FI65246C - Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 4-oxo-4h-pyrimido(2,1-a)isokinolin-3-karboxylsyraderivat - Google Patents
Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 4-oxo-4h-pyrimido(2,1-a)isokinolin-3-karboxylsyraderivat Download PDFInfo
- Publication number
- FI65246C FI65246C FI782849A FI782849A FI65246C FI 65246 C FI65246 C FI 65246C FI 782849 A FI782849 A FI 782849A FI 782849 A FI782849 A FI 782849A FI 65246 C FI65246 C FI 65246C
- Authority
- FI
- Finland
- Prior art keywords
- isoquinoline
- compound
- alkyl
- pyrimido
- mixture
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C331/00—Derivatives of thiocyanic acid or of isothiocyanic acid
- C07C331/16—Isothiocyanates
- C07C331/18—Isothiocyanates having isothiocyanate groups bound to acyclic carbon atoms
- C07C331/22—Isothiocyanates having isothiocyanate groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
- C07C331/24—Isothiocyanates having isothiocyanate groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI824509A FI68051C (fi) | 1977-09-21 | 1982-12-29 | Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 3-(1h-tetrazol-5-yl)-4h-pyrimido(2,1-a)isokinolin-4-oner samt farmaceutiskt godtagbara salter av dessa foereningar |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83526677 | 1977-09-21 | ||
| US05/835,266 US4127720A (en) | 1977-09-21 | 1977-09-21 | Pyrimido[2,1-a]isoquinoline derivatives having antiallergy activity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI782849A FI782849A (fi) | 1979-03-22 |
| FI65246B FI65246B (fi) | 1983-12-30 |
| FI65246C true FI65246C (fi) | 1984-04-10 |
Family
ID=25269074
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI782849A FI65246C (fi) | 1977-09-21 | 1978-09-18 | Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 4-oxo-4h-pyrimido(2,1-a)isokinolin-3-karboxylsyraderivat |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4127720A (nl) |
| JP (1) | JPS5463099A (nl) |
| AU (1) | AU522646B2 (nl) |
| BE (1) | BE870634A (nl) |
| CA (1) | CA1108613A (nl) |
| CH (1) | CH642967A5 (nl) |
| DE (1) | DE2841126A1 (nl) |
| DK (1) | DK164553C (nl) |
| FI (1) | FI65246C (nl) |
| FR (1) | FR2404010A1 (nl) |
| GB (1) | GB2004876B (nl) |
| GR (1) | GR72144B (nl) |
| IE (1) | IE47189B1 (nl) |
| LU (1) | LU80272A1 (nl) |
| NL (1) | NL190071C (nl) |
| SE (1) | SE438335B (nl) |
| YU (2) | YU41598B (nl) |
| ZA (1) | ZA785354B (nl) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4209620A (en) * | 1978-06-19 | 1980-06-24 | Bristol-Myers Company | Substituted 3-(1H-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives having antiallergy activity |
| US4472401A (en) * | 1981-11-27 | 1984-09-18 | Roussel Uclaf | Pyrimido-quinoxalines having antiallergic properties |
| NO162019C (no) * | 1983-11-23 | 1989-10-25 | Fujisawa Pharmaceutical Co | Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrimidoiskinolinderivater. |
| GB8331228D0 (en) * | 1983-11-23 | 1983-12-29 | Fujisawa Pharmaceutical Co | Pyrimidoisoquinoline derivatives |
| US4661592A (en) * | 1984-06-27 | 1987-04-28 | G. D. Searle & Co. | 4H-pyrimido[2,1-a]isoquinolin-4-one derivatives |
| JP2000509028A (ja) * | 1996-04-13 | 2000-07-18 | アストラ・フアーマシユウテイカルズ・リミテツド | アミノイソキノリンおよびアミノチエノピリジン誘導体ならびに抗炎症剤としてのそれらの使用 |
| JP2008524232A (ja) * | 2004-12-20 | 2008-07-10 | ワイス | ラパマイシン誘導体及び神経障害の治療におけるその使用 |
| DK1828202T3 (da) * | 2004-12-20 | 2012-05-07 | Wyeth Llc | Rapamycinanaloge samt deres anvendelse ved behandling af neurologiske, proliferative og inflammatoriske lidelser |
