FI84135B - Foerlaengd lagring av roeda blodceller. - Google Patents

Foerlaengd lagring av roeda blodceller. Download PDF

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Publication number
FI84135B
FI84135B FI861137A FI861137A FI84135B FI 84135 B FI84135 B FI 84135B FI 861137 A FI861137 A FI 861137A FI 861137 A FI861137 A FI 861137A FI 84135 B FI84135 B FI 84135B
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FI
Finland
Prior art keywords
mmol
suspension medium
blood cells
red blood
suspension
Prior art date
Application number
FI861137A
Other languages
English (en)
Finnish (fi)
Other versions
FI861137A0 (fi
FI84135C (sv
FI861137A (fi
Inventor
Harold T Meryman
Marne Hornblower
Ralph Syring
Original Assignee
American Nat Red Cross
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Nat Red Cross filed Critical American Nat Red Cross
Publication of FI861137A0 publication Critical patent/FI861137A0/fi
Publication of FI861137A publication Critical patent/FI861137A/fi
Application granted granted Critical
Publication of FI84135B publication Critical patent/FI84135B/fi
Publication of FI84135C publication Critical patent/FI84135C/sv

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/18—Erythrocytes

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Organic Insulating Materials (AREA)
  • External Artificial Organs (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Claims (8)

1. Suspensionsmedium för förlängd lagring av röda blodcel-ler vid ca4°C, kännetecknat av att suspensionen väsentligen bestär av ca 80-150 mmol glukos, 30-80 mmol mannitol, 6-90 mmol kaliumcitrat, 1-5 mmol adenin och 10-200 mmol ammoniumklorid eller -acetat i vattenlösning med ett pH av ca 6,8-7,2 justerat med fosfatsalt och osmolariten av ca 180-220 milli-osmolar, i vilken suspensions röda blod-celler kan lagras i livsduglig form.
2. Suspensionsmedium enligt patentkrav 1, kännetecknat av att den innehäller ca 110 mmol glukos, 55 mmol mannitol, 7,9 mmol kaliumcitrat, 2 mmol adenin och 50 mmol ammoniumklorid eller -acetat.
3. Suspensionsmedium enligt patentkrav 1, kännetecknat av att pH hälls i värdet av ca 7,0 genom att justera pH-värdet med lämpliga mängder av en- eller tvä-basisk kaliumfosfat.
4. Suspensionsmedium enligt patentkrav 1, kännetecknat av att osmolariteten är ca 200 mOsm.
5. Förfarande för lagring av röda blodceller för förlängda tidsperioder vid ca 4°C, kännetecknat av att blodceller suspenderas i ett medium, som väsentligen bestär ίο 84 I 35 av ca 80-150 mmol glukos, 30-80 mmol mannitol, 6-90 mmol kaliumcitrat, 1-5 mmol adenin och 10-200 mmol ammoniumklorid eller -acetat i vattenlösning med ett pH av ca 6,8-7,2 justerat med fosfatsalt och en osmolaritet av ca 180-220 milliosmolar, vilken suspensions möjliggör lagring av röda blodceller i livsduglig form.
6. Förfarande enligt patentkrav 1, känneteck- n a t av att suspensionsmediet innehäller ca 110 mmol glukos, 55 mmol mannitol, 7,9 mmol kaliumcitrat, 2 mmol adenin och 50 mmol ammoniumklorid eller -acetat.
7. Förfarande enligt patentkrav 1, känneteck- n a t av att pH hälls i vSrdet av ca 7,0 genom att justera pH-värdet med lämpliga mängder av en- eller tväbasisk ka-liumfosfat.
8. Förfarande enligt patentkrav 1, känneteck-n a t av att osmolariteten är ca 200 mOsm.
FI861137A 1984-07-19 1986-03-18 Förlängd lagring av röda blodceller FI84135C (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US06/632,242 US4585735A (en) 1984-07-19 1984-07-19 Prolonged storage of red blood cells
US63224284 1984-07-19
US8501185 1985-06-21
PCT/US1985/001185 WO1986000809A1 (en) 1984-07-19 1985-06-21 Prolonged storage of red blood cells

Publications (4)

