KR840009292A - 1,3-비스(디메틸아미노)-2-프로필-4-클로로페녹시-아세테이트 및 이의 산부가염의 제조방법 - Google Patents
1,3-비스(디메틸아미노)-2-프로필-4-클로로페녹시-아세테이트 및 이의 산부가염의 제조방법 Download PDFInfo
- Publication number
- KR840009292A KR840009292A KR1019840002367A KR840002367A KR840009292A KR 840009292 A KR840009292 A KR 840009292A KR 1019840002367 A KR1019840002367 A KR 1019840002367A KR 840002367 A KR840002367 A KR 840002367A KR 840009292 A KR840009292 A KR 840009292A
- Authority
- KR
- South Korea
- Prior art keywords
- dimethylamino
- bis
- chlorophenoxy
- general formula
- propyl
- Prior art date
Links
- 239000002253 acid Substances 0.000 title claims 3
- 150000003839 salts Chemical class 0.000 title claims 3
- RTHMFWSTLJGBPA-UHFFFAOYSA-N 2-[4-chloro-1,5-bis(dimethylamino)-6-propylcyclohexa-2,4-dien-1-yl]oxyacetic acid Chemical compound CCCC1C(N(C)C)=C(Cl)C=CC1(OCC(O)=O)N(C)C RTHMFWSTLJGBPA-UHFFFAOYSA-N 0.000 title claims 2
- 238000000034 method Methods 0.000 title claims 2
- 150000001875 compounds Chemical class 0.000 claims 3
- -1 halogenocarbonyl Chemical group 0.000 claims 2
- JGVZJRHAZOBPMW-UHFFFAOYSA-N 1,3-bis(dimethylamino)propan-2-ol Chemical compound CN(C)CC(O)CN(C)C JGVZJRHAZOBPMW-UHFFFAOYSA-N 0.000 claims 1
- VRBVHQUSAOKVDH-UHFFFAOYSA-N 2-(4-chlorophenoxy)acetyl chloride Chemical compound ClC(=O)COC1=CC=C(Cl)C=C1 VRBVHQUSAOKVDH-UHFFFAOYSA-N 0.000 claims 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims 1
- YXUURMMMLNKQFH-UHFFFAOYSA-N [4-chloro-1,5-bis(dimethylamino)-6-propylcyclohexa-2,4-dien-1-yl] ethaneperoxoate Chemical compound C(C)(=O)OOC1(C(C(=C(C=C1)Cl)N(C)C)CCC)N(C)C YXUURMMMLNKQFH-UHFFFAOYSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 229910052783 alkali metal Inorganic materials 0.000 claims 1
- 150000001340 alkali metals Chemical class 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000007858 starting material Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C219/20—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C219/22—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Fats And Perfumes (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Detergent Compositions (AREA)
- Devices For Use In Laboratory Experiments (AREA)
- Photoreceptors In Electrophotography (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (3)
- 다음 일반식(Ⅲ)의 화합물과 다음 일반식(Ⅲ)의 화합물을 반응시키고, 반응혼합물로 부터 얻어진 다음일반식(Ⅰ)의 화합물을 그의 산부가염의 형태로 임의로 분리함을 특징으로 하는 다음 일반식(I)의 1,3-비스(디메틸아미노)-2-프로필-4-클로로페녹시 아세테이트 및 그의 산부가염의 제조방법.상기식에서, R1은 카르복시, 시아노, 알콕시카르보닐, 할로게노카르보닐, 4-클로로페녹시 아세톡시카르보닐 또는 일반식-COOMeI의 기이고, MeI은 알칼리금속 또는 암모늄이온이다.상기식에서, R2는 히드록시 또는 할로겐원자이다.
- 제1항에 있어서, 출발물질로서 (4-클로로페녹시) 아세틸 클로라이드 및 1,3-비스(디메틸아미노)-2-프로판올을 사용함을 특징으로 하는 방법.
