FI81562B - Foerfarande foer framstaellning av syraadditionssalter av 1,3-bis(dimetylamino)-2-propyl-4-klorfenoxiacetat och anvaendningen av dessa som laekemedel. - Google Patents
Foerfarande foer framstaellning av syraadditionssalter av 1,3-bis(dimetylamino)-2-propyl-4-klorfenoxiacetat och anvaendningen av dessa som laekemedel. Download PDFInfo
- Publication number
- FI81562B FI81562B FI841611A FI841611A FI81562B FI 81562 B FI81562 B FI 81562B FI 841611 A FI841611 A FI 841611A FI 841611 A FI841611 A FI 841611A FI 81562 B FI81562 B FI 81562B
- Authority
- FI
- Finland
- Prior art keywords
- bis
- formula
- dimethylamino
- compound
- propyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C219/20—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C219/22—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Fats And Perfumes (AREA)
- Photoreceptors In Electrophotography (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Detergent Compositions (AREA)
- Devices For Use In Laboratory Experiments (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (2)
1. Menetelmä lääkeaineina, erityisesti aivotoimintojen virkistäjänä käytettävien, kaavan I mukaisen l,3-bis(dimetyyli-amino)-2-propyyli-4-kloorifenoksiasetaatin fysiologisesti sopivien happoadditiosuolojen valmistamiseksi uti3 -------- ch3 I /=\ 0 CH2 ci-/ \-0-CH2-C-0-CH (Kaava I) N / CHp ">1 ch5 tunnettu siitä, että yleisen kaavan II muotoa olevat yhdisteet, ___ »O 0-CH2-r1 (Kaava II) joissa rI on karboksyyli-, syano-, alkoksikarbonyyli-, halo-geenikarbonyyli-, 4-kloorifenoksiasetyylioksikarbonyyliryhmä, tai ryhmä muotoa -COOMe1, jossa Me* on alkalimetalli-ioni, muutetaan yleisen kaavan m muotoa olevan yhdisteen avulla CH5 CH3 ^N-CH2-CH-CH2-N (Kaava III) CH3 I NsCH3 R2 jossa r2 on hydroksyyliryhmä tai halogeeniatomi, ja muodostunut, kaavan I mukaisen yhdisteen happoadditiosuola eristetään reaktioliuoksesta. 2. patenttivaatimuksen 1 mukainen menetelmä, tunnettu siitä, että lähtöaineina käytetään 4-kloorifenokeietikkahappo-kloridia ja 1,3-bis-(dimetyyliamino)-2-propanolia. 11 81562
1. Förfarande för framställning av som läkemedel, speciellt tili stimulering av hjärnfunktionen, användbara fysiologiskt kompatibla syraadditionsalter av 1,3-bis(dimetylamino)-2-propyl-4-klorfenoxiacetat enligt formeln I ch3^ ch3^ I /=v o ch2 C1—^ y-0-CH2-C-0-CH (Fornel I) ch5 ch5 kännetecknat därav, att man omvandlar föreningar med den allmänna formeln II O. (Formel II) o-ch2-r1 väri Rl betecknar karboxyl-, cyano-, alkoxikarbony1-, halogen-karbonyl-, 4-klorfenoxi-acetyloxikarbonylgrupp, eller en grupp med formeln -COOMe* med Me1 = en alkalimetall-ion, med en förening med den allmänna formeln III CH3x ^CH3 ^ N-:h2-CH-CH2-:.tn (Fornel III) ch3 I CH3 R2 väri R1 betecknar en hydroxylgrupp eller halogenatom, och isolerar det bildade syraadditonssaltet av föreningen enligt formeln I ur reaktionsblandningen. Förfarande enligt patentkrav 1, kännetecknat därav, att man som utgangsämne använder 4-klorfenoxiättiksyra-klorid och 1,3-bis-(dimetylamino)-2-propanol.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU149683 | 1983-05-02 | ||
| HU831496A HU190589B (en) | 1983-05-02 | 1983-05-02 | Process for preparing acid additional salts of 4-chloro-phenoxy-acetic acid-1,3-bis/dimethyl-amino/-2-propyl-ester |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI841611A0 FI841611A0 (fi) | 1984-04-24 |
| FI841611A FI841611A (fi) | 1984-11-03 |
| FI81562B true FI81562B (fi) | 1990-07-31 |
| FI81562C FI81562C (sv) | 1990-11-12 |
Family
ID=10954727
