FI86423B - Foerfarande foer framstaellning av n-sulfamyl-3-(2-guanidino-tiazol-4-yl-metyltio)-propionamidin. - Google Patents

Foerfarande foer framstaellning av n-sulfamyl-3-(2-guanidino-tiazol-4-yl-metyltio)-propionamidin. Download PDF

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Publication number
FI86423B
FI86423B FI863657A FI863657A FI86423B FI 86423 B FI86423 B FI 86423B FI 863657 A FI863657 A FI 863657A FI 863657 A FI863657 A FI 863657A FI 86423 B FI86423 B FI 86423B
Authority
FI
Finland
Prior art keywords
formula
famotidine
sulfamyl
guanidinothiazol
yield
Prior art date
Application number
FI863657A
Other languages
English (en)
Finnish (fi)
Other versions
FI86423C (sv
FI863657A0 (fi
FI863657A (fi
Inventor
Nee Csongor Eva Agai
Kalman Harsanyi
Gyoergy Domany
Istvan Szabadkai
Erik Bogsch
Ferenc Trischler
Peter Bod
Eva Fekecs
Bela Hegedus
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10963968&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI86423(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Publication of FI863657A0 publication Critical patent/FI863657A0/fi
Publication of FI863657A publication Critical patent/FI863657A/fi
Application granted granted Critical
Publication of FI86423B publication Critical patent/FI86423B/fi
Publication of FI86423C publication Critical patent/FI86423C/sv

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Claims (3)

1. Förfarande för framställning av N-sulfamyl-3-(2-guanidinotiazol-4-ylmetyltio)propionamidin (famotidin) 5 med formeln (I) nh2 H,N N-s f h ] \^\nso2nh2 (1) h/^n^s^ 10 genom S-alkylering av 2-guanidinotiazol-4-ylmetantiol, som erhällits frän S-(2-guanidinotiazol-4-ylmetyl)isotiokarb-amid-dihydroklorid med formeln (III) NH2 J2N N-S-^^NHpCl© (III) n/^s' S ' H N
2 H0 θ Clö 20 genom behandling in situ med en bas, känneteck-n a t därav, att man utför S-alkyleringen med en N-sulfa-myl-3-halogenpropionamidin med formeln (II) NH, HX I (II)
25. NS02NH2 väri X är halogen, i en blandning av vatten och en C^-al-kanol i närvaro av 4,0 - 4,1 mol av bas per en mol av fö-- reningen med formeln III vid en temperatur av 20 - 35 °C. 30 2. Förfarande enligt patentkravet 1, känne- t e c k n a t därav, att man använder natriumhydroxid som bas. : 3. Förfarande enligt patentkravet 2, känne- t e c k n a t därav, att man använder natriumhydroxid som 35 en 40-procentig vattenlösning. li
FI863657A 1985-09-11 1986-09-10 Förfarande för framställning av N-sulfamyl-3-(2-guanidinotiazol-4-ylme tyltio)propionamidin FI86423C (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU342485 1985-09-11
HU853424A HU194845B (en) 1985-09-11 1985-09-11 Process for production of n-sulphamil-3-/2-guanidintiazolil-4-methil-tio/-propion-amidin

Publications (4)

Publication Number Publication Date
FI863657A0 FI863657A0 (fi) 1986-09-10
FI863657A FI863657A (fi) 1987-03-12
FI86423B true FI86423B (fi) 1992-05-15
FI86423C FI86423C (sv) 1992-08-25

Family

ID=10963968

Family Applications (1)

Application Number Title Priority Date Filing Date
FI863657A FI86423C (sv) 1985-09-11 1986-09-10 Förfarande för framställning av N-sulfamyl-3-(2-guanidinotiazol-4-ylme tyltio)propionamidin

Country Status (22)

Country Link
US (1) US4835281A (sv)
JP (1) JPH0645609B2 (sv)
KR (1) KR910000237B1 (sv)
CN (1) CN1013674B (sv)
AR (1) AR240319A1 (sv)
AT (1) AT386824B (sv)
AU (1) AU587279B2 (sv)
BE (1) BE905409A (sv)
CA (1) CA1263120A (sv)
DD (1) DD249479A5 (sv)
DK (1) DK169920B1 (sv)
ES (1) ES2001677A6 (sv)
FI (1) FI86423C (sv)
GB (1) GB2180237B (sv)
GE (1) GEP19960471B (sv)
GR (1) GR862308B (sv)
HU (1) HU194845B (sv)
NL (1) NL8602225A (sv)
NO (1) NO163010C (sv)
PT (1) PT83348B (sv)
SE (1) SE8603797L (sv)
SU (1) SU1450743A3 (sv)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU194845B (en) * 1985-09-11 1988-03-28 Richter Gedeon Vegyeszet Process for production of n-sulphamil-3-/2-guanidintiazolil-4-methil-tio/-propion-amidin
HU196775B (en) * 1986-08-05 1989-01-30 Richter Gedeon Vegyeszet Process for production of morfologically unique new modifications of famotidin and medical compositions containing such substances
IL86330A0 (en) * 1987-06-22 1988-11-15 Marga Investigacion Famotidine polymorphic forms and their preparation
US5731442A (en) * 1997-03-11 1998-03-24 Albemarle Corporation Synthesis of thiazole derivatives
US5856500A (en) * 1997-03-11 1999-01-05 Albemarle Corporation Synthesis of thiazole derivatives
AU772188B2 (en) * 1998-11-17 2004-04-08 Nitromed, Inc. Nitrosated and nitrosylated H2 receptor antagonist compounds, compositions and methods of use
US20110143340A1 (en) * 2007-11-01 2011-06-16 Biocept, Inc. Non-invasive isolation of fetal nucleic acid

