FI66604C - Foerfarande foer framstaellning av nya 5h-2,3-bensodiazepinderivat med inverkan pao det centrala nervsystemet - Google Patents

Foerfarande foer framstaellning av nya 5h-2,3-bensodiazepinderivat med inverkan pao det centrala nervsystemet Download PDF

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Publication number
FI66604C
FI66604C FI793209A FI793209A FI66604C FI 66604 C FI66604 C FI 66604C FI 793209 A FI793209 A FI 793209A FI 793209 A FI793209 A FI 793209A FI 66604 C FI66604 C FI 66604C
Authority
FI
Finland
Prior art keywords
benzodiazepine
general formula
group
methyl
compound
Prior art date
Application number
FI793209A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI66604B (fi
FI793209A (fi
Inventor
Jeno Koeroesi
Tibor Lang
Jozsef Szekely
Ferenc Andrasi
Gabor Zolyomi
Jozsef Borsy
Nee Horvath Katali Goldschmidt
Tamas Hamori
Nee Czibula Gabriella Szabo
Nee Dunai Kovacs Zsuz Meszaros
Erzsebet Miglecz
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar
Publication of FI793209A publication Critical patent/FI793209A/fi
Publication of FI66604B publication Critical patent/FI66604B/fi
Application granted granted Critical
Publication of FI66604C publication Critical patent/FI66604C/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/02—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/76—Benzo[c]pyrans

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI793209A 1978-10-19 1979-10-16 Foerfarande foer framstaellning av nya 5h-2,3-bensodiazepinderivat med inverkan pao det centrala nervsystemet FI66604C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU78GO1426A HU179018B (en) 1978-10-19 1978-10-19 Process for producing new 5h-2,3-benzodiazepine derivatives
HUGO001426 1978-10-19

Publications (3)

Publication Number Publication Date
FI793209A FI793209A (fi) 1980-04-20
FI66604B FI66604B (fi) 1984-07-31
FI66604C true FI66604C (fi) 1984-11-12

Family

ID=10996876

Family Applications (1)

Application Number Title Priority Date Filing Date
FI793209A FI66604C (fi) 1978-10-19 1979-10-16 Foerfarande foer framstaellning av nya 5h-2,3-bensodiazepinderivat med inverkan pao det centrala nervsystemet

Country Status (25)

