FI882505A - Foerfarande foer framstaellning av terapeutiskt anvaendbara alkoxi-substituerade dihydrobensopyran-2-karboxylatderivat. - Google Patents

Foerfarande foer framstaellning av terapeutiskt anvaendbara alkoxi-substituerade dihydrobensopyran-2-karboxylatderivat. Download PDF

Info

Publication number
FI882505A
FI882505A FI882505A FI882505A FI882505A FI 882505 A FI882505 A FI 882505A FI 882505 A FI882505 A FI 882505A FI 882505 A FI882505 A FI 882505A FI 882505 A FI882505 A FI 882505A
Authority
FI
Finland
Prior art keywords
karboxylatderivat
dihydrobensopyran
substituerade
alkoxi
foerfarande foer
Prior art date
Application number
FI882505A
Other languages
English (en)
Finnish (fi)
Other versions
FI882505A0 (fi
Inventor
Stevan Wakefield Djuric
Robert Larry Shone
Stella Siu Tzyy Yu
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of FI882505A0 publication Critical patent/FI882505A0/fi
Publication of FI882505A publication Critical patent/FI882505A/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/66—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/24—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
FI882505A 1987-05-29 1988-05-27 Foerfarande foer framstaellning av terapeutiskt anvaendbara alkoxi-substituerade dihydrobensopyran-2-karboxylatderivat. FI882505A (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5713687A 1987-05-29 1987-05-29
US07/188,708 US4889871A (en) 1987-05-29 1988-05-12 Alkoxy-substituted dihydrobenzopyran-2-carboxylate derivatives

Publications (2)

Publication Number Publication Date
FI882505A0 FI882505A0 (fi) 1988-05-27
FI882505A true FI882505A (fi) 1988-11-30

Family

ID=26736113

Family Applications (1)

Application Number Title Priority Date Filing Date
FI882505A FI882505A (fi) 1987-05-29 1988-05-27 Foerfarande foer framstaellning av terapeutiskt anvaendbara alkoxi-substituerade dihydrobensopyran-2-karboxylatderivat.

Country Status (17)

