FI813967L - Nya karbocykliner foerfarande foer deras framstaellning och deas anvaendning som laekemedel - Google Patents
Nya karbocykliner foerfarande foer deras framstaellning och deas anvaendning som laekemedelInfo
- Publication number
- FI813967L FI813967L FI813967A FI813967A FI813967L FI 813967 L FI813967 L FI 813967L FI 813967 A FI813967 A FI 813967A FI 813967 A FI813967 A FI 813967A FI 813967 L FI813967 L FI 813967L
- Authority
- FI
- Finland
- Prior art keywords
- hydrogen
- karbocykliner
- deas
- nya
- free
- Prior art date
Links
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000001931 aliphatic group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- -1 hydroxymethylene Chemical class 0.000 abstract 2
- 101100294106 Caenorhabditis elegans nhr-3 gene Proteins 0.000 abstract 1
- XZFRIPGNUQRGPI-WLPVIMDJSA-N Carbacyclin Chemical class C1\C(=C\CCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@@H]21 XZFRIPGNUQRGPI-WLPVIMDJSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
- C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
- C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4015—Esters of acyclic unsaturated acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Cardiology (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Pyrane Compounds (AREA)
- Tires In General (AREA)
- Polyesters Or Polycarbonates (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19803048906 DE3048906A1 (de) | 1980-12-19 | 1980-12-19 | Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
DE3048906 | 1980-12-19 |
Publications (3)
Publication Number | Publication Date |
---|---|
FI813967L true FI813967L (fi) | 1982-06-20 |
FI71122B FI71122B (fi) | 1986-08-14 |
FI71122C FI71122C (fi) | 1986-11-24 |
Family
ID=6120200
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI813967A FI71122C (fi) | 1980-12-19 | 1981-12-10 | Foerfarande foer framstaellning av blodtrycksaenkande och trombosytaggregationshaemmande karbacyklinderivat |
Country Status (21)
Country | Link |
---|---|
US (2) | US4423067A (fi) |
EP (1) | EP0055208B1 (fi) |
JP (1) | JPS57145833A (fi) |
AT (1) | ATE12094T1 (fi) |
AU (1) | AU548662B2 (fi) |
CA (1) | CA1223255A (fi) |
CS (1) | CS232719B2 (fi) |
DE (2) | DE3048906A1 (fi) |
DK (1) | DK169815B1 (fi) |
ES (1) | ES508124A0 (fi) |
FI (1) | FI71122C (fi) |
GR (1) | GR77633B (fi) |
HU (1) | HU187398B (fi) |
IE (1) | IE52432B1 (fi) |
IL (1) | IL64577A0 (fi) |
NO (1) | NO155537C (fi) |
NZ (1) | NZ199319A (fi) |
PH (1) | PH19419A (fi) |
SU (1) | SU1367856A3 (fi) |
YU (1) | YU293081A (fi) |
ZA (1) | ZA818788B (fi) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3048906A1 (de) * | 1980-12-19 | 1982-07-15 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
DE3306125A1 (de) * | 1983-02-18 | 1984-08-23 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
JPS58188850A (ja) * | 1982-04-26 | 1983-11-04 | Sumitomo Chem Co Ltd | 新規ビシクロオクタン誘導体およびその製造法 |
DE3225287A1 (de) * | 1982-07-02 | 1984-01-05 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue carbacyclinamide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
DE3225288A1 (de) * | 1982-07-02 | 1984-01-19 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
DE3226550A1 (de) * | 1982-07-13 | 1984-01-19 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
JPS59141536A (ja) * | 1983-02-01 | 1984-08-14 | Sumitomo Chem Co Ltd | 新規ビシクロオクタン誘導体 |
DE3306123A1 (de) * | 1983-02-18 | 1984-09-06 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
JPS60181041A (ja) * | 1984-02-29 | 1985-09-14 | Sankyo Co Ltd | カルバサイクリン誘導体 |
JPS60172941A (ja) * | 1984-02-16 | 1985-09-06 | Sankyo Co Ltd | カルバサイクリン類 |
ES8705382A1 (es) * | 1983-07-26 | 1987-05-01 | Sankyo Co | Un procedimiento para la preparacion de nuevos derivados de carbaciclina. |
