FI82451B - Foerfarande foer framstaellning av terapeutiskt anvaendbara kinolinderivat. - Google Patents
Foerfarande foer framstaellning av terapeutiskt anvaendbara kinolinderivat. Download PDFInfo
- Publication number
- FI82451B FI82451B FI862381A FI862381A FI82451B FI 82451 B FI82451 B FI 82451B FI 862381 A FI862381 A FI 862381A FI 862381 A FI862381 A FI 862381A FI 82451 B FI82451 B FI 82451B
- Authority
- FI
- Finland
- Prior art keywords
- general formula
- group
- compounds
- acid addition
- radiation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
- C07D215/46—Nitrogen atoms attached in position 4 with hydrocarbon radicals, substituted by nitrogen atoms, attached to said nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Claims (3)
1. Förfarande för framställning av nya terapeutiskt använd-bara kinolinderivat med den allmänna formeln I NH-, I 2 , V N^r2 och syraadditionssalter därav, (varvid R1 representerar väte och R2 representerar hydroxi-Ci_4-alkyl eller Ci_4-alkoxi-Ci_4~ alkyl eller en grupp med den allmänna formeln IV li Civ) väri de prickade linjerna representerar eventuella bindningar och m är 0 eller 1 eller r! och R2 tillsammans med den kväveatom, som de är bundna tili, bildar en morfolinogrupp, en eventuellt hydroxyl-gruppssubstituerad piperidinogrupp eller en eventuellt alkylgruppssubstituerad piperazinogrupp), kännetecknat av att ett kinolinderivat med den allmänna formeln II II V i9 82451 (ιι) (väri Y stär för en lämnande grupp) eller ett syraadditions-salt därav omsätts med ett guanidinderivat med den allmänna formeln III NH II ^R1 (m) nh-5-c-nC % 1 (väri R1 och R2 har samma betydelse som ovan) eller ett syraadditionssalt därav och, om sä önskas, en sälunda er-h&llen förening med den allmänna formeln I omvandlas tili ett farmaceutiskt godtagbart syraadditionssalt därav eller en förening med den allmänna formeln I frisätts frän ett sait därav.
2. Förfarande enligt patentkrav 1, kännetecknat av att säsom utgängsämne används föreningar med den allmänna formeln II, väri Y stär för halogen, företrädesvis klor.
3. Förfarande enligt patentkrav 1 eller 2 för framställning av N-(3-nitro-4-kinolyl)-morfolinokarboxamid, kännetecknat av att en 4-halo-3-nitrokinolin - företrädesvis 4-klor-3-nitrokinolin - omsätts med morfolinokarboxamid.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU219385 | 1985-06-04 | ||
| HU852193A HU195487B (en) | 1985-06-04 | 1985-06-04 | Process for producing quinoline derivatives |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI862381A0 FI862381A0 (fi) | 1986-06-04 |
| FI862381A FI862381A (fi) | 1986-12-05 |
| FI82451B true FI82451B (fi) | 1990-11-30 |
| FI82451C FI82451C (sv) | 1991-03-11 |
Family
ID=10958222
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI862381A FI82451C (sv) | 1985-06-04 | 1986-06-04 | Förfarande för framställning av terapeutiskt användbara kinolinderivat |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US4652562A (sv) |
| JP (1) | JPS6248668A (sv) |
| KR (1) | KR930006775B1 (sv) |
| CN (1) | CN1012957B (sv) |
| AT (1) | AT392469B (sv) |
| AU (1) | AU588883B2 (sv) |
| BE (1) | BE904864A (sv) |
| CA (1) | CA1266650A (sv) |
| CH (1) | CH668069A5 (sv) |
| CS (1) | CS257793B2 (sv) |
| DD (1) | DD247448A5 (sv) |
| DE (1) | DE3618724C2 (sv) |
| DK (1) | DK162841C (sv) |
| ES (1) | ES8707231A1 (sv) |
| FI (1) | FI82451C (sv) |
| FR (1) | FR2582835B1 (sv) |
| GB (1) | GB2176185B (sv) |
| GR (1) | GR861452B (sv) |
| HU (1) | HU195487B (sv) |
| IL (1) | IL79024A0 (sv) |
| IT (1) | IT1204377B (sv) |
