FI67848C - Foerfarande foer framstaellning av terapeutiskt anvaendbara esrar av 9-substituerade hypoxantinderivat - Google Patents

Foerfarande foer framstaellning av terapeutiskt anvaendbara esrar av 9-substituerade hypoxantinderivat Download PDF

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Publication number
FI67848C
FI67848C FI810774A FI810774A FI67848C FI 67848 C FI67848 C FI 67848C FI 810774 A FI810774 A FI 810774A FI 810774 A FI810774 A FI 810774A FI 67848 C FI67848 C FI 67848C
Authority
FI
Finland
Prior art keywords
npt
cells
acid
compounds
blood
Prior art date
Application number
FI810774A
Other languages
English (en)
Finnish (fi)
Other versions
FI810774L (fi
FI67848B (fi
Inventor
Lionel Norton Simon
Alfredo Giner-Sorolla
Alvin Guttag
Original Assignee
Sloan Kettering Inst Cancer
Newport Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sloan Kettering Inst Cancer, Newport Pharmaceuticals filed Critical Sloan Kettering Inst Cancer
Publication of FI810774L publication Critical patent/FI810774L/fi
Publication of FI67848B publication Critical patent/FI67848B/fi
Application granted granted Critical
Publication of FI67848C publication Critical patent/FI67848C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Transplantation (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
FI810774A 1980-03-14 1981-03-13 Foerfarande foer framstaellning av terapeutiskt anvaendbara esrar av 9-substituerade hypoxantinderivat FI67848C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/130,334 US4340726A (en) 1980-03-14 1980-03-14 Esters
US13033480 1980-03-14

Publications (3)

Publication Number Publication Date
FI810774L FI810774L (fi) 1981-09-15
FI67848B FI67848B (fi) 1985-02-28
FI67848C true FI67848C (fi) 1985-06-10

Family

ID=22444200

Family Applications (1)

Application Number Title Priority Date Filing Date
FI810774A FI67848C (fi) 1980-03-14 1981-03-13 Foerfarande foer framstaellning av terapeutiskt anvaendbara esrar av 9-substituerade hypoxantinderivat

Country Status (26)

Country Link
US (1) US4340726A (pl)
EP (1) EP0036077B1 (pl)
JP (1) JPS572287A (pl)
KR (1) KR850000320B1 (pl)
AT (1) ATE8995T1 (pl)
AU (1) AU535052B2 (pl)
CA (1) CA1159827A (pl)
CS (1) CS235514B2 (pl)
DD (1) DD156813A5 (pl)
DE (1) DE3165476D1 (pl)
DK (1) DK154768C (pl)
ES (1) ES500321A0 (pl)
FI (1) FI67848C (pl)
GR (1) GR74807B (pl)
HU (1) HU187324B (pl)
IE (1) IE51019B1 (pl)
IL (1) IL62258A (pl)
IN (1) IN155441B (pl)
NO (1) NO155579C (pl)
NZ (1) NZ196295A (pl)
PH (1) PH19148A (pl)
PL (1) PL129094B1 (pl)
PT (1) PT72665B (pl)
RO (1) RO82509A (pl)
YU (1) YU41973B (pl)
ZA (1) ZA811181B (pl)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4423050A (en) * 1981-05-21 1983-12-27 Syntex (U.S.A.) Inc. 9-(1,3-Dihydroxy-2-propoxymethyl)guanine as antiviral agent
JPS58135878A (ja) * 1981-09-22 1983-08-12 Suntory Ltd 新規アイラントン誘導体及びその製造法
AU564576B2 (en) * 1981-09-24 1987-08-20 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Purine derivatives
US4451478A (en) * 1982-03-12 1984-05-29 Newport Pharmaceuticals International, Inc. Imidazole compounds
US4609662A (en) * 1982-10-14 1986-09-02 Burroughs Wellcome Co. Method for using purine derivatives
HUT36464A (en) * 1983-05-24 1985-09-30 Newport Pharmaceuticals Process for producing erythro-4-amino-3-/2-hydroxy-3-alkyl/-imidazol-5-carboxamide
JP3005959B2 (ja) * 1989-03-31 2000-02-07 ヤンマー農機株式会社 乗用田植機における植付部伝動構造
US5614504A (en) * 1990-08-01 1997-03-25 The University Of South Florida Method of making inosine monophosphate derivatives and immunopotentiating uses thereof
US6420374B1 (en) 1990-11-30 2002-07-16 Fred Hutchinson Cancer Research Center Use of xanthines as immunosuppressants and to inhibit allograft reactions
US6338963B1 (en) 1994-07-25 2002-01-15 Neotherapeutics, Inc. Use of carbon monoxide dependent guanylyl cyclase modifiers to stimulate neuritogenesis
BE1008977A5 (fr) * 1994-12-27 1996-10-01 Solvay Adjuvants pour vaccins.
WO1999057120A1 (en) 1998-05-04 1999-11-11 Neotherapeutics, Inc. Novel serotonin-like 9-substituted hypoxanthine and methods of use
US6297226B1 (en) 1999-10-15 2001-10-02 Neotherapeutics, Inc. Synthesis and methods of use of 9-substituted guanine derivatives
US6288069B1 (en) 1999-11-16 2001-09-11 Neotherapeutics, Inc. Use of 9-substituted hypoxanthine derivatives to stimulate regeneration of nervous tissue
US6407237B1 (en) 2001-02-21 2002-06-18 Neotherapeutics, Inc. Crystal forms of 9-substituted hypoxanthine derivatives
US6849735B1 (en) 2000-06-23 2005-02-01 Merck Eprova Ag Methods of synthesis for 9-substituted hypoxanthine derivatives
DE60144123D1 (de) 2000-07-07 2011-04-07 Spectrum Pharmaceuticals Inc Verfahren zur Behandlung von Arzneimittelinduzierter peripherer Neuropathie und verwandten Krankheitsformen
US6759427B2 (en) * 2001-04-20 2004-07-06 Spectrum Pharmaceuticals, Inc. Synthesis and methods of use of tetrahydroindolone analogues and derivatives
US20030055249A1 (en) * 2001-07-17 2003-03-20 Fick David B. Synthesis and methods of use of pyrimidine analogues and derivatives
KR101494056B1 (ko) * 2003-10-03 2015-02-16 쓰리엠 이노베이티브 프로퍼티즈 컴파니 피라졸로피리딘 및 그의 유사체