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6056143B2 (ja) * 1979-08-02 1985-12-09 山之内製薬株式会社 アミジン誘導体ならびにその製造法
US4808589A (en) * 1982-02-20 1989-02-28 Smith Kline & French Laboratories Limited Pyrimidone derivatives
US4496737A (en) * 1982-09-27 1985-01-29 Merck & Co., Inc. Process for preparing sulfamylamidine antisecretory agents
ES8504157A1 (es) * 1983-10-07 1985-04-01 Inke Sa Procedimiento para la obtencion de (-1amino-3-(((2-((diaminometileno) amino)-4-tiazolil)metil)tio)propilideno)sulfamida
ES8506665A1 (es) * 1984-05-07 1985-08-01 Inke Sa Procedimiento para la obtencion de la 1-amino-3-2-diamino-metilen-amino-4-tiazolil-metil-tio-propiliden-sulfamida.
ES536322A0 (es) * 1984-09-27 1985-08-01 Bioiberica Procedimiento para la obtencion del n-aminosolfenil-3-(((2-guanidin-4-tiazonil)metil)tio) propionamidina
ES536803A0 (es) * 1984-10-17 1985-08-01 Inke Sa Procedimiento para la obtencion de la (1-amino-3(((2-((diamino-metilen) amino)-4-tiazolil)metil)tio)propiliden)sulfamida
HU194845B (en) * 1985-09-11 1988-03-28 Richter Gedeon Vegyeszet Process for production of n-sulphamil-3-/2-guanidintiazolil-4-methil-tio/-propion-amidin
HU193608B (en) * 1985-09-11 1987-11-30 Richter Gedeon Vegyeszet Process for production of new dervatives of n-sulphanol-propion-amidine
JP3751649B2 (ja) * 1994-12-01 2006-03-01 関西ペイント株式会社 自動車外板塗膜の一時保護方法

Also Published As

Publication number Publication date
CN86105909A (zh) 1987-05-13
NO863616L (no) 1987-03-12
GB2180237A (en) 1987-03-25
BE905409A (fr) 1986-12-31
FI86423C (sv) 1992-08-25
AU6256986A (en) 1987-03-12
KR870003078A (ko) 1987-04-15
KR910000237B1 (ko) 1991-01-23
GB2180237B (en) 1989-09-06
AU587279B2 (en) 1989-08-10
GEP19960471B (en) 1996-05-13
NO163010B (no) 1989-12-11
US4835281A (en) 1989-05-30
ES2001677A6 (es) 1988-06-01
SE8603797L (sv) 1987-03-12
FI863657A0 (fi) 1986-09-10
PT83348B (pt) 1988-07-29
HU194845B (en) 1988-03-28
DK434586A (da) 1987-03-12
DK434586D0 (da) 1986-09-10
NL8602225A (nl) 1987-04-01
ATA243486A (de) 1988-03-15
AR240319A1 (es) 1990-03-30
NO863616D0 (no) 1986-09-10
FI863657A (fi) 1987-03-12
NO163010C (no) 1990-03-21
GR862308B (en) 1987-01-02
PT83348A (pt) 1986-10-01
CN1013674B (zh) 1991-08-28
JPH0645609B2 (ja) 1994-06-15
SE8603797D0 (sv) 1986-09-10
DK169920B1 (da) 1995-04-03
AT386824B (de) 1988-10-25
DD249479A5 (de) 1987-09-09
JPS6296481A (ja) 1987-05-02
HUT42766A (en) 1987-08-28
GB8621742D0 (en) 1986-10-15
CA1263120A (en) 1989-11-21
SU1450743A3 (ru) 1989-01-07

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Date Code Title Description
FG Patent granted

Owner name: RICHTER GEDEON VEGYESZETI GYAR R.T.

MA Patent expired