FI77841B - Foerfarande foer framstaellning av terapeutiskt anvaendbara 1,1-difenylpropanolderivat. - Google Patents
Foerfarande foer framstaellning av terapeutiskt anvaendbara 1,1-difenylpropanolderivat. Download PDFInfo
- Publication number
- FI77841B FI77841B FI834789A FI834789A FI77841B FI 77841 B FI77841 B FI 77841B FI 834789 A FI834789 A FI 834789A FI 834789 A FI834789 A FI 834789A FI 77841 B FI77841 B FI 77841B
- Authority
- FI
- Finland
- Prior art keywords
- formula
- propan
- phenyl
- carbon atoms
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Medicinal Preparation (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Breakers (AREA)
- Luminescent Compositions (AREA)
- Digital Magnetic Recording (AREA)
Claims (2)
1. Förfarande för framställning av terapeutiskt användbara 1,1-difenylpropan-l-ol-derivat med formeln (I), R-,
1 OH 5 c2H5 väri Rl och R2 betyder oberoende av varandra väte eller en alkyl med 1-4 kolatomer, R3 är halogen, trihalometyl, alkyl med 1-4 kolatomer, eller alkoxi med 1-4 kolatomer, R4 är fenyl eller dialkylaminokarbonyl eller alkoxi- karbonyl, som innehaller 1-5 kolatomer i alkyl-respektive alkoxidelarna, n är 1, 2 eller 3, kännetecknad därav, att a) man omsätter en propiofenon med formeln (II) «ry*'**'-*' *"> <^.η5 väri n har samma innebörd som ovan, och R4 är en fenylgrupp, med en metallorganisk förening med formeln (lii) 34 7 7 8 41 *3 väri Ri, R2 och R3 har samma innebörd som ovan, M är en alkalimetall, företrädesvis litium, natrium eller kalium eller en grupp MgX, väri, X betyder halogen, eller b) man omsätter en bensofenon med formeln (IV), *R 0 väri Ri, R2, R3 och n har samma innebörd som ovan och R4 är en fenylgrupp, med en metallorganisk förening som innehäller en etylgrupp, företrädesvis med en etylmagnesiumhalid eller med etyllitium, eller c) man omsätter en propiofenon med formeln (V), <~1.3X p-' väri Ri, R2 och R3 har samma innebörd som ovan, med en Grignard-förening med formeln (VI), 35 77641 M^vowt—λ Γ Υ~Μ3Χ (VI) väri n har samma innebord som ovan, R4 är en fenylgrupp och X är halogen, eller d) man omsätter en förening med formeln (VII) ..... *3 väri Ri, R2 och R3 har samma innebörd som ovan, företrädes-vis i formen av ett alkalimetallfenolat eller kvartärt am-moniumfenolat, med en förening med formeln (VIII), X-(C-H^-(VIII) väri n och R4 har samma innebörd som ovan och X representerar en arylsulfonyloxi- eller alkylsulfonyloxi-grupp eller en halogenatom, företrädesvis i närvaro av ett ämne som binder syra, eller e) man reducerar en förening med formeln (IX),
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU824181A HU190053B (en) | 1982-12-28 | 1982-12-28 | Process for the production of new 1,1-diphenyl-propanol-derivatives, as well as of therapeutic preparations containing them |
| HU418182 | 1982-12-28 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI834789A0 FI834789A0 (fi) | 1983-12-27 |
| FI834789A FI834789A (fi) | 1984-06-29 |
| FI77841B true FI77841B (fi) | 1989-01-31 |
| FI77841C FI77841C (sv) | 1989-05-10 |
Family
ID=10967229
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI834789A FI77841C (sv) | 1982-12-28 | 1983-12-27 | Förfarande för framställning av terapeutiskt användbara 1,1-difenylpro panolderivat. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4605785A (sv) |
| EP (1) | EP0116787B1 (sv) |
| JP (1) | JPS59130828A (sv) |
| AT (1) | ATE25968T1 (sv) |
| AU (1) | AU562377B2 (sv) |
| CA (1) | CA1250857A (sv) |
| DE (1) | DE3370322D1 (sv) |
| DK (1) | DK159650C (sv) |
| ES (5) | ES8600188A1 (sv) |
