FI82934B - Foerfarande foer framstaellning av farmakologiskt verksamt 8-klor-6,11-dihydro-11-(4-piperidyliden)-5h benzo/5,6/cyklohepta/1,2-b/pyridin. - Google Patents

Foerfarande foer framstaellning av farmakologiskt verksamt 8-klor-6,11-dihydro-11-(4-piperidyliden)-5h benzo/5,6/cyklohepta/1,2-b/pyridin. Download PDF

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Publication number
FI82934B
FI82934B FI853675A FI853675A FI82934B FI 82934 B FI82934 B FI 82934B FI 853675 A FI853675 A FI 853675A FI 853675 A FI853675 A FI 853675A FI 82934 B FI82934 B FI 82934B
Authority
FI
Finland
Prior art keywords
benzo
dihydro
chloro
piperidylidene
cyclohepta
Prior art date
Application number
FI853675A
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English (en)
Finnish (fi)
Other versions
FI853675L (fi
FI82934C (sv
FI853675A0 (fi
Inventor
Frank J Villani
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24320550&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI82934(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Publication of FI853675L publication Critical patent/FI853675L/fi
Publication of FI853675A0 publication Critical patent/FI853675A0/fi
Publication of FI82934B publication Critical patent/FI82934B/fi
Application granted granted Critical
Publication of FI82934C publication Critical patent/FI82934C/sv

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered

Claims (2)

1. Förfarande för framstälning av farmakologiskt verkaani 8-klor-6,11-dihydro-11-(4-piperidyl iden)-5H-benso[5,6]cyklo-hepta-[l,2-b]pyridin med strukturformeln I H och dess farmaceutiskt godtagbara salter, känneteck-n a d därav, att a) 8-klor-6,11-dihydro-ll-(l-etoxikarbonyl-4-piperidyliden)-5H-benso[5,6]cyklohepta-[l,2-b]pyridin dekarbetoxyleras; eller b) 8-klor-6,ll-dihydro-ll-(l-nietyl-4-piperidyliden)-5H-benso- [5,6]cyklohepta-[1,2-b]pyridin demetyleras, varefter föreningen isoleras i fri form eller i form av sitt sait.
2. Förfarande enligt patentkravet 1, kännetecknat därav, att ett ättiksyrasalt av föreningen med formeln I framställs.
FI853675A 1984-02-15 1985-09-25 Förfarande för framställning av farmakologiskt verksamt 8-klor-6,11-di hydro-11-(4-piperidyliden)-5H-benzo/5,6/cyklohepta/1,2-b/pyridin FI82934C (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US58030484A 1984-02-15 1984-02-15
US58030484 1984-02-15
PCT/US1985/000187 WO1985003707A1 (en) 1984-02-15 1985-02-08 8-CHLORO-6,11-DIHYDRO-11-(4-PIPERIDYLIDENE)-5H-BENZO AD5,6 BDCYCLOHEPTA AD1,2-b BDPYRIDINE AND ITS SALTS, PROCESSES FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS
US8500187 1985-02-08

Publications (4)

Publication Number Publication Date
FI853675L FI853675L (fi) 1985-09-25
FI853675A0 FI853675A0 (fi) 1985-09-25
FI82934B true FI82934B (fi) 1991-01-31
FI82934C FI82934C (sv) 1991-05-10

Family

ID=24320550

Family Applications (1)

Application Number Title Priority Date Filing Date
FI853675A FI82934C (sv) 1984-02-15 1985-09-25 Förfarande för framställning av farmakologiskt verksamt 8-klor-6,11-di hydro-11-(4-piperidyliden)-5H-benzo/5,6/cyklohepta/1,2-b/pyridin

Country Status (12)

Country Link
US (1) US4659716A (sv)
EP (1) EP0152897B1 (sv)
JP (1) JPS61501205A (sv)
AT (1) ATE47140T1 (sv)
AU (1) AU570306B2 (sv)
DE (2) DE3573600D1 (sv)
DK (1) DK163059C (sv)
FI (1) FI82934C (sv)
HU (1) HU194864B (sv)
LU (1) LU90738I2 (sv)
NL (1) NL300042I2 (sv)
WO (1) WO1985003707A1 (sv)

