FI880757A - Menetelmä valmistaa terapeuttisesti vaikuttavia tyydytettyjä heterosyklisiä karboksamidijohdoksia - Google Patents
Menetelmä valmistaa terapeuttisesti vaikuttavia tyydytettyjä heterosyklisiä karboksamidijohdoksia Download PDFInfo
- Publication number
- FI880757A FI880757A FI880757A FI880757A FI880757A FI 880757 A FI880757 A FI 880757A FI 880757 A FI880757 A FI 880757A FI 880757 A FI880757 A FI 880757A FI 880757 A FI880757 A FI 880757A
- Authority
- FI
- Finland
- Prior art keywords
- therapeutically active
- saturated heterocyclic
- carboxamide derivatives
- process prepares
- heterocyclic carboxamide
- Prior art date
Links
- 229940053202 antiepileptics carboxamide derivative Drugs 0.000 title 1
- 125000000623 heterocyclic group Chemical group 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62036950 | 1987-02-20 | ||
| JP3695087 | 1987-02-20 | ||
| JP12525987 | 1987-05-21 | ||
| JP12525987 | 1987-05-21 | ||
| JP24949987 | 1987-10-01 | ||
| JP24949987 | 1987-10-01 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI880757A0 FI880757A0 (fi) | 1988-02-18 |
| FI880757A true FI880757A (fi) | 1988-08-21 |
| FI93113B FI93113B (fi) | 1994-11-15 |
| FI93113C FI93113C (fi) | 1995-02-27 |
Family
ID=27289284
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI880757A FI93113C (fi) | 1987-02-20 | 1988-02-18 | Menetelmä valmistaa terapeuttisesti vaikuttavia tyydytettyjä heterosyklisiä karboksamidijohdoksia |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4987132A (fi) |
| EP (1) | EP0279681A3 (fi) |
| CN (1) | CN1030415A (fi) |
| AU (2) | AU618726B2 (fi) |
| DK (1) | DK86688A (fi) |
| FI (1) | FI93113C (fi) |
| HU (1) | HUT50335A (fi) |
| NO (2) | NO880740L (fi) |
Families Citing this family (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0350145A3 (en) * | 1988-04-28 | 1990-07-04 | Yamanouchi Pharmaceutical Co. Ltd. | Pyridylthiazolidine carboxamide derivatives and their intermediates and production of both |
| DE3928144A1 (de) * | 1989-08-25 | 1991-02-28 | Hoechst Ag | Zyklische pyridin-2,4- und -2,5-dicarbonsaeurediamide, verfahren zu deren herstellung sowie deren verwendung |
| US5470851A (en) * | 1990-06-27 | 1995-11-28 | Sankyo Company, Limited | Thiazolidinecarboxylic acid amide derivatives and their therapeutic uses |
| ZA914888B (en) * | 1990-06-27 | 1992-04-29 | Sankyo Co | Thiazolidinecarboxylic acid amide derivatives having antiallergic activity,their preparation and their use |
| US5120749A (en) * | 1991-02-20 | 1992-06-09 | Abbott Laboratories | Platelet activating antagonists |
| WO1992015294A1 (en) * | 1991-03-04 | 1992-09-17 | Center For Innovative Technology | Neolignan derivatives as platelet activating factor receptor antagonists and 5-lipoxygenase inhibitors |
| US5120751A (en) * | 1991-03-29 | 1992-06-09 | Abbott Laboratories | Benzoylphenyl pyridinylthiazolidine compounds as platelet activating antagonists |
| US5149704A (en) * | 1991-05-03 | 1992-09-22 | Abbott Laboratories | Platelet activating antagonists |
| FR2678265B1 (fr) * | 1991-06-27 | 1994-01-14 | Synthelabo | Derives de 4-(2-phenylethyl)piperidine, leur preparation et leur application en therapeutique. |
| EP0524846A1 (fr) * | 1991-06-27 | 1993-01-27 | Synthelabo | Dérivés de 2-(pipéridin-1-y1) éthanol, leur préparation et leur application en thérapeutique |
| NO924963L (no) * | 1991-12-27 | 1993-06-28 | Sankyo Co | Pyridyltiazolidinkarboksylsyreamid-derivater og fremgangsmaate til fremstilling derav |
| GB9200210D0 (en) * | 1992-01-07 | 1992-02-26 | British Bio Technology | Compounds |