Publication Number Publication Date
FI861137A0 FI861137A0 (fi) 1986-03-18
FI861137A FI861137A (fi) 1986-03-18
FI84135B true FI84135B (fi) 1991-07-15
FI84135C FI84135C (sv) 1991-10-25

Family

ID=24534708

Family Applications (1)

Application Number Title Priority Date Filing Date
FI861137A FI84135C (sv) 1984-07-19 1986-03-18 Förlängd lagring av röda blodceller

Country Status (12)

Country Link
US (1) US4585735A (sv)
EP (1) EP0187816B1 (sv)
JP (1) JPS61502750A (sv)
AT (1) ATE66814T1 (sv)
AU (1) AU569958B2 (sv)
CA (1) CA1254838A (sv)
DE (1) DE3584010D1 (sv)
DK (1) DK168079B1 (sv)
FI (1) FI84135C (sv)
IL (1) IL75707A (sv)
NO (1) NO167075C (sv)
WO (1) WO1986000809A1 (sv)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0687062B2 (ja) * 1985-05-10 1994-11-02 株式会社京都医科学研究所 血液中の解糖阻止方法
US4675185A (en) * 1985-12-06 1987-06-23 Baxter Travenol Laboratories, Inc. Solution for stabilizing red blood cells during storage
JPS6360931A (ja) * 1986-08-29 1988-03-17 Noboru Sato 血液または血液製剤保存液およびこれを用いた血液または血液製剤の保存方法
US5045446A (en) * 1988-08-26 1991-09-03 Cryopharm Corporation Lyophilization of cells
IL90188A0 (en) * 1988-05-18 1989-12-15 Cryopharm Corp Process and medium for the lyophilization of erythrocytes
US4874690A (en) * 1988-08-26 1989-10-17 Cryopharm Corporation Lyophilization of red blood cells
IL95912A (en) * 1989-10-06 1998-08-16 American Nat Red Cross A method for extending the shelf life of blood cells
US5250303A (en) * 1989-10-06 1993-10-05 The American National Red Cross Procedure for storing red cells with prolonged maintenance of cellular concentrations of ATP and 2,3 DPG
DE3938907C2 (de) * 1989-11-24 1999-11-04 Dade Behring Marburg Gmbh Mittel zum Lagern und Suspendieren von Zellen, insbesondere Erythrozyten
US5147776A (en) * 1990-02-26 1992-09-15 University Of Iowa Research Foundation Use of 2,5-anhydromannitol for control of pH during blood storage
US5545516A (en) * 1990-05-01 1996-08-13 The American National Red Cross Inactivation of extracellular enveloped viruses in blood and blood components by phenthiazin-5-ium dyes plus light
CA2071833C (en) * 1990-11-07 1998-11-03 Jean-Marc Payrat Red blood cell storage solution
EP0510185B1 (en) * 1990-11-07 1996-12-11 Baxter International Inc. Blood platelet storage medium
EP0793414A2 (en) * 1994-11-14 1997-09-10 Pall Corporation Long-term blood component storage system and method
US5601972A (en) * 1995-03-24 1997-02-11 Organ, Inc. Long term storage of red cells in unfrozen solution
US20040053208A1 (en) * 1995-08-29 2004-03-18 V. I. TECHNOLOGIES, Inc. Methods to selectively inactivate parasites in biological compositions
US5736313A (en) * 1995-10-20 1998-04-07 The United States Of America As Represented By The Secretary Of The Navy Method of lyophilizing platelets by incubation with high carbohydrate concentrations and supercooling prior to freezing
EP0973383A4 (en) * 1997-01-21 2001-08-22 American Nat Red Cross INTRACELLULAR AND EXTRACELLULAR DECONTAMINATION OF WHOLE BLOOD AND BLOOD COMPONENTS WITH AMPHIPHILEN PHENOTHIAZINE-5-IUM DYES AND LIGHT
US5789151A (en) * 1997-05-15 1998-08-04 The Regents Of The University Of California Prolonged cold storage of red blood cells by oxygen removal and additive usage
US20030215784A1 (en) * 1998-07-21 2003-11-20 Dumont Larry Joe Method and apparatus for inactivation of biological contaminants using photosensitizers
US7049110B2 (en) * 1998-07-21 2006-05-23 Gambro, Inc. Inactivation of West Nile virus and malaria using photosensitizers
US7498156B2 (en) * 1998-07-21 2009-03-03 Caridianbct Biotechnologies, Llc Use of visible light at wavelengths of 500 to 550 nm to reduce the number of pathogens in blood and blood components
US20070099170A1 (en) * 1998-07-21 2007-05-03 Navigant Biotechnologies, Inc. Method for treatment and storage of blood and blood products using endogenous alloxazines and acetate
US6267925B1 (en) 1998-12-07 2001-07-31 Haemonetics Corporation Method for cryopreservation and recovery of red blood cells
US7220747B2 (en) 1999-07-20 2007-05-22 Gambro, Inc. Method for preventing damage to or rejuvenating a cellular blood component using mitochondrial enhancer
US6770478B2 (en) 2000-02-10 2004-08-03 The Regents Of The University Of California Erythrocytic cells and method for preserving cells
CA2397362A1 (en) * 2000-02-10 2001-08-16 The Regents Of The University Of California Therapeutic platelets and methods
US7985588B2 (en) * 2000-06-02 2011-07-26 Caridianbct Biotechnologies, Llc Induction of and maintenance of nucleic acid damage in pathogens using riboflavin and light
US7648699B2 (en) * 2000-06-02 2010-01-19 Caridianbct Biotechnologies, Llc Preventing transfusion related complications in a recipient of a blood transfusion
TW590780B (en) * 2000-06-02 2004-06-11 Gambro Inc Additive solutions containing riboflavin
US6548241B1 (en) * 2000-11-28 2003-04-15 Gambro, Inc. Storage solution containing photosensitizer for inactivation of biological contaminants
US20020131958A1 (en) * 2001-01-22 2002-09-19 John Chapman Method for purifying a biological composition
WO2003090793A1 (en) * 2002-04-24 2003-11-06 Gambro, Inc. Removal of adenine during a process of pathogen reducing blood and blood components
US8828226B2 (en) 2003-03-01 2014-09-09 The Trustees Of Boston University System for assessing the efficacy of stored red blood cells using microvascular networks
EP1635638A1 (en) * 2003-06-20 2006-03-22 Pall Corporation Processing of platelet-containing biological fluids
US9314014B2 (en) 2004-02-18 2016-04-19 University Of Maryland, Baltimore Compositions and methods for the storage of red blood cells
US20100021879A1 (en) * 2007-01-19 2010-01-28 The Regents Of The University Of Michigan Compositions and methods for preserving red blood cells
WO2009018309A2 (en) * 2007-08-01 2009-02-05 Caridianbct Biotechnologies, Llc Pathogen inactivation of whole blood
US8835104B2 (en) 2007-12-20 2014-09-16 Fenwal, Inc. Medium and methods for the storage of platelets
US8871434B2 (en) * 2008-03-21 2014-10-28 Fenwal, Inc. Red blood cell storage medium for extended storage
US8968992B2 (en) * 2008-03-21 2015-03-03 Fenwal, Inc. Red blood cell storage medium for extended storage
US12089589B2 (en) 2009-10-12 2024-09-17 Hemanext Inc. Irradiation of red blood cells and anaerobic storage
US9199016B2 (en) 2009-10-12 2015-12-01 New Health Sciences, Inc. System for extended storage of red blood cells and methods of use
NZ599890A (en) 2009-10-12 2014-03-28 Univ Pittsburgh Oxygen depletion devices and methods for removing oxygen from red blood cells
US11284616B2 (en) 2010-05-05 2022-03-29 Hemanext Inc. Irradiation of red blood cells and anaerobic storage
