FI70021C - Ett (9 eller 11)-brom-14-oxo-15-hydroxi-e-homoeburnanderivat anvaendbart som mellanprodukt vid framstaellning av terapeutiskt vaerdefulla bromvincaminsyraestrar - Google Patents

Ett (9 eller 11)-brom-14-oxo-15-hydroxi-e-homoeburnanderivat anvaendbart som mellanprodukt vid framstaellning av terapeutiskt vaerdefulla bromvincaminsyraestrar Download PDF

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Publication number
FI70021C
FI70021C FI802410A FI802410A FI70021C FI 70021 C FI70021 C FI 70021C FI 802410 A FI802410 A FI 802410A FI 802410 A FI802410 A FI 802410A FI 70021 C FI70021 C FI 70021C
Authority
FI
Finland
Prior art keywords
oxo
bromo
hydroxy
acid
homoeburnan
Prior art date
Application number
FI802410A
Other languages
English (en)
Finnish (fi)
Other versions
FI802410A (fi
FI70021B (fi
Inventor
Csaba Szantay
Lajos Szabo
Gyoergy Kalaus
Lajos Dancsi
Tibor Keve
Ferenc Drexler
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Publication of FI802410A publication Critical patent/FI802410A/fi
Publication of FI70021B publication Critical patent/FI70021B/fi
Application granted granted Critical
Publication of FI70021C publication Critical patent/FI70021C/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

Claims (6)

1. Ett (9 eller 11)-brom-14-oxo-15-hydroxi-E-homoebur-nanderivat användbart som mellanprodukt vid framställning av terapeutiskt värdefulla bromvincaminsyraestrar, känne- t e c k n a t därav, att den har formeln la eller lb Br ifViTl (Ia) BOX C-Hj. H 25 _Pi (lb) h<A"TT H 2H5 samt syraadditionsalter och optiskt aktiva isomerer av före-ningarna med formeln la eller lb.
2. ( + )-9-brom-14-oxo-15-hydroxi-E-homoeburnan-(3 o( , 1 7 ol) .
3. {_+)-11 -brom-1 4-oxo-1 5-hydroxi-R-homoeburnan- (3a(, 17^).
4. (+)-3(S), 17(S)-9-brom-14-oxo-l5-hydroxi-E-homoeburnan.
5. (+)-3(S), 17(S)-11-brom-14-oxo-l5-hydroxi-E-homoeburnan.
6. Förfarande för framställning av racemiska eller optiskt aktiva (9-eller 11)-brom-14-oxo-15-hydroxi-E-homoeburnanderivat med de allmänna formlerna (Ia) och (Ib), is 70021 Br . Il 11 u Jl \ (Ia) ΪΐΛ i2H5 n n^o (Ib) or—(__ H0« kns samt syraadditionssalter av dessa föreningar , kanne-t e c k n a t därav, att ett racemiskt eller optiskt aktivt 15-hydroxi-E-homoeburnanderivat med den allmänna formeln II CnCTi \ N N \ (II) H 25 eller ett syraadditionssalt därav behandlas med ett bromerings-medel, och ifali önskvärt, separeras föreningarna med de allmänna formlerna (Ia) och (Ib), vilka bildats vid reaktionen, frän varandra, och den erhällna föreningen omvandlas tili ett syraadditionssalt och/eller uppdelas i optiska isomerer, ifall sä önskas.
FI802410A 1979-08-06 1980-08-01 Ett (9 eller 11)-brom-14-oxo-15-hydroxi-e-homoeburnanderivat anvaendbart som mellanprodukt vid framstaellning av terapeutiskt vaerdefulla bromvincaminsyraestrar FI70021C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU79RI721A HU180928B (en) 1979-08-06 1979-08-06 Process for preparing new brominated 15-hydroxy-e-homo-eburane derivatives
HURI000721 1979-08-06

Publications (3)

Publication Number Publication Date
FI802410A FI802410A (fi) 1981-02-07
FI70021B FI70021B (fi) 1986-01-31
FI70021C true FI70021C (fi) 1986-09-12

