FI66592C - Foerfarande foer framstaellning av terapeutiskt anvaendbara sustituerade fenylketoner - Google Patents

Foerfarande foer framstaellning av terapeutiskt anvaendbara sustituerade fenylketoner Download PDF

Info

Publication number
FI66592C
FI66592C FI752350A FI752350A FI66592C FI 66592 C FI66592 C FI 66592C FI 752350 A FI752350 A FI 752350A FI 752350 A FI752350 A FI 752350A FI 66592 C FI66592 C FI 66592C
Authority
FI
Finland
Prior art keywords
acid
formula
group
solution
addition salt
Prior art date
Application number
FI752350A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI752350A (da
FI66592B (fi
Inventor
Cedric Herbert Hassall
William Henry Johnson
Antonin Kroehn
Carey Ernest Smithen
William Anthony Thomas
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of FI752350A publication Critical patent/FI752350A/fi
Application granted granted Critical
Publication of FI66592B publication Critical patent/FI66592B/fi
Publication of FI66592C publication Critical patent/FI66592C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06043—Leu-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C07K5/06095—Arg-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Furan Compounds (AREA)
FI752350A 1974-08-20 1975-08-20 Foerfarande foer framstaellning av terapeutiskt anvaendbara sustituerade fenylketoner FI66592C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB36567/74A GB1517164A (en) 1974-08-20 1974-08-20 Substituted-phenyl ketones and a process for the manufacture thereof
GB3656774 1974-08-20
GB2182175 1975-05-21
GB2182175 1975-05-21

Publications (3)

Publication Number Publication Date
FI752350A FI752350A (da) 1976-02-21
FI66592B FI66592B (fi) 1984-07-31
FI66592C true FI66592C (fi) 1984-11-12

Family

ID=26255542

Family Applications (1)

Application Number Title Priority Date Filing Date
FI752350A FI66592C (fi) 1974-08-20 1975-08-20 Foerfarande foer framstaellning av terapeutiskt anvaendbara sustituerade fenylketoner

Country Status (19)

Country Link
JP (1) JPS6018656B2 (da)
AR (1) AR217041A1 (da)
AT (1) AT348985B (da)
AU (1) AU502104B2 (da)
CA (1) CA1177069A (da)
CH (1) CH620900A5 (da)
DD (1) DD123086A5 (da)
DE (1) DE2537069A1 (da)
DK (1) DK149284C (da)
ES (1) ES440315A1 (da)
FI (1) FI66592C (da)
FR (1) FR2282261A1 (da)
GB (1) GB1517164A (da)
IL (1) IL47936A (da)
LU (1) LU73219A1 (da)
NL (1) NL7509884A (da)
NO (1) NO150199C (da)
PH (1) PH16616A (da)
SE (1) SE426319B (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2754112A1 (de) * 1977-12-05 1979-06-13 Kali Chemie Pharma Gmbh 1,4-benzodiazepinderivate, ihre salze und diese verbindungen enthaltende arzneipraeparate
IN184976B (da) * 1996-06-13 2000-10-14 Ranbaxy Lab Ltd

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3709898A (en) * 1971-02-09 1973-01-09 Upjohn Co Process for the production of triazolobenzodiazepines and intermediates
JPS526861B2 (da) * 1972-05-27 1977-02-25
ZA735932B (en) * 1972-09-21 1974-07-31 Hoffmann La Roche Benzodiazepine derivatives

