FI66602C - Foerfarande foer framstaellning av terapeutiskt aktiva alfa-hydroxi- eller alfa(hydroxialkyl)-laktam-n-aettiksyror eller deras amider - Google Patents
Foerfarande foer framstaellning av terapeutiskt aktiva alfa-hydroxi- eller alfa(hydroxialkyl)-laktam-n-aettiksyror eller deras amider Download PDFInfo
- Publication number
- FI66602C FI66602C FI791421A FI791421A FI66602C FI 66602 C FI66602 C FI 66602C FI 791421 A FI791421 A FI 791421A FI 791421 A FI791421 A FI 791421A FI 66602 C FI66602 C FI 66602C
- Authority
- FI
- Finland
- Prior art keywords
- alpha
- formula
- lactam
- hydroxyalkyl
- acetic acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/08—Oxygen atoms
- C07D223/10—Oxygen atoms attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D227/00—Heterocyclic compounds containing rings having one nitrogen atom as the only ring hetero atom, according to more than one of groups C07D203/00 - C07D225/00
- C07D227/02—Heterocyclic compounds containing rings having one nitrogen atom as the only ring hetero atom, according to more than one of groups C07D203/00 - C07D225/00 with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D227/06—Heterocyclic compounds containing rings having one nitrogen atom as the only ring hetero atom, according to more than one of groups C07D203/00 - C07D225/00 with only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D227/08—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Polyamides (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1816078 | 1978-05-08 | ||
| GB1816078 | 1978-05-08 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI791421A FI791421A (fi) | 1979-11-09 |
| FI66602B FI66602B (fi) | 1984-07-31 |
| FI66602C true FI66602C (fi) | 1984-11-12 |
Family
ID=10107678
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI791421A FI66602C (fi) | 1978-05-08 | 1979-05-03 | Foerfarande foer framstaellning av terapeutiskt aktiva alfa-hydroxi- eller alfa(hydroxialkyl)-laktam-n-aettiksyror eller deras amider |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US4221789A (hu) |
| EP (1) | EP0005689B1 (hu) |
| JP (1) | JPS54154760A (hu) |
| AT (1) | ATE27T1 (hu) |
| AU (1) | AU522815B2 (hu) |
| BE (1) | BE876067A (hu) |
| CA (1) | CA1119593A (hu) |
| DE (2) | DE2960194D1 (hu) |
| DK (1) | DK150064C (hu) |
| ES (1) | ES480299A1 (hu) |
| FI (1) | FI66602C (hu) |
| FR (1) | FR2425433A1 (hu) |
| GR (1) | GR67631B (hu) |
| HU (1) | HU178362B (hu) |
| IT (1) | IT7948950A0 (hu) |
| NL (1) | NL7903536A (hu) |
| NO (1) | NO150639C (hu) |
| PL (1) | PL117056B1 (hu) |
| PT (1) | PT69582A (hu) |
| SE (1) | SE7903864L (hu) |
| SU (2) | SU1093245A3 (hu) |
| YU (1) | YU41340B (hu) |
| ZA (1) | ZA792175B (hu) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2944456C2 (de) * | 1979-11-03 | 1982-04-01 | Hoechst Ag, 6000 Frankfurt | Verfahren zur Herstellung von N-α -Alkoxyalkyl-carbonsäureamiden |
| US4396616A (en) * | 1981-09-04 | 1983-08-02 | Merck & Co., Inc. | Substituted enantholactam derivatives as antihypertensives |
| EP0089900B1 (en) * | 1982-03-24 | 1985-12-27 | Prodes S.A. | New n-((2-oxo-1-pyrrolidinyl)acetyl)piperazines, the methods of producing such new compounds and their salts as well as pharmaceutical preparations for therapeutic use containing these compounds or salts |
| US4608201A (en) * | 1984-05-21 | 1986-08-26 | Ppg Industries, Inc. | Process for preparing lactam imides |
| CA1322199C (en) * | 1987-07-15 | 1993-09-14 | Masami Eigyo | N-¬(2-oxopyrrolidin-1-yl) acetyl)| piperazine derivatives and drug for senile dementia |
| IT1242043B (it) * | 1990-12-21 | 1994-02-02 | Sigma Tau Ind Farmaceuti | Derivati della 1,2,3,4,-tetraidronaftilammina ad attivita' nootropica e composizioni farmaceutiche che li contengono. |
| IT1245870B (it) * | 1991-06-05 | 1994-10-25 | Sigma Tau Ind Farmaceuti | 3-acilammino-2-pirrolidinoni quali attivatori dei processi di appremdimento e della memoria e composizioni farmaceutiche comprendenti tali composti |
| US5510477A (en) * | 1994-03-01 | 1996-04-23 | The Procter & Gamble Company | Process for the acylation of lactams |
| AU1369001A (en) * | 1995-12-13 | 2001-03-22 | Abbott Laboratories | Retroviral protease inhibiting compounds |
| US5914332A (en) | 1995-12-13 | 1999-06-22 | Abbott Laboratories | Retroviral protease inhibiting compounds |
| US7834043B2 (en) * | 2003-12-11 | 2010-11-16 | Abbott Laboratories | HIV protease inhibiting compounds |
| ES2637497T3 (es) | 2008-10-16 | 2017-10-13 | The Johns Hopkins University | Procedimientos y composiciones para la mejora de la función cognitiva |
| CN109662964A (zh) * | 2010-02-09 | 2019-04-23 | 约翰斯.霍普金斯大学 | 用于改善认知功能的方法和组合物 |
| CA2891122C (en) | 2012-11-14 | 2021-07-20 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
| US10806717B2 (en) | 2013-03-15 | 2020-10-20 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
| AU2014228512A1 (en) | 2013-03-15 | 2015-10-01 | Agenebio, Inc. | Methods and compositions for improving cognitive function |
| CA2986598C (en) | 2015-05-22 | 2023-09-26 | Agenebio, Inc. | Extended release pharmaceutical compositions of levetiracetam |
| JP6785838B2 (ja) | 2015-08-05 | 2020-11-18 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | 新規な置換グリシン誘導のｆｘｉａ阻害剤 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2657215A (en) * | 1950-03-10 | 1953-10-27 | Goodrich Co B F | Method for the preparation of novel n-(2-carboxyalkyl) succinimides |
| DE1081896B (de) * | 1959-03-28 | 1960-05-19 | Bayer Ag | Verfahren zur Herstellung von ª-Amino-ª-hydroxycarbonsaeuren |
| GB1039113A (en) | 1964-08-06 | 1966-08-17 | Ucb Sa | New n-substituted lactams |
| GB1309692A (en) * | 1970-02-13 | 1973-03-14 | Ucb Sa | N-substituted lactams |
| US3751262A (en) * | 1970-06-30 | 1973-08-07 | Allied Chem | Ruminant feed supplement |
| GB1539817A (en) * | 1976-10-22 | 1979-02-07 | Ucb Sa | N-substituted lactams |
-
1979
- 1979-05-02 AT AT79870012T patent/ATE27T1/de not_active IP Right Cessation
- 1979-05-02 DE DE7979870012T patent/DE2960194D1/de not_active Expired
- 1979-05-02 EP EP79870012A patent/EP0005689B1/fr not_active Expired
- 1979-05-03 DK DK182379A patent/DK150064C/da not_active IP Right Cessation
- 1979-05-03 SE SE7903864A patent/SE7903864L/xx unknown
- 1979-05-03 NO NO791477A patent/NO150639C/no unknown
- 1979-05-03 FI FI791421A patent/FI66602C/fi not_active IP Right Cessation
- 1979-05-04 NL NL7903536A patent/NL7903536A/xx not_active Application Discontinuation
- 1979-05-07 PL PL1979215420A patent/PL117056B1/pl unknown
- 1979-05-07 IT IT7948950A patent/IT7948950A0/it unknown
- 1979-05-07 AU AU46816/79A patent/AU522815B2/en not_active Expired
- 1979-05-07 US US06/036,987 patent/US4221789A/en not_active Expired - Lifetime
- 1979-05-07 ES ES480299A patent/ES480299A1/es not_active Expired
- 1979-05-07 BE BE1/9378A patent/BE876067A/xx unknown
- 1979-05-07 CA CA000325925A patent/CA1119593A/en not_active Expired
- 1979-05-07 PT PT69582A patent/PT69582A/pt unknown
- 1979-05-07 ZA ZA792175A patent/ZA792175B/xx unknown
- 1979-05-07 FR FR7911537A patent/FR2425433A1/fr not_active Withdrawn
- 1979-05-07 GR GR59038A patent/GR67631B/el unknown
- 1979-05-08 YU YU1069/79A patent/YU41340B/xx unknown
- 1979-05-08 DE DE19792918523 patent/DE2918523A1/de not_active Withdrawn
- 1979-05-08 HU HU79UE94A patent/HU178362B/hu not_active IP Right Cessation
- 1979-05-08 JP JP5622979A patent/JPS54154760A/ja active Granted
- 1979-05-08 SU SU792763201A patent/SU1093245A3/ru active
- 1979-11-26 SU SU792847114A patent/SU969701A1/ru active
Also Published As
| Publication number | Publication date |
|---|---|
| YU106979A (en) | 1983-04-30 |
| FR2425433A1 (fr) | 1979-12-07 |
| IT7948950A0 (it) | 1979-05-07 |
| ES480299A1 (es) | 1980-08-16 |
| NO150639B (no) | 1984-08-13 |
| CA1119593A (en) | 1982-03-09 |
| FI66602B (fi) | 1984-07-31 |
| DE2960194D1 (en) | 1981-04-16 |
| DK182379A (da) | 1979-11-09 |
| EP0005689A1 (fr) | 1979-11-28 |
| DK150064C (da) | 1987-06-15 |
| SU969701A1 (ru) | 1982-10-30 |
| NL7903536A (nl) | 1979-11-12 |
| PT69582A (fr) | 1979-06-01 |
| DE2918523A1 (de) | 1979-11-15 |
| PL215420A1 (hu) | 1980-02-11 |
| SE7903864L (sv) | 1979-11-09 |
| BE876067A (fr) | 1979-11-07 |
| FI791421A (fi) | 1979-11-09 |
| NO150639C (no) | 1984-11-21 |
| GR67631B (hu) | 1981-09-01 |
| DK150064B (da) | 1986-12-01 |
| HU178362B (en) | 1982-04-28 |
| JPS54154760A (en) | 1979-12-06 |
| AU4681679A (en) | 1979-11-15 |
| ZA792175B (en) | 1980-05-28 |
| YU41340B (en) | 1987-02-28 |
| SU1093245A3 (ru) | 1984-05-15 |
| EP0005689B1 (fr) | 1981-03-18 |
| ATE27T1 (de) | 1981-04-15 |
| PL117056B1 (en) | 1981-07-31 |
| NO791477L (no) | 1979-11-09 |
| JPS6220982B2 (hu) | 1987-05-11 |
| AU522815B2 (en) | 1982-06-24 |
| US4221789A (en) | 1980-09-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed | ||
| MM | Patent lapsed |
Owner name: UCB, S.A. |