JPS5492979A - 33fluoroo100piperazinoo8 substituted 10*111dihydrodibenzo *b*f* thiepin and its salts and their manufacture - Google Patents

33fluoroo100piperazinoo8 substituted 10*111dihydrodibenzo *b*f* thiepin and its salts and their manufacture

Info

Publication number
JPS5492979A
JPS5492979A JP15770178A JP15770178A JPS5492979A JP S5492979 A JPS5492979 A JP S5492979A JP 15770178 A JP15770178 A JP 15770178A JP 15770178 A JP15770178 A JP 15770178A JP S5492979 A JPS5492979 A JP S5492979A
Authority
JP
Japan
Prior art keywords
thiepin
salts
substituted
manufacture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP15770178A
Other languages
English (en)
Other versions
JPS638109B2 (ja
Inventor
Purochibua Mirosurabu
Rajisunaa Mirosurabu
Shinderaa Kareru
Jireku Jiri
Barutoru Buakurabu
Mechisobua Jirina
Dorabaku Antonin
Rangusadoru Reon
Pomikaseku Jiyosefu
Mikushiku Furanchiseku
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Spofa Spojene Podniky Pro Zdravotnickou Vyrobu
Original Assignee
Spofa Spojene Podniky Pro Zdravotnickou Vyrobu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Spofa Spojene Podniky Pro Zdravotnickou Vyrobu filed Critical Spofa Spojene Podniky Pro Zdravotnickou Vyrobu
Publication of JPS5492979A publication Critical patent/JPS5492979A/ja
Publication of JPS638109B2 publication Critical patent/JPS638109B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/10—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms
    • C07C17/14—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms in the side-chain of aromatic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/08—Preparation of carboxylic acids or their salts, halides or anhydrides from nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/02—Seven-membered rings
    • C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D337/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D337/14—[b,f]-condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP15770178A 1977-12-22 1978-12-22 33fluoroo100piperazinoo8 substituted 10*111dihydrodibenzo *b*f* thiepin and its salts and their manufacture Granted JPS5492979A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CS778728A CS196893B1 (en) 1977-12-22 1977-12-22 3-fluor-10-piperazino-8-substituted 10,11-dihydro-dibenzothiepines

Publications (2)

Publication Number Publication Date
JPS5492979A true JPS5492979A (en) 1979-07-23
JPS638109B2 JPS638109B2 (ja) 1988-02-19

Family

ID=5438253

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15770178A Granted JPS5492979A (en) 1977-12-22 1978-12-22 33fluoroo100piperazinoo8 substituted 10*111dihydrodibenzo *b*f* thiepin and its salts and their manufacture

Country Status (13)

Country Link
US (1) US4243805A (ja)
JP (1) JPS5492979A (ja)
AT (1) AT368151B (ja)
BE (1) BE872496A (ja)
CA (1) CA1100134A (ja)
CH (1) CH642077A5 (ja)
CS (1) CS196893B1 (ja)
DE (1) DE2855703C2 (ja)
DK (1) DK521078A (ja)
FI (1) FI66374C (ja)
FR (1) FR2412312A1 (ja)
GB (1) GB2010843B (ja)
SE (1) SE442403B (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008505874A (ja) * 2004-07-08 2008-02-28 アストラゼネカ・アクチエボラーグ 呼吸器疾患処置用の置換酸

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3029365A1 (de) * 1980-08-01 1982-03-25 Bayer Ag, 5090 Leverkusen Verfahren zur (alpha)-bromierung von gegebenenfalls substituierten fluortoluolen und gemischen von in (alpha)-stellung verschieden hoch bromierten, gegebenenfalls substituierten fluortoluolen
CS249455B1 (en) * 1985-01-24 1987-03-12 Miroslav Protiva N-substituted 2-chloro-7-fluoro-10-piperazino-10,11-dihydrodibenzo(b,f)thiepines and their salts and method of their preparation
US5700445A (en) * 1994-12-12 1997-12-23 Allelix Biopharmaceuticals, Inc. N-methyl piperazine compounds having dopamine receptor affinity
WO2002018954A2 (en) 2000-08-30 2002-03-07 Chemocentryx, Inc. Inhibition of cmv infection and dissemination
US20050250767A1 (en) * 2003-01-23 2005-11-10 Weiner David M Use of N-desmethylclozapine to treat human neuropsychiatric disease
EP1994932A1 (en) * 2003-01-23 2008-11-26 Arcadia Pharmaceuticals Inc. Use of N-desmethylclozapine to treat human psychosis
US7550454B2 (en) * 2003-12-22 2009-06-23 Acadia Pharmaceuticals, Inc. Amino substituted diaryl[a,d]cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders
WO2006001866A2 (en) * 2004-04-01 2006-01-05 Acadia Pharmaceuticals Inc. Crystalline forms of n-desmethylclozapine
DE102004049728A1 (de) * 2004-10-11 2006-04-13 Merck Patent Gmbh Verfahren zur Herstellung von monosubstituierten Piperazinderivaten
US20070105836A1 (en) * 2005-10-31 2007-05-10 Lars Pettersson Prodrugs of muscarinic agonists and methods of treatment of neuropsychiatric disorders
US10525376B2 (en) 2015-07-20 2020-01-07 W. L. Gore & Associates, Inc. Affinity chromatography devices
WO2019092044A1 (en) * 2017-11-08 2019-05-16 Centre National De La Recherche Scientifique Dihydrobenzo[b][1]benzothiepin compounds useful in therapy

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS49135983A (ja) * 1973-03-30 1974-12-27
DE2600182A1 (de) * 1975-01-06 1976-07-08 Spofa Vereinigte Pharma Werke Psychotrop und antimikrobiell wirksame polysubstituierte 10-piperazinodibenzo (b,f) thiepinderivate

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2412521A1 (de) * 1973-03-30 1974-10-10 Hoffmann La Roche Tricyclische verbindungen
JPS5835449B2 (ja) * 1979-08-31 1983-08-02 中興化成工業株式会社 表面に波型状凹凸部を有する無機質繊維織布管の製造方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS49135983A (ja) * 1973-03-30 1974-12-27
DE2600182A1 (de) * 1975-01-06 1976-07-08 Spofa Vereinigte Pharma Werke Psychotrop und antimikrobiell wirksame polysubstituierte 10-piperazinodibenzo (b,f) thiepinderivate

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008505874A (ja) * 2004-07-08 2008-02-28 アストラゼネカ・アクチエボラーグ 呼吸器疾患処置用の置換酸
JP4869225B2 (ja) * 2004-07-08 2012-02-08 アストラゼネカ・アクチエボラーグ 呼吸器疾患処置用の置換酸

Also Published As

Publication number Publication date
DE2855703C2 (de) 1987-02-26
SE442403B (sv) 1985-12-23
DK521078A (da) 1979-06-23
JPS638109B2 (ja) 1988-02-19
BE872496A (fr) 1979-03-30
CH642077A5 (de) 1984-03-30
DE2855703A1 (de) 1979-06-28
AT368151B (de) 1982-09-27
SE7813114L (sv) 1979-06-23
CS196893B1 (en) 1980-04-30
US4243805A (en) 1981-01-06
FI66374B (fi) 1984-06-29
GB2010843A (en) 1979-07-04
CA1100134A (en) 1981-04-28
GB2010843B (en) 1982-08-18
FI66374C (fi) 1984-10-10
FR2412312B1 (ja) 1982-10-29
FR2412312A1 (fr) 1979-07-20
FI783607A (fi) 1979-06-23
ATA892578A (de) 1982-01-15

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