Also Published As

Publication number Publication date
JPS51125048A (en) 1976-11-01
FR2282261A1 (fr) 1976-03-19
SE426319B (sv) 1982-12-27
DK149284B (da) 1986-04-21
NL7509884A (nl) 1976-02-24
AT348985B (de) 1979-03-12
FI752350A (da) 1976-02-21
AU8407475A (en) 1977-02-24
ES440315A1 (es) 1977-09-16
DK373975A (da) 1976-02-21
LU73219A1 (da) 1977-04-15
CA1177069A (en) 1984-10-30
AU502104B2 (en) 1979-07-12
JPS6018656B2 (ja) 1985-05-11
IL47936A (en) 1980-01-31
PH16616A (en) 1983-11-28
CH620900A5 (en) 1980-12-31
NO752876L (da) 1976-02-23
NO150199B (no) 1984-05-28
FI66592B (fi) 1984-07-31
ATA642175A (de) 1978-08-15
DD123086A5 (da) 1976-11-20
NO150199C (no) 1984-09-05
AR217041A1 (es) 1980-02-29
DK149284C (da) 1986-10-13
IL47936A0 (en) 1975-11-25
GB1517164A (en) 1978-07-12
SE7509268L (sv) 1976-02-23
FR2282261B1 (da) 1978-11-10
DE2537069A1 (de) 1976-03-04
DE2537069C2 (da) 1988-09-08

Similar Documents

Publication Publication Date Title
AU679085B2 (en) Benzodiazepine analogs
Sternbach The benzodiazepine story
AU640113B2 (en) Benzodiazepine analogs
KR100223662B1 (ko) 자동 금전 출납기를 사용하여 송금된 돈을 지급하는 전자 송금 시스템 및 방법
Yang et al. Solid phase synthesis of Fmoc N-methyl amino acids: Application of the Fukuyama amine synthesis
NL8201326A (nl) N-gesubstitueerde amidoaminozuren.
Pinza et al. Synthesis and pharmacological activity of a series of dihydro-1H-pyrrolo [1, 2-a] imidazole-2, 5 (3H, 6H)-diones, a novel class of potent cognition enhancers
PT86980B (pt) Processo para a preparacao de analogos de benzodiazepina
JPH10513462A (ja) トロンビンインヒビター
IE914156A1 (en) Hiv protease inhibitors
FI91409C (fi) Menetelmä ja välituotteita uusien, terapeuttisesti käyttökelpoisten karbonyyliamino(tetrahydropyrrolo tai heksahydropyrido)/3,2,1-jk//1,4/bentsodiatsepinonijohdannaisten valmistamiseksi
Lenman Synthesis of fused 1, 2, 5-triazepine-1, 5-diones and some N 2-and N 3-substituted derivatives: potential conformational mimetics for cis-peptidyl prolinamides1
FI66592C (fi) Foerfarande foer framstaellning av terapeutiskt anvaendbara sustituerade fenylketoner
US4007219A (en) Benzophenone glycinamide derivatives
Hirai et al. Amino acid amide derivatives of 2-[3-(aminomethyl)-4H-1, 2, 4-triazol-4-yl] benzophenones, a novel class of annulated peptidoaminobenzophenones
US3757008A (en) Sses for preparing same 1 - (carboxyl-heteroalkyl) - 1,4-benzodiazepine derivatives and proce
WO1994024151A1 (en) 1,5 benzodiazepine derivatives having cck and/or gastrin antagonistic activity
US4071525A (en) Substituted phenyl ketones
US4044017A (en) Substituted phenyl ketones
US4046751A (en) Substituted phenyl ketones
van Niel et al. CCKB selective receptor ligands: Novel 1, 3, 5-trisubstituted benzazepin-2-ones
JPS6249267B2 (da)
US4045569A (en) Optically active 1,4-benzodiazepines and process for use as a tranquilizer
FI67376C (fi) Foerfarande foer framstaellning av nya 1-alkylkarbamoyl-2-oxo-3-alkoxikarbonyl-5-halogenfenyl-7-klor-2,3-dihydro-1h-benzodiazepiner
Han et al. Homologs of 1, 2, 5‐hexahydro‐3‐one‐1H‐1, 4‐diazepine (DAP) as novel dipeptidomimetics and molecular scaffolds: Efficient preparation of synthons

Legal Events

Date Code Title Description
MM Patent lapsed

Owner name: F. HOFFMANN-LA ROCHE & CO. AG