| US5530141A (en) * | 1992-03-04 | 1996-06-25 | Center For Innovative Technology | 2,4-diaryl-1,3-dithiolanes; 2,4-diaryl-1,3-dioxolanes; 2,4-diaryl-1,3-oxathiolanes; and 2,5-diaryl-1,3-oxathiolanes for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase |
| US5639782A (en) * | 1992-03-04 | 1997-06-17 | Center For Innovative Technology | Neolignan derivatives as platelet activating factor receptor antagonists and 5-lipoxygenase inhibitors |
| US5700817A (en) * | 1992-06-30 | 1997-12-23 | Pohang Iron & Steel Co., Ltd. | Cyclic lipid derivatives as potent PAF antagonists |
| EP0607374B1 (en) * | 1992-06-30 | 1999-04-07 | Pohang Iron & Steel Co., Ltd. | Novel cyclic lipid derivatives as potent paf antagonists |
| WO1994001403A1 (en) * | 1992-07-08 | 1994-01-20 | Shell Internationale Research Maatschappij B.V. | Piperidine derivatives |
| US5463083A (en) * | 1992-07-13 | 1995-10-31 | Cytomed, Inc. | Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders |
| US5648486A (en) * | 1992-07-13 | 1997-07-15 | Cytomed, Inc. | Compounds and methods for the treatment of inflammatory and immune disorders |
| US5358938A (en) * | 1992-07-13 | 1994-10-25 | Cytomed, Inc. | Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase |
| US5434151A (en) * | 1992-08-24 | 1995-07-18 | Cytomed, Inc. | Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase |
| WO1994001430A1 (en) | 1992-07-13 | 1994-01-20 | Cytomed, Inc. | 2,5-diaryl tetrahydro-thiophenes, -furans and analogs for the treatment of inflammatory and immune disorders |
| EP0656356A1 (en) * | 1992-08-21 | 1995-06-07 | Japan Tobacco Inc. | Dioxacycloalkane compound with renin-inhibiting activity |
| GB9304919D0 (en) * | 1993-03-10 | 1993-04-28 | Celltech Ltd | Chemical compounds |
| US6245774B1 (en) | 1994-06-21 | 2001-06-12 | Celltech Therapeutics Limited | Tri-substituted phenyl or pyridine derivatives |
| US5786354A (en) * | 1994-06-21 | 1998-07-28 | Celltech Therapeutics, Limited | Tri-substituted phenyl derivatives and processes for their preparation |
| GB9412573D0 (en) | 1994-06-22 | 1994-08-10 | Celltech Ltd | Chemical compounds |
| GB9412571D0 (en) | 1994-06-22 | 1994-08-10 | Celltech Ltd | Chemical compounds |
| US5703093A (en) * | 1995-05-31 | 1997-12-30 | Cytomed, Inc. | Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders |
| US5750565A (en) * | 1995-05-25 | 1998-05-12 | Cytomed, Inc. | Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders |
| US5792776A (en) * | 1994-06-27 | 1998-08-11 | Cytomed, Inc., | Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders |
| GB9523675D0 (en) | 1995-11-20 | 1996-01-24 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9622363D0 (en) | 1996-10-28 | 1997-01-08 | Celltech Therapeutics Ltd | Chemical compounds |
| WO1998028281A1 (en) | 1996-12-23 | 1998-07-02 | Celltech Therapeutics Limited | Fused polycyclic 2-aminopyrimidine derivatives, their preparation and their use as protein tyrosine kinase inhibitors |
| GB9705361D0 (en) | 1997-03-14 | 1997-04-30 | Celltech Therapeutics Ltd | Chemical compounds |
| JP2002501518A (ja) * | 1997-05-30 | 2002-01-15 | セルテック セラピューティックス リミテッド | 抗炎症性チロシン誘導体 |
| US6207665B1 (en) | 1997-06-12 | 2001-03-27 | Schering Aktiengesellschaft | Piperazine derivatives and their use as anti-inflammatory agents |
| GB9713087D0 (en) * | 1997-06-20 | 1997-08-27 | Celltech Therapeutics Ltd | Chemical compounds |
| US6329372B1 (en) | 1998-01-27 | 2001-12-11 | Celltech Therapeutics Limited | Phenylalanine derivatives |
| US6555562B1 (en) * | 1998-02-26 | 2003-04-29 | Celltech R&D Limited | Phenylalanine derivatives |
| GB9805655D0 (en) | 1998-03-16 | 1998-05-13 | Celltech Therapeutics Ltd | Chemical compounds |
| US6521626B1 (en) | 1998-03-24 | 2003-02-18 | Celltech R&D Limited | Thiocarboxamide derivatives |