| NL (1) | NL8601434A (sv) |
| NO (1) | NO165635C (sv) |
| PH (1) | PH24135A (sv) |
| PL (1) | PL146498B1 (sv) |
| PT (1) | PT82712B (sv) |
| SE (1) | SE466308B (sv) |
| SU (1) | SU1398773A3 (sv) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6331286B1 (en) | 1998-12-21 | 2001-12-18 | Photogen, Inc. | Methods for high energy phototherapeutics |
| US8974363B2 (en) * | 1997-12-11 | 2015-03-10 | Provectus Pharmatech, Inc. | Topical medicaments and methods for photodynamic treatment of disease |
| US8557298B2 (en) * | 1998-08-06 | 2013-10-15 | Provectus Pharmatech, Inc. | Medicaments for chemotherapeutic treatment of disease |
| US20090117199A1 (en) * | 1998-08-06 | 2009-05-07 | Scott Timothy C | Method of treatment of cancer |
| US20020001567A1 (en) * | 1998-12-21 | 2002-01-03 | Photogen, Inc. | Intracorporeal medicaments for high energy phototherapeutic treatment of disease |
| US7384623B1 (en) | 1998-12-21 | 2008-06-10 | Provectus Pharmatech, Inc. | High energy phototherapeutic agents |
| US8470296B2 (en) * | 1998-12-21 | 2013-06-25 | Provectus Pharmatech, Inc. | Intracorporeal medicaments for high energy phototherapeutic treatment of disease |
| US20040053928A1 (en) * | 2000-09-21 | 2004-03-18 | Davies David Thomas | Quinoline derivatives as antibacterials |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU165520B (sv) * | 1972-05-05 | 1974-09-28 | ||
| IE47458B1 (en) * | 1977-11-07 | 1984-03-21 | Leo Pharm Prod Ltd | Quinolylguanidine derivatives |
-
1985
- 1985-06-04 HU HU852193A patent/HU195487B/hu not_active IP Right Cessation
-
1986
- 1986-05-28 CH CH2153/86A patent/CH668069A5/de not_active IP Right Cessation
- 1986-05-30 DD DD86290766A patent/DD247448A5/de not_active IP Right Cessation
- 1986-06-03 KR KR1019860004409A patent/KR930006775B1/ko not_active IP Right Cessation
- 1986-06-03 BE BE0/216734A patent/BE904864A/fr not_active IP Right Cessation
- 1986-06-03 AT AT1492/86A patent/AT392469B/de not_active IP Right Cessation
- 1986-06-03 CN CN86103688A patent/CN1012957B/zh not_active Expired
- 1986-06-03 PH PH33848A patent/PH24135A/en unknown
- 1986-06-04 US US06/870,396 patent/US4652562A/en not_active Expired - Fee Related
- 1986-06-04 AU AU58344/86A patent/AU588883B2/en not_active Ceased
- 1986-06-04 ES ES555708A patent/ES8707231A1/es not_active Expired
- 1986-06-04 FI FI862381A patent/FI82451C/sv not_active IP Right Cessation
- 1986-06-04 DE DE3618724A patent/DE3618724C2/de not_active Expired - Fee Related
- 1986-06-04 NL NL8601434A patent/NL8601434A/nl not_active Application Discontinuation
- 1986-06-04 CA CA000510779A patent/CA1266650A/en not_active Expired - Lifetime
- 1986-06-04 FR FR8608039A patent/FR2582835B1/fr not_active Expired
- 1986-06-04 JP JP61130006A patent/JPS6248668A/ja active Granted
- 1986-06-04 GB GB08613530A patent/GB2176185B/en not_active Expired
- 1986-06-04 IT IT20667/86A patent/IT1204377B/it active
- 1986-06-04 CS CS864112A patent/CS257793B2/cs unknown
- 1986-06-04 NO NO862230A patent/NO165635C/no unknown
- 1986-06-04 PL PL1986259871A patent/PL146498B1/pl unknown
- 1986-06-04 IL IL79024A patent/IL79024A0/xx not_active IP Right Cessation
- 1986-06-04 GR GR861452A patent/GR861452B/el unknown
- 1986-06-04 PT PT82712A patent/PT82712B/pt unknown
- 1986-06-04 DK DK262186A patent/DK162841C/da not_active IP Right Cessation
- 1986-06-04 SE SE8602524A patent/SE466308B/sv not_active IP Right Cessation
- 1986-06-04 SU SU864027590A patent/SU1398773A3/ru active
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed | ||
| MM | Patent lapsed |
Owner name: EGIS GYOGYSZERGYAR |