FI66395C - 3-acetoxi-9alfa 11beta-epoxipregna-1,3,5-triener och motsvarande 3,5-diener anvaendbara som mellanprodukt vid framstaellning av 6alfa-halogen substituerade pregna-1,4-dien-3-oner ochpregn-4-en-3-oner och ett foerfarande foer framstaellning a dessa mellanprodukter - Google Patents

3-acetoxi-9alfa 11beta-epoxipregna-1,3,5-triener och motsvarande 3,5-diener anvaendbara som mellanprodukt vid framstaellning av 6alfa-halogen substituerade pregna-1,4-dien-3-oner ochpregn-4-en-3-oner och ett foerfarande foer framstaellning a dessa mellanprodukter Download PDF

Info

Publication number
FI66395C
FI66395C FI791124A FI791124A FI66395C FI 66395 C FI66395 C FI 66395C FI 791124 A FI791124 A FI 791124A FI 791124 A FI791124 A FI 791124A FI 66395 C FI66395 C FI 66395C
Authority
FI
Finland
Prior art keywords
epoxy
pregna
och
faring
oner
Prior art date
Application number
FI791124A
Other languages
English (en)
Finnish (fi)
Other versions
FI791124A (fi
FI66395B (fi
Inventor
Peter Macdonald
Original Assignee
Prochem Ets
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prochem Ets filed Critical Prochem Ets
Publication of FI791124A publication Critical patent/FI791124A/fi
Publication of FI66395B publication Critical patent/FI66395B/fi
Application granted granted Critical
Publication of FI66395C publication Critical patent/FI66395C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Epoxy Compounds (AREA)

Claims (5)

1. S-acetcxi-^, 11/¾ -epoxipregna-1,3,5-triener och motsvarande 3,5-diener med den allmänna formeln I, vilka är användbara som mellanprodukt vid framställning av 6°*—halogen-substituerade pregna-1,4-dien-3-oner och pregn-4-en-3-oner H2C"R3 C=0 ^ 2 jC tlTRl ° L \ H 3 C - C - 0^^ · ' väri en dubbelbindning kan vara närvarande i 1,2-ställningen, R3 är väte eller en metylgrupp i oi- eller /B-ställningen, R2 är väte eller en hydroxi- eller acetoxigrupp, eller R^ och R2 bildar tillsammans en 16,17-isopropylidendioxigrupp, och R^ är en acyloxi-grupp innehällande 2-5 C-atomer.
2. Förfarande för framställning av föreningar med den allmänna formeln 1, väri R^, R2 och R^ har de i patentkravet 1 angivna betydelserna och väri en dubbelbindning kan vara närvarande i 1,2-ställningen, kännetecknat därav, att en motsvarande -keto-pregnadien ellerΔ^-3-keto-pregnen med den allmänna formeln III h29-r3 c=o 1**2 III [>
FI791124A 1978-04-05 1979-04-05 3-acetoxi-9alfa 11beta-epoxipregna-1,3,5-triener och motsvarande 3,5-diener anvaendbara som mellanprodukt vid framstaellning av 6alfa-halogen substituerade pregna-1,4-dien-3-oner ochpregn-4-en-3-oner och ett foerfarande foer framstaellning a dessa mellanprodukter FI66395C (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
NL7803655 1978-04-05
NL7803656 1978-04-05
NL7803655 1978-04-05
NL7803656 1978-04-05
NLAANVRAGE7902333,A NL187577C (nl) 1978-04-05 1979-03-23 3-acetoxy-9beta,11beta-epoxy-pregna-1,3,5-trienen, werkwijze voor de bereiding daarvan en werkwijze voor de bereiding van 6alfa-halogeen-pregna-1,4-dieen-3-onen.
NL7902333 1979-03-23

Publications (3)

Publication Number Publication Date
FI791124A FI791124A (fi) 1979-10-06
FI66395B FI66395B (fi) 1984-06-29
FI66395C true FI66395C (fi) 1984-10-10

Family

ID=27352047

Family Applications (1)

Application Number Title Priority Date Filing Date
FI791124A FI66395C (fi) 1978-04-05 1979-04-05 3-acetoxi-9alfa 11beta-epoxipregna-1,3,5-triener och motsvarande 3,5-diener anvaendbara som mellanprodukt vid framstaellning av 6alfa-halogen substituerade pregna-1,4-dien-3-oner ochpregn-4-en-3-oner och ett foerfarande foer framstaellning a dessa mellanprodukter

Country Status (9)

Country Link
US (1) US4255331A (sv)
JP (1) JPS6425793A (sv)
CH (1) CH639655A5 (sv)
DE (1) DE2913147A1 (sv)
FI (1) FI66395C (sv)
FR (1) FR2421914A1 (sv)
GB (1) GB2018258B (sv)
NL (1) NL187577C (sv)
PH (1) PH16138A (sv)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4188322A (en) * 1978-04-28 1980-02-12 Blasinachim S.P.A. Process for the preparation of 6-halo-pregnanes
DE3069074D1 (en) 1979-11-16 1984-10-04 Sterosynt Ltd 6-alpha-9-alpha-difluoro-16-beta-methyl-prednisolone-17,21 diesters and pharmaceutical compositions containing them
HU182775B (en) * 1981-10-15 1984-03-28 Richter Gedeon Vegyeszet Process for preparing new 3-chloro-pregnane derivatives
FR2701262B1 (fr) * 1993-02-05 1995-03-24 Roussel Uclaf Nouveau procédé de préparation de stéroïdes 6 alpa, 9 alpha-difluorés et nouveaus intermédiaires.
GB0017988D0 (en) * 2000-07-21 2000-09-13 Glaxo Group Ltd Novel process
IT1319663B1 (it) * 2000-11-17 2003-10-23 Farmabios Srl Processo per la preparazione di fluoro-steroidi.
PT102628B (pt) * 2001-06-12 2010-09-09 Hovione Farmaciencia S A Novo processo de preparação de flumetasona e do seu análogo 17-carboxilo androsteno
EP1275656A1 (en) * 2001-07-11 2003-01-15 Genchem Pharma Limited Preparation of 9alpha-fluoro-11beta-hydroxypregnane 16,17-acetal derivatives
CA2473471A1 (en) * 2001-11-29 2003-06-12 Taro Pharmaceuticals U.S.A., Inc. Method for the preparation of 6-alpha-fluoro corticosteroids
DE60303687D1 (de) * 2002-12-09 2006-04-27 Sicor Inc Prozess zur herstellung von 6 alpa-fluorierten pregnanen
CA2805832A1 (en) 2010-07-20 2012-01-26 Taro Pharmaceutical Industries Ltd. Process for the preparation of 17-desoxy-corticosteroids