| GB9811159D0 (en) | 1998-05-22 | 1998-07-22 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9811969D0 (en) * | 1998-06-03 | 1998-07-29 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9812088D0 (en) | 1998-06-05 | 1998-08-05 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9814414D0 (en) | 1998-07-03 | 1998-09-02 | Celltech Therapeutics Ltd | Chemical compounds |
| US6184226B1 (en) | 1998-08-28 | 2001-02-06 | Scios Inc. | Quinazoline derivatives as inhibitors of P-38 α |
| GB9821061D0 (en) | 1998-09-28 | 1998-11-18 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9821222D0 (en) | 1998-09-30 | 1998-11-25 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9825652D0 (en) | 1998-11-23 | 1999-01-13 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9826174D0 (en) | 1998-11-30 | 1999-01-20 | Celltech Therapeutics Ltd | Chemical compounds |
| US6518283B1 (en) * | 1999-05-28 | 2003-02-11 | Celltech R&D Limited | Squaric acid derivatives |
| GB9914258D0 (en) | 1999-06-18 | 1999-08-18 | Celltech Therapeutics Ltd | Chemical compounds |
| US6534513B1 (en) | 1999-09-29 | 2003-03-18 | Celltech R&D Limited | Phenylalkanoic acid derivatives |
| GB9924862D0 (en) * | 1999-10-20 | 1999-12-22 | Celltech Therapeutics Ltd | Chemical compounds |
| US6455539B2 (en) | 1999-12-23 | 2002-09-24 | Celltech R&D Limited | Squaric acid derivates |
| WO2001079173A2 (en) | 2000-04-17 | 2001-10-25 | Celltech R & D Limited | Enamine derivatives as cell adhesion molecules |
| US6403608B1 (en) | 2000-05-30 | 2002-06-11 | Celltech R&D, Ltd. | 3-Substituted isoquinolin-1-yl derivatives |
| US6545013B2 (en) | 2000-05-30 | 2003-04-08 | Celltech R&D Limited | 2,7-naphthyridine derivatives |
| EP1301488A1 (en) | 2000-07-07 | 2003-04-16 | Celltech R&D Limited | Squaric acid derivatives containing a bicyclic heteroaromatic ring as integrin antagonists |
| CA2417059A1 (en) | 2000-08-02 | 2002-02-07 | Celltech R&D Limited | 3-substituted isoquinolin-1-yl derivatives |
| WO2002096888A1 (de) * | 2001-05-29 | 2002-12-05 | Schering Aktiengesellschaft | Cdk inhibitorische pyrimidine, deren herstellung und verwendung als arzneimittel |
| PT1567490E (pt) * | 2002-12-04 | 2011-12-09 | Univ Virginia Commonwealth | Agentes contra a falciformação |
| AU2004218115A1 (en) | 2003-03-07 | 2004-09-16 | Astellas Pharma Inc. | Nitrogenous heterocyclic derivative having 2,6-disubstituted styryl |
| CN1902184A (zh) | 2003-11-18 | 2007-01-24 | 田纳西大学研究基金会 | 噻唑烷酮酰胺、噻唑烷羧酸酰胺、其制备方法及其用途 |
| US7119208B2 (en) * | 2003-12-03 | 2006-10-10 | Virginia Commonwealth University | Anti-sickling agents |
| JP2007521339A (ja) * | 2004-02-06 | 2007-08-02 | バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト | ケモカイン阻害性ピペラジン誘導体、及び多発性骨髄腫を治療するためのそれらの使用 |
| UY30892A1 (es) * | 2007-02-07 | 2008-09-02 | Smithkline Beckman Corp | Inhibidores de la actividad akt |
| US9029408B2 (en) | 2008-06-16 | 2015-05-12 | Gtx, Inc. | Compounds for treatment of cancer |
| US9447049B2 (en) | 2010-03-01 | 2016-09-20 | University Of Tennessee Research Foundation | Compounds for treatment of cancer |
| US8822513B2 (en) | 2010-03-01 | 2014-09-02 | Gtx, Inc. | Compounds for treatment of cancer |
| PT2959900T (pt) | 2008-06-16 | 2017-06-22 | Univ Tennessee Res Found | Composto para tratamento do cancro |
| PE20120003A1 (es) * | 2009-01-30 | 2012-02-12 | Glaxosmithkline Llc | Hidrocloruro de n-{(1s)-2-amino-1-[(3-fluorofenil)metil)etil}-5-cloro-4-(4-cloro-1-metil-1h-pirazol-5-il)-2-tiofenocarboxamida cristalino |
| CN102883607B (zh) | 2010-03-01 | 2015-07-22 | Gtx公司 | 用于治疗癌的化合物 |
| CN104529942B (zh) * | 2014-12-10 | 2018-05-15 | 天津孚音生物科技发展有限公司 | 一种伐诺司林的合成方法 |
