FI84135B - Foerlaengd lagring av roeda blodceller. - Google Patents

Foerlaengd lagring av roeda blodceller. Download PDF

Info

Publication number
FI84135B
FI84135B FI861137A FI861137A FI84135B FI 84135 B FI84135 B FI 84135B FI 861137 A FI861137 A FI 861137A FI 861137 A FI861137 A FI 861137A FI 84135 B FI84135 B FI 84135B
Authority
FI
Finland
Prior art keywords
mmol
suspension medium
blood cells
red blood
suspension
Prior art date
Application number
FI861137A
Other languages
English (en)
Finnish (fi)
Other versions
FI861137A (fi
FI84135C (sv
FI861137A0 (fi
Inventor
Harold T Meryman
Marne Hornblower
Ralph Syring
Original Assignee
American Nat Red Cross
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Nat Red Cross filed Critical American Nat Red Cross
Publication of FI861137A publication Critical patent/FI861137A/fi
Publication of FI861137A0 publication Critical patent/FI861137A0/fi
Publication of FI84135B publication Critical patent/FI84135B/fi
Application granted granted Critical
Publication of FI84135C publication Critical patent/FI84135C/sv

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/18—Erythrocytes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Organic Insulating Materials (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • External Artificial Organs (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Claims (8)

1. Suspensionsmedium för förlängd lagring av röda blodcel-ler vid ca4°C, kännetecknat av att suspensionen väsentligen bestär av ca 80-150 mmol glukos, 30-80 mmol mannitol, 6-90 mmol kaliumcitrat, 1-5 mmol adenin och 10-200 mmol ammoniumklorid eller -acetat i vattenlösning med ett pH av ca 6,8-7,2 justerat med fosfatsalt och osmolariten av ca 180-220 milli-osmolar, i vilken suspensions röda blod-celler kan lagras i livsduglig form.
2. Suspensionsmedium enligt patentkrav 1, kännetecknat av att den innehäller ca 110 mmol glukos, 55 mmol mannitol, 7,9 mmol kaliumcitrat, 2 mmol adenin och 50 mmol ammoniumklorid eller -acetat.
3. Suspensionsmedium enligt patentkrav 1, kännetecknat av att pH hälls i värdet av ca 7,0 genom att justera pH-värdet med lämpliga mängder av en- eller tvä-basisk kaliumfosfat.
4. Suspensionsmedium enligt patentkrav 1, kännetecknat av att osmolariteten är ca 200 mOsm.
5. Förfarande för lagring av röda blodceller för förlängda tidsperioder vid ca 4°C, kännetecknat av att blodceller suspenderas i ett medium, som väsentligen bestär ίο 84 I 35 av ca 80-150 mmol glukos, 30-80 mmol mannitol, 6-90 mmol kaliumcitrat, 1-5 mmol adenin och 10-200 mmol ammoniumklorid eller -acetat i vattenlösning med ett pH av ca 6,8-7,2 justerat med fosfatsalt och en osmolaritet av ca 180-220 milliosmolar, vilken suspensions möjliggör lagring av röda blodceller i livsduglig form.
6. Förfarande enligt patentkrav 1, känneteck- n a t av att suspensionsmediet innehäller ca 110 mmol glukos, 55 mmol mannitol, 7,9 mmol kaliumcitrat, 2 mmol adenin och 50 mmol ammoniumklorid eller -acetat.
7. Förfarande enligt patentkrav 1, känneteck- n a t av att pH hälls i vSrdet av ca 7,0 genom att justera pH-värdet med lämpliga mängder av en- eller tväbasisk ka-liumfosfat.
8. Förfarande enligt patentkrav 1, känneteck-n a t av att osmolariteten är ca 200 mOsm.
FI861137A 1984-07-19 1986-03-18 Förlängd lagring av röda blodceller FI84135C (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US63224284 1984-07-19
US06/632,242 US4585735A (en) 1984-07-19 1984-07-19 Prolonged storage of red blood cells
PCT/US1985/001185 WO1986000809A1 (en) 1984-07-19 1985-06-21 Prolonged storage of red blood cells
US8501185 1985-06-21

Publications (4)

Publication Number Publication Date
FI861137A FI861137A (fi) 1986-03-18
FI861137A0 FI861137A0 (fi) 1986-03-18
FI84135B true FI84135B (fi) 1991-07-15
FI84135C FI84135C (sv) 1991-10-25

Family

ID=24534708

Family Applications (1)

Application Number Title Priority Date Filing Date
FI861137A FI84135C (sv) 1984-07-19 1986-03-18 Förlängd lagring av röda blodceller

Country Status (12)