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU75903A1 (sv) * 1976-09-29 1978-05-16
US3047596A (en) * 1959-11-17 1962-07-31 Merck & Co Inc 6alpha-halogen-9alpha-halogen-delta-pregnadiene-3-one compounds
SE339685B (sv) * 1967-06-16 1971-10-18 Warner Lambert Pharmaceutical
DE2365992C3 (de) * 1972-03-09 1982-05-19 The Upjohn Co., 49001 Kalamazoo, Mich. 6α-Fluor-17,21-dihydroxy-16β-methylpregna-4,9(11)-dien-3,20-dion-17,21-diacetat und Verfahren zu dessen Herstellung
US4188322A (en) * 1978-04-28 1980-02-12 Blasinachim S.P.A. Process for the preparation of 6-halo-pregnanes

Also Published As

Publication number Publication date
DE2913147A1 (de) 1979-10-18
DE2913147C2 (sv) 1988-06-30
FI791124A (fi) 1979-10-06
FI66395B (fi) 1984-06-29
NL187577C (nl) 1991-11-18
FR2421914B1 (sv) 1983-07-22
GB2018258A (en) 1979-10-17
PH16138A (en) 1983-07-08
US4255331A (en) 1981-03-10
NL187577B (nl) 1991-06-17
NL7902333A (nl) 1979-10-09
CH639655A5 (de) 1983-11-30
FR2421914A1 (fr) 1979-11-02
JPH0217560B2 (sv) 1990-04-20
JPS6425793A (en) 1989-01-27
GB2018258B (en) 1983-02-02

Similar Documents

Publication Publication Date Title
CA1056371A (en) Polyhalogeno-steroids and processes for their manufacture
FI66395C (fi) 3-acetoxi-9alfa 11beta-epoxipregna-1,3,5-triener och motsvarande 3,5-diener anvaendbara som mellanprodukt vid framstaellning av 6alfa-halogen substituerade pregna-1,4-dien-3-oner ochpregn-4-en-3-oner och ett foerfarande foer framstaellning a dessa mellanprodukter
CH533094A (de) Verfahren zur Herstellung neuer Steroide
JP2721002B2 (ja) アンドロスタ‐１，４‐ジエン‐３，１７‐ジオンの６‐メチレン誘導体の合成における改良
HU216638B (hu) Új eljárás 11-oxo-szteroid-származékok előállítására
US5310896A (en) Process for preparing Δ1,4 -pregnadiene-3,20-diones
CA1159049A (en) Process for the preparation of 6-halo-pregnanes
HU214717B (hu) Új eljárás 6alfa,9alfa-difluorozott szteroidok előállítására
US4525303A (en) Process for preparation of steroids
RU2260596C1 (ru) Способ получения флуметазона, соединение
KR100284824B1 (ko) 16알파-메틸화 스테로이드의 제조 방법
EP0003519A1 (de) Neue in 17-Position substituierte Steroide der Pregnanreihe, ihre Herstellung und Verwendung
US4950428A (en) Novel steroids
DK146017B (da) Analogifremgangsmaade til fremstilling af 17alfa-acyloxy-9alfa,21-dihalogen-11beta-hydroxy-6alfa-fluor-16beta-methyl-pregna-1,4-dien-3,20-dion-forbindelser
EP1422235B1 (en) Stereoselective method of producing 6alpha-fluoropregnanes and intermediaries
US2666067A (en) Simultaneous oxidation and halogenation of steroids
EP0005523B1 (de) D-Homosteroide, Verfahren zu deren Herstellung
US4113722A (en) Steroidal[16α,17-b]benzodioxins
KR820001643B1 (ko) 6-할로-프레그난류의 개량된 제조방법
EP0001737A1 (de) 17-Alpha-(3-Jodbenzoyloxy)-9-Alpha-chlor-4-pregnen-3.20-dione, deren D-Homo-analoga und Verfahren zu ihrer Herstellung
DE3324403A1 (de) Androsten-17-dithioketale und diese verbindungen enthaltende arzeimittel
KR800001381B1 (ko) D-호모스테로이드의 제조방법
JPS6363555B2 (sv)
GB2065660A (en) Anti inflammatory 2- bromo-6 beta -fluoro-9 alpha -halo steroids of the pregna-1,4-dien-3-one series
IT9048031A1 (it) 6 fluoro 6 metilpregn-4-ene-3, 20 dioni e 6-fluoro-6-metilpregna-l, 4-diene-3, 20-dioni, procedimento per la loro preparazione e composizioni farmaceutiche ad attivita' anti-infiammatoria che li contengono

Legal Events

Date Code Title Description
MM Patent lapsed
MM Patent lapsed

Owner name: SIBLA S.R.L.