Country Link
US (1) US4889871A (fr)
EP (1) EP0292977B1 (fr)
JP (1) JP2758902B2 (fr)
KR (1) KR880013914A (fr)
AU (1) AU611153B2 (fr)
CA (1) CA1337660C (fr)
DE (1) DE3864582D1 (fr)
DK (1) DK290188A (fr)
ES (1) ES2051796T3 (fr)
FI (1) FI882505A (fr)
GR (1) GR3003177T3 (fr)
IE (1) IE60687B1 (fr)
IL (1) IL86502A (fr)
NO (1) NO171063C (fr)
NZ (1) NZ224807A (fr)
PH (1) PH26153A (fr)
PT (1) PT87603B (fr)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0300404A3 (fr) * 1987-07-20 1990-07-18 G.D. Searle & Co. Dérivés di- et tétrahydronaphtyliques comme agents anti-allergiques
IL89713A0 (en) * 1988-03-29 1989-09-28 Ciba Geigy Ag Novel alkanophenones
IL89840A (en) * 1988-04-06 1996-10-31 Lipha Substituted flavonoid compounds and salts thereof their preparation and pharmaceutical composition containing them
US5219883A (en) * 1988-05-20 1993-06-15 G. D. Searle & Co. 2,2-di-substituted benzopyran leukotriene-D4 antagonists
US4931574A (en) * 1988-08-23 1990-06-05 Hoffmann-La Roche Inc. Process for the preparation of benzopyrans
WO1990012010A1 (fr) * 1989-04-07 1990-10-18 Pfizer Inc. Chromans substitues pour le traitement de l'asthme, de l'arthrite et de maladies apparentees
US5073562A (en) * 1990-05-10 1991-12-17 G. D. Searle & Co. Alkoxy-substituted dihydrobenzopyran-2-carboxylic acids and derivatives thereof
US5212198A (en) * 1990-05-10 1993-05-18 G. D. Searle & Co. Alkoxy-substituted dihydrobenzopyran-2-carboxylic acids and derivatives thereof
US5192782A (en) * 1990-05-10 1993-03-09 G. D. Searle & Co. Alkoxy-substituted dihydrobenzopyran-2-carboxylic acids and derivatives thereof
US5051438A (en) * 1990-05-16 1991-09-24 G. D. Searle & Co. Alkoxy-substituted dihydrobenzopyran-2-carboxylic acids and derivatives thereof, compositions and use
US5124350A (en) * 1990-06-28 1992-06-23 G. D. Searle & Co. Leukotriene b4 antagonists
FR2665159B1 (fr) * 1990-07-24 1992-11-13 Rhone Poulenc Sante Nouveaux derives de la pyridine et de la quinoleine, leur preparation et les compositions pharmaceutiques qui les contiennent.
JP3334087B2 (ja) * 1990-09-10 2002-10-15 アヴェンティス ファーマシューティカルズ インコーポレイテッド 選択的ロイコトリエンｂ▲４▼拮抗剤活性を示す置換された二環式アリール化合物
US5488160A (en) * 1991-06-11 1996-01-30 Ciba-Geigy Corporation Amidino compounds, their manufacture and method of treatment
US5451700A (en) * 1991-06-11 1995-09-19 Ciba-Geigy Corporation Amidino compounds, their manufacture and methods of treatment
US5273999A (en) * 1991-09-10 1993-12-28 Hoffmann-La Roche Inc. Carboxylic acid leukotriene B4 antagonists
WO1993012783A1 (fr) * 1991-12-27 1993-07-08 Kureha Chemical Industry Co., Ltd. Pommade oleagineuse
US5550152A (en) * 1992-01-23 1996-08-27 Pfizer Inc. Benzopyran and related LTB4 antagonists
RU2124002C1 (ru) * 1992-02-05 1998-12-27 Берингер Ингельхейм КГ Производные амидина, смесь их изомеров или отдельные изомеры и их соли, фармацевтическая композиция, обладающая антагонистическим действием в отношении лейкотриена b4
US5352690A (en) * 1992-07-01 1994-10-04 Eli Lilly And Company 1,2,4-trioxygenated benzene derivatives useful as leukotriene antagonists
JPH0625764A (ja) * 1992-07-08 1994-02-01 Sumitomo Metal Ind Ltd フェロスクラップ中の銅の除去・回収方法
US5324743A (en) * 1992-12-10 1994-06-28 Eli Lilly And Company Leukotriene B4 antagonists
DE4309285A1 (de) * 1993-03-23 1994-09-29 Boehringer Ingelheim Kg Heterocyclen enthaltende Amidinderivate, ihre Herstellung und Verwendung
US5380740A (en) * 1993-04-28 1995-01-10 G. D. Searle & Co. Anti-inflammatory compounds, compositions and method of use thereof
ES2084547B1 (es) * 1993-07-12 1997-01-16 Pfizer Antagonistas benzopiranicos y relacionados de leucotrieno b4.
US5457124A (en) * 1993-12-07 1995-10-10 Hoffmann-La Roche Inc. Carboxylic acid Leukotriene B4 antagonists
WO1995032201A1 (fr) * 1994-05-25 1995-11-30 G.D. Searle & Co. Derives de dihydrobenzopyrane-2-sulfonimides alcoxy-substitues, leur preparation et leur utilisation en tant qu'antagonistes de leucotriene b4
US5516917A (en) * 1994-06-08 1996-05-14 G. D. Searle & Co. Leukotriene B4 antagonists
US5543428A (en) * 1994-08-31 1996-08-06 Eli Lilly And Company Method for treating resistant tumors
EP1129707A3 (fr) * 1994-08-31 2002-02-27 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Procédés d'identification et de traitement de tumeurs résistantes
KR100232340B1 (ko) * 1994-10-13 1999-12-01 디. 제이. 우드, 스피겔 알렌 제이 류코트리엔 b4(ltb4) 길항물질로서의 벤조피란 및 벤조-축합된 화합물
JP2983295B2 (ja) * 1994-10-13 1999-11-29 ファイザー・インコーポレーテッド ベンゾピランおよびベンゾ縮合した化合物、それらの製造方法ならびにロイコトリエンｂ▲下４▼（ｌｔｂ▲下４▼）アンタゴニストとしてのそれらの使用
IL121931A (en) * 1996-10-17 2000-02-17 Pfizer Pharmaceutical compositions for preventing allograft rejection
MXPA01002127A (es) * 1998-08-28 2003-03-27 Biomedicines Inc Metodo para mitigar los efectos adversos de la interleucina-2.
US6436987B1 (en) 2000-06-08 2002-08-20 Pfizer Inc. Crystalline forms of (3S-trans)-2-[3,4-dihydro-4-hydroxy-3-(phenylmethyl)-2H-1-benzopyran-7-yl]-4-(trifluoromethyl)-benzoic acid
JP2004513090A (ja) * 2000-09-27 2004-04-30 メルク　エンド　カムパニー　インコーポレーテッド 糖尿病及び脂質異常症の治療のためのベンゾピランカルボン酸誘導体
AU2002248221B2 (en) 2000-10-31 2006-08-17 Merck & Co., Inc. Benzopyrancarboxylic acid derivatives for the treatment of diabetes and lipid disorders
US20040242676A1 (en) * 2003-05-30 2004-12-02 Alessi Thomas R. Method of mitigating the adverse effects of IL-2
US8093253B2 (en) * 2008-03-06 2012-01-10 Hoffmann-La Roche Inc. Leukotriene B4 inhibitors