Country Link
US (1) US4585735A (sv)
EP (1) EP0187816B1 (sv)
JP (1) JPS61502750A (sv)
AT (1) ATE66814T1 (sv)
AU (1) AU569958B2 (sv)
CA (1) CA1254838A (sv)
DE (1) DE3584010D1 (sv)
DK (1) DK168079B1 (sv)
FI (1) FI84135C (sv)
IL (1) IL75707A (sv)
NO (1) NO167075C (sv)
WO (1) WO1986000809A1 (sv)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0687062B2 (ja) * 1985-05-10 1994-11-02 株式会社京都医科学研究所 血液中の解糖阻止方法
US4675185A (en) * 1985-12-06 1987-06-23 Baxter Travenol Laboratories, Inc. Solution for stabilizing red blood cells during storage
JPS6360931A (ja) * 1986-08-29 1988-03-17 Noboru Sato 血液または血液製剤保存液およびこれを用いた血液または血液製剤の保存方法
US5045446A (en) * 1988-08-26 1991-09-03 Cryopharm Corporation Lyophilization of cells
IL90188A0 (en) * 1988-05-18 1989-12-15 Cryopharm Corp Process and medium for the lyophilization of erythrocytes
US4874690A (en) * 1988-08-26 1989-10-17 Cryopharm Corporation Lyophilization of red blood cells
IL95912A (en) * 1989-10-06 1998-08-16 American Nat Red Cross A method for extending the shelf life of blood cells
CA2067134C (en) * 1989-10-06 2001-02-13 Harold T. Meryman Procedure for storing red cells with prolonged maintenance of cellular concentrations of atp and 2,3 dpg
DE3938907C2 (de) * 1989-11-24 1999-11-04 Dade Behring Marburg Gmbh Mittel zum Lagern und Suspendieren von Zellen, insbesondere Erythrozyten
US5147776A (en) * 1990-02-26 1992-09-15 University Of Iowa Research Foundation Use of 2,5-anhydromannitol for control of pH during blood storage
US5545516A (en) * 1990-05-01 1996-08-13 The American National Red Cross Inactivation of extracellular enveloped viruses in blood and blood components by phenthiazin-5-ium dyes plus light
CA2071833C (en) * 1990-11-07 1998-11-03 Jean-Marc Payrat Red blood cell storage solution
WO1992008349A1 (en) * 1990-11-07 1992-05-29 Baxter International Inc. Blood platelet storage medium
AU4286996A (en) * 1994-11-14 1996-06-06 Pall Corporation Long-term blood component storage system and method
US5601972A (en) * 1995-03-24 1997-02-11 Organ, Inc. Long term storage of red cells in unfrozen solution
US20040053208A1 (en) * 1995-08-29 2004-03-18 V. I. TECHNOLOGIES, Inc. Methods to selectively inactivate parasites in biological compositions
US5736313A (en) * 1995-10-20 1998-04-07 The United States Of America As Represented By The Secretary Of The Navy Method of lyophilizing platelets by incubation with high carbohydrate concentrations and supercooling prior to freezing
CA2278245A1 (en) * 1997-01-21 1998-07-23 The American National Red Cross Intracellular and extracellular decontamination of whole blood and blood components by amphiphilic phenothiazin-5-ium dyes plus light
US5789151A (en) * 1997-05-15 1998-08-04 The Regents Of The University Of California Prolonged cold storage of red blood cells by oxygen removal and additive usage
US20070099170A1 (en) * 1998-07-21 2007-05-03 Navigant Biotechnologies, Inc. Method for treatment and storage of blood and blood products using endogenous alloxazines and acetate
US20030215784A1 (en) * 1998-07-21 2003-11-20 Dumont Larry Joe Method and apparatus for inactivation of biological contaminants using photosensitizers
US7049110B2 (en) * 1998-07-21 2006-05-23 Gambro, Inc. Inactivation of West Nile virus and malaria using photosensitizers
US7498156B2 (en) * 1998-07-21 2009-03-03 Caridianbct Biotechnologies, Llc Use of visible light at wavelengths of 500 to 550 nm to reduce the number of pathogens in blood and blood components
US6267925B1 (en) 1998-12-07 2001-07-31 Haemonetics Corporation Method for cryopreservation and recovery of red blood cells
US7220747B2 (en) 1999-07-20 2007-05-22 Gambro, Inc. Method for preventing damage to or rejuvenating a cellular blood component using mitochondrial enhancer
US6770478B2 (en) 2000-02-10 2004-08-03 The Regents Of The University Of California Erythrocytic cells and method for preserving cells
AU2001234978A1 (en) * 2000-02-10 2001-08-20 The Regents Of The University Of California Therapeutic platelets and methods
US7985588B2 (en) * 2000-06-02 2011-07-26 Caridianbct Biotechnologies, Llc Induction of and maintenance of nucleic acid damage in pathogens using riboflavin and light
TW590780B (en) * 2000-06-02 2004-06-11 Gambro Inc Additive solutions containing riboflavin
US7648699B2 (en) * 2000-06-02 2010-01-19 Caridianbct Biotechnologies, Llc Preventing transfusion related complications in a recipient of a blood transfusion
