FI773936A - 7epsilon-(alkoxikarbonyl)-6epsilon alkyl/halo-17-hydroxy-3-oxo-17alfa pregn-4-ene-21-karboxylsyra-y-laktoner och motsvarande 21-karboxylsyror deras salter och estrar - Google Patents

7epsilon-(alkoxikarbonyl)-6epsilon alkyl/halo-17-hydroxy-3-oxo-17alfa pregn-4-ene-21-karboxylsyra-y-laktoner och motsvarande 21-karboxylsyror deras salter och estrar

Info

Publication number
FI773936A
FI773936A FI773936A FI773936A FI773936A FI 773936 A FI773936 A FI 773936A FI 773936 A FI773936 A FI 773936A FI 773936 A FI773936 A FI 773936A FI 773936 A FI773936 A FI 773936A
Authority
FI
Finland
Prior art keywords
lactoner
carboxylsyra
7epsilon
6epsilon
17alfa
Prior art date
Application number
FI773936A
Other languages
English (en)
Finnish (fi)
Inventor
Richard Mathias Weier
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of FI773936A publication Critical patent/FI773936A/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/001—Lactones
    • C07J21/003—Lactones at position 17
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
FI773936A 1976-12-27 1977-12-27 7epsilon-(alkoxikarbonyl)-6epsilon alkyl/halo-17-hydroxy-3-oxo-17alfa pregn-4-ene-21-karboxylsyra-y-laktoner och motsvarande 21-karboxylsyror deras salter och estrar FI773936A (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/754,136 US4069219A (en) 1976-12-27 1976-12-27 7ξ-(Alkoxycarbonyl)-6ξ-alkyl/halo-17-hydroxy-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactones and corresponding 21-carboxylic acids, their salts, and esters

Publications (1)

Publication Number Publication Date
FI773936A true FI773936A (fi) 1978-06-28

Family

ID=25033598

Family Applications (1)

Application Number Title Priority Date Filing Date
FI773936A FI773936A (fi) 1976-12-27 1977-12-27 7epsilon-(alkoxikarbonyl)-6epsilon alkyl/halo-17-hydroxy-3-oxo-17alfa pregn-4-ene-21-karboxylsyra-y-laktoner och motsvarande 21-karboxylsyror deras salter och estrar

Country Status (19)

Country Link
US (1) US4069219A (de)
JP (1) JPS5382767A (de)
AU (1) AU518862B2 (de)
BE (1) BE862365A (de)
CA (1) CA1099702A (de)
CH (6) CH637403A5 (de)
DE (1) DE2758279A1 (de)
DK (1) DK577377A (de)
FI (1) FI773936A (de)
FR (1) FR2375253A1 (de)
GB (1) GB1575986A (de)
IE (1) IE46128B1 (de)
IL (1) IL53692A (de)
NL (1) NL7714428A (de)
NO (2) NO774464L (de)
NZ (1) NZ186119A (de)
PT (1) PT67455B (de)
SE (1) SE7714764L (de)
ZA (1) ZA777684B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3111951A1 (de) * 1981-03-23 1982-09-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen 7(alpha)-alkoxycarbonyl-15ss-methylen-4-androstene, verfahren zu ihrer herstellung und verwendung als arzneimittel
JPS5921698A (ja) * 1982-07-22 1984-02-03 シエ−リング・アクチエンゲゼルシヤフト １７α−プレグネ−４−エン−３−オキソ−２１−カルボン酸エステル、その製法およびこれを含有する抗アンドロゲン作用を有する医薬
DE3330084A1 (de) * 1983-08-17 1985-03-07 Schering AG, 1000 Berlin und 4709 Bergkamen 7(alpha)-alkoxycarbonyl-3-oxo-17(alpha)-pregn-4-en-21,17-carbolactone und deren 21-carbonsaeuresalze, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
ATE365171T1 (de) * 1995-12-11 2007-07-15 Searle Llc Verfahren zur herstellung einer epoxyverbindung
US7297716B2 (en) * 2000-10-23 2007-11-20 Shanbrom Technologies, Llc Enhanced production of blood components, blood cells and plasma without freezing
US7411006B2 (en) * 2000-10-23 2008-08-12 Shanbrom Technologies, Llc Enhanced production of blood clotting factors and fibrin fabric
US8389687B2 (en) * 2000-10-23 2013-03-05 Shanbrom Technologies, Llc Polyvinylpyrrolidone cryoprecipitate extraction of clotting factors
WO2003082895A2 (en) * 2002-03-22 2003-10-09 Pharmacia & Upjohn Company Process to prepare eplerenone
PL376919A1 (pl) * 2002-11-06 2006-01-09 Pharmacia & Upjohn Company Llc Sposoby wytwarzania 7-karboksy-podstawionych steroidów
DE60312029T2 (de) * 2002-11-07 2007-06-21 Pharmacia & Upjohn Co. Llc, Kalamazoo Verfahren zur herstellung c-7 substituierter 5-androstene
HUE027858T2 (en) 2005-07-21 2016-11-28 Bayer Pharma AG Process for the preparation of 3-oxo-pregn-4-ene-21,17-carbolactones by the metal-free oxidation of 17- (3-hydroxypropyl) -3,17-dihydroxyandrostanes \ t
ATE403668T1 (de) 2005-07-21 2008-08-15 Bayer Schering Pharma Ag Verfahren zur herstellung von 3-oxo-pregn-4-en-21,17-carbolactonen durch die metallfreie oxidation von 17-(3-hydroxypropyl)-3,17- dihydroxyandrostanen

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE787940A (fr) * 1971-08-25 1973-02-26 Searle & Co Nouveaux medicaments diuretiques et hypotenseurs et procede de leur preparation
GB1368006A (en) * 1972-08-24 1974-09-25 Searle & Co 4alpha,7alpha-carbonyl-5-cyano-17-hzydroxy-3-oxo-5beta,17alpha- pregnane-21-carboxylic acid ypsilon-lactone
US3972871A (en) * 1975-09-22 1976-08-03 G. D. Searle & Co. 6β,17-Dihydroxy-7α-(lower alkoxy)carbonyl-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactones and congeners

Also Published As

Publication number Publication date
BE862365A (fr) 1978-06-27
CH637408A5 (de) 1983-07-29
CH638536A5 (de) 1983-09-30
NO820059L (no) 1978-06-28
SE7714764L (sv) 1978-06-28
IE46128B1 (en) 1983-02-23
IE46128L (en) 1978-06-27
CH637404A5 (de) 1983-07-29
NZ186119A (en) 1979-08-31
IL53692A (en) 1982-07-30
FR2375253A1 (fr) 1978-07-21
PT67455A (en) 1978-01-01
CH637403A5 (de) 1983-07-29
NL7714428A (nl) 1978-06-29
DE2758279A1 (de) 1978-06-29
DK577377A (da) 1978-06-28
NO774464L (no) 1978-06-28
AU3201277A (en) 1979-06-28
FR2375253B1 (de) 1981-04-30
US4069219A (en) 1978-01-17
GB1575986A (en) 1980-10-01
CA1099702A (en) 1981-04-21
JPS5382767A (en) 1978-07-21
CH637405A5 (de) 1983-07-29
ZA777684B (en) 1979-08-29
AU518862B2 (en) 1981-10-22
IL53692A0 (en) 1978-03-10
PT67455B (en) 1979-05-25
CH635595A5 (de) 1983-04-15

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Legal Events

Date Code Title Description
FD Application lapsed

Owner name: G D SEARLE & CO.