Country Link
US (1) US4322346A (ru)
JP (1) JPS5592377A (ru)
AT (1) AT373589B (ru)
AU (1) AU532079B2 (ru)
BE (1) BE879404A (ru)
BG (1) BG60270B1 (ru)
CA (1) CA1125749A (ru)
CH (1) CH643835A5 (ru)
CS (1) CS236456B2 (ru)
DD (1) DD146596A5 (ru)
DE (1) DE2940483A1 (ru)
DK (1) DK155327C (ru)
ES (1) ES485163A1 (ru)
FI (1) FI66604C (ru)
FR (1) FR2439189A1 (ru)
GB (1) GB2034706B (ru)
GR (1) GR74034B (ru)
HU (1) HU179018B (ru)
IT (1) IT1220947B (ru)
NL (1) NL190552C (ru)
NO (1) NO152048C (ru)
PL (1) PL124063B1 (ru)
SE (1) SE439919B (ru)
SU (1) SU1402258A3 (ru)
YU (1) YU41887B (ru)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU186760B (en) * 1981-03-12 1985-09-30 Gyogyszerkutato Intezet Process for preparing 3,4-dihydro-5h-2,3-aenzodiazepine derivatives
HU191702B (en) * 1984-06-27 1987-03-30 Gyogyszerkutato Intezet New process for preparing 1-aryl-5 h-2,3-benzodiazepines
HU191698B (en) * 1984-07-27 1987-03-30 Gyogyszerkutato Intezet Process for producing new 1-aryl-5h-2beta-benzodiazepines
HU195788B (en) * 1986-05-21 1988-07-28 Gyogyszerkutato Intezet Process for producing 1-/hydroxy-stiryl/-5h-2,3-benzobiazepines and pharmaceutical compositions containing them
JPH01311400A (ja) * 1988-06-09 1989-12-15 Kyocera Corp 発光標識体の点灯方法
JPH0251568U (ru) * 1988-10-07 1990-04-11
JPH0324693U (ru) * 1989-07-18 1991-03-14
HU207055B (en) * 1990-10-17 1993-03-01 Gyogyszerkutato Intezet Process for producing new 5h-2,3-benzodiazepine derivative and pharmaceutical compositions comprising same
HU208429B (en) * 1991-05-03 1993-10-28 Gyogyszerkutato Intezet Process for producing 1-/3-chloro-phenyl/-4-methyl-7,8-dimethoxy-5h-2,3-benzodiazepine of high purity
WO1993000095A2 (en) * 1991-06-28 1993-01-07 Smithkline Beecham Corporation Bicyclic fibrinogen antagonists
US5939412A (en) * 1992-06-26 1999-08-17 Smithkline Beecham Corporation Bicyclic fibrinogen antagonists
US6458784B1 (en) 1994-06-29 2002-10-01 Smithkline Beecham Corporation Vitronectin receptor antagonists
SK283859B6 (sk) * 1995-02-09 2004-03-02 EGIS Gyógyszergyár Rt. 1-[2'-(Substituovaný)vinyl]-5H-2,3-benzodiazepínové deriváty, spôsob ich prípravy a medziprodukty na ich prípravu, liečivá ich obsahujúce a ich použitie
EP0726256A1 (en) * 1995-02-09 1996-08-14 Egis Gyogyszergyar Rt. 1-Arylvinyl-3,4-dihydro-5H-2,3-benzodiazepine derivatives useful for the treatment of central nervous system disorders
HU224435B1 (hu) * 1995-02-09 2005-10-28 EGIS Gyógyszergyár Rt. Benzodiazepin-származékok, eljárás előállításukra, alkalmazásukra és ezeket tartalmazó gyógyászati készítmények
US5977101A (en) * 1995-06-29 1999-11-02 Smithkline Beecham Corporation Benzimidazoles/Imidazoles Linked to a Fibrinogen Receptor Antagonist Template Having Vitronectin Receptor Antagonist Activity
DE19604920A1 (de) * 1996-02-01 1997-08-07 Schering Ag Neue 2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel
ES2111493B1 (es) * 1996-02-08 1999-08-01 Egyt Gyogyszervegyeszeti Gyar Derivados de 1-(2- (vinilo substituido ) ) -5h-2,3-benzo-diazepina, procedimiento para su preparacion, composiciones farmaceuticas que los contienen y utilizaciones correspondientes.
ZA972746B (en) * 1996-04-04 1998-10-09 Egyt Gyogyszervegyeszeti Gyar Novel 2,3-benzodiazepine derivatives
HU9600871D0 (en) * 1996-04-04 1996-05-28 Gyogyszerkutato Intezet New 2,3-benzodiazepine derivatives
HUP9701284A3 (en) * 1997-07-24 2005-11-28 Egyt Gyogyszervegyeszeti Gyar Use of 2,3-benzodiazepine derivatives for producing pharmaceutical compositions for treating and prophylacting illnesses and conditions connected with the endogene opioide system
HU227128B1 (en) * 1999-07-07 2010-07-28 Egyt Gyogyszervegyeszeti Gyar New 2,3-benzodiazepine derivatives
FR2824065A1 (fr) * 2001-04-26 2002-10-31 Neuro3D Composes inhibiteurs des phosphodiesterases des nucleotides cycliques, preparation et utilisations
US6649607B2 (en) * 2001-05-18 2003-11-18 Vela Pharmaceuticals, Inc. Compositions and methods for treating or preventing convulsions or seizures
PT1545546E (pt) * 2002-09-13 2007-07-02 Motac Neuroscience Ltd Tratamento da discinesia com 2, 3-benzodiazepinas
EP1539135B1 (en) * 2002-09-17 2007-04-25 Motac Neuroscience Limited Treatment of dyskinesia
US7745431B2 (en) * 2002-12-03 2010-06-29 Vela Acquisition Corporation Pharmaceutical composition of 1-(3,4-dimethoxyphenyl)-4-methyl-5-ethyl-7-methoxy-8-hydroxy-5H-2,3-benzodiazepine and uses thereof
US6864251B2 (en) * 2002-12-03 2005-03-08 Vela Pharmaceuticals, Inc. Treatment of LTB4-mediated inflammatory disorders with optically-pure (R)-2,3-benzodiazepines
US7022700B2 (en) * 2002-12-03 2006-04-04 Vela Pharmaceuticals, Inc. Method of increasing neutrophil production using optically-pure (R)-2,3-benzodiazepines
MXPA05005893A (es) * 2002-12-03 2006-02-08 Vela Pharmaceuticals Inc Composicion farmaceutica de 1-(3-hidroxi -4-metoxifenil) -4-metil-5 -etil-7, 8-dimetoxi- 5h-2, 3-benzodiazepina y usos de la misma.
US6638928B1 (en) 2002-12-03 2003-10-28 Vela Pharmaceuticals, Inc. Treatment of irritable bowel syndrome and nonulcer dyspepsia with substituted 2,3-benzodiazepines
US20040162284A1 (en) * 2003-02-19 2004-08-19 Harris Herbert W. Method of lowering body temperature with (S) tofisopam
US20040224943A1 (en) * 2003-02-19 2004-11-11 Leventer Steven M. Method of lowering body temperature with (R) - 2,3-benzodiazepines
US20070021412A1 (en) * 2003-05-16 2007-01-25 Vela Pharmaceuticals, Inc. Treatment of gastrointestinal dysfunction and related stress with an enantiomerically-pure (S) 2,3-benzodiazepine
JP4611308B2 (ja) * 2003-05-16 2011-01-12 ヴェラ アクイジション コーポレイション 鏡像的に純粋な（ｒ）２，３−ベンゾジアゼピンを使用する胃腸の機能不全及び関連するストレスの治療
US20040254173A1 (en) * 2003-06-13 2004-12-16 Leventer Steven M. Modulation of dopamine responses with substituted (S)-2,3-benzodiazepines
HUP0302449A3 (en) * 2003-08-04 2005-06-28 Egis Gyogyszergyar Nyilvanosan 8-chloro-2,3-benzodiazepine derivatives, pharmaceutical compositions containing them and process for producing them
US7541355B2 (en) * 2005-05-23 2009-06-02 Vela Acquisition Corporation Conversion process for 2,3-benzodiazepine enantiomers

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE30014E (en) 1966-12-09 1979-05-29 Egyesult Gyogyazer-es Tapozergyar 1-(3,4-Dimethoxy-phenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5H-2,3-benzodiazepine
DK118660B (da) * 1966-12-09 1970-09-21 Egyt Gyogyszervegyeszeti Gyar Analogifremgangsmåde til fremstilling af 1-(3',4'-dimethoxyphenyl)-3-methyl-4-ethyl-6,7-dimethoxy-isoquinolin-N-imid.
GB1202579A (en) * 1966-12-09 1970-08-19 Egyt Gyogyszervegyeszeti Gyar Pharmacologically active new isoquinoline derivative and process for preparing same
ZA712798B (en) * 1970-11-06 1972-02-23 Egyt Gyogyszervegyeszeti Gyar New,pharmaceutically active 2,3-diazabicyclo(5.4.0)undecapentaene derivative and process for preparing same

Also Published As

Publication number Publication date
JPS6350354B2 (ru) 1988-10-07
NL7907692A (nl) 1980-04-22
NO152048B (no) 1985-04-15
BG60270B2 (bg) 1994-03-31
FR2439189B1 (ru) 1984-11-30
SE439919B (sv) 1985-07-08
YU41887B (en) 1988-02-29
FI66604B (fi) 1984-07-31
CS236456B2 (en) 1985-05-15
NL190552C (nl) 1994-04-18
GB2034706B (en) 1982-08-04
FR2439189A1 (fr) 1980-05-16
DK155327B (da) 1989-03-28
IT7926579A0 (it) 1979-10-18
NO793349L (no) 1980-04-22
AU532079B2 (en) 1983-09-15
CH643835A5 (de) 1984-06-29
JPS5592377A (en) 1980-07-12
DE2940483A1 (de) 1980-04-30
GB2034706A (en) 1980-06-11
US4322346A (en) 1982-03-30
DE2940483C2 (ru) 1989-06-22
AT373589B (de) 1984-02-10
ES485163A1 (es) 1980-06-16
ATA647279A (de) 1983-06-15
GR74034B (ru) 1984-06-06
PL219034A1 (ru) 1980-12-01
CA1125749A (en) 1982-06-15
YU241079A (en) 1984-02-29
HU179018B (en) 1982-08-28
SE7908481L (sv) 1980-04-20
IT1220947B (it) 1990-06-21
NL190552B (nl) 1993-11-16
NO152048C (no) 1985-07-24
DD146596A5 (de) 1981-02-18
FI793209A (fi) 1980-04-20
SU1402258A3 (ru) 1988-06-07
DK440179A (da) 1980-04-20
BE879404A (fr) 1980-04-15
BG60270B1 (bg) 1994-03-31
PL124063B1 (en) 1982-12-31
DK155327C (da) 1989-08-21

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Owner name: E GY T GYOGYSZERVEGYOERZETI GYOER