US6548241B1 (en) * 2000-11-28 2003-04-15 Gambro, Inc. Storage solution containing photosensitizer for inactivation of biological contaminants
US20020131958A1 (en) * 2001-01-22 2002-09-19 John Chapman Method for purifying a biological composition
US7183045B2 (en) * 2002-04-24 2007-02-27 Gambro Inc. Removal of adenine during a pathogen reduction process in whole blood or red blood cell by dilution
US8828226B2 (en) 2003-03-01 2014-09-09 The Trustees Of Boston University System for assessing the efficacy of stored red blood cells using microvascular networks
WO2004112477A1 (en) * 2003-06-20 2004-12-29 Pall Corporation Processing of platelet-containing biological fluids
US9314014B2 (en) * 2004-02-18 2016-04-19 University Of Maryland, Baltimore Compositions and methods for the storage of red blood cells
WO2008089337A1 (en) * 2007-01-19 2008-07-24 The Regents Of The University Of Michigan Compositions and methods for preserving red blood cells
JP2010535235A (ja) * 2007-08-01 2010-11-18 カリディアンビーシーティ バイオテクノロジーズ，エルエルシー 全血の病原性不活性化
US8835104B2 (en) 2007-12-20 2014-09-16 Fenwal, Inc. Medium and methods for the storage of platelets
US8968992B2 (en) * 2008-03-21 2015-03-03 Fenwal, Inc. Red blood cell storage medium for extended storage
US8871434B2 (en) * 2008-03-21 2014-10-28 Fenwal, Inc. Red blood cell storage medium for extended storage
US9199016B2 (en) 2009-10-12 2015-12-01 New Health Sciences, Inc. System for extended storage of red blood cells and methods of use
NZ622456A (en) 2009-10-12 2015-09-25 New Health Sciences Inc Blood storage bag system and depletion devices with oxygen and carbon dioxide depletion capabilities
JP2013507447A (ja) 2009-10-12 2013-03-04 ニュー ヘルス サイエンシーズ、インク． 酸素減損装置及び赤血球から酸素を除去する方法
US11284616B2 (en) 2010-05-05 2022-03-29 Hemanext Inc. Irradiation of red blood cells and anaerobic storage
EP2490751B1 (en) 2009-10-23 2016-11-09 Fenwal, Inc. Methods and systems for providing red blood cell products with reduced plasma
US20130203042A1 (en) * 2009-10-23 2013-08-08 Fenwal, Inc. Methods and systems for processing biological fluids
US8980542B2 (en) 2010-02-16 2015-03-17 Viacell, Llc Arginine-containing compositions and methods for treating red blood cells
US20110229871A1 (en) 2010-02-16 2011-09-22 Ericson Daniel G Nucleoside-containing compositions and methods for treating red blood cells
ES2959120T3 (es) 2010-08-25 2024-02-20 Hemanext Inc Método para potenciar la calidad y la supervivencia de glóbulos rojos durante el almacenamiento
PT3539381T (pt) 2010-11-05 2023-09-26 Hemanext Inc Irradiação de glóbulos vermelhos e armazenamento anaeróbico
US9067004B2 (en) 2011-03-28 2015-06-30 New Health Sciences, Inc. Method and system for removing oxygen and carbon dioxide during red cell blood processing using an inert carrier gas and manifold assembly
WO2012139017A1 (en) 2011-04-07 2012-10-11 Fenwal, Inc. Automated methods and systems for providing platelet concentrates with reduced residual plasma volumes and storage media for such platelet concentrates
JP6097293B2 (ja) 2011-08-10 2017-03-15 ニュー・ヘルス・サイエンシーズ・インコーポレイテッドＮｅｗ Ｈｅａｌｔｈ Ｓｃｉｅｎｃｅｓ， Ｉｎｃ． 一体型の白血球、酸素及び／又は二酸化炭素減損・血漿分離フィルタ装置
EP2874641A4 (en) 2012-07-23 2016-10-12 Oneday Biotech And Pharma Ltd COMPOSITIONS INCREASING THE GLUTATHION RATE AND USES THEREOF
US9877476B2 (en) 2013-02-28 2018-01-30 New Health Sciences, Inc. Gas depletion and gas addition devices for blood treatment
CN113694272A (zh) 2015-03-10 2021-11-26 希玛奈克斯特股份有限公司 氧减少一次性套件、装置及其使用方法
KR102661405B1 (ko) 2015-04-23 2024-04-25 헤마넥스트 인코포레이티드 혐기성 혈액 저장 용기
US11013771B2 (en) 2015-05-18 2021-05-25 Hemanext Inc. Methods for the storage of whole blood, and compositions thereof
BR112018073923A2 (pt) 2016-05-27 2019-02-26 New Health Sciences, Inc. armazenamento anaeróbico de sangue e método de inativação de patógenos
CN110907642A (zh) * 2019-12-02 2020-03-24 青岛农业大学 一种快速检测犬细小病毒抗原、抗体的试剂盒及方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2532183C3 (de) * 1975-07-18 1982-03-04 Behringwerke Ag, 3550 Marburg Polyionische isotonische Salzlösung zur Konservierung von Erythrozyten oder zur Perfusion und zur Konservierung von zur Transplantion bestimmter Organen
JPS56139419A (en) * 1980-03-31 1981-10-30 Kuraray Co Ltd Erythrocytic preservative and erythrocytic pharmaceutical for preservation
FR2542617B2 (fr) * 1982-07-09 1986-06-06 Rgl Transfusion Sanguine Centr Solution protectrice pour la conservation de cellules fonctionnelles