US4971987A (en) * | 1984-07-27 | 1990-11-20 | Schering Aktiengesellschaft | New carbacycline, process for their production and their use as a drug |
DE3428266A1 (de) * | 1984-07-27 | 1986-01-30 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
JPH0680027B2 (ja) * | 1985-09-18 | 1994-10-12 | 財団法人相模中央化学研究所 | プロスタサイクリン類及びこれらを含有する薬剤 |
JP2716986B2 (ja) | 1987-07-17 | 1998-02-18 | シエーリング アクチエンゲゼルシヤフト | 9‐ハロゲン‐(z)‐プロスタグランジン誘導体、その製法及び薬剤としてのその使用 |
US5891910A (en) * | 1987-07-17 | 1999-04-06 | Schering Aktiengesellschaft | 9-halogen-(Z) prostaglandin derivatives, process for their production and their use as pharmaceutical agents |
DE3835162A1 (de) * | 1988-10-13 | 1990-04-19 | Schering Ag | (1s,2s,3r,5r)-2-((3s)-2-halogen-3-hydroxy-1-alken(inyl))-3-trialkylsilyloxy-7,7-(2,2-dimethyl-trimethylendioxy)-bicyclo-(3.3.0)-octan-verbindungen und verfahren zu deren herstellung |
DE19828881A1 (de) | 1998-06-22 | 1999-12-23 | Schering Ag | Oxidationsinhibitor bei Prostan-Derivaten |
ATE306256T1 (de) | 1999-08-05 | 2005-10-15 | Teijin Ltd | Mittel zur besserung der neuropathie, die als wirkstoff stickstoffhaltige verbindungen enthalten |
US20090035260A1 (en) * | 2002-07-29 | 2009-02-05 | Therapicon Srl | Enhanced nasal composition of active peptide |
US20090124697A1 (en) * | 2003-12-16 | 2009-05-14 | United Therapeutics Corporation | Inhalation formulations of treprostinil |
KR101161889B1 (ko) * | 2003-12-16 | 2012-07-02 | 유나이티드 쎄러퓨틱스 코포레이션 | 허혈성 병변의 치료 및 예방을 위한 트레프로스티닐의 용도 |
ITMI20040235A1 (it) * | 2004-02-13 | 2004-05-13 | Therapicon Srl | Preparazione farmaceutica per il cavo orale |
BRPI0513866A (pt) * | 2004-07-26 | 2008-05-20 | Cotherix Inc | composição, micropartìculas, método para o tratamento da hipertensão pulmonar, e dispositivo de inalação |
CA2654492C (en) * | 2006-05-15 | 2017-06-27 | United Therapeutics Corporation | Treprostinil administration using a metered dose inhaler |
DE102006026786A1 (de) | 2006-06-07 | 2007-12-13 | Joachim Kern | Dosierinhalator |
WO2008058766A1 (en) | 2006-11-16 | 2008-05-22 | Bayer Schering Pharma Aktiengesellschaft | Ep2 and ep4 agonists as agents for the treatment of influenza a viral infection |
EP2488168A1 (en) | 2009-10-14 | 2012-08-22 | Gemmus Pharma Inc. | Combination therapy treatment for viral infections |
KR102456567B1 (ko) | 2013-08-09 | 2022-10-19 | 알데릭스, 인코포레이티드 | 인산염 수송을 억제하기 위한 화합물 및 방법 |
US10799653B2 (en) | 2017-01-09 | 2020-10-13 | United Therapeutics Corporation | Aerosol delivery device and method for manufacturing and operating the same |
EP3972599A1 (en) | 2019-05-21 | 2022-03-30 | Ardelyx, Inc. | Combination for lowering serum phosphate in a patient |
IL296567A (en) | 2020-04-17 | 2022-11-01 | United Therapeutics Corp | Terfostinil for use in the treatment of interstitial lung disease |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4036075A (en) * | 1976-05-05 | 1977-07-19 | Outboard Marine Corporation | Variable speed power transmission including means for minimizing backlash |
JPS5495552A (en) * | 1978-01-06 | 1979-07-28 | Sankyo Co Ltd | Prostacyline derivative and its preparation |
GB2038333B (en) * | 1978-01-26 | 1982-10-06 | Erba Farmitalia | 12 -formyl- (20 12)octanor-9-deoxy-9 -methylene pgi derivatives |
US4705806A (en) * | 1978-02-13 | 1987-11-10 | Morton Jr Douglas R | Prostacyclin analogs |
US4238414A (en) * | 1978-02-13 | 1980-12-09 | The Upjohn Company | 2-Decarboxy-2-aminomethyl-6a-carba-PGI2 compounds |
JPS54119441A (en) * | 1978-03-09 | 1979-09-17 | Sumitomo Chem Co Ltd | Novel bicyclooctane derivative |
DE2912409A1 (de) * | 1978-03-31 | 1979-10-11 | Ono Pharmaceutical Co | 6,9-methano-pgi tief 2 -analoge |
DE2845770A1 (de) * | 1978-10-19 | 1980-04-30 | Schering Ag | Neue prostacyclin-derivate und verfahren zu ihrer herstellung |
