FI66374C - Foerfarande foer framstaellning av terapeutiskt aktiva 3-fluor-10-piperazino-8-substituerade 10,11-dihydrodibenso(b f)tiepiner - Google Patents
Foerfarande foer framstaellning av terapeutiskt aktiva 3-fluor-10-piperazino-8-substituerade 10,11-dihydrodibenso(b f)tiepiner Download PDFInfo
- Publication number
- FI66374C FI66374C FI783607A FI783607A FI66374C FI 66374 C FI66374 C FI 66374C FI 783607 A FI783607 A FI 783607A FI 783607 A FI783607 A FI 783607A FI 66374 C FI66374 C FI 66374C
- Authority
- FI
- Finland
- Prior art keywords
- formula
- group
- fluoro
- dihydrodibenzo
- thiepine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
- C07C17/10—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms
- C07C17/14—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms in the side-chain of aromatic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/08—Preparation of carboxylic acids or their salts, halides or anhydrides from nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/205—Radicals derived from carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
- C07D337/02—Seven-membered rings
- C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D337/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D337/14—[b,f]-condensed
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CS872877 | 1977-12-22 | ||
CS778728A CS196893B1 (en) | 1977-12-22 | 1977-12-22 | 3-fluor-10-piperazino-8-substituted 10,11-dihydro-dibenzothiepines |
Publications (3)
Publication Number | Publication Date |
---|---|
FI783607A FI783607A (fi) | 1979-06-23 |
FI66374B FI66374B (fi) | 1984-06-29 |
FI66374C true FI66374C (fi) | 1984-10-10 |
Family
ID=5438253
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI783607A FI66374C (fi) | 1977-12-22 | 1978-11-24 | Foerfarande foer framstaellning av terapeutiskt aktiva 3-fluor-10-piperazino-8-substituerade 10,11-dihydrodibenso(b f)tiepiner |
Country Status (13)
Country | Link |
---|---|
US (1) | US4243805A (cs) |
JP (1) | JPS5492979A (cs) |
AT (1) | AT368151B (cs) |
BE (1) | BE872496A (cs) |
CA (1) | CA1100134A (cs) |
CH (1) | CH642077A5 (cs) |
CS (1) | CS196893B1 (cs) |
DE (1) | DE2855703C2 (cs) |
DK (1) | DK521078A (cs) |
FI (1) | FI66374C (cs) |
FR (1) | FR2412312A1 (cs) |
GB (1) | GB2010843B (cs) |
SE (1) | SE442403B (cs) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3029365A1 (de) * | 1980-08-01 | 1982-03-25 | Bayer Ag, 5090 Leverkusen | Verfahren zur (alpha)-bromierung von gegebenenfalls substituierten fluortoluolen und gemischen von in (alpha)-stellung verschieden hoch bromierten, gegebenenfalls substituierten fluortoluolen |
CS249455B1 (en) * | 1985-01-24 | 1987-03-12 | Miroslav Protiva | N-substituted 2-chloro-7-fluoro-10-piperazino-10,11-dihydrodibenzo(b,f)thiepines and their salts and method of their preparation |
US5700445A (en) * | 1994-12-12 | 1997-12-23 | Allelix Biopharmaceuticals, Inc. | N-methyl piperazine compounds having dopamine receptor affinity |
WO2002018954A2 (en) | 2000-08-30 | 2002-03-07 | Chemocentryx, Inc. | Inhibition of cmv infection and dissemination |
US20050250767A1 (en) * | 2003-01-23 | 2005-11-10 | Weiner David M | Use of N-desmethylclozapine to treat human neuropsychiatric disease |
EP1994932A1 (en) * | 2003-01-23 | 2008-11-26 | Arcadia Pharmaceuticals Inc. | Use of N-desmethylclozapine to treat human psychosis |
US7550454B2 (en) * | 2003-12-22 | 2009-06-23 | Acadia Pharmaceuticals, Inc. | Amino substituted diaryl[a,d]cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders |
WO2006001866A2 (en) * | 2004-04-01 | 2006-01-05 | Acadia Pharmaceuticals Inc. | Crystalline forms of n-desmethylclozapine |
GB0415320D0 (en) * | 2004-07-08 | 2004-08-11 | Astrazeneca Ab | Novel compounds |
DE102004049728A1 (de) * | 2004-10-11 | 2006-04-13 | Merck Patent Gmbh | Verfahren zur Herstellung von monosubstituierten Piperazinderivaten |
US20070105836A1 (en) * | 2005-10-31 | 2007-05-10 | Lars Pettersson | Prodrugs of muscarinic agonists and methods of treatment of neuropsychiatric disorders |
US10525376B2 (en) | 2015-07-20 | 2020-01-07 | W. L. Gore & Associates, Inc. | Affinity chromatography devices |
WO2019092044A1 (en) * | 2017-11-08 | 2019-05-16 | Centre National De La Recherche Scientifique | Dihydrobenzo[b][1]benzothiepin compounds useful in therapy |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2412521A1 (de) * | 1973-03-30 | 1974-10-10 | Hoffmann La Roche | Tricyclische verbindungen |