| FI (1) | FI77841C (sv) |
| GR (1) | GR79154B (sv) |
| HU (1) | HU190053B (sv) |
| IL (1) | IL70549A (sv) |
| ZA (1) | ZA839609B (sv) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU191966B (en) * | 1984-10-25 | 1987-04-28 | Richter Gedeon Vegyeszet | Fodder additive and process for producing same |
| US7858825B2 (en) * | 2007-02-15 | 2010-12-28 | Colorado State University Research Foundation | Acid and base stable diphenylmethanol derivatives and methods of use |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4094908A (en) * | 1973-08-15 | 1978-06-13 | Richter Gedeon Vegyeszeti Gyar Rt. | Alpha-substituted benzhydrol derivatives |
| HU168432B (sv) * | 1973-08-15 | 1976-04-28 | ||
| JPS5195049A (en) * | 1975-02-12 | 1976-08-20 | * **********so*****no***tsu*****************************************ni*no | |
| EP0002408A1 (fr) * | 1977-11-26 | 1979-06-13 | SOCIETE DE RECHERCHES INDUSTRIELLES S.O.R.I. Société anonyme dite: | Nouveaux composés phénoxy-alcanols substitués, leur procédé de préparation et leur application en thérapeutique |
-
1982
- 1982-12-28 HU HU824181A patent/HU190053B/hu not_active IP Right Cessation
-
1983
- 1983-12-23 EP EP83307965A patent/EP0116787B1/en not_active Expired
- 1983-12-23 DE DE8383307965T patent/DE3370322D1/de not_active Expired
- 1983-12-23 AT AT83307965T patent/ATE25968T1/de not_active IP Right Cessation
- 1983-12-23 CA CA000444254A patent/CA1250857A/en not_active Expired
- 1983-12-23 AU AU22904/83A patent/AU562377B2/en not_active Ceased
- 1983-12-27 IL IL70549A patent/IL70549A/xx unknown
- 1983-12-27 ES ES528451A patent/ES8600188A1/es not_active Expired
- 1983-12-27 US US06/565,838 patent/US4605785A/en not_active Expired - Fee Related
- 1983-12-27 FI FI834789A patent/FI77841C/sv not_active IP Right Cessation
- 1983-12-27 JP JP58244941A patent/JPS59130828A/ja active Granted
- 1983-12-27 ZA ZA839609A patent/ZA839609B/xx unknown
- 1983-12-27 DK DK602383A patent/DK159650C/da not_active IP Right Cessation
- 1983-12-28 GR GR73368A patent/GR79154B/el unknown
-
1985
- 1985-06-01 ES ES543781A patent/ES8604084A1/es not_active Expired
- 1985-06-01 ES ES543783A patent/ES8608467A1/es not_active Expired
- 1985-06-01 ES ES543784A patent/ES8604086A1/es not_active Expired
- 1985-06-01 ES ES543782A patent/ES8604085A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ATE25968T1 (de) | 1987-04-15 |
| ES543783A0 (es) | 1986-07-16 |
| ES8604086A1 (es) | 1986-01-16 |
| ES8608467A1 (es) | 1986-07-16 |
| DK602383A (da) | 1984-06-29 |
| EP0116787B1 (en) | 1987-03-18 |
| FI834789A0 (fi) | 1983-12-27 |
| ES543782A0 (es) | 1986-01-16 |
| CA1250857A (en) | 1989-03-07 |
| ES543781A0 (es) | 1986-01-16 |
| IL70549A0 (en) | 1984-03-30 |
| HU190053B (en) | 1986-08-28 |
| DK159650C (da) | 1991-04-08 |
| ES543784A0 (es) | 1986-01-16 |
| DE3370322D1 (en) | 1987-04-23 |
| IL70549A (en) | 1986-09-30 |
| JPS59130828A (ja) | 1984-07-27 |
| ZA839609B (en) | 1984-08-29 |
| GR79154B (sv) | 1984-10-02 |
| US4605785A (en) | 1986-08-12 |
| FI834789A (fi) | 1984-06-29 |
| AU2290483A (en) | 1984-07-05 |
| ES8604085A1 (es) | 1986-01-16 |
| ES8604084A1 (es) | 1986-01-16 |
| HUT34943A (en) | 1985-05-28 |
| AU562377B2 (en) | 1987-06-11 |
| FI77841C (sv) | 1989-05-10 |
| ES528451A0 (es) | 1985-10-01 |
| JPH0237902B2 (sv) | 1990-08-28 |
| ES8600188A1 (es) | 1985-10-01 |
| DK159650B (da) | 1990-11-12 |
| DK602383D0 (da) | 1983-12-27 |
| EP0116787A1 (en) | 1984-08-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed | ||
| MM | Patent lapsed |
Owner name: RICHTER GEDEON VEGYESZETI GYAR R.T. |