US4346041A (en) * | 1980-02-28 | 1982-08-24 | The Upjohn Company | Composition and process |
US4338457A (en) * | 1980-02-28 | 1982-07-06 | The Upjohn Company | Composition and process |
CA1201712A (en) * | 1980-02-28 | 1986-03-11 | Paul A. Aristoff | Carbacyclin analogs |
DE3168001D1 (en) * | 1980-03-21 | 1985-02-14 | Sumitomo Chemical Co | Bicyclooctane derivatives, processes for producing them, pharmaceutical compositions containing them, their use as pharmaceuticals and precursors thereof |
US4420632A (en) * | 1980-04-15 | 1983-12-13 | The Upjohn Company | Composition and process |
US4306076A (en) * | 1980-04-23 | 1981-12-15 | The Upjohn Company | Inter-phenylene CBA compounds |
DE3048906A1 (de) * | 1980-12-19 | 1982-07-15 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
US4349689A (en) * | 1980-12-22 | 1982-09-14 | The Upjohn Company | Methano carbacyclin analogs |
DE3121155A1 (de) * | 1981-05-22 | 1982-12-09 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
-
1980
- 1980-12-19 DE DE19803048906 patent/DE3048906A1/de not_active Withdrawn
-
1981
- 1981-12-09 CS CS819138A patent/CS232719B2/cs unknown
- 1981-12-10 FI FI813967A patent/FI71122C/fi not_active IP Right Cessation
- 1981-12-10 SU SU813363101A patent/SU1367856A3/ru active
- 1981-12-14 YU YU02930/81A patent/YU293081A/xx unknown
- 1981-12-17 AT AT81730124T patent/ATE12094T1/de not_active IP Right Cessation
- 1981-12-17 GR GR66826A patent/GR77633B/el unknown
- 1981-12-17 EP EP81730124A patent/EP0055208B1/de not_active Expired
- 1981-12-17 DE DE8181730124T patent/DE3169305D1/de not_active Expired
- 1981-12-18 JP JP56203814A patent/JPS57145833A/ja active Granted
- 1981-12-18 DK DK564181A patent/DK169815B1/da not_active IP Right Cessation
- 1981-12-18 NZ NZ199319A patent/NZ199319A/en unknown
- 1981-12-18 AU AU78676/81A patent/AU548662B2/en not_active Ceased
- 1981-12-18 ES ES508124A patent/ES508124A0/es active Granted
- 1981-12-18 NO NO814357A patent/NO155537C/no unknown
- 1981-12-18 CA CA000392646A patent/CA1223255A/en not_active Expired
- 1981-12-18 PH PH26655A patent/PH19419A/en unknown
- 1981-12-18 ZA ZA818788A patent/ZA818788B/xx unknown
- 1981-12-18 IE IE2997/81A patent/IE52432B1/en not_active IP Right Cessation
- 1981-12-18 HU HU813874A patent/HU187398B/hu not_active IP Right Cessation
- 1981-12-18 IL IL64577A patent/IL64577A0/xx not_active IP Right Cessation
- 1981-12-21 US US06/333,099 patent/US4423067A/en not_active Expired - Lifetime
-
1985
- 1985-05-28 US US06/738,545 patent/US4708963A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ATE12094T1 (de) | 1985-03-15 |
FI71122C (fi) | 1986-11-24 |
GR77633B (fi) | 1984-09-25 |
ZA818788B (en) | 1982-11-24 |
CS913881A2 (en) | 1984-06-18 |
ES8300090A1 (es) | 1982-11-01 |
NO814357L (no) | 1982-06-21 |
DK169815B1 (da) | 1995-03-06 |
AU548662B2 (en) | 1986-01-02 |
FI71122B (fi) | 1986-08-14 |
CS232719B2 (en) | 1985-02-14 |
IE812997L (en) | 1982-06-19 |
IE52432B1 (en) | 1987-10-28 |
SU1367856A3 (ru) | 1988-01-15 |
ES508124A0 (es) | 1982-11-01 |
YU293081A (en) | 1983-10-31 |
JPS6228937B2 (fi) | 1987-06-23 |
DE3048906A1 (de) | 1982-07-15 |
IL64577A0 (en) | 1982-03-31 |
PH19419A (en) | 1986-04-10 |
EP0055208A2 (de) | 1982-06-30 |
EP0055208A3 (en) | 1982-08-25 |
DK564181A (da) | 1982-06-20 |
EP0055208B1 (de) | 1985-03-13 |
JPS57145833A (en) | 1982-09-09 |
NZ199319A (en) | 1985-07-12 |
HU187398B (en) | 1985-12-28 |
DE3169305D1 (en) | 1985-04-18 |
NO155537B (no) | 1987-01-05 |
CA1223255A (en) | 1987-06-23 |
AU7867681A (en) | 1982-06-24 |
US4708963A (en) | 1987-11-24 |
US4423067A (en) | 1983-12-27 |
NO155537C (no) | 1987-04-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM | Patent lapsed | ||
MM | Patent lapsed |
Owner name: SCHERING AKTIENGESELLSCHAFT |