 | American Cyanamid Co | Process for 1,2-dithiole-3-thiones |
| US3214442A (en) * | 1963-06-26 | 1965-10-26 | American Cyanamid Co | 4, 5-dicyano-1, 3-dithiole-2-thione oxide and its preparation |
| US3847943A (en) * | 1972-09-08 | 1974-11-12 | P Warner | Preparing anethole trithione using sulfolane solvent |
-
1988
- 1988-05-27 EP EP88401304A patent/EP0343303A1/de not_active Withdrawn
-
1989
- 1989-04-21 KR KR1019890005296A patent/KR970011289B1/ko not_active IP Right Cessation
- 1989-04-25 ZA ZA893037A patent/ZA893037B/xx unknown
- 1989-04-28 AR AR89313802A patent/AR247207A1/es active
- 1989-05-10 PT PT90521A patent/PT90521B/pt not_active IP Right Cessation
- 1989-05-21 DZ DZ890078A patent/DZ1340A1/fr active
- 1989-05-22 DD DD89328800A patent/DD283820A5/de unknown
- 1989-05-22 HU HU892514A patent/HU203745B/hu unknown
- 1989-05-23 ES ES89109207T patent/ES2058386T3/es not_active Expired - Lifetime
- 1989-05-23 EP EP89109207A patent/EP0343573B1/de not_active Expired - Lifetime
- 1989-05-23 DE DE8989109207T patent/DE58905106D1/de not_active Expired - Lifetime
- 1989-05-25 NZ NZ229274A patent/NZ229274A/xx unknown
- 1989-05-25 IL IL90407A patent/IL90407A0/xx not_active IP Right Cessation
- 1989-05-26 CN CN89103718A patent/CN1027893C/zh not_active Expired - Fee Related
- 1989-05-26 DK DK198902566A patent/DK175286B1/da not_active IP Right Cessation
- 1989-05-26 JP JP1131700A patent/JP2718429B2/ja not_active Expired - Lifetime
- 1989-05-26 US US07/357,271 patent/US5096920A/en not_active Expired - Lifetime
- 1989-05-26 FI FI892571A patent/FI88503C/sv not_active IP Right Cessation
- 1989-05-26 AU AU35216/89A patent/AU624141B2/en not_active Ceased
- 1989-05-26 NO NO892147A patent/NO172579C/no not_active IP Right Cessation
- 1989-05-29 CA CA000601030A patent/CA1332609C/en not_active Expired - Fee Related
- 1989-06-12 IE IE177789A patent/IE63291B1/en not_active IP Right Cessation
-
1993
- 1993-09-21 GR GR930400136T patent/GR3009107T3/el unknown
-
1994
- 1994-02-09 CN CN94101573A patent/CN1047171C/zh not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Patent granted |
Owner name: SOLVAY PHARMACEUTICALS GMBH |
|
| BB | Publication of examined application | ||
| TC | Name/ company changed in patent |
Owner name: SOLVAY PHARMACEUTICALS GMBH |
|
| FG | Patent granted |
Owner name: SOLVAY PHARMACEUTICALS GMBH |
|
| MA | Patent expired |