Family

ID=11001104

Family Applications (1)

Application Number Title Priority Date Filing Date
FI802410A FI70021C (fi) 1979-08-06 1980-08-01 Ett (9 eller 11)-brom-14-oxo-15-hydroxi-e-homoeburnanderivat anvaendbart som mellanprodukt vid framstaellning av terapeutiskt vaerdefulla bromvincaminsyraestrar

Country Status (22)

Country Link
US (2) US4285865A (sv)
JP (1) JPS5636488A (sv)
AT (1) AT375080B (sv)
AU (1) AU534494B2 (sv)
BE (1) BE884567A (sv)
CA (1) CA1137473A (sv)
CH (1) CH647779A5 (sv)
DE (1) DE3026601A1 (sv)
DK (1) DK337180A (sv)
ES (1) ES494034A0 (sv)
FI (1) FI70021C (sv)
GB (1) GB2058756B (sv)
HU (1) HU180928B (sv)
IL (1) IL60587A (sv)
IT (1) IT1132533B (sv)
NL (1) NL8004350A (sv)
NO (1) NO802345L (sv)
NZ (1) NZ194571A (sv)
PH (1) PH15612A (sv)
SE (1) SE438858B (sv)
SU (1) SU931107A3 (sv)
ZA (1) ZA804302B (sv)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU180927B (en) * 1979-07-13 1983-05-30 Richter Gedeon Vegyeszet Process for producing 1k-hydroximino-e-homoe-eburane de rivatives
HU180929B (en) * 1979-08-13 1983-05-30 Richter Gedeon Vegyeszet Process for producing new bromo-vincamone derivatives
HU187139B (en) * 1982-06-30 1985-11-28 Richter Gedeon Vegyeszet Process for preparing new eburnan derivatives

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3770724A (en) * 1970-03-31 1973-11-06 Roussel Uclaf Process for preparing pentacyclic alkaloids
FR2206090A1 (en) * 1972-11-16 1974-06-07 Omnium Chimique Sa Homovincamone-contg. medicaments - with vasodilating, spasmolytic anti-arrhythmic and anti-ischaemic properties
DK139358B (da) * 1973-12-18 1979-02-05 Sandoz Ag Analogifremgangsmåde til fremstilling af vincaminderivater eller syreadditionssalte deraf.
GB2010833B (en) * 1977-11-25 1982-04-15 Scras Homoerburnamine preparation
FR2445328A1 (fr) * 1978-07-12 1980-07-25 Richter Gedeon Vegyeszet Derives du 14-oxo-e-homo-eburnane, leur procede de preparation et leur utilisation comme medicament

Also Published As

Publication number Publication date
SE8005560L (sv) 1981-02-07
CA1137473A (en) 1982-12-14
CH647779A5 (de) 1985-02-15
US4343738A (en) 1982-08-10
IL60587A0 (en) 1980-09-16
ES8106526A1 (es) 1981-08-01
AU6110380A (en) 1981-02-12
ES494034A0 (es) 1981-08-01
FI802410A (fi) 1981-02-07
IT8024015A0 (it) 1980-08-05
AT375080B (de) 1984-06-25
NO802345L (no) 1981-02-09
FI70021B (fi) 1986-01-31
JPS5636488A (en) 1981-04-09
SU931107A3 (ru) 1982-05-23
IT1132533B (it) 1986-07-02
NZ194571A (en) 1982-11-23
GB2058756B (en) 1984-02-08
NL8004350A (nl) 1981-02-10
IL60587A (en) 1983-05-15
DE3026601A1 (de) 1981-02-26
SE438858B (sv) 1985-05-13
DK337180A (da) 1981-02-07
BE884567A (fr) 1981-02-02
HU180928B (en) 1983-05-30
AU534494B2 (en) 1984-02-02
GB2058756A (en) 1981-04-15
ZA804302B (en) 1981-09-30
PH15612A (en) 1983-02-28
ATA396480A (de) 1983-11-15
US4285865A (en) 1981-08-25

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Owner name: RICHTER GEDEON VEGYESZETI GYAR R.T.