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2940966A (en) * 1958-05-15 1960-06-14 Daniel R Bullard Glucoside of 2-amino-4-hydroxy-6-(1', 2'-dihydroxypropyl)-pteridine
US3862189A (en) * 1973-08-14 1975-01-21 Warner Lambert Co Aralkyl-substituted purines and pyrimidines as antianginal bronchodilator agents
US4138562A (en) * 1977-02-09 1979-02-06 The Regents Of The University Of Minnesota Adenosine deaminase resistant antiviral purine nucleosides and method of preparation
DE2714883A1 (de) * 1977-04-02 1978-10-12 Basf Ag Nicht-glykosidische theophyllin- zucker-derivate
JPS55113786A (en) * 1979-02-23 1980-09-02 Toyo Jozo Co Ltd Novel substance, nepranosin b or f and its preparation
US4221910A (en) * 1978-09-15 1980-09-09 Newport Pharmaceuticals International, Inc. 9-(Hydroxy alkyl)purines
US4221909A (en) * 1978-09-15 1980-09-09 Sloan-Kettering Institute For Cancer Research P-Acetamidobenzoic acid salts of 9-(hydroxyalkyl) purines
US4221794A (en) * 1979-06-21 1980-09-09 Newport Pharmaceuticals International, Inc. Method of imparting immunomodulating and antiviral activity

Also Published As

Publication number Publication date
NO810723L (no) 1981-09-15
DK115081A (da) 1981-09-15
US4340726A (en) 1982-07-20
ZA811181B (en) 1982-01-27
EP0036077B1 (en) 1984-08-15
YU65181A (en) 1984-02-29
NO155579C (no) 1987-04-22
DE3165476D1 (en) 1984-09-20
EP0036077A3 (en) 1982-01-13
GR74807B (pl) 1984-08-12
ES8202825A1 (es) 1982-03-01
AU535052B2 (en) 1984-03-01
IE51019B1 (en) 1986-09-03
FI810774L (fi) 1981-09-15
CA1159827A (en) 1984-01-03
DK154768B (da) 1988-12-19
PL230115A1 (pl) 1981-11-13
RO82509B (ro) 1983-08-30
PH19148A (en) 1986-01-15
PT72665A (en) 1981-04-01
NO155579B (no) 1987-01-12
KR830005224A (ko) 1983-08-03
DD156813A5 (de) 1982-09-22
KR850000320B1 (ko) 1985-03-20
CS235514B2 (en) 1985-05-15
JPH031311B2 (pl) 1991-01-10
NZ196295A (en) 1983-09-02
AU6802581A (en) 1981-09-17
IL62258A (en) 1984-12-31
IN155441B (pl) 1985-02-02
ATE8995T1 (de) 1984-09-15
YU41973B (en) 1988-04-30
IE810552L (en) 1981-09-14
FI67848B (fi) 1985-02-28
DK154768C (da) 1989-06-19
PL129094B1 (en) 1984-03-31
EP0036077A2 (en) 1981-09-23
JPS572287A (en) 1982-01-07
PT72665B (en) 1982-06-08
HU187324B (en) 1985-12-28
RO82509A (ro) 1983-09-26
ES500321A0 (es) 1982-03-01

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Legal Events

Date Code Title Description
MM Patent lapsed

Owner name: NEWPORT PHARMACEUTICALS INTERNATIONAL, INC.

Owner name: SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH