FI80457B - Nya saosom mellanprodukter anvaendbara 3-pyridylpyrrolotiazol- och tiazinderivat och foerfarande foer framstaellning daerav. - Google Patents

Nya saosom mellanprodukter anvaendbara 3-pyridylpyrrolotiazol- och tiazinderivat och foerfarande foer framstaellning daerav. Download PDF

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Publication number
FI80457B
FI80457B FI840108A FI840108A FI80457B FI 80457 B FI80457 B FI 80457B FI 840108 A FI840108 A FI 840108A FI 840108 A FI840108 A FI 840108A FI 80457 B FI80457 B FI 80457B
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FI
Finland
Prior art keywords
kpa
total
temperature
reduced pressure
under reduced
Prior art date
Application number
FI840108A
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English (en)
Finnish (fi)
Other versions
FI840108A (fi
FI80457C (sv
FI840108A0 (fi
Inventor
Daniel Farge
Jean-Louis Fabre
Claude James
Daniel Lave
Original Assignee
Rhone Poulenc Sante
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8300453A external-priority patent/FR2541280B1/fr
Priority claimed from FR8300454A external-priority patent/FR2539417A1/fr
Application filed by Rhone Poulenc Sante filed Critical Rhone Poulenc Sante
Publication of FI840108A0 publication Critical patent/FI840108A0/fi
Publication of FI840108A publication Critical patent/FI840108A/fi
Priority to FI870975A priority Critical patent/FI80460C/sv
Priority to FI870974A priority patent/FI80459C/sv
Publication of FI80457B publication Critical patent/FI80457B/fi
Application granted granted Critical
Publication of FI80457C publication Critical patent/FI80457C/sv

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
    • C07D279/06—1,3-Thiazines; Hydrogenated 1,3-thiazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Claims (7)

1. Nya, säsom mellanprodukter användbara 3-pyridyl-pyrrolotiazol- och -tiazinderivat med de allmänna formlerna 5 CN
10 E—l2TJL(ch=ch)^-<ζ % Ia CN - ζώ-o R CN 20 ^—nv yJ--—<LJ> i vilka formler p är 0 eller 1 och R är en väteatom eller en lägre alkyl- eller fenylradikal, samt deras syraaddi-tionssalter, och ifall sädana finns, deras metallsalter och additionssalter med kvävebasen.
2. Förfarande för framställning av nya derivat enligt 30 patentkravet 1, kännetecknat därav, att 2-klor-äkrylnitril omsätts med en förening med den allmänna formeln s^|—COOH
35. L N-CO- (CH=CH)—-<\~\y IIIa 28 80457 eller med en förening med den allmänna formeln S\—COO H S “ -N
5. N-CO--<f ^ IHB eller med en förening med den allmänna formeln 10 —COOH SNrJ-C0--\ / 111(2 15. vilka formler IIIA, ΙΙΙβ och ΙΙΙς R och p har samma be-tydelse som i patentkravet 1, i acetanhydrid vid 80-130°C, varefter den sälunda erhällna föreningen isoleras och vid behov omvandlas tili ett additionssalt med en syra. il
FI840108A 1983-01-13 1984-01-12 Nya såsom mellanprodukter användbara 3-pyridylpyrrolotiazol- och tiazi nderivat och förfarande för framställning därav FI80457C (sv)

Priority Applications (2)

Application Number Priority Date Filing Date Title
FI870975A FI80460C (sv) 1983-01-13 1987-03-05 Nya 3- eller 5-(3-pyridyl)-1H,3H-pyrrolo/1,2-c/tiazol-7-S-alkyltiokarb oximidat, vilka är mellanprodukter vid framställning av motsvarande te rapeutiskt användbara 7-karboxamiddialkylhydrazon- och 7-piperidinokar boimidylpyrrolotiazolderivat
FI870974A FI80459C (sv) 1983-01-13 1987-03-05 Nya 3- eller 5-(3-pyridyl)substituerade 1H,3H-pyrrolo/1,2-c/tiazol-7-k arboxylsyror, vilka är mellanprodukter vid framställning av motsvarand e terapeutiskt användbara pyrrolotiazol-7-karboxylsyraamider och förfa rande för framställning därav

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR8300453 1983-01-13
FR8300453A FR2541280B1 (fr) 1983-01-13 1983-01-13 Nouveaux derives du 1h, 3h-pyrrolo (1,2c) thiazolecarboxamide-7, leur preparation et les medicaments qui les contiennent
FR8300454 1983-01-13
FR8300454A FR2539417A1 (fr) 1983-01-13 1983-01-13 Nouveaux pyrrolo-1, 2 heterocycles, leur preparation et les medicaments qui les contiennent

Publications (4)

Publication Number Publication Date
FI840108A0 FI840108A0 (fi) 1984-01-12
FI840108A FI840108A (fi) 1984-07-14
FI80457B true FI80457B (fi) 1990-02-28
FI80457C FI80457C (sv) 1990-06-11

Family

ID=26223238

Family Applications (1)

