FI86744B - Foerfarande foer framstaellning av eglinfoereningar. - Google Patents

Foerfarande foer framstaellning av eglinfoereningar. Download PDF

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Publication number
FI86744B
FI86744B FI844545A FI844545A FI86744B FI 86744 B FI86744 B FI 86744B FI 844545 A FI844545 A FI 844545A FI 844545 A FI844545 A FI 844545A FI 86744 B FI86744 B FI 86744B
Authority
FI
Finland
Prior art keywords
eglin
dna
solution
coli
sequence
Prior art date
Application number
FI844545A
Other languages
English (en)
Finnish (fi)
Other versions
FI844545L (fi
FI86744C (sv
FI844545A0 (fi
Inventor
Francois Meyer
Manfred Liersch
Hans Rink
Sefik Alkan
Walter Maerki
Peter Sieber
Werner Rittel
Ursula Seemueller
Hans Fritz
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of FI844545A0 publication Critical patent/FI844545A0/fi
Publication of FI844545L publication Critical patent/FI844545L/fi
Application granted granted Critical
Publication of FI86744B publication Critical patent/FI86744B/fi
Publication of FI86744C publication Critical patent/FI86744C/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/38—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Claims (3)

1. Förfarande för f raitista lining av en eglinförening med formeln XIV' VGluPheGlySerGluLeuLysSerPheProGluValValGlyLysThrValAspGlnAlaArgGlu T y rPheThrLeuHi sTyrProGlnTyrAspValWPheLeuProGluGlySer Pr oValThrLeuAsp LeuArgTyrAsnArgValArgValPheTyrAsnProGlyThrAsnValValAsnHisValProHis ValGly (XIV), i vilken formel V är Thr eller N-acetyl-Thr och W är Tyr eller His, och salter därav, kännetecknat därav, att en Escherichia coli- eller Saccharomvces cere-visiae-stam. som är transformerad med en expressionsplas-mid, som innehäller en DNA-sekvens, som kodar för eglin och är reglerad med en expressionskontrollsekvens, odlas i ett sädant växtmedium, som innehäller assimilerbara koi- och kvävekällar, och den nämnda eglinföreningen fri-görs frän mikro-organismceller och isoleras, och vid be-hov, en enligt förfarandet erhällen blandning av förenin-gar med formeln XIV avskiljes tili enskilda komponenter, och/eller ett erhället sait överföres i en fri polypeptid eller en erhällen polypeptid överföres i ett sait därav.
2. Förfarande enligt patentkravet 1, kännetecknat därav, att man framställer eglin C.
3. Förfarande enligt patentkravet 1, kännetecknat därav, att man framställer Na-acetyl-eglin C.
FI844545A 1983-11-21 1984-11-19 Förfarande för framställning av eglinföreningar FI86744C (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH642283 1983-11-21
CH642283 1983-11-21
CH186384 1984-04-13
CH186384 1984-04-13

Publications (4)

Publication Number Publication Date
FI844545A0 FI844545A0 (fi) 1984-11-19
FI844545L FI844545L (fi) 1985-05-22
FI86744B true FI86744B (fi) 1992-06-30
FI86744C FI86744C (sv) 1992-10-12

Family

ID=25688872

Family Applications (1)

Application Number Title Priority Date Filing Date
FI844545A FI86744C (sv) 1983-11-21 1984-11-19 Förfarande för framställning av eglinföreningar

Country Status (17)

Country Link
US (1) US20020142414A1 (sv)
EP (1) EP0146785B1 (sv)
JP (1) JPH0730119B2 (sv)
KR (1) KR850004791A (sv)
AR (1) AR241800A1 (sv)
CA (1) CA1297437C (sv)
DE (1) DE3481320D1 (sv)
DK (1) DK550984A (sv)
ES (1) ES8608580A1 (sv)
FI (1) FI86744C (sv)
GR (1) GR80965B (sv)
HU (1) HU203784B (sv)
IE (1) IE57895B1 (sv)
IL (1) IL73569A (sv)
NO (1) NO172547C (sv)
NZ (1) NZ210267A (sv)
PT (1) PT79519B (sv)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61152695A (ja) * 1984-12-26 1986-07-11 Nippon Shinyaku Co Ltd 長鎖ｄｎａの合成法
JPS6339414U (sv) * 1986-08-29 1988-03-14
EP0263072B1 (en) 1986-10-03 1994-03-23 Ciba-Geigy Ag Novel lymphokine related peptides
US5180667A (en) * 1988-03-07 1993-01-19 Ciba-Geigy Corporation Genes encoding eglin C mutants
EP0332576B1 (de) * 1988-03-07 1994-04-06 Ciba-Geigy Ag Modifizierte Proteine
DE3939801A1 (de) * 1989-12-01 1991-06-06 Basf Ag Neue proteine und ihre herstellung
US5604201A (en) * 1993-01-08 1997-02-18 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University, A Non-Profit Organization Methods and reagents for inhibiting furin endoprotease
JP2013192526A (ja) * 2012-03-22 2013-09-30 Sanyo Chem Ind Ltd タンパク質溶液、このタンパク質溶液のプロテアーゼ活性の回復方法及びこのタンパク質溶液を含有する洗剤組成物
CN108456708A (zh) * 2018-06-20 2018-08-28 齐齐哈尔龙江阜丰生物科技有限公司 一种发酵制备苏氨酸的培养基
EP4225337A1 (en) * 2020-10-06 2023-08-16 Mayo Foundation for Medical Education and Research Methods and materials for treating gastrointestinal disorders
US11187700B1 (en) * 2021-01-28 2021-11-30 Eckhard Kemmann Closed system for enlarging viral and bacterial particles for identification by diffraction scanning

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2808396C2 (de) * 1978-02-27 1984-04-19 Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn Protease-Inhibitoren

Also Published As

Publication number Publication date
DE3481320D1 (de) 1990-03-15
KR850004791A (ko) 1985-07-27
JPH0730119B2 (ja) 1995-04-05
EP0146785A1 (de) 1985-07-03
ES537829A0 (es) 1986-06-16
NO844617L (no) 1985-05-22
PT79519B (en) 1986-12-11
PT79519A (en) 1984-12-01
IE842966L (en) 1985-05-21
NZ210267A (en) 1988-11-29
FI844545L (fi) 1985-05-22
FI86744C (sv) 1992-10-12
NO172547C (no) 1993-08-04
AU3571884A (en) 1985-05-30
IL73569A (en) 1991-05-12
US20020142414A1 (en) 2002-10-03
CA1297437C (en) 1992-03-17
DK550984D0 (da) 1984-11-20
JPS60192592A (ja) 1985-10-01
NO172547B (no) 1993-04-26
IE57895B1 (en) 1993-05-05
FI844545A0 (fi) 1984-11-19
DK550984A (da) 1985-05-22
HUT36864A (en) 1985-10-28
GR80965B (en) 1985-03-20
ES8608580A1 (es) 1986-06-16
AR241800A1 (es) 1992-12-30
AU596347B2 (en) 1990-05-03
HU203784B (en) 1991-09-30
EP0146785B1 (de) 1990-02-07
IL73569A0 (en) 1985-02-28

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Owner name: NOVARTIS AG

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Owner name: NOVARTIS AG