FI66395C - 3-acetoxi-9alfa 11beta-epoxipregna-1,3,5-triener och motsvarande 3,5-diener anvaendbara som mellanprodukt vid framstaellning av 6alfa-halogen substituerade pregna-1,4-dien-3-oner ochpregn-4-en-3-oner och ett foerfarande foer framstaellning a dessa mellanprodukter - Google Patents
3-acetoxi-9alfa 11beta-epoxipregna-1,3,5-triener och motsvarande 3,5-diener anvaendbara som mellanprodukt vid framstaellning av 6alfa-halogen substituerade pregna-1,4-dien-3-oner ochpregn-4-en-3-oner och ett foerfarande foer framstaellning a dessa mellanprodukter Download PDFInfo
- Publication number
- FI66395C FI66395C FI791124A FI791124A FI66395C FI 66395 C FI66395 C FI 66395C FI 791124 A FI791124 A FI 791124A FI 791124 A FI791124 A FI 791124A FI 66395 C FI66395 C FI 66395C
- Authority
- FI
- Finland
- Prior art keywords
- epoxy
- pregna
- och
- faring
- oner
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/0026—Oxygen-containing hetero ring cyclic ketals
- C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
- C07J71/0015—Oxiranes at position 9(11)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Epoxy Compounds (AREA)
Claims (5)
1. S-acetcxi-^, 11/¾ -epoxipregna-1,3,5-triener och motsvarande 3,5-diener med den allmänna formeln I, vilka är användbara som mellanprodukt vid framställning av 6°*—halogen-substituerade pregna-1,4-dien-3-oner och pregn-4-en-3-oner H2C"R3 C=0 ^ 2 jC tlTRl ° L \ H 3 C - C - 0^^ · ' väri en dubbelbindning kan vara närvarande i 1,2-ställningen, R3 är väte eller en metylgrupp i oi- eller /B-ställningen, R2 är väte eller en hydroxi- eller acetoxigrupp, eller R^ och R2 bildar tillsammans en 16,17-isopropylidendioxigrupp, och R^ är en acyloxi-grupp innehällande 2-5 C-atomer.
2. Förfarande för framställning av föreningar med den allmänna formeln 1, väri R^, R2 och R^ har de i patentkravet 1 angivna betydelserna och väri en dubbelbindning kan vara närvarande i 1,2-ställningen, kännetecknat därav, att en motsvarande -keto-pregnadien ellerΔ^-3-keto-pregnen med den allmänna formeln III h29-r3 c=o 1**2 III [>
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL7803655 | 1978-04-05 | ||
NL7803655 | 1978-04-05 | ||
NL7803656 | 1978-04-05 | ||
NL7803656 | 1978-04-05 | ||
NLAANVRAGE7902333,A NL187577C (nl) | 1978-04-05 | 1979-03-23 | 3-acetoxy-9beta,11beta-epoxy-pregna-1,3,5-trienen, werkwijze voor de bereiding daarvan en werkwijze voor de bereiding van 6alfa-halogeen-pregna-1,4-dieen-3-onen. |
NL7902333 | 1979-03-23 |
Publications (3)
Publication Number | Publication Date |
---|---|
FI791124A FI791124A (fi) | 1979-10-06 |
FI66395B FI66395B (fi) | 1984-06-29 |
FI66395C true FI66395C (fi) | 1984-10-10 |
Family
ID=27352047
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI791124A FI66395C (fi) | 1978-04-05 | 1979-04-05 | 3-acetoxi-9alfa 11beta-epoxipregna-1,3,5-triener och motsvarande 3,5-diener anvaendbara som mellanprodukt vid framstaellning av 6alfa-halogen substituerade pregna-1,4-dien-3-oner ochpregn-4-en-3-oner och ett foerfarande foer framstaellning a dessa mellanprodukter |
Country Status (9)
Country | Link |
---|---|
US (1) | US4255331A (sv) |
JP (1) | JPS6425793A (sv) |
CH (1) | CH639655A5 (sv) |
DE (1) | DE2913147A1 (sv) |
FI (1) | FI66395C (sv) |
FR (1) | FR2421914A1 (sv) |
GB (1) | GB2018258B (sv) |
NL (1) | NL187577C (sv) |