JP6199557B2 (ja) 2009-10-12 2017-09-20 ニュー ヘルス サイエンシーズ、インク．Ｎｅｗ Ｈｅａｌｔｈ Ｓｃｉｅｎｃｅｓ， Ｉｎｃ． 酸素及び二酸化炭素の減損能力をもつ血液保存袋システム及び減損装置
EP2490751B1 (en) 2009-10-23 2016-11-09 Fenwal, Inc. Methods and systems for providing red blood cell products with reduced plasma
US20130203042A1 (en) * 2009-10-23 2013-08-08 Fenwal, Inc. Methods and systems for processing biological fluids
US20110229871A1 (en) * 2010-02-16 2011-09-22 Ericson Daniel G Nucleoside-containing compositions and methods for treating red blood cells
EP2536416B1 (en) 2010-02-16 2018-06-13 Viacell, LLC Arginine-containing storage and/or rejuvenating compositions and methods for storing or rejuvenating red blood cells
EP4091645A1 (en) 2010-08-25 2022-11-23 Hemanext Inc. Method for enhancing red blood cell quality and survival during storage
JP5859558B2 (ja) 2010-11-05 2016-02-10 ニュー・ヘルス・サイエンシーズ・インコーポレイテッドＮｅｗ Ｈｅａｌｔｈ Ｓｃｉｅｎｃｅｓ， Ｉｎｃ． 赤血球の照射及び嫌気性保存
US9067004B2 (en) 2011-03-28 2015-06-30 New Health Sciences, Inc. Method and system for removing oxygen and carbon dioxide during red cell blood processing using an inert carrier gas and manifold assembly
JP2014518547A (ja) 2011-04-07 2014-07-31 フェンウォール、インコーポレイテッド 削減された残存血漿容積を有する血小板濃縮物を提供するための自動化方法とシステムおよびそのような血小板濃縮物のための貯蔵媒体
EP4074395B1 (en) 2011-08-10 2024-01-24 Hemanext Inc. Integrated leukocyte, oxygen and/or co2 depletion, and plasma separation filter device
CN104717970A (zh) 2012-07-23 2015-06-17 万德-生物技术及制药有限公司 提高谷胱甘肽的组合物及其用途
WO2014134503A1 (en) 2013-02-28 2014-09-04 New Health Sciences, Inc. Gas depletion and gas addition devices for blood treatment
KR102701691B1 (ko) 2015-03-10 2024-08-30 헤마넥스트 인코포레이티드 산소 감소 1회용 키트, 장치 및 이의 사용 방법
CN107847395B (zh) 2015-04-23 2021-10-15 新健康科学股份有限公司 厌氧血液储存容器
BR122021024410B1 (pt) 2015-05-18 2022-05-03 Hemanext Inc Métodos para gerenciar um banco de sangue e para prover fornecimento de produtos de sangue total armazenados para medicina de transfusão
IL303240A (en) 2016-05-27 2023-07-01 Hemanext Inc Anaerobic blood storage and pathogen inactivation method
CN110907642A (zh) * 2019-12-02 2020-03-24 青岛农业大学 一种快速检测犬细小病毒抗原、抗体的试剂盒及方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2532183C3 (de) * 1975-07-18 1982-03-04 Behringwerke Ag, 3550 Marburg Polyionische isotonische Salzlösung zur Konservierung von Erythrozyten oder zur Perfusion und zur Konservierung von zur Transplantion bestimmter Organen
JPS56139419A (en) * 1980-03-31 1981-10-30 Kuraray Co Ltd Erythrocytic preservative and erythrocytic pharmaceutical for preservation
FR2542617B2 (fr) * 1982-07-09 1986-06-06 Rgl Transfusion Sanguine Centr Solution protectrice pour la conservation de cellules fonctionnelles

Also Published As

Publication number Publication date
JPS61502750A (ja) 1986-11-27
EP0187816A1 (en) 1986-07-23
EP0187816A4 (en) 1988-04-06
WO1986000809A1 (en) 1986-02-13
ATE66814T1 (de) 1991-09-15
NO167075C (no) 1991-10-02
IL75707A0 (en) 1985-11-29
FI861137A0 (fi) 1986-03-18
EP0187816B1 (en) 1991-09-04
US4585735A (en) 1986-04-29
FI84135C (sv) 1991-10-25
JPH0572888B2 (sv) 1993-10-13
DK119986A (da) 1986-03-14
CA1254838A (en) 1989-05-30
AU4605285A (en) 1986-02-25
DE3584010D1 (de) 1991-10-10
DK119986D0 (da) 1986-03-14
AU569958B2 (en) 1988-02-25
IL75707A (en) 1989-02-28
NO167075B (no) 1991-06-24
DK168079B1 (da) 1994-02-07
FI861137A (fi) 1986-03-18
NO860913L (no) 1986-03-11

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