WO2007009355A1 - Injection de paclitaxel et sa méthode de préparation - Google Patents

Injection de paclitaxel et sa méthode de préparation Download PDF

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Publication number
WO2007009355A1
WO2007009355A1 PCT/CN2006/001665 CN2006001665W WO2007009355A1 WO 2007009355 A1 WO2007009355 A1 WO 2007009355A1 CN 2006001665 W CN2006001665 W CN 2006001665W WO 2007009355 A1 WO2007009355 A1 WO 2007009355A1
Authority
WO
WIPO (PCT)
Prior art keywords
paclitaxel
injection
preparation
stabilizer
solvent
Prior art date
Application number
PCT/CN2006/001665
Other languages
English (en)
Chinese (zh)
Inventor
Jianming Chen
Baoan Gao
Zundong Huang
Haisheng Chen
Qin Xiao
Chengan Huang
Original Assignee
Holley Pharmaceuticals Co. Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Holley Pharmaceuticals Co. Ltd. filed Critical Holley Pharmaceuticals Co. Ltd.
Publication of WO2007009355A1 publication Critical patent/WO2007009355A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid

Abstract

L’invention concerne une injection de paclitaxel et sa méthode de préparation. Ladite injection de paclitaxel consiste en du paclitaxel 0,01-2 % (p/v) et du stabilisateur 1-70%(p/v), le reste étant du solvant pour injection, le stabilisateur étant un ou plusieurs agents sélectionnés à partir du phospholipide de graine de soja, du phospholipide de jaune d'oeuf, de Tween-80, du cholestérol, du cholate de sodium, de Poloxamer 188 et de la monooléine. Elle se prépare comme suit : dissoudre le stabilisateur dans ledit solvant par agitation thermique ou ultrasonique, ajouter le paclitaxel, agiter, filtrer, charger dans des contenants et stériliser. Elle a un faible effet secondaire toxique et est stable.
PCT/CN2006/001665 2005-07-20 2006-07-13 Injection de paclitaxel et sa méthode de préparation WO2007009355A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CNA2005100279133A CN1723887A (zh) 2005-07-20 2005-07-20 一种紫杉醇注射剂及其制备方法
CN200510027913.3 2005-07-20

Publications (1)

Publication Number Publication Date
WO2007009355A1 true WO2007009355A1 (fr) 2007-01-25

Family

ID=35923602

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2006/001665 WO2007009355A1 (fr) 2005-07-20 2006-07-13 Injection de paclitaxel et sa méthode de préparation

Country Status (2)

Country Link
CN (1) CN1723887A (fr)
WO (1) WO2007009355A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019081285A1 (fr) 2017-10-27 2019-05-02 Basf Se Procédé de préparation d'éthylène-amines
WO2019081283A1 (fr) 2017-10-27 2019-05-02 Basf Se Procédé de préparation d'éthylèneamines

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101190213B (zh) * 2006-11-30 2011-07-13 天津天士力集团有限公司 一种多西紫杉醇注射液及其制备方法
CN101190214B (zh) * 2007-01-31 2010-09-15 广东庆发药业有限公司 紫杉醇注射液及其制备方法
WO2008098415A1 (fr) * 2007-02-14 2008-08-21 Beijing Century Biocom Pharmaceutical Technology Co., Ltd. Composition pharmaceutique contenant du taxane et son procédé de préparation et d'application
CN101574318B (zh) * 2009-05-31 2011-06-15 海口市制药厂有限公司 一种紫杉醇注射液的制备方法
CN106880589B (zh) * 2017-03-07 2020-01-07 华北制药股份有限公司 一种紫杉醇注射液及其制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1421201A (zh) * 2002-12-16 2003-06-04 天津大学 紫杉烷类的注射药制剂
JP2005225818A (ja) * 2004-02-13 2005-08-25 Otsuka Pharmaceut Factory Inc パクリタキセル又はドセタキセルの医薬組成物
CN1714785A (zh) * 2004-06-28 2006-01-04 胡宇方 一种含有紫杉醇类化合物的浓缩乳化剂及其使用方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1421201A (zh) * 2002-12-16 2003-06-04 天津大学 紫杉烷类的注射药制剂
JP2005225818A (ja) * 2004-02-13 2005-08-25 Otsuka Pharmaceut Factory Inc パクリタキセル又はドセタキセルの医薬組成物
CN1714785A (zh) * 2004-06-28 2006-01-04 胡宇方 一种含有紫杉醇类化合物的浓缩乳化剂及其使用方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JOURNAL OF SHENYANG PHARMACEUTICAL UNIVERSITY, vol. 21, no. 2, March 2004 (2004-03-01), pages 101 - 104, XP001249217 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019081285A1 (fr) 2017-10-27 2019-05-02 Basf Se Procédé de préparation d'éthylène-amines
WO2019081283A1 (fr) 2017-10-27 2019-05-02 Basf Se Procédé de préparation d'éthylèneamines

Also Published As

Publication number Publication date
CN1723887A (zh) 2006-01-25

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