Families Citing this family (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3677842D1 (de) * 1985-05-13 1991-04-11 Schering Corp Verfahren zur herstellung von piperidyliden-dihydrodibenzo(a,d)zykloheptenen und deren azoderivate, so hergestellte verbindungen und ihre anwendung zur vorbereitung von heilmitteln.
US4804666A (en) * 1985-08-14 1989-02-14 Schering Corporation Antiallergic 6,11-dihydro-11-(4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines
US4873335A (en) * 1986-03-12 1989-10-10 Schering Corporation 3-phenethyl-2-benzene-amides or aza-derivatives thereof
US5089496A (en) * 1986-10-31 1992-02-18 Schering Corporation Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
US4826853A (en) * 1986-10-31 1989-05-02 Schering Corporation 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use
US5665726A (en) * 1986-10-31 1997-09-09 Schering Corporation Benzo[5,6]cycloheptapyridines, compositions and methods of use
US5438062A (en) * 1986-10-31 1995-08-01 Schering Corporation Benzo(5,6)cycloheptapyridines, compositions and methods of use
NZ228888A (en) * 1988-04-28 1991-12-23 Schering Corp Derivatives of piperidine, piperidylidene and piperazine and pharmaceutical compositions
US4910205A (en) * 1988-05-02 1990-03-20 Schering Corporation Transdermal delivery of loratadine
US4990535A (en) 1989-05-03 1991-02-05 Schering Corporation Pharmaceutical composition comprising loratadine, ibuprofen and pseudoephedrine
IE68935B1 (en) * 1990-06-22 1996-07-24 Schering Corp Bis-benzo or benzopyrido cyclohepta piperidene piperidylidene and piperazine compounds compositions and methods of use
ES2040177B1 (es) * 1992-03-06 1994-05-16 S A Tamarang Procedimiento para la sintesis de la 8-cloro-6, 11-dihidro-11, (1-etoxicarbonil-4-piperidiliden) -5h-benzo (5,6) ciclohepta-(1,2-b) piridina.
US5561117A (en) * 1992-03-27 1996-10-01 Schering Corporation Bridged bis-aryl carbinol derivatives, compositions and methods of use
EP0635012B1 (en) * 1992-03-27 1996-07-10 Schering Corporation Unbridged bis-aryl carbinol derivatives, compositions and methods of use
ES2042421B1 (es) * 1992-05-22 1994-08-01 Uriach & Cia Sa J Procedimiento para la obtencion de la 8-cloro-11-*1-*(5-metil-3-piridil)metil*-4-piperidiliden*-6,11-dihidro-5h-benzo*5,6*ciclohepta*1,2-b*piridina.
US5631365A (en) 1993-09-21 1997-05-20 Schering Corporation Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
US7214683B1 (en) 1994-12-30 2007-05-08 Sepracor Inc. Compositions of descarboethoxyloratadine
US5595997A (en) * 1994-12-30 1997-01-21 Sepracor Inc. Methods and compositions for treating allergic rhinitis and other disorders using descarboethoxyloratadine
US7211582B1 (en) 1994-12-30 2007-05-01 Sepracor Inc. Methods for treating urticaria using descarboethoxyloratadine
TW522014B (en) * 1997-02-07 2003-03-01 Sepracor Inc Lactose-free, non-hygroscopic and anhydrous pharmaceutical unit dosage form containing descarboethoxyloratadine
US5900421A (en) * 1997-02-11 1999-05-04 Sepracor Inc. Methods and compositions for treating allergic asthma and dermatitis using descarboethoxyloratadine
US5939426A (en) * 1997-02-28 1999-08-17 Sepracor Inc. Methods for treating urinary incontinence using descarboethoxyloratadine
US5998620A (en) * 1997-03-25 1999-12-07 Schering Corporation Synthesis of intermediates useful in preparing tricyclic compounds
ES2180976T3 (es) * 1997-04-25 2003-02-16 Schering Plough Kabushiki Kais Colirio conteniendo un metabolito de loratidina.
UA62976C2 (en) * 1997-07-02 2004-01-15 Schering Corp Polymorphs of 8-chloro-6,11-dihydro-11-(4-piperidylidene)-5h-benzo[5,6]cyclohepta[1,2-b]pyridine
