DK521078A - 3-fluor-10-piperazino-8-substituerede 10,11-dihydrodibenzo (b,f) thiepiner deres syreaddiionssalte en fremgangsmaade til frmstilling af dem og praeparater indeholdende dem - Google Patents

3-fluor-10-piperazino-8-substituerede 10,11-dihydrodibenzo (b,f) thiepiner deres syreaddiionssalte en fremgangsmaade til frmstilling af dem og praeparater indeholdende dem

Info

Publication number
DK521078A
DK521078A DK521078A DK521078A DK521078A DK 521078 A DK521078 A DK 521078A DK 521078 A DK521078 A DK 521078A DK 521078 A DK521078 A DK 521078A DK 521078 A DK521078 A DK 521078A
Authority
DK
Denmark
Prior art keywords
thiepines
dihydrodibenzo
piperazino
fluoro
substituted
Prior art date
Application number
DK521078A
Other languages
Danish (da)
English (en)
Inventor
M Protiva
M Rajsner
K Sindelar
J Jilek
V Bartl
J Metysova
A Dlabac
L Langsadl
J Pomykacek
F Miksik
Original Assignee
Spofa Vereinigte Pharma Werke
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Spofa Vereinigte Pharma Werke filed Critical Spofa Vereinigte Pharma Werke
Publication of DK521078A publication Critical patent/DK521078A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/10—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms
    • C07C17/14—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms in the side-chain of aromatic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/08—Preparation of carboxylic acids or their salts, halides or anhydrides from nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/02—Seven-membered rings
    • C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D337/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D337/14—[b,f]-condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK521078A 1977-12-22 1978-11-22 3-fluor-10-piperazino-8-substituerede 10,11-dihydrodibenzo (b,f) thiepiner deres syreaddiionssalte en fremgangsmaade til frmstilling af dem og praeparater indeholdende dem DK521078A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CS778728A CS196893B1 (en) 1977-12-22 1977-12-22 3-fluor-10-piperazino-8-substituted 10,11-dihydro-dibenzothiepines

Publications (1)

Publication Number Publication Date
DK521078A true DK521078A (da) 1979-06-23

Family

ID=5438253

Family Applications (1)

Application Number Title Priority Date Filing Date
DK521078A DK521078A (da) 1977-12-22 1978-11-22 3-fluor-10-piperazino-8-substituerede 10,11-dihydrodibenzo (b,f) thiepiner deres syreaddiionssalte en fremgangsmaade til frmstilling af dem og praeparater indeholdende dem

Country Status (13)

Country Link
US (1) US4243805A (cs)
JP (1) JPS5492979A (cs)
AT (1) AT368151B (cs)
BE (1) BE872496A (cs)
CA (1) CA1100134A (cs)
CH (1) CH642077A5 (cs)
CS (1) CS196893B1 (cs)
DE (1) DE2855703C2 (cs)
DK (1) DK521078A (cs)
FI (1) FI66374C (cs)
FR (1) FR2412312A1 (cs)
GB (1) GB2010843B (cs)
SE (1) SE442403B (cs)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3029365A1 (de) * 1980-08-01 1982-03-25 Bayer Ag, 5090 Leverkusen Verfahren zur (alpha)-bromierung von gegebenenfalls substituierten fluortoluolen und gemischen von in (alpha)-stellung verschieden hoch bromierten, gegebenenfalls substituierten fluortoluolen
CS249455B1 (en) * 1985-01-24 1987-03-12 Miroslav Protiva N-substituted 2-chloro-7-fluoro-10-piperazino-10,11-dihydrodibenzo(b,f)thiepines and their salts and method of their preparation
US5700445A (en) * 1994-12-12 1997-12-23 Allelix Biopharmaceuticals, Inc. N-methyl piperazine compounds having dopamine receptor affinity
WO2002018954A2 (en) 2000-08-30 2002-03-07 Chemocentryx, Inc. Inhibition of cmv infection and dissemination
US20050250767A1 (en) * 2003-01-23 2005-11-10 Weiner David M Use of N-desmethylclozapine to treat human neuropsychiatric disease
EP1994932A1 (en) * 2003-01-23 2008-11-26 Arcadia Pharmaceuticals Inc. Use of N-desmethylclozapine to treat human psychosis
US7550454B2 (en) * 2003-12-22 2009-06-23 Acadia Pharmaceuticals, Inc. Amino substituted diaryl[a,d]cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders
WO2006001866A2 (en) * 2004-04-01 2006-01-05 Acadia Pharmaceuticals Inc. Crystalline forms of n-desmethylclozapine
GB0415320D0 (en) * 2004-07-08 2004-08-11 Astrazeneca Ab Novel compounds
DE102004049728A1 (de) * 2004-10-11 2006-04-13 Merck Patent Gmbh Verfahren zur Herstellung von monosubstituierten Piperazinderivaten
US20070105836A1 (en) * 2005-10-31 2007-05-10 Lars Pettersson Prodrugs of muscarinic agonists and methods of treatment of neuropsychiatric disorders
US10525376B2 (en) 2015-07-20 2020-01-07 W. L. Gore & Associates, Inc. Affinity chromatography devices
WO2019092044A1 (en) * 2017-11-08 2019-05-16 Centre National De La Recherche Scientifique Dihydrobenzo[b][1]benzothiepin compounds useful in therapy