- 유효성분으로서 1,3-비스(디메틸아미노)-2-프로필-4-클로로페녹시아세테이트 및 이의 산부가염과 제약에 수용할 수 있는 적당한 불활성 담체를 혼합함을 특징으로 하는 제약 조성물.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU831496A HU190589B (en) | 1983-05-02 | 1983-05-02 | Process for preparing acid additional salts of 4-chloro-phenoxy-acetic acid-1,3-bis/dimethyl-amino/-2-propyl-ester |
| HU1496/83 | 1983-05-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR840009292A true KR840009292A (ko) | 1984-12-26 |
Family
ID=10954727
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019840002367A KR840009292A (ko) | 1983-05-02 | 1984-05-02 | 1,3-비스(디메틸아미노)-2-프로필-4-클로로페녹시-아세테이트 및 이의 산부가염의 제조방법 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US4661618A (ko) |
| EP (1) | EP0127000B1 (ko) |
| JP (1) | JPS606646A (ko) |
| KR (1) | KR840009292A (ko) |
| AT (1) | ATE24712T1 (ko) |
| AU (1) | AU565723B2 (ko) |
| BG (1) | BG42833A3 (ko) |
| CA (1) | CA1246602A (ko) |
| CS (1) | CS241081B2 (ko) |
| DD (1) | DD216449A5 (ko) |
| DE (1) | DE3461924D1 (ko) |
| DK (1) | DK214884A (ko) |
| EG (1) | EG16744A (ko) |
| ES (1) | ES8506259A1 (ko) |
| FI (1) | FI81562C (ko) |
| HU (1) | HU190589B (ko) |
| IL (1) | IL71714A (ko) |
| NZ (1) | NZ208011A (ko) |
| PL (1) | PL142906B1 (ko) |
| SU (2) | SU1376937A3 (ko) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3546273A (en) * | 1967-06-01 | 1970-12-08 | Merck & Co Inc | Ester derivatives of 2-(4-halophenoxy)alkanoic acids |
| JPS5135896B2 (ko) * | 1973-06-20 | 1976-10-05 |
-
1983
- 1983-05-02 HU HU831496A patent/HU190589B/hu unknown
-
1984
- 1984-04-03 EG EG271/84A patent/EG16744A/xx active
- 1984-04-24 FI FI841611A patent/FI81562C/fi not_active IP Right Cessation
- 1984-04-26 CA CA000452851A patent/CA1246602A/en not_active Expired
- 1984-04-27 DK DK214884A patent/DK214884A/da not_active Application Discontinuation
- 1984-04-27 SU SU843732702A patent/SU1376937A3/ru active
- 1984-04-27 BG BG8465259A patent/BG42833A3/xx unknown
- 1984-04-28 CS CS843217A patent/CS241081B2/cs unknown
- 1984-04-30 DD DD84262463A patent/DD216449A5/de not_active IP Right Cessation
- 1984-04-30 ES ES532062A patent/ES8506259A1/es not_active Expired
- 1984-05-01 IL IL71714A patent/IL71714A/xx unknown
- 1984-05-01 NZ NZ208011A patent/NZ208011A/en unknown
- 1984-05-02 PL PL1984247504A patent/PL142906B1/pl unknown
- 1984-05-02 EP EP84104880A patent/EP0127000B1/de not_active Expired
- 1984-05-02 AT AT84104880T patent/ATE24712T1/de not_active IP Right Cessation
- 1984-05-02 AU AU27610/84A patent/AU565723B2/en not_active Ceased
- 1984-05-02 DE DE8484104880T patent/DE3461924D1/de not_active Expired
- 1984-05-02 KR KR1019840002367A patent/KR840009292A/ko not_active Application Discontinuation
- 1984-05-02 US US06/606,347 patent/US4661618A/en not_active Expired - Fee Related
- 1984-05-02 JP JP59087964A patent/JPS606646A/ja active Granted
-
1985
- 1985-07-02 SU SU853915275A patent/SU1326572A1/ru active
Also Published As
| Publication number | Publication date |
|---|---|
| CA1246602A (en) | 1988-12-13 |
| ES532062A0 (es) | 1985-07-01 |
| FI841611A (fi) | 1984-11-03 |
| HUT34150A (en) | 1985-02-28 |
| DK214884A (da) | 1984-11-03 |
| AU2761084A (en) | 1984-11-08 |
| AU565723B2 (en) | 1987-09-24 |
| SU1376937A3 (ru) | 1988-02-23 |
| CS241081B2 (en) | 1986-03-13 |
| PL247504A1 (en) | 1985-03-26 |
| FI81562C (fi) | 1990-11-12 |
| HU190589B (en) | 1986-09-29 |
| EP0127000B1 (de) | 1987-01-07 |
| NZ208011A (en) | 1987-06-30 |
| IL71714A0 (en) | 1984-09-30 |
| IL71714A (en) | 1987-09-16 |
| ATE24712T1 (de) | 1987-01-15 |
| FI81562B (fi) | 1990-07-31 |
| BG42833A3 (en) | 1988-02-15 |
| US4661618A (en) | 1987-04-28 |
| SU1326572A1 (ru) | 1987-07-30 |
| JPS606646A (ja) | 1985-01-14 |
| PL142906B1 (en) | 1987-12-31 |
| CS321784A2 (en) | 1985-06-13 |
| JPH0527616B2 (ko) | 1993-04-21 |
| EP0127000A1 (de) | 1984-12-05 |
| FI841611A0 (fi) | 1984-04-24 |
| ES8506259A1 (es) | 1985-07-01 |
| DD216449A5 (de) | 1984-12-12 |
| DK214884D0 (da) | 1984-04-27 |
| EG16744A (en) | 1990-12-30 |
| DE3461924D1 (en) | 1987-02-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| WITB | Written withdrawal of application |