US6506767B1 (en) 1997-07-02 2003-01-14 Schering Corporation 8-chloro-6,11-dihydro-11-(4-piperidylidine)-5H-benzo[5,6]cyclohepta[1-2-b] pyridine
US6140337A (en) 1997-12-23 2000-10-31 Schering Corporation Methods for the treatment of mental disorders
US6132758A (en) * 1998-06-01 2000-10-17 Schering Corporation Stabilized antihistamine syrup
PT968715E (pt) * 1998-06-30 2004-12-31 Pfizer Prod Inc Loratadina para utilizacao como agente anti-arritmico
CZ300843B6 (cs) * 1998-07-10 2009-08-26 Schering Corporation Stabilizovaný farmaceutický prostredek na bázi dekarbonylethoxyloratadinu
US6423721B1 (en) 1998-09-10 2002-07-23 Schering Corporation Methods and compositions for treating sinusitis, otitis media and other related disorders using antihistamines
US6271378B1 (en) 1998-12-18 2001-08-07 Schering Corporation Process for preparing tricyclic compounds having antihistaminic activity
US6555139B2 (en) 1999-06-28 2003-04-29 Wockhardt Europe Limited Preparation of micron-size pharmaceutical particles by microfluidization
US6100274A (en) * 1999-07-07 2000-08-08 Schering Corporation 8-chloro-6,11-dihydro-11- ](4-piperidylidine)-5H-benzo[5,6]cyclohepta[1,2-bpyridine oral compositions
JP2003508422A (ja) 1999-09-02 2003-03-04 ノストラム・ファーマスーティカルズ・インコーポレイテッド 放出制御ペレット製剤
AU7704200A (en) * 1999-09-21 2001-04-24 Schering Corporation Treating allergic and inflammatory conditions
CA2383214A1 (en) * 1999-09-22 2001-03-29 Schering Corporation Treating allergic and inflammatory conditions
US6114346A (en) * 1999-10-22 2000-09-05 Schering Corporation Treating sleep disorders using desloratadine
WO2001045668A2 (en) 1999-12-20 2001-06-28 Schering Corporation Stable extended release oral dosage composition comprising pseudoephedrine and desloratadine
WO2001045676A2 (en) 1999-12-20 2001-06-28 Schering Corporation Extended release oral dosage composition
US7405223B2 (en) 2000-02-03 2008-07-29 Schering Corporation Treating allergic and inflammatory conditions
EP1251851A1 (en) * 2000-02-03 2002-10-30 Schering Corporation Treating allergic and inflammatory conditions
DE60141596D1 (de) * 2000-10-23 2010-04-29 Euro Celtique Sa Transdermales system zur verabreichung von loratadin und dessen verwendung
AU2002220248A1 (en) * 2000-11-06 2002-05-15 Andrx Pharmaceuticals, Inc. Once a day antihistamine and decongestant formulation
HU226998B1 (en) * 2000-11-23 2010-04-28 Richter Gedeon Nyrt Desloratadine hemisulphate, process for the preparation thereof and pharmaceutical compositions containing the same
CA2435573A1 (en) * 2001-01-24 2002-08-01 Summamus Pharma Inc. Alkyl aryl polyether alcohol polymers for improvement of nasal breathing
US20030021849A1 (en) * 2001-04-09 2003-01-30 Ben-Zion Dolitzky Polymorphs of fexofenadine hydrochloride
US20020177608A1 (en) * 2001-04-09 2002-11-28 Ben-Zion Dolitzky Polymorphs of fexofenadine hydrochloride
US6599913B1 (en) * 2001-06-29 2003-07-29 Schering Corporation Treating allergic and inflammatory conditions
US6720002B2 (en) * 2001-07-20 2004-04-13 R.P. Scherer Technologies, Inc. Antihistamine formulations for soft capsule dosage forms
JP4401167B2 (ja) 2001-08-21 2010-01-20 シェーリング コーポレイション 三環式ケトン中間体の合成プロセス
WO2003086275A2 (en) * 2002-04-15 2003-10-23 Sun Pharmaceutical Industries Limited Preperation of desloratatine
US20030004179A1 (en) * 2002-05-21 2003-01-02 Affrime Melton B Treating allergic and inflammatory conditions
JP2005532356A (ja) * 2002-06-10 2005-10-27 テバ ファーマシューティカル インダストリーズ リミティド 塩酸フェキソフェナジンの多型体ｘｖｉ
US20040001885A1 (en) * 2002-06-27 2004-01-01 Unchalee Kositprapa Rapidly disintegrating antihistamine formulation
GB0216383D0 (en) * 2002-07-13 2002-08-21 Astrazeneca Ab Compounds
KR20050069976A (ko) * 2002-08-05 2005-07-05 산도즈 아게 데스로라타딘 헤미푸마레이트의 신규 염 및 다형체
JP2006505590A (ja) * 2002-10-23 2006-02-16 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ヒスタミンｈ３受容体調節物質としてのフェニルピペリジンおよびフェニルピロリジン
US8092831B2 (en) * 2002-11-08 2012-01-10 Andrx Pharmaceuticals, Llc Antihistamine and decongestant system
EP1507774A1 (en) * 2003-03-12 2005-02-23 Biogal Gyogyszergyar Rt. Processes for preparation of polymorphic forms of desloratadine
US20060135547A1 (en) * 2003-03-12 2006-06-22 Toth Zoltan G Stable pharmaceutical compositions of desloratadine and processes for preparation of polymorphic forms of desloratadine
WO2004080997A1 (en) * 2003-03-13 2004-09-23 Morepen Laboratories Limited Process for the preparation of loratadine
MXPA06012281A (es) * 2004-04-26 2007-07-18 Teva Pharma Formas cristalinas de clorhidrato de fexofenadina y procesos para su preparacion.
EA011894B1 (ru) * 2004-07-07 2009-06-30 Эгиш Дьёдьсердьяр Нирт. Новая псевдополиморфная форма деслоратадина, образованная с диоксидом углерода
WO2006006184A2 (en) * 2004-07-08 2006-01-19 Morepen Laboratories Limited A process for the manufacturing of loratadine and its intermediates
NL1026634C2 (nl) * 2004-07-12 2006-01-16 Willem Jacob Van Der Burg Psychofarmaceutisch preparaat en werkzame stof daarin.
JP2008506679A (ja) * 2004-07-16 2008-03-06 シプラ・リミテッド 抗ヒスタミン組成物
MX2007001561A (es) * 2004-08-04 2007-04-16 Schering Corp Formulacion farmaceutica que comprende pleconaril para tratamiento de enfermedades de vias aereas.
EP1685106A2 (en) * 2004-09-28 2006-08-02 Teva Pharmaceutical Industries, Inc. Fexofendadine crystal form and processes for its preparation thereof
US20070009558A1 (en) * 2004-12-22 2007-01-11 David Harris Sugar-free storage-stable antihistaminic syrups
US20070004671A1 (en) * 2005-05-20 2007-01-04 Agarwal Sudeep K Stable desloratadine compositions
US20070036859A1 (en) * 2005-08-11 2007-02-15 Perry Ronald L Sustained release antihistamine and decongestant composition
US20070060756A1 (en) * 2005-08-11 2007-03-15 Orchid Chemicals & Pharmaceuticals Ltd. Process for the preparation of desloratadine
US20070135472A1 (en) * 2005-12-01 2007-06-14 Glenmark Pharmaceuticals Limited Novel crystalline forms of desloratadine and processes for their preparation
CA2541045A1 (en) * 2006-03-24 2007-09-24 Pharmascience Inc. A descarbonylethoxyloratadine containing pharmaceutical composition
BRPI0711871A2 (pt) * 2006-06-01 2011-12-06 Schering Corp composições farmacêuticas para liberação sustentada de fenilefrina
EP2366381A1 (en) * 2006-06-01 2011-09-21 MSD Consumer Care, Inc. Phenylephrine pharmaceutical formulations and compositions for colonic absorption
EP2023957A2 (en) * 2006-06-07 2009-02-18 Morton Grove Pharmaceuticals, Inc. Oral liquid loratadine formulations and methods
HU230417B1 (hu) * 2006-10-26 2016-05-30 Egis Gyógyszergyár Zrt Eljárás desloratadine szén-dioxiddal képezett adduktjának előállítására
WO2008107777A2 (en) * 2007-03-06 2008-09-12 Cadila Pharmaceuticals Limited Improved method for the preparation of desloratadine with reduced levels of organic solvents
US20090054338A1 (en) * 2007-08-06 2009-02-26 Aberg A K Gunnar Synergisms between repartitioning and immunomodulating compounds
US20090082385A1 (en) * 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched desloratidine
WO2010021681A2 (en) * 2008-08-18 2010-02-25 Combinatorx (Singapore) Pte. Ltd. Compositions and methods for treatment of viral diseases
TR200806298A2 (tr) 2008-08-22 2010-03-22 Bi̇lgi̇ç Mahmut Farmasötik formülasyon