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2412521A1 (de) * 1973-03-30 1974-10-10 Hoffmann La Roche Tricyclische verbindungen
DE2412520C2 (de) * 1973-03-30 1982-09-16 F. Hoffmann-La Roche & Co. AG, 4002 Basel Tricyclische Verbindungen, Verfahren zu deren Herstellung und diese enthaltende Präparate
FI753625A (cs) * 1975-01-06 1976-07-07 Spofa Vereinigte Pharma Werke
JPS5835449B2 (ja) * 1979-08-31 1983-08-02 中興化成工業株式会社 表面に波型状凹凸部を有する無機質繊維織布管の製造方法

Also Published As

Publication number Publication date
DE2855703C2 (de) 1987-02-26
SE442403B (sv) 1985-12-23
JPS638109B2 (cs) 1988-02-19
BE872496A (fr) 1979-03-30
CH642077A5 (de) 1984-03-30
DE2855703A1 (de) 1979-06-28
AT368151B (de) 1982-09-27
JPS5492979A (en) 1979-07-23
SE7813114L (sv) 1979-06-23
CS196893B1 (en) 1980-04-30
US4243805A (en) 1981-01-06
FI66374B (fi) 1984-06-29
GB2010843A (en) 1979-07-04
CA1100134A (en) 1981-04-28
GB2010843B (en) 1982-08-18
FI66374C (fi) 1984-10-10
FR2412312B1 (cs) 1982-10-29
FR2412312A1 (fr) 1979-07-20
FI783607A (fi) 1979-06-23
ATA892578A (de) 1982-01-15

Similar Documents

Publication Publication Date Title
DK92378A (da) Substituerede phenoxybenzyloxycarbonylderivater fremgangsmaade til deres femstilling og deres anvendelse som insecticider og acaricider
BR7805845A (pt) Processo para a preparacao de derivados de tienotiazina,compostos assim obtidos,processo para a fabricacao de preparacoes contendo tais compostos,e composicoes assim obtidas
DK488885D0 (da) 9-amino-1,2,3,4-tetrahydroacridin-1-ol og beslaegtede forbindelser, enfremgangsmaade til deres fremstilling og deres anvendelse som laegemidler
DK157196C (da) Krystallinsk 4,1',6'-trichlor-4,1',6,-tridesoxygalactosaccharose, anvendelse deraf som soedemiddel og soedemiddel indeholdende denne
NO802446L (no) Optisk aktive 1-,4-dihydropyridin, fremgangsmaate til deres fremstilling og deres anvendelse som legemiddel
IL54930A (en) Herbicidal preparations containing 1,2,3-thiadiazole-5-carboxylic acid derivatives
DK313276A (da) 2',4-dichlor-4'-benzoylureido-diphenylethere, fremgangsmade til deres fremstilling og deres anvendelse som insecticider
AR225939A1 (es) Un procedimiento para preparar derivados de 1-hidroxi-3-alquilo-6,6-dimetil-9-amino o 9-piperidino o 9-morfolino-6a,7,8,9,10a-hexahidro-6n-dibenzo-(b,d)pirano
DK381985D0 (da) 3-pyridylforbindelser, deres fremstilling og anvendelse som laegemiddel
DK316186A (da) Stabilt prostaglandin-indeholdende praeparat til ikke-laegemiddel-anvendelse
DK498080A (da) Fremgangsmaade til fremstilling af 4!-epidaunorubicin, 3!,4!-diepidaunorubicin og disses doxorubicinanaloge
DK521078A (da) 3-fluor-10-piperazino-8-substituerede 10,11-dihydrodibenzo (b,f) thiepiner deres syreaddiionssalte en fremgangsmaade til frmstilling af dem og praeparater indeholdende dem
DK528879A (da) Fremgangsmaade til fremstilling af et farmaceutisk praeparat indeholdende isosorbiddinitrat
NO770060L (no) 1,2-benzisotiazolinon-2, fremgangsm}te til deres fremstilling og deres anvendelse som legemiddel.
DK13978A (da) Fremgangsmaade til fremstilling af 11betasubstituerede 1,3,5(,0)-triensteroider
DK319676A (da) 2',3,6'-trichlor-4-cyano-4'-benzoylureido-diphenylethere, fremgangsmade til deres fremstilling og deres anvendelse som insecticider
DK5379A (da) 1-aza-(2,2,2)-bicyclooctanderivater mellemprodukter hertil og fremgangsmaade til deres fremstilling og deres anvendelse som laegemidler
NO790934L (no) 2,6-dialkoksybenzamider og fremgangsmaate til deres fremstilling
DK161512C (da) Pentafluorbenzyloxycarbonylderivater, deres anvendelse som insekticider og acaricider samt insekticidt og acaricidt middel indeholdende dem
DK350278A (da) 1,3-diphenoxypropan-2-onderivater fremgangsmaade til fremstilling heraf og anvendelsen heraf som laegemiddel
DK354777A (da) N-sulfenylerede oximcarbamater fremgangsmade til deres fremstilling og deres anvendelse som insecticider acaricider og nematodicider
DK582578A (da) 2,4-thiazolidindion-derivater og fremgangsmaade til deres fremstilling
DK270077A (da) 6,7-benzomorphanderivater og fremgangsmade til deres fremstillling
DK147337C (da) Krystallinsk 3,4-dihydro-2-methyl-4-oxo-2h-1,2-benzothiazin-3-carboxylsyre-1,1-dioxid til anvendelse som mellemprodukt ved fremstilling af 3,4-dihydro-2-methyl-4-oxo-2h-1,2-benzothiazin-3-carboxamid-1,1-dioxid-forbindelser og fremgangsmaade til fremstilling af syren
DK191679A (da) Substituerede alkanyl-azolyl-oximcarbamater samt fremgangsmaader til deres fremstilling og deres anvendelse som insecticider acaricider og nematodicider

Legal Events

Date Code Title Description
AHB Application shelved due to non-payment