FI86690C - Foerfarande foer framstaellning av oxazafosforinloesningar - Google Patents

Foerfarande foer framstaellning av oxazafosforinloesningar Download PDF

Info

Publication number
FI86690C
FI86690C FI873064A FI873064A FI86690C FI 86690 C FI86690 C FI 86690C FI 873064 A FI873064 A FI 873064A FI 873064 A FI873064 A FI 873064A FI 86690 C FI86690 C FI 86690C
Authority
FI
Finland
Prior art keywords
solutions
ethanol
framework
cyclophosphamide
oxazaphosphorines
Prior art date
Application number
FI873064A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI873064L (fi
FI86690B (fi
FI873064A0 (fi
Inventor
Otto Isaac
Dieter Sauerbier
Klaus Molge
Werner Weigert
Original Assignee
Asta Medica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Medica Ag filed Critical Asta Medica Ag
Publication of FI873064A0 publication Critical patent/FI873064A0/fi
Publication of FI873064L publication Critical patent/FI873064L/fi
Application granted granted Critical
Publication of FI86690B publication Critical patent/FI86690B/fi
Publication of FI86690C publication Critical patent/FI86690C/fi

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Detergent Compositions (AREA)
  • Cosmetics (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Paper (AREA)
  • Carbon And Carbon Compounds (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Inks, Pencil-Leads, Or Crayons (AREA)
FI873064A 1986-07-11 1987-07-10 Foerfarande foer framstaellning av oxazafosforinloesningar FI86690C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3623369 1986-07-11
DE3623369 1986-07-11

Publications (4)

Publication Number Publication Date
FI873064A0 FI873064A0 (fi) 1987-07-10
FI873064L FI873064L (fi) 1988-01-12
FI86690B FI86690B (fi) 1992-06-30
FI86690C true FI86690C (fi) 1992-10-12

Family

ID=6304930

Family Applications (1)

Application Number Title Priority Date Filing Date
FI873064A FI86690C (fi) 1986-07-11 1987-07-10 Foerfarande foer framstaellning av oxazafosforinloesningar

Country Status (16)

Country Link
US (1) US4952575A (enExample)
EP (1) EP0254902B1 (enExample)
JP (1) JPS6323888A (enExample)
KR (1) KR880001282A (enExample)
AT (1) ATE66609T1 (enExample)
AU (1) AU598282B2 (enExample)
CA (1) CA1289886C (enExample)
DE (2) DE3772482D1 (enExample)
DK (1) DK168322B1 (enExample)
ES (1) ES2038623T3 (enExample)
FI (1) FI86690C (enExample)
GR (1) GR3002618T3 (enExample)
IE (1) IE59897B1 (enExample)
IL (1) IL83141A (enExample)
PT (1) PT85293B (enExample)
ZA (1) ZA875059B (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5051257A (en) * 1989-05-09 1991-09-24 Pietronigro Dennis D Antineoplastic solution and method for treating neoplasms
RO113611B1 (ro) * 1990-08-03 1998-09-30 Asta Pharma Ag Preparate solide de ifosfamida, administrate oral si procedeu de obtinere
US5227373A (en) * 1991-10-23 1993-07-13 Bristol-Myers Squibb Co. Lyophilized ifosfamide compositions
DE59813853D1 (de) * 1997-10-13 2007-02-01 Stada Arzneimittel Ag Flüssige darreichungsformen oxazaphosphorinhaltiger pharmazeutischer produkte
US7205404B1 (en) * 1999-03-05 2007-04-17 Metabasis Therapeutics, Inc. Phosphorus-containing prodrugs
AUPQ849900A0 (en) * 2000-06-30 2000-07-27 Dbl Australia Pty Ltd. Injectable composition
US6613927B1 (en) 2002-02-08 2003-09-02 American Pharmaceutical Partners, Inc. Sterile lyophilized ifosfamide and associated methods
CN1694713A (zh) * 2002-09-05 2005-11-09 印度血清及疫苗有限公司 oxazaphosphorine和美司钠的液态稳定组合物
US7199111B2 (en) * 2002-12-02 2007-04-03 Bharat Serums & Vaccines Ltd. Aqueous ifosfamide compositions for parenteral administration and a process for their preparations
CA2580202A1 (en) * 2004-09-13 2006-03-23 Bharat Serums & Vaccines Ltd. Stable emulsion compositions for intravenous administration having antimicrobial preservative efficacy
US10449210B2 (en) 2014-02-13 2019-10-22 Ligand Pharmaceuticals Inc. Prodrug compounds and their uses
CN106456654A (zh) * 2014-05-09 2017-02-22 奥罗医学制药有限公司 环磷酰胺液体浓缩制剂
US9994600B2 (en) 2014-07-02 2018-06-12 Ligand Pharmaceuticals, Inc. Prodrug compounds and uses therof
US10849916B2 (en) 2014-07-11 2020-12-01 Dr. Reddys Laboratories Limited Stable liquid formulations of cyclophosphamide and its impurities
WO2016005962A2 (en) 2014-07-11 2016-01-14 Dr. Reddy’S Laboratories Limited Stable liquid formulations of cyclophosphamide and processes
US10993952B2 (en) * 2015-02-16 2021-05-04 Leiutis Pharmaceuticals Pvt. Ltd. Stable ready to use cyclophosphamide liquid formulations
RU2020126177A (ru) 2018-01-09 2022-02-10 Лиганд Фармасьютикалз, Инк. Ацетальные соединения и их терапевтическое применение
WO2022038072A1 (en) * 2020-08-17 2022-02-24 Sandoz Ag Parenteral pharmaceutical composition comprising cyclophosphamide and a mixture of liquids