| EP3793999A4 (en) | 2018-05-17 | 2021-11-03 | Bionomics Limited | PAIN TREATMENT COMPOUNDS AND THEIR USES |
| CN111057735B (zh) * | 2020-01-06 | 2021-10-15 | 浙江工业大学 | 一种解淀粉芽孢杆菌酯酶在拆分N-BOC-DL-α-氨基丁酸甲酯中的应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3592905A (en) | 1969-10-30 | 1971-07-13 | Merck & Co Inc | Therapeutic methods |
| FR2356423A1 (fr) | 1976-07-01 | 1978-01-27 | Oeriu Simion | Derives de l'acide thiazolidinecarboxylique, leur preparation et leur application comme medicaments |
| US4430344A (en) * | 1978-04-08 | 1984-02-07 | Santen Pharmaceutical Co., Ltd. | Antihypertensive 4-thiazolidinecarboxylic acids |
| DE3170401D1 (en) * | 1980-07-28 | 1985-06-13 | Ciba Geigy Ag | Triazoline derivatives and processes for their preparation |
| FR2541280B1 (fr) * | 1983-01-13 | 1985-06-21 | Rhone Poulenc Sante | Nouveaux derives du 1h, 3h-pyrrolo (1,2c) thiazolecarboxamide-7, leur preparation et les medicaments qui les contiennent |
| JPS6090012A (ja) * | 1983-10-24 | 1985-05-21 | Nippon Mining Co Ltd | 濾過装置 |
| US4656190A (en) | 1983-11-14 | 1987-04-07 | Merck & Co., Inc. | Indene derivatives and their use as PAF-antagonists |
| GB8418424D0 (en) | 1984-07-19 | 1984-08-22 | Scras | Inhibition of platelets aggregation |
| EP0178261A3 (en) | 1984-10-10 | 1986-12-30 | Sandoz Ag | Substituted 2-furanyl or 5-oxo-2-furanyl-alkoxy phosphoryl alkyl cyclimmonium salts |
| HU200177B (en) * | 1985-06-18 | 1990-04-28 | Biogal Gyogyszergyar | Process for producing thiazolidinecarboxylic acids and pharmaceutical compositions comprising such compounds |
| US4621038A (en) | 1985-06-24 | 1986-11-04 | Xerox Corporation | Photoconductive imaging members with novel symmetrical fluorinated squaraine compounds |
| DE3531498A1 (de) * | 1985-09-04 | 1987-03-05 | Bayer Ag | Dihydropyridin-2-hydroxyamine, verfahren zur herstellung und ihre verwendung in arzneimitteln |
| IT1196485B (it) * | 1986-07-14 | 1988-11-16 | Zambon Spa | Derivati dell'acido tiazolidin-4-carbossilico ad attivita' farmaceutica |
| JPS63225373A (ja) * | 1986-07-24 | 1988-09-20 | Sumitomo Pharmaceut Co Ltd | 新規チアゾリジン−４−オン誘導体およびその酸付加塩 |
| DE3635744A1 (de) * | 1986-10-21 | 1988-04-28 | Bayer Ag | Substituierte aminoketale |
-
1988
- 1988-02-16 CN CN88100590.8A patent/CN1030415A/zh not_active Withdrawn
- 1988-02-18 FI FI880757A patent/FI93113C/fi not_active IP Right Cessation
- 1988-02-19 EP EP88301397A patent/EP0279681A3/en not_active Withdrawn
- 1988-02-19 HU HU88811A patent/HUT50335A/hu unknown
- 1988-02-19 NO NO880740A patent/NO880740L/no unknown
- 1988-02-19 DK DK086688A patent/DK86688A/da not_active Application Discontinuation
- 1988-02-22 AU AU12080/88A patent/AU618726B2/en not_active Ceased
- 1988-08-16 US US07/232,899 patent/US4987132A/en not_active Expired - Fee Related
-
1992
- 1992-04-01 AU AU14013/92A patent/AU646156B2/en not_active Ceased
-
1993
- 1993-12-08 NO NO934470A patent/NO934470D0/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU1208088A (en) | 1988-08-25 |
| EP0279681A3 (en) | 1989-11-15 |
| FI93113C (fi) | 1995-02-27 |
| DK86688A (da) | 1988-08-22 |
| US4987132A (en) | 1991-01-22 |
| AU1401392A (en) | 1992-06-25 |
| EP0279681A2 (en) | 1988-08-24 |
| FI880757A0 (fi) | 1988-02-18 |
| AU618726B2 (en) | 1992-01-09 |
| CN1030415A (zh) | 1989-01-18 |
| FI93113B (fi) | 1994-11-15 |
| DK86688D0 (da) | 1988-02-19 |
| NO880740D0 (no) | 1988-02-19 |
| NO880740L (no) | 1988-08-22 |
| NO934470D0 (no) | 1993-12-08 |
| AU646156B2 (en) | 1994-02-10 |
| NO934470L (no) | 1988-08-22 |
| HUT50335A (en) | 1990-01-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB | Publication of examined application | ||
| MM | Patent lapsed | ||
| MM | Patent lapsed |
Owner name: YAMANOUCHI PHARMACEUTICAL CO., LTD. |