| WO2022216552A2 (en) * | 2021-04-04 | 2022-10-13 | Baruch S. Blumberg Institute | Novel hepatoselective polyadenylating polymerases inhibitors and their method of use |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1356937A (en) * | 1970-08-27 | 1974-06-19 | Wellcome Found | Pyrimido-isoquinolines |
| BE792648A (fr) * | 1971-12-13 | 1973-06-12 | May & Baker Ltd | Derives de l'isoquinoleine |
| CA1033731A (en) * | 1974-04-01 | 1978-06-27 | Saul B. Kadin | Process for preparing 1-oxo-1h-6-hydroxypyrimido (1,2-a)quinoline-2-carboxylic acids and derivatives |
| US4066766A (en) * | 1975-03-03 | 1978-01-03 | Pfizer Inc. | 1-Oxo-6-substituted pyrimido [1,2-a]quinoline-2-carboxylic acids and derivatives thereof and their use as antiallergy agents |
| US4017625A (en) * | 1975-08-01 | 1977-04-12 | Pfizer Inc. | Anti-allergic N-(5-tetrazolyl)-1-oxo-1H-6-alkoxypyrimido-[1,2-a]quinoline-2-carboxamides and intermediates therefor |
| SU685156A3 (ru) * | 1975-08-01 | 1979-09-05 | Пфайзер Инк (Фирма) | Способ получени -(5-тетразолил(1-оксо-1н-пиримидо-)1,2-а) хинолин-2-карбоксамида |
| US4033961A (en) * | 1975-10-07 | 1977-07-05 | Warner-Lambert Company | Pyrido[2-1-b]quinazolin-ones and their methods of preparation |
-
1977
- 1977-09-21 US US05/835,266 patent/US4127720A/en not_active Expired - Lifetime
-
1978
- 1978-09-18 FI FI782849A patent/FI65246C/fi not_active IP Right Cessation
- 1978-09-19 DK DK413578A patent/DK164553C/da not_active IP Right Cessation
- 1978-09-20 YU YU2227/78A patent/YU41598B/xx unknown
- 1978-09-20 BE BE190606A patent/BE870634A/xx not_active IP Right Cessation
- 1978-09-20 GB GB7837548A patent/GB2004876B/en not_active Expired
- 1978-09-20 ZA ZA00785354A patent/ZA785354B/xx unknown
- 1978-09-20 CA CA311,680A patent/CA1108613A/en not_active Expired
- 1978-09-20 IE IE1897/78A patent/IE47189B1/en not_active IP Right Cessation
- 1978-09-20 SE SE7809887A patent/SE438335B/sv not_active IP Right Cessation
- 1978-09-21 FR FR7827136A patent/FR2404010A1/fr active Granted
- 1978-09-21 NL NLAANVRAGE7809626,A patent/NL190071C/nl not_active IP Right Cessation
- 1978-09-21 JP JP11523278A patent/JPS5463099A/ja active Granted
- 1978-09-21 GR GR57274A patent/GR72144B/el unknown
- 1978-09-21 DE DE19782841126 patent/DE2841126A1/de active Granted
- 1978-09-21 LU LU80272A patent/LU80272A1/xx unknown
- 1978-09-21 AU AU40042/78A patent/AU522646B2/en not_active Expired
- 1978-09-21 CH CH988878A patent/CH642967A5/de not_active IP Right Cessation
-
1985
- 1985-04-15 YU YU635/85A patent/YU44501B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CH642967A5 (de) | 1984-05-15 |
| NL190071B (nl) | 1993-05-17 |
| GR72144B (nl) | 1983-09-20 |
| FR2404010B1 (nl) | 1980-10-31 |
| FR2404010A1 (fr) | 1979-04-20 |
| LU80272A1 (fr) | 1979-06-01 |
| GB2004876B (en) | 1982-03-10 |
| DK413578A (da) | 1979-03-22 |
| DE2841126C2 (nl) | 1990-05-17 |
| IE47189B1 (en) | 1984-01-11 |
| NL190071C (nl) | 1993-10-18 |
| AU4004278A (en) | 1980-03-27 |
| FI65246B (fi) | 1983-12-30 |
| BE870634A (fr) | 1979-03-20 |
| DE2841126A1 (de) | 1979-04-05 |
| YU41598B (en) | 1987-10-31 |
| SE7809887L (sv) | 1979-03-22 |
| IE781897L (en) | 1979-03-21 |
| US4127720A (en) | 1978-11-28 |
| JPS6212225B2 (nl) | 1987-03-17 |
| YU63585A (en) | 1986-04-30 |
| FI782849A (fi) | 1979-03-22 |
| ZA785354B (en) | 1979-09-26 |
| YU44501B (en) | 1990-08-31 |
| JPS5463099A (en) | 1979-05-21 |
| SE438335B (sv) | 1985-04-15 |
| YU222778A (en) | 1984-02-29 |
| DK164553C (da) | 1992-11-30 |
| GB2004876A (en) | 1979-04-11 |
| NL7809626A (nl) | 1979-03-23 |
| AU522646B2 (en) | 1982-06-17 |
| CA1108613A (en) | 1981-09-08 |
| DK164553B (da) | 1992-07-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed | ||
| MM | Patent lapsed |
Owner name: BRISTOL-MYERS CO |