EP2411380A1 (en) * 2009-03-26 2012-02-01 Ranbaxy Laboratories Limited Process for the preparation of desloratadine
JP2012530140A (ja) 2009-06-16 2012-11-29 メルク・シャープ・アンド・ドーム・コーポレーション グルココルチコイド受容体アゴニストとしての新規［３，２−ｃ］ヘテロアリールステロイド、組成物およびこの使用
ATE525064T1 (de) 2009-07-01 2011-10-15 Tiefenbacher Alfred E Gmbh & Co Kg Pharmazeutische zusammensetzung mit desloratadin
CA2690490C (en) 2010-01-19 2012-06-26 Accucaps Industries Limited Pharmaceutical formulations of loratadine for encapsulation and combinations thereof
WO2011146030A2 (en) 2010-05-18 2011-11-24 Mahmut Bilgic Effervescent antihistamine formulations
DE102010044246B4 (de) 2010-09-02 2015-06-25 Johnson Controls Gmbh Kopfstütze mit zwei Flügelelementen und Verfahren zur Montage eines Flügelelementes
TR201007652A2 (tr) 2010-09-20 2012-04-24 Bi̇lgi̇ç Mahmut Sinerjik etki.
TR201009396A2 (tr) 2010-11-11 2012-05-21 Bi̇lgi̇ç Mahmut Desloratadin granüller
US8778971B2 (en) 2012-10-23 2014-07-15 Bridge Pharma, Inc. Medicinal treatment of dermal diseases in companion animals
US8557846B1 (en) 2012-10-23 2013-10-15 Bridge Pharma, Inc. Medicinal treatment of dermal diseases in dogs
US20150272941A1 (en) 2012-10-30 2015-10-01 Bridge Pharma, Inc. Medicinal treatment of chronic pulmonary inflammatory diseases with norketotifen
US20140120121A1 (en) 2012-10-30 2014-05-01 Bridge Pharma, Inc. Medicinal treatment of atopic inflammatory diseases
US9138431B2 (en) 2013-08-06 2015-09-22 Bridge Pharma, Inc. Methods of treatment of histamine H-4 receptor-related pruritus
US10525057B2 (en) 2013-09-24 2020-01-07 Otsuka Pharmaceutical Co., Ltd. Method of providing aripiprazole to patients having impaired CYP2D6 or CYP3A4 enzyme function
CN104961724B (zh) * 2015-06-08 2018-01-30 惠州信立泰药业有限公司 一种获得高纯度地氯雷他定的先进生产工艺
RU2631619C2 (ru) * 2015-08-03 2017-09-25 Общество с ограниченной ответственностью "Трейдсервис" Диспергируемая в воде таблетка дезлоратадина и способ ее изготовления
CN107400083A (zh) * 2017-08-28 2017-11-28 四川大学 一种3‑[2‑(3‑氯苯基)乙基]‑2‑吡啶甲腈的制备方法
CN107556237B (zh) * 2017-08-28 2020-11-24 四川大学 一种3-(2-苯乙基)-2-吡啶甲酰胺类化合物的制备方法
CA3199160A1 (en) 2020-12-04 2022-06-09 Cecilia Jannette Munoz Martinez Pharmaceutical combination of a corticosteroid and an antihistamine for the treatment and control of the inflammatory component of allergic processes
CN112898268A (zh) * 2021-04-07 2021-06-04 深圳振强生物技术有限公司 一种地氯雷他定杂质的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL132137C (sv) * 1963-04-24
US3391143A (en) * 1966-05-16 1968-07-02 Smith Kline French Lab 9-piperidyl and 9-piperidylidene derivatives of acridan
US3717647A (en) * 1971-04-09 1973-02-20 Schering Corp Alpha-nicotinoyl phenylacetonitriles
US4282233B1 (en) * 1980-06-19 2000-09-05 Schering Corp Antihistaminic 11-(4-piperidylidene)-5h-benzoÄ5,6Ü-cyclohepta-Ä1,2Ü-pyridines

Also Published As

Publication number Publication date
HU194864B (en) 1988-03-28
HUT38332A (en) 1986-05-28
ATE47140T1 (de) 1989-10-15
EP0152897B1 (en) 1989-10-11
DE10199025I1 (de) 2001-08-02
DE10199025I2 (de) 2004-04-01
JPS61501205A (ja) 1986-06-19
NL300042I2 (nl) 2001-07-02
NL300042I1 (nl) 2001-06-01
FI853675L (fi) 1985-09-25
AU570306B2 (en) 1988-03-10
FI82934C (sv) 1991-05-10
WO1985003707A1 (en) 1985-08-29
DE3573600D1 (en) 1989-11-16
DK469485D0 (da) 1985-10-14
JPH0572910B2 (sv) 1993-10-13
EP0152897A1 (en) 1985-08-28
DK163059C (da) 1992-06-09
DK163059B (da) 1992-01-13
AU3993885A (en) 1985-09-10
US4659716A (en) 1987-04-21
LU90738I2 (fr) 2001-05-09
DK469485A (da) 1985-10-14
FI853675A0 (fi) 1985-09-25

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