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI841611A FI81562C (sv) | 1983-05-02 | 1984-04-24 | Förfarande för framställning av syraadditionssalter av 1,3-bis(dimetyl amino)-2-propyl-4-klorfenoxiacetat och användningen av dessa som läkem edel |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US4661618A (sv) |
| EP (1) | EP0127000B1 (sv) |
| JP (1) | JPS606646A (sv) |
| KR (1) | KR840009292A (sv) |
| AT (1) | ATE24712T1 (sv) |
| AU (1) | AU565723B2 (sv) |
| BG (1) | BG42833A3 (sv) |
| CA (1) | CA1246602A (sv) |
| CS (1) | CS241081B2 (sv) |
| DD (1) | DD216449A5 (sv) |
| DE (1) | DE3461924D1 (sv) |
| DK (1) | DK214884A (sv) |
| EG (1) | EG16744A (sv) |
| ES (1) | ES532062A0 (sv) |
| FI (1) | FI81562C (sv) |
| HU (1) | HU190589B (sv) |
| IL (1) | IL71714A (sv) |
| NZ (1) | NZ208011A (sv) |
| PL (1) | PL142906B1 (sv) |
| SU (2) | SU1376937A3 (sv) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3546273A (en) * | 1967-06-01 | 1970-12-08 | Merck & Co Inc | Ester derivatives of 2-(4-halophenoxy)alkanoic acids |
| JPS5135896B2 (sv) * | 1973-06-20 | 1976-10-05 |
-
1983
- 1983-05-02 HU HU831496A patent/HU190589B/hu unknown
-
1984
- 1984-04-03 EG EG271/84A patent/EG16744A/xx active
- 1984-04-24 FI FI841611A patent/FI81562C/sv not_active IP Right Cessation
- 1984-04-26 CA CA000452851A patent/CA1246602A/en not_active Expired
- 1984-04-27 BG BG065259A patent/BG42833A3/xx unknown
- 1984-04-27 DK DK214884A patent/DK214884A/da not_active Application Discontinuation
- 1984-04-27 SU SU843732702A patent/SU1376937A3/ru active
- 1984-04-28 CS CS843217A patent/CS241081B2/cs unknown
- 1984-04-30 ES ES532062A patent/ES532062A0/es active Granted
- 1984-04-30 DD DD84262463A patent/DD216449A5/de not_active IP Right Cessation
- 1984-05-01 IL IL71714A patent/IL71714A/xx unknown
- 1984-05-01 NZ NZ208011A patent/NZ208011A/en unknown
- 1984-05-02 PL PL1984247504A patent/PL142906B1/pl unknown
- 1984-05-02 EP EP84104880A patent/EP0127000B1/de not_active Expired
- 1984-05-02 JP JP59087964A patent/JPS606646A/ja active Granted
- 1984-05-02 US US06/606,347 patent/US4661618A/en not_active Expired - Fee Related
- 1984-05-02 DE DE8484104880T patent/DE3461924D1/de not_active Expired
- 1984-05-02 AT AT84104880T patent/ATE24712T1/de not_active IP Right Cessation
- 1984-05-02 AU AU27610/84A patent/AU565723B2/en not_active Ceased
- 1984-05-02 KR KR1019840002367A patent/KR840009292A/ko not_active Application Discontinuation
-
1985
- 1985-07-02 SU SU853915275A patent/SU1326572A1/ru active
Also Published As
| Publication number | Publication date |
|---|---|
| IL71714A (en) | 1987-09-16 |
| JPH0527616B2 (sv) | 1993-04-21 |
| EG16744A (en) | 1990-12-30 |
| DD216449A5 (de) | 1984-12-12 |
| AU565723B2 (en) | 1987-09-24 |
| IL71714A0 (en) | 1984-09-30 |
| NZ208011A (en) | 1987-06-30 |
| HU190589B (en) | 1986-09-29 |
| FI841611A (fi) | 1984-11-03 |
| PL247504A1 (en) | 1985-03-26 |
| ATE24712T1 (de) | 1987-01-15 |
| AU2761084A (en) | 1984-11-08 |
| CA1246602A (en) | 1988-12-13 |
| SU1376937A3 (ru) | 1988-02-23 |
| DE3461924D1 (en) | 1987-02-12 |
| CS241081B2 (en) | 1986-03-13 |
| US4661618A (en) | 1987-04-28 |
| CS321784A2 (en) | 1985-06-13 |
| KR840009292A (ko) | 1984-12-26 |
| FI81562C (sv) | 1990-11-12 |
| PL142906B1 (en) | 1987-12-31 |
| JPS606646A (ja) | 1985-01-14 |
| HUT34150A (en) | 1985-02-28 |
| FI841611A0 (fi) | 1984-04-24 |
| SU1326572A1 (ru) | 1987-07-30 |
| ES8506259A1 (es) | 1985-07-01 |
| BG42833A3 (en) | 1988-02-15 |
| DK214884D0 (da) | 1984-04-27 |
| EP0127000B1 (de) | 1987-01-07 |
| ES532062A0 (es) | 1985-07-01 |
| DK214884A (da) | 1984-11-03 |
| EP0127000A1 (de) | 1984-12-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed | ||
| MM | Patent lapsed |
Owner name: BIOGAL GYOGYSZERGYAR RT. |