FI67700C - Foerfarande foer framstaellning av nya terapeutiskt anvaendbara fenyl-kinolizidiner - Google Patents

Foerfarande foer framstaellning av nya terapeutiskt anvaendbara fenyl-kinolizidiner Download PDF

Info

Publication number
FI67700C
FI67700C FI811102A FI811102A FI67700C FI 67700 C FI67700 C FI 67700C FI 811102 A FI811102 A FI 811102A FI 811102 A FI811102 A FI 811102A FI 67700 C FI67700 C FI 67700C
Authority
FI
Finland
Prior art keywords
octahydro
quinolizin
compounds
ras
racemate
Prior art date
Application number
FI811102A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI811102L (fi
FI67700B (fi
Inventor
Rene Imhof
Emilio Kyburz
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of FI811102L publication Critical patent/FI811102L/fi
Priority to FI840364A priority Critical patent/FI70015C/fi
Priority to FI840365A priority patent/FI70016C/fi
Application granted granted Critical
Publication of FI67700B publication Critical patent/FI67700B/fi
Publication of FI67700C publication Critical patent/FI67700C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C07D211/76—Oxygen atoms attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FI811102A 1980-04-11 1981-04-09 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara fenyl-kinolizidiner FI67700C (fi)

Priority Applications (2)

Application Number Priority Date Filing Date Title
FI840364A FI70015C (fi) 1980-04-11 1984-01-30 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara fenyl-kinolizidiner
FI840365A FI70016C (fi) 1980-04-11 1984-01-30 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara fenyl-kinolizidiner

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH278480 1980-04-11
CH278480 1980-04-11
CH70181 1981-02-03
CH70181 1981-02-03

Publications (3)

Publication Number Publication Date
FI811102L FI811102L (fi) 1981-10-12
FI67700B FI67700B (fi) 1985-01-31
FI67700C true FI67700C (fi) 1985-05-10

Family

ID=25685419

Family Applications (1)

Application Number Title Priority Date Filing Date
FI811102A FI67700C (fi) 1980-04-11 1981-04-09 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara fenyl-kinolizidiner

Country Status (18)

Country Link
US (2) US4391978A (es)
EP (1) EP0037990B1 (es)
AU (1) AU540599B2 (es)
CA (1) CA1142933A (es)
CS (1) CS222696B2 (es)
DE (1) DE3167549D1 (es)
DK (1) DK116181A (es)
ES (1) ES501232A0 (es)
FI (1) FI67700C (es)
HU (1) HU185633B (es)
IE (1) IE51108B1 (es)
IL (1) IL62592A (es)
MC (1) MC1392A1 (es)
NO (1) NO153258C (es)
NZ (1) NZ196682A (es)
PH (1) PH19199A (es)
PT (1) PT72840B (es)
ZW (1) ZW5581A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK116181A (da) * 1980-04-11 1981-10-12 Hoffmann La Roche Fremgangsmaade til fremstilling af quinolizidinderivater
EP0094744A1 (en) * 1982-04-23 1983-11-23 Beecham Group Plc Azabicyclobenzamides, their preparation and their pharmaceutical compositions
US4716172A (en) * 1986-04-10 1987-12-29 Mcneilab, Inc. 4-substituted octahydroquinolizine analgesic compounds and octahydroquinolizinium intermediates
US6770658B2 (en) 1998-09-09 2004-08-03 Inflazyme Pharmaceuticals Ltd. Substituted γ-phenyl-Δ-lactams and uses related thereto
KR100917545B1 (ko) * 2004-11-30 2009-09-16 에프. 호프만-라 로슈 아게 당뇨병 치료를 위한 ｄｐｐ-ⅳ 억제제로서의 치환된벤조퀴놀리진
EP3737680A1 (en) 2018-01-08 2020-11-18 F. Hoffmann-La Roche AG Octahydropyrido[1,2-alpha]pyrazines as magl inhibitors

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3394141A (en) * 1965-11-12 1968-07-23 Fabio Sparatore Z-benzyaminobenzimidazoles
US3852452A (en) * 1970-02-10 1974-12-03 Ayerst Mckenna & Harrison Benzocycloheptaisoquinoline derivatives as cns depressants
US3692791A (en) * 1970-05-18 1972-09-19 American Home Prod SUBSTITUTED 2-t-BUTYL-OCTAHYDRO-2H-QUINOLIZINES
US3948923A (en) * 1972-03-06 1976-04-06 Bayer Aktiengesellschaft Pentahydroqunolizine derivatives
US3997547A (en) * 1975-07-14 1976-12-14 Morton-Norwich Products, Inc. Phenylimino-2H-quinolizines
GB1593146A (en) * 1976-11-05 1981-07-15 Beecham Group Ltd Octahydro-quinolizinyl benzamide derivatives
MC1289A1 (fr) * 1978-10-13 1980-07-22 Hoffmann La Roche Phenyl quinolizidines
DK116181A (da) * 1980-04-11 1981-10-12 Hoffmann La Roche Fremgangsmaade til fremstilling af quinolizidinderivater
US4339582A (en) * 1981-08-18 1982-07-13 Miles Laboratories, Inc. Quinolizidine-propionanilide compounds