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3530147A1 (de) * 1985-08-23 1987-02-26 Bayer Ag Verwendung von diazaphosphorinen zur bekaempfung von endoparasiten

Also Published As

Publication number Publication date
PT85293B (pt) 1990-03-30
EP0254902A3 (en) 1988-08-03
AU7554987A (en) 1988-01-14
PT85293A (de) 1987-08-01
JPS6323888A (ja) 1988-02-01
GR3002618T3 (en) 1993-01-25
CA1289886C (en) 1991-10-01
IL83141A0 (en) 1987-12-31
AU598282B2 (en) 1990-06-21
DE3772482D1 (de) 1991-10-02
EP0254902B1 (de) 1991-08-28
FI873064L (fi) 1988-01-12
DK359387D0 (da) 1987-07-10
IL83141A (en) 1992-11-15
FI86690B (fi) 1992-06-30
DE3722043A1 (de) 1988-01-14
FI873064A0 (fi) 1987-07-10
ES2038623T3 (es) 1993-08-01
KR880001282A (ko) 1988-04-22
DK168322B1 (da) 1994-03-14
IE871867L (en) 1988-01-11
EP0254902A2 (de) 1988-02-03
DK359387A (da) 1988-01-12
IE59897B1 (en) 1994-04-20
US4952575A (en) 1990-08-28
ATE66609T1 (de) 1991-09-15
ZA875059B (en) 1988-02-24
JPH0543711B2 (enExample) 1993-07-02

Similar Documents

Publication Publication Date Title
FI86690C (fi) Foerfarande foer framstaellning av oxazafosforinloesningar
EP0546018A1 (en) FLORFENICOL CONTAINING MEDICINAL PRODUCT.
JPS61165322A (ja) スパガリン類の注射用凍結乾燥製剤
EP0055029B1 (en) Preparations for the treatment of dermatoses
KR20010078754A (ko) 통증 경감 방법 및 통증 경감용 경피 조성물
US3265573A (en) Benzothiadiazinesulfonamide-1, 1-dioxide composition
US4654345A (en) Occular formulation comprising bromocriptine
DK167559B1 (da) Buprenorphinholdigt farmaceutisk suppositorium
JP4850426B2 (ja) 安定な高濃度エダラボン注射液
KR100251395B1 (ko) 피소스티그민 유도체와 이의 용도 및 이를 함유한 제약적 조제물
IE63156B1 (en) Dry substances and stable suspensions
US4157391A (en) Cholesterol derivative-based medicaments acting on bio-protective mechanisms
DE69422637T2 (de) Transdermale zusammensetzung von n-(n-(5-(4-(aminoiminomethyl)phenyl-1-oxopentyl)-l-alpha-aspartyl)-l-phenylalanin oder deren esterderivaten und ihre pharmazeutischverwendbaren salze
GB2029700A (en) Etomidate-containing compositions
US4594243A (en) Base composition for medicament and pharmaceutical composition for external medication
WO2007009355A1 (fr) Injection de paclitaxel et sa méthode de préparation
US4301175A (en) E-Type prostaglandin compositions
EP0419890A2 (en) Stable pharmaceutical formulations for antineoplastic compounds having more than one ethyleneimine group, and method
JP3103535B2 (ja) カルシトニン類のプレフィルドシリンジ製剤
AT390881B (de) Verfahren zur herstellung von pharmazeutischen loesungen von oxazaphosphorinen mit verbesserter stabilitaet
UA73961C2 (uk) Використання треосульфану для підготовки пацієнтів перед трансплантацією кісткового мозку або стовбурових клітин крові
KR100228752B1 (ko) 난용성 약물인 비페닐디메틸디카르복실레이트를 주성분으로 함유하는 액제 및 그 제조방법
JPS632926A (ja) 安定な、注射可能な制吐性組成物
EP0272849B1 (en) Use of 2-oxo-imidazolidine derivatives in the treatment of kidney diseases
US3923805A (en) Propoxyphene derivative

Legal Events

Date Code Title Description
FG Patent granted

Owner name: ASTA MEDICA AKTIENGESELLSCHAFT

MA Patent expired