AU598282B2 - Solutions of oxazaphosphorins having improved stability and process for the preparation thereof - Google Patents

Solutions of oxazaphosphorins having improved stability and process for the preparation thereof Download PDF

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Publication number
AU598282B2
AU598282B2 AU75549/87A AU7554987A AU598282B2 AU 598282 B2 AU598282 B2 AU 598282B2 AU 75549/87 A AU75549/87 A AU 75549/87A AU 7554987 A AU7554987 A AU 7554987A AU 598282 B2 AU598282 B2 AU 598282B2
Authority
AU
Australia
Prior art keywords
oxazaphosphorin
solution
solutions
preparation
ethanol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU75549/87A
Other languages
English (en)
Other versions
AU7554987A (en
Inventor
Otto Dr. Isaac
Klaus Dr. Molge
Klaus Sauerbier
Werner Dr. Weigert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asta Medica GmbH
Original Assignee
Asta Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Pharma AG filed Critical Asta Pharma AG
Publication of AU7554987A publication Critical patent/AU7554987A/en
Application granted granted Critical
Publication of AU598282B2 publication Critical patent/AU598282B2/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Detergent Compositions (AREA)
  • Cosmetics (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Paper (AREA)
  • Carbon And Carbon Compounds (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Inks, Pencil-Leads, Or Crayons (AREA)
AU75549/87A 1986-07-11 1987-07-10 Solutions of oxazaphosphorins having improved stability and process for the preparation thereof Expired AU598282B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3623369 1986-07-11
DE3623369 1986-07-11

Publications (2)

Publication Number Publication Date
AU7554987A AU7554987A (en) 1988-01-14
AU598282B2 true AU598282B2 (en) 1990-06-21

Family

ID=6304930

Family Applications (1)

Application Number Title Priority Date Filing Date
AU75549/87A Expired AU598282B2 (en) 1986-07-11 1987-07-10 Solutions of oxazaphosphorins having improved stability and process for the preparation thereof

Country Status (16)

Country Link
US (1) US4952575A (enExample)
EP (1) EP0254902B1 (enExample)
JP (1) JPS6323888A (enExample)
KR (1) KR880001282A (enExample)
AT (1) ATE66609T1 (enExample)
AU (1) AU598282B2 (enExample)
CA (1) CA1289886C (enExample)
DE (2) DE3722043A1 (enExample)
DK (1) DK168322B1 (enExample)
ES (1) ES2038623T3 (enExample)
FI (1) FI86690C (enExample)
GR (1) GR3002618T3 (enExample)
IE (1) IE59897B1 (enExample)
IL (1) IL83141A (enExample)
PT (1) PT85293B (enExample)
ZA (1) ZA875059B (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5051257A (en) * 1989-05-09 1991-09-24 Pietronigro Dennis D Antineoplastic solution and method for treating neoplasms
RO113611B1 (ro) * 1990-08-03 1998-09-30 Asta Pharma Ag Preparate solide de ifosfamida, administrate oral si procedeu de obtinere
US5227373A (en) * 1991-10-23 1993-07-13 Bristol-Myers Squibb Co. Lyophilized ifosfamide compositions
WO1999018973A2 (de) * 1997-10-13 1999-04-22 Stada Arzneimittel Ag Flüssige darreichungsformen oxazaphosphorinhaltiger pharmazeutischer produkte
US7205404B1 (en) * 1999-03-05 2007-04-17 Metabasis Therapeutics, Inc. Phosphorus-containing prodrugs
AUPQ849900A0 (en) * 2000-06-30 2000-07-27 Dbl Australia Pty Ltd. Injectable composition
US6613927B1 (en) 2002-02-08 2003-09-02 American Pharmaceutical Partners, Inc. Sterile lyophilized ifosfamide and associated methods
EA008776B1 (ru) * 2002-09-05 2007-08-31 Бхарат Сирумс Энд Вэксинс Лтд. Жидкая стабильная композиция оксазафосфорина с месной
US7199111B2 (en) * 2002-12-02 2007-04-03 Bharat Serums & Vaccines Ltd. Aqueous ifosfamide compositions for parenteral administration and a process for their preparations
CA2580202A1 (en) * 2004-09-13 2006-03-23 Bharat Serums & Vaccines Ltd. Stable emulsion compositions for intravenous administration having antimicrobial preservative efficacy
EP3623364A1 (en) 2014-02-13 2020-03-18 Ligand Pharmaceuticals, Inc. Prodrug compounds and their uses
US20150320774A1 (en) * 2014-05-09 2015-11-12 AuroMedics Pharma LLC Formulations of cyclophosphamide liquid concentrate
CN106687118A (zh) 2014-07-02 2017-05-17 配体药物公司 前药化合物及其用途
WO2016005962A2 (en) 2014-07-11 2016-01-14 Dr. Reddy’S Laboratories Limited Stable liquid formulations of cyclophosphamide and processes
US10849916B2 (en) 2014-07-11 2020-12-01 Dr. Reddys Laboratories Limited Stable liquid formulations of cyclophosphamide and its impurities
US10993952B2 (en) 2015-02-16 2021-05-04 Leiutis Pharmaceuticals Pvt. Ltd. Stable ready to use cyclophosphamide liquid formulations
WO2019139919A1 (en) 2018-01-09 2019-07-18 Ligand Pharmaceuticals, Inc. Acetal compounds and therapeutic uses thereof
US20230310468A1 (en) * 2020-08-17 2023-10-05 Sandoz Ag Parenteral pharmaceutical composition comprising cyclophosphamide and a mixture of liquids

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3530147A1 (de) * 1985-08-23 1987-02-26 Bayer Ag Verwendung von diazaphosphorinen zur bekaempfung von endoparasiten

Also Published As

Publication number Publication date
DK168322B1 (da) 1994-03-14
GR3002618T3 (en) 1993-01-25
DK359387A (da) 1988-01-12
EP0254902A2 (de) 1988-02-03
DK359387D0 (da) 1987-07-10
ES2038623T3 (es) 1993-08-01
KR880001282A (ko) 1988-04-22
FI86690B (fi) 1992-06-30
FI86690C (fi) 1992-10-12
PT85293B (pt) 1990-03-30
IL83141A (en) 1992-11-15
ATE66609T1 (de) 1991-09-15
IL83141A0 (en) 1987-12-31
DE3772482D1 (de) 1991-10-02
FI873064A0 (fi) 1987-07-10
FI873064L (fi) 1988-01-12
EP0254902A3 (en) 1988-08-03
US4952575A (en) 1990-08-28
AU7554987A (en) 1988-01-14
IE59897B1 (en) 1994-04-20
ZA875059B (en) 1988-02-24
JPH0543711B2 (enExample) 1993-07-02
IE871867L (en) 1988-01-11
JPS6323888A (ja) 1988-02-01
DE3722043A1 (de) 1988-01-14
CA1289886C (en) 1991-10-01
PT85293A (de) 1987-08-01
EP0254902B1 (de) 1991-08-28

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