Also Published As

Publication number Publication date
ATE66814T1 (de) 1991-09-15
AU4605285A (en) 1986-02-25
IL75707A0 (en) 1985-11-29
NO860913L (no) 1986-03-11
DK119986D0 (da) 1986-03-14
FI861137A (fi) 1986-03-18
NO167075B (no) 1991-06-24
DK119986A (da) 1986-03-14
WO1986000809A1 (en) 1986-02-13
NO167075C (no) 1991-10-02
JPH0572888B2 (sv) 1993-10-13
EP0187816A1 (en) 1986-07-23
US4585735A (en) 1986-04-29
DK168079B1 (da) 1994-02-07
JPS61502750A (ja) 1986-11-27
FI84135C (sv) 1991-10-25
CA1254838A (en) 1989-05-30
FI861137A0 (fi) 1986-03-18
AU569958B2 (en) 1988-02-25
EP0187816B1 (en) 1991-09-04
IL75707A (en) 1989-02-28
EP0187816A4 (en) 1988-04-06
DE3584010D1 (de) 1991-10-10

Similar Documents

Publication Publication Date Title
FI84135B (fi) Foerlaengd lagring av roeda blodceller.
CA1270199A (en) Preservation of living tissue
CA2030757C (en) Agent for the storage and suspension of cells, especially erythrocytes
US4572899A (en) Aqueous solution for suspending and storing cells, especially erthrocytes
US6060233A (en) Methods for the lyophilization of platelets, platelet membranes or erythrocytes
US4675185A (en) Solution for stabilizing red blood cells during storage
US6743575B2 (en) Compositions and methods for the preservation of living tissues
JP2002516254A (ja) ヒト赤血球の低温保存
US5543316A (en) Injectable culture medium for maintaining viability of myoblast cells
JP2000516963A (ja) 酸素除去・添加剤使用による赤血球長期保存法
US4609372A (en) Heat sterilizable storage solution for red blood cells
CA1317225C (en) Use of adenosine, hypoxanthine and ribose-containing solution for improved protection of the heart during surgery
KR100253819B1 (ko) 혈액 보존제 및 혈액 보존 방법
Meryman et al. Refrigerated storage of washed red cells
SU493059A3 (ru) Способ консервировани крови
US6037116A (en) Compositions comprising betaine, sodium citrate and sodium chloride and methods for the preservation of biological materials
GB2057247A (en) Method of preserving sperm of domestic animals
JP2001524081A (ja) 生きた生物学的物質の保存用組成物およびその使用方法
CN1553817A (zh) 用储存的红血球改善氧传送的方法
乾靖夫 et al. Gluconeogenesis in the eel. II. Gluconeogenesis in the alloxanized eel.
US20040229203A1 (en) Compositions and methods for the preservation of living tissues
Minten et al. Optimal storage temperature and benefit of hypothermic cardioplegic arrest for long‐term preservation of donor hearts: a study in the dog
Chesters Cell‐Free Protein Synthesis by Rumen Protozoa
SCHLAEGER et al. Polyribosomes in tumor cells during induction of ribonuclease by cytostatic treatment
Romero Active calcium transport in red cell ghosts resealed in dextran solutions

Legal Events

Date Code Title Description
FG Patent granted

Owner name: AMERICAN NATIONAL RED CROSS

MA Patent expired