Application Number Title Priority Date Filing Date
FI840108A FI80457C (sv) 1983-01-13 1984-01-12 Nya såsom mellanprodukter användbara 3-pyridylpyrrolotiazol- och tiazi nderivat och förfarande för framställning därav

Country Status (21)

Country Link
US (1) US4539400A (sv)
EP (1) EP0124384B1 (sv)
KR (1) KR910001285B1 (sv)
AU (1) AU562833B2 (sv)
BG (3) BG37839A3 (sv)
CA (1) CA1221366A (sv)
DD (1) DD216021A5 (sv)
DE (1) DE3465199D1 (sv)
DK (1) DK14084A (sv)
ES (3) ES8407059A1 (sv)
FI (1) FI80457C (sv)
GR (1) GR81681B (sv)
HU (3) HU196216B (sv)
IE (1) IE56840B1 (sv)
IL (1) IL70665A (sv)
MA (1) MA20003A1 (sv)
NO (1) NO167205C (sv)
NZ (1) NZ206808A (sv)
PL (2) PL142255B1 (sv)
PT (1) PT77953B (sv)
SU (1) SU1277899A3 (sv)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2557111B1 (fr) * 1983-12-21 1986-04-11 Rhone Poulenc Sante Nouveaux derives ortho-condenses du pyrrole, leur preparation et les medicaments qui les contiennent
GB8903592D0 (en) * 1989-02-16 1989-04-05 Boots Co Plc Therapeutic agents
EP0479951A4 (en) * 1989-06-26 1992-12-09 The Research Foundation Of State University Of New York Bis-acyloxymethyl derivatives
DE4419315A1 (de) * 1994-06-01 1995-12-07 Merckle Gmbh Heteropyrrolizinverbindungen und deren Anwendung in der Pharmazie
DE4419247A1 (de) * 1994-06-01 1995-12-07 Merckle Gmbh Sulfonylierte Pyrrolizincarbonsäureamide und deren Anwendung in der Pharmazie
DE4419246A1 (de) * 1994-06-01 1995-12-07 Merckle Gmbh Heteroarylsubstituierte Pyrrolizinverbindungen und deren Anwendung in der Pharmazie
DE10004157A1 (de) * 2000-02-01 2001-08-02 Merckle Gmbh Chem Pharm Fabrik 4-Pyridyl-und 2,4-Pyrimidinyl-substituierte Pyrrolderivate und ihre Anwendung in der Pharmazie

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1401707A (fr) * 1963-07-03 1965-06-04 Kodak Pathe Nouveaux colorants, nouveaux composés intermédiaires servant à les préparer et produits photographiques les contenant
US3544590A (en) * 1967-04-28 1970-12-01 Exxon Research Engineering Co Cyclic amines and the process for their formation
US3642807A (en) * 1970-06-18 1972-02-15 Schering Corp Certain 1-/dilower-alkyl amino-loweralkyl/-2-phenyl indolizines and quaternary salts thereof
US3865839A (en) * 1973-03-01 1975-02-11 Hoechst Co American Thiopyranopyrrolylsalicyclic acids and derivatives thereof

Also Published As

Publication number Publication date
DE3465199D1 (en) 1987-09-10
NO167205C (no) 1991-10-23
SU1277899A3 (ru) 1986-12-15
ES528875A0 (es) 1984-09-01
ES8407059A1 (es) 1984-09-01
PL251306A1 (en) 1985-09-24
AU562833B2 (en) 1987-06-18
GR81681B (sv) 1984-12-12
HU196216B (en) 1988-10-28
HU196215B (en) 1988-10-28
EP0124384B1 (fr) 1987-08-05
ES531060A0 (es) 1984-12-01
ES531061A0 (es) 1985-04-16
KR910001285B1 (ko) 1991-02-28
IE840065L (en) 1984-07-13
HUT34192A (en) 1985-02-28
BG37996A3 (en) 1985-09-16
PT77953A (fr) 1984-02-01
BG37839A3 (en) 1985-08-15
IE56840B1 (en) 1992-01-01
KR840007417A (ko) 1984-12-07
BG37840A3 (en) 1985-08-15
MA20003A1 (fr) 1984-10-01
ES8504822A1 (es) 1985-04-16
IL70665A (en) 1987-08-31
FI840108A (fi) 1984-07-14
CA1221366A (fr) 1987-05-05
PL142255B1 (en) 1987-10-31
FI80457C (sv) 1990-06-11
US4539400A (en) 1985-09-03
EP0124384A1 (fr) 1984-11-07
PL142254B1 (en) 1987-10-31
DK14084D0 (da) 1984-01-12
AU2320384A (en) 1984-07-19
IL70665A0 (en) 1984-04-30
FI840108A0 (fi) 1984-01-12
DD216021A5 (de) 1984-11-28
ES8501770A1 (es) 1984-12-01
PT77953B (fr) 1986-06-11
NO167205B (no) 1991-07-08
NO840108L (no) 1984-07-16
PL251305A1 (en) 1985-09-24
DK14084A (da) 1984-07-14
NZ206808A (en) 1986-04-11
HU193276B (en) 1987-09-28

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Owner name: RHONE-POULENC SANTE