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1384530A (en) * 1971-07-29 1975-02-19 Fisons Ltd Chromone derivatives
US4006245A (en) * 1971-07-29 1977-02-01 Fisons Limited Chemical compounds
EP0017332B1 (fr) * 1979-03-20 1985-07-31 FISONS plc Composés hétérocycliques à activité pharmaceutique, procédés pour leur préparation et compositions les contenant
DE3275295D1 (en) * 1981-11-12 1987-03-05 Fisons Plc Anti-srs-a carboxylic acid derivatives, processes for their production, and pharmaceutical formulation containing them
ZA844519B (en) * 1983-06-24 1985-02-27 Hoffmann La Roche Dihydrobenzopyran derivatives
US4665203A (en) * 1983-08-08 1987-05-12 G. D. Searle & Co. Substituted dihydrobenzopyrans useful as leukotriene D4 inhibitors
AU548450B2 (en) * 1983-08-08 1985-12-12 G.D. Searle & Co. Substituted dihydrobenzopyrans
US4565882A (en) * 1984-01-06 1986-01-21 G. D. Searle & Co. Substituted dihydrobenzopyran-2-carboxylates
US4546194A (en) * 1984-05-29 1985-10-08 G. D. Searle & Co. Substituted chromanon-2-yl alkanols and derivatives thereof
EP0205699B1 (fr) * 1985-06-28 1989-03-22 International Business Machines Corporation TRC couleur à masque d'ombre avec résolution et/ou brillance améliorée
ZA873745B (en) * 1986-06-04 1988-10-26 Daiichi Seiyaku Co Benzopyran derivatives
US4885309A (en) * 1986-08-01 1989-12-05 Hoffmann-La Roche Inc. Therapeutic treatment of leukotriene-mediated dermal inflammation by topical administration of 3,4-dihydro-2H-1-benzopyran derivatives

Also Published As

Publication number Publication date
DK290188D0 (da) 1988-05-27
IL86502A0 (en) 1988-11-15
JPS6438045A (en) 1989-02-08
EP0292977A1 (fr) 1988-11-30
NO882317L (no) 1988-11-30
IE881611L (en) 1988-11-29
AU1668188A (en) 1988-12-01
IL86502A (en) 1994-07-31
AU611153B2 (en) 1991-06-06
NO171063C (no) 1993-01-20
NO171063B (no) 1992-10-12
GR3003177T3 (en) 1993-02-17
NO882317D0 (no) 1988-05-26
KR880013914A (ko) 1988-12-22
US4889871A (en) 1989-12-26
JP2758902B2 (ja) 1998-05-28
CA1337660C (fr) 1995-11-28
EP0292977B1 (fr) 1991-09-04
FI882505A0 (fi) 1988-05-27
IE60687B1 (en) 1994-08-10
NZ224807A (en) 1991-03-26
DE3864582D1 (de) 1991-10-10
PH26153A (en) 1992-03-18
ES2051796T3 (es) 1994-07-01
PT87603A (pt) 1988-06-01
DK290188A (da) 1988-11-30
PT87603B (pt) 1992-12-31

Similar Documents

Publication Publication Date Title
FI882505A0 (fi) Foerfarande foer framstaellning av terapeutiskt anvaendbara alkoxi-substituerade dihydrobensopyran-2-karboxylatderivat.
FI881841A0 (fi) Slagborr foer aostadkommande av borrhaol.
FI881201A (fi) Foerfarande foer framstaellning av granulerat byggnadsmaterial av avfall.
FI870360A0 (fi) Nytt foerfarande foer framstaellning av natriumkarboximetylcellulosa.
FI870963A (fi) Foerfarande foer plantering av plantor.
FI870122A0 (fi) Konjugat av biologiska molekyler.
FI871566A0 (fi) Regleringsanordning foer ytbehandlingsanordning av materialbana.
FI871783A (fi) Foerfarande foer avlaegsnande av latenta egenskaper.
FI871153A0 (fi) Anordning foer vertikalkvistning av traed.
FI871007A0 (fi) Anordning foer uppsamling av olja fraon havet.
FI871581A (fi) Anordning foer installering av uppraett taeckdike.
FI870741A0 (fi) Anordning foer utbyte av foerpackningslaoda.
FI871677A0 (fi) Foerfarande foer behandling av problemavfall.
FI871678A0 (fi) Hydrerkrackningskatalyt foer framstaellning av mittendestillat.
FI871797A0 (fi) Foerfarande foer gjutning av skalyta.
FI871519A0 (fi) Foerfarande foer framstaellning av en dryck.
FI872112A0 (fi) Anordning foer tagning av blodprov.
FI871775A0 (fi) Foerfarande foer uppsamling av olja fraon vatten.
FI871803A0 (fi) Anlaeggning foer utforming av en laoda fraon laodaemne.
FI871386A0 (fi) Foerfarande foer framstaellning av kompositprodukter.
FI870635A0 (fi) Foerfarande foer balansering av ramsaog.
FI871008A0 (fi) Anordning foer matning av djur.
FI870396A (fi) Anordning foer foerbaettring av styrning av larvmatta.
FI872030A (fi) Foerfarande foer separering av arabinos.
FI870605A (fi) Foerfarande foer framstaellning av en tryckgivarfiber.

Legal Events

Date Code Title Description
FD Application lapsed
MM Patent lapsed

Owner name: G D SEARLE & CO.