DE2412520C2 (de) * | 1973-03-30 | 1982-09-16 | F. Hoffmann-La Roche & Co. AG, 4002 Basel | Tricyclische Verbindungen, Verfahren zu deren Herstellung und diese enthaltende Präparate |
FI753625A (cs) * | 1975-01-06 | 1976-07-07 | Spofa Vereinigte Pharma Werke | |
JPS5835449B2 (ja) * | 1979-08-31 | 1983-08-02 | 中興化成工業株式会社 | 表面に波型状凹凸部を有する無機質繊維織布管の製造方法 |
-
1977
- 1977-12-22 CS CS778728A patent/CS196893B1/cs unknown
-
1978
- 1978-11-17 FR FR7832559A patent/FR2412312A1/fr active Granted
- 1978-11-22 DK DK521078A patent/DK521078A/da not_active Application Discontinuation
- 1978-11-24 FI FI783607A patent/FI66374C/fi not_active IP Right Cessation
- 1978-12-04 BE BE192114A patent/BE872496A/xx not_active IP Right Cessation
- 1978-12-14 AT AT0892578A patent/AT368151B/de not_active IP Right Cessation
- 1978-12-14 GB GB7848581A patent/GB2010843B/en not_active Expired
- 1978-12-20 SE SE7813114A patent/SE442403B/sv not_active IP Right Cessation
- 1978-12-21 CH CH1305178A patent/CH642077A5/de not_active IP Right Cessation
- 1978-12-21 CA CA318,360A patent/CA1100134A/en not_active Expired
- 1978-12-22 JP JP15770178A patent/JPS5492979A/ja active Granted
- 1978-12-22 DE DE2855703A patent/DE2855703C2/de not_active Expired
- 1978-12-22 US US05/972,323 patent/US4243805A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE2855703C2 (de) | 1987-02-26 |
SE442403B (sv) | 1985-12-23 |
DK521078A (da) | 1979-06-23 |
JPS638109B2 (cs) | 1988-02-19 |
BE872496A (fr) | 1979-03-30 |
CH642077A5 (de) | 1984-03-30 |
DE2855703A1 (de) | 1979-06-28 |
AT368151B (de) | 1982-09-27 |
JPS5492979A (en) | 1979-07-23 |
SE7813114L (sv) | 1979-06-23 |
CS196893B1 (en) | 1980-04-30 |
US4243805A (en) | 1981-01-06 |
FI66374B (fi) | 1984-06-29 |
GB2010843A (en) | 1979-07-04 |
CA1100134A (en) | 1981-04-28 |
GB2010843B (en) | 1982-08-18 |
FR2412312B1 (cs) | 1982-10-29 |
FR2412312A1 (fr) | 1979-07-20 |
FI783607A (fi) | 1979-06-23 |
ATA892578A (de) | 1982-01-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FI66374C (fi) | Foerfarande foer framstaellning av terapeutiskt aktiva 3-fluor-10-piperazino-8-substituerade 10,11-dihydrodibenso(b f)tiepiner | |
US3862225A (en) | D-ring substituted tetracyclines | |
Baudy et al. | Reaction of N-substituted thioamides with gem-dicyano epoxides: a new synthetic route to anhydro-4-hydroxythiazolium hydroxides | |
Ackrell et al. | Synthesis and antiinflammatory activity of 6, 11-dihydro-11-oxodibenzo [b, e] thiepinalkanoic acids and related compounds | |
Cornforth | Oxazoles and oxazolones | |
Zinnes et al. | 1, 2-Benzothiazines. 6. 3-Carbamoyl-4-hydroxy-2H-1, 2-benzothiazine 1, 1-dioxides as antiinflammatory agents | |
US4007203A (en) | 4-(1-Pyrolidenyl)-2H-1-benzothiopyran-3-carboxanilide | |
US4046778A (en) | Processes for the preparation of 4-hydroxy-2H-1-benzothiopyran-3-carboxamide 1,1-dioxides | |
FI63566B (fi) | Foerfarande foer framstaellning av nya terapeutiskt anvaendbara dibenso(d,g)(1,3,6)dioxazocin-derivat och av deras fysiologiskt godtagbara syraadditionssalter | |
RU2260004C2 (ru) | СПОСОБ ПОЛУЧЕНИЯ БЕНЗО[b]ТИОФЕНОВ | |
IE47210B1 (en) | Improvements in the production of heterocyclic benzamide compounds | |
US3551435A (en) | Certain 4-(pyridylmethylene)-3,4-dihydro-1-benzothiepin-5(2h)-ones | |
US3487085A (en) | Dihydrothieno benzothiepene | |
US3822267A (en) | 1 substituted 4 piperazino cycloalkylthiazoles | |
US4022780A (en) | Process for the manufacture of indole derivatives | |
US3057861A (en) | Basic derivatives of trifluoromethyl- | |
US3528977A (en) | Substituted t-aminophenylalanines | |
US3222388A (en) | Diaryl-acetonitriles and 2,2,3- triarylpropionitriles | |
CA1054630A (en) | Substituted indanylpropionic acids | |
FI58632B (fi) | Foerfarande foer framstaellning av anilider med antitussiv verkan | |
US2797227A (en) | Basic esters of 2-norcamphanecarboxylic acid and of bicyclo [2. 2. 2]-octane-2-carboxic acids, their salts, and nuclearly alkylated substitution products thereof | |
Buzas et al. | Synthesis and psychoanaleptic properties of new compounds structurally related to diphenhydramine | |
US3549621A (en) | 12-substituted-6h-dibenz(b,f)(1,4)oxazocin-11(12h) ones | |
DK143652B (da) | Analogifremgangsmaade til fremstilling af azatetracycler ellersyreadditionssalte deraf | |
PT85310B (pt) | Processo para a preparacao de pirrolidino-2,5-dionas com ligacao espiro e de compostos intermediarios |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM | Patent lapsed |
Owner name: SPOFA SPOJENé PODNIKY PRO ZDRAVOTNICKOU |