Also Published As

Publication number Publication date
NO153258B (no) 1985-11-04
ZW5581A1 (en) 1981-11-18
DE3167549D1 (en) 1985-01-17
CA1142933A (en) 1983-03-15
IL62592A (en) 1984-12-31
PT72840A (en) 1981-05-01
US4684731A (en) 1987-08-04
MC1392A1 (fr) 1982-04-27
AU6910781A (en) 1981-10-15
FI811102L (fi) 1981-10-12
IL62592A0 (en) 1981-06-29
NO153258C (no) 1986-02-12
FI67700B (fi) 1985-01-31
IE810822L (en) 1981-10-11
CS222696B2 (en) 1983-07-29
ES8207175A1 (es) 1982-09-16
NO811263L (no) 1981-10-12
IE51108B1 (en) 1986-10-01
ES501232A0 (es) 1982-09-16
US4391978A (en) 1983-07-05
DK116181A (da) 1981-10-12
PT72840B (en) 1983-01-10
HU185633B (en) 1985-03-28
EP0037990B1 (de) 1984-12-05
PH19199A (en) 1986-01-31
EP0037990A1 (de) 1981-10-21
NZ196682A (en) 1984-03-30
AU540599B2 (en) 1984-11-29

Similar Documents

Publication Publication Date Title
FI64376B (fi) Foerfarande foer framstaellning av en farmakologiskt anvaendbar 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol
US5466689A (en) Morpholine derivatives and their use
FI98455C (fi) Menetelmä terapeuttisesti aktiivisten indolijohdannaisten valmistamiseksi
US6150355A (en) Phenylpiperidine derivative
US3957850A (en) Phenylacetic acid derivatives
JPS63174988A (ja) ヘテロアリール３‐オキソ‐プロバンニトリル誘導体及びその製造方法
FI67700C (fi) Foerfarande foer framstaellning av nya terapeutiskt anvaendbara fenyl-kinolizidiner
US20080188498A1 (en) Pyridopyrimidinone compounds with antimalarial activity
PL84191B1 (en) 3-aroyl-alkenyleneimines[us3835149a]
FI70017B (fi) Foerfarande foer framstaellning av nya farmakologiskt aktiva fenylkinolizidiner
US5446050A (en) Azabicyclo amides and esters as 5-HT3 receptor antagonists
JPH066571B2 (ja) ２−ピロリドン誘導体
CS219944B2 (en) Method of making the racemic and optically unite derivatives of the 1-phenyl-2-cyclohexen-1-alkylamine
PL85479B1 (en) Pyridine salt of 2,5-dihydroxy benzene sulfonate p-chlorophenoxy isobutyric ester and a method for the preparation thereof[us3876651a]
FR2593818A1 (fr) Derives d'acylaminomethyl-3 imidazo(1,2-a)pyridine, leur preparation et leur application en therapeutique
US3978064A (en) 3-Aminomethylene-6,7-dimethoxy-2-methyl-4-oxo-1,2,3,4-tetrahydro-1-quinoline carboxylic acid esters and intermediates leading thereto
JP2008523045A (ja) ニューロンニコチン性アセチルコリン特異的受容体部位に結合し、コリン作動性機能の調節および習慣性障害の治療に有用である１，２，３，３ａ，８，８ａ−ヘキサヒドロ−２，７ａ−ジアダ−シクロペンタ［ａ］インデン−７−オン誘導体
US4977176A (en) Pilocarpine compounds which are used as pharmaceutical agents
EP1313703B1 (en) Prodrugs to nmda receptor ligands
EP0228314A2 (en) Use of ethanol/amine derivatives in treating or preventing hyperlipemia
US4788301A (en) Novel allylic amines
JP3090500B2 (ja) ピリド〔３，４−ｂ〕ピロロ〔１，２−ｅ〕〔１，４，５〕オキサジアゼピンおよび関連する同族体
US4851416A (en) Berban derivatives as α2 -adrenergic antagonists
AU2001285894A1 (en) Prodrugs to NMDA receptor ligands
EP0434202B1 (en) Azabicyclo amides and esters as 5-HT3 receptor antagonists

Legal Events

Date Code Title Description
MM Patent lapsed

Owner name: F HOFFMANN-LA ROCHE & CO