PH (1) | PH16138A (sv) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4188322A (en) * | 1978-04-28 | 1980-02-12 | Blasinachim S.P.A. | Process for the preparation of 6-halo-pregnanes |
DE3068965D1 (en) | 1979-11-16 | 1984-09-20 | Sterosynt Ltd | 6-alpha-fluoro-16-methyl-prednisolone-17,21 diesters and pharmaceutical compositions containing them |
HU182775B (en) * | 1981-10-15 | 1984-03-28 | Richter Gedeon Vegyeszet | Process for preparing new 3-chloro-pregnane derivatives |
FR2701262B1 (fr) * | 1993-02-05 | 1995-03-24 | Roussel Uclaf | Nouveau procédé de préparation de stéroïdes 6 alpa, 9 alpha-difluorés et nouveaus intermédiaires. |
GB0017988D0 (en) * | 2000-07-21 | 2000-09-13 | Glaxo Group Ltd | Novel process |
IT1319663B1 (it) * | 2000-11-17 | 2003-10-23 | Farmabios Srl | Processo per la preparazione di fluoro-steroidi. |
PT102628B (pt) * | 2001-06-12 | 2010-09-09 | Hovione Farmaciencia S A | Novo processo de preparação de flumetasona e do seu análogo 17-carboxilo androsteno |
EP1275656A1 (en) * | 2001-07-11 | 2003-01-15 | Genchem Pharma Limited | Preparation of 9alpha-fluoro-11beta-hydroxypregnane 16,17-acetal derivatives |
BR0214520A (pt) | 2001-11-29 | 2006-05-30 | Taro Pharmaceuticals Usa Inc | método para a preparação de corticosteróides de 6alfa-fluoro |
AU2003298339A1 (en) * | 2002-12-09 | 2004-06-30 | Sicor Inc. | Process for the preparation of pregnanes |
US20130211069A1 (en) | 2010-07-20 | 2013-08-15 | Taro Pharmaceutical Industries Ltd. | Process for the preparation of 17-desoxy-corticosteroids |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
LU75903A1 (sv) * | 1976-09-29 | 1978-05-16 | ||
US3047596A (en) * | 1959-11-17 | 1962-07-31 | Merck & Co Inc | 6alpha-halogen-9alpha-halogen-delta-pregnadiene-3-one compounds |
SE339685B (sv) * | 1967-06-16 | 1971-10-18 | Warner Lambert Pharmaceutical | |
DE2365992C3 (de) * | 1972-03-09 | 1982-05-19 | The Upjohn Co., 49001 Kalamazoo, Mich. | 6α-Fluor-17,21-dihydroxy-16β-methylpregna-4,9(11)-dien-3,20-dion-17,21-diacetat und Verfahren zu dessen Herstellung |
US4188322A (en) * | 1978-04-28 | 1980-02-12 | Blasinachim S.P.A. | Process for the preparation of 6-halo-pregnanes |
-
1979
- 1979-03-23 NL NLAANVRAGE7902333,A patent/NL187577C/xx not_active IP Right Cessation
- 1979-04-02 DE DE19792913147 patent/DE2913147A1/de active Granted
- 1979-04-03 US US06/026,677 patent/US4255331A/en not_active Expired - Lifetime
- 1979-04-04 CH CH314779A patent/CH639655A5/de not_active IP Right Cessation
- 1979-04-04 GB GB7911796A patent/GB2018258B/en not_active Expired
- 1979-04-05 PH PH22354A patent/PH16138A/en unknown
- 1979-04-05 FR FR7910137A patent/FR2421914A1/fr active Granted
- 1979-04-05 FI FI791124A patent/FI66395C/fi not_active IP Right Cessation
-
1988
- 1988-06-08 JP JP63141437A patent/JPS6425793A/ja active Granted
Also Published As
Publication number | Publication date |
---|---|
NL187577C (nl) | 1991-11-18 |
FR2421914B1 (sv) | 1983-07-22 |
FR2421914A1 (fr) | 1979-11-02 |
JPS6425793A (en) | 1989-01-27 |
PH16138A (en) | 1983-07-08 |
DE2913147C2 (sv) | 1988-06-30 |
CH639655A5 (de) | 1983-11-30 |
JPH0217560B2 (sv) | 1990-04-20 |
FI66395B (fi) | 1984-06-29 |
DE2913147A1 (de) | 1979-10-18 |
NL187577B (nl) | 1991-06-17 |
NL7902333A (nl) | 1979-10-09 |
US4255331A (en) | 1981-03-10 |
GB2018258A (en) | 1979-10-17 |
FI791124A (fi) | 1979-10-06 |
GB2018258B (en) | 1983-02-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM | Patent lapsed | ||
MM | Patent lapsed |
Owner name: SIBLA S.R.L. |