FI63399C - Foerfarande foer framstaellning av farmakologiskt vaerdefulla 2'-hydroxi-2-(5-isoxazolylmetyl)-6,7-bensomorfaner och derassyraadditionssalter - Google Patents

Foerfarande foer framstaellning av farmakologiskt vaerdefulla 2'-hydroxi-2-(5-isoxazolylmetyl)-6,7-bensomorfaner och derassyraadditionssalter Download PDF

Info

Publication number
FI63399C
FI63399C FI781025A FI781025A FI63399C FI 63399 C FI63399 C FI 63399C FI 781025 A FI781025 A FI 781025A FI 781025 A FI781025 A FI 781025A FI 63399 C FI63399 C FI 63399C
Authority
FI
Finland
Prior art keywords
hydroxy
isoxazolylmethyl
formula
benzomorphane
methyl
Prior art date
Application number
FI781025A
Other languages
English (en)
Finnish (fi)
Other versions
FI781025A7 (fi
FI63399B (fi
Inventor
Herbert Merz
Klaus Stockhaus
Original Assignee
Boehringer Sohn Ingelheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim
Publication of FI781025A7 publication Critical patent/FI781025A7/fi
Application granted granted Critical
Publication of FI63399B publication Critical patent/FI63399B/fi
Publication of FI63399C publication Critical patent/FI63399C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
FI781025A 1977-04-15 1978-04-04 Foerfarande foer framstaellning av farmakologiskt vaerdefulla 2'-hydroxi-2-(5-isoxazolylmetyl)-6,7-bensomorfaner och derassyraadditionssalter FI63399C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2716687 1977-04-15
DE19772716687 DE2716687A1 (de) 1977-04-15 1977-04-15 2'-hydroxy-2-(5-isoxazolylmethyl)-6,7benzomorphane, deren saeureadditionssalze und diese enthaltende arzneimittel

Publications (3)

Publication Number Publication Date
FI781025A7 FI781025A7 (fi) 1978-10-16
FI63399B FI63399B (fi) 1983-02-28
FI63399C true FI63399C (fi) 1983-06-10

Family

ID=6006359

Family Applications (1)

Application Number Title Priority Date Filing Date
FI781025A FI63399C (fi) 1977-04-15 1978-04-04 Foerfarande foer framstaellning av farmakologiskt vaerdefulla 2'-hydroxi-2-(5-isoxazolylmetyl)-6,7-bensomorfaner och derassyraadditionssalter

Country Status (25)

Country Link
US (1) US4133888A (da)
JP (1) JPS53130671A (da)
AT (3) AT358192B (da)
AU (1) AU514938B2 (da)
BE (1) BE866013A (da)
CA (1) CA1079726A (da)
CH (1) CH638519A5 (da)
DE (1) DE2716687A1 (da)
DK (1) DK144678C (da)
ES (3) ES468798A1 (da)
FI (1) FI63399C (da)
FR (1) FR2387228A1 (da)
GB (1) GB1575156A (da)
GR (1) GR64819B (da)
IE (1) IE46722B1 (da)
IL (1) IL54509A (da)
IT (1) IT1102595B (da)
LU (1) LU79430A1 (da)
NL (1) NL7803977A (da)
NO (1) NO148418C (da)
NZ (1) NZ186971A (da)
PH (1) PH13854A (da)
PT (1) PT67907B (da)
SE (1) SE430160B (da)
ZA (1) ZA782149B (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1575009A (en) * 1976-06-21 1980-09-17 Acf Chemiefarma Nv 6,7-benzomorphan derivatives
NL7907800A (nl) 1979-10-23 1981-04-27 Acf Chemiefarma Nv Nieuwe 6,7-benzomorfanderivaten en zuuradditiezouten daarvan, farmaceutische preparaten die een dergelijke verbinding bevatten, alsmede werkwijze voor het bereiden van deze verbindingen en de farmaceutische preparaten.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3499906A (en) * 1966-05-20 1970-03-10 Merck & Co Inc 5,9-diethyl-2'-hydroxy-2-substituted-6,7-benzomorphans
CS166802B2 (da) * 1971-02-08 1976-03-29 Boehringer Sohn Ingelheim
US3853889A (en) * 1973-07-18 1974-12-10 Bristol Myers Co 3,14-substituted-8-oxamorphinans
DE2411382C3 (de) * 1974-03-09 1979-09-06 C.H. Boehringer Sohn, 6507 Ingelheim 2-Tetrahydrofurfuryl-6,7-benzomorphane, Verfahren zur Herstellung und deren Verwendung
DE2437610A1 (de) * 1974-08-05 1976-02-26 Boehringer Sohn Ingelheim Neue 5,9-beta-disubstituierte 2-tetrahydrofurfuryl-6,7-benzomorphane, deren saeureadditionssalze, ihre verwendung als arzneimittel und verfahren zu deren herstellung

Also Published As

Publication number Publication date
IL54509A0 (en) 1978-07-31
AT360667B (de) 1981-01-26
FR2387228A1 (fr) 1978-11-10
AT360666B (de) 1981-01-26
IL54509A (en) 1982-04-30
CA1079726A (en) 1980-06-17
DK144678C (da) 1982-10-11
DK144678B (da) 1982-05-10
NO781310L (no) 1978-10-17
IT7848887A0 (it) 1978-04-13
ATA241978A (de) 1980-01-15
FI781025A7 (fi) 1978-10-16
GR64819B (en) 1980-06-03
JPS53130671A (en) 1978-11-14
ES468798A1 (es) 1978-12-01
US4133888A (en) 1979-01-09
AT358192B (de) 1980-08-25
ATA552079A (de) 1980-06-15
ZA782149B (en) 1979-12-27
IE46722B1 (en) 1983-09-07
ES472407A1 (es) 1979-04-01
NL7803977A (nl) 1978-10-17
PT67907B (fr) 1980-06-16
DK163578A (da) 1978-10-16
NO148418C (no) 1983-10-05
LU79430A1 (de) 1979-05-25
AU3509878A (en) 1979-10-18
DE2716687A1 (de) 1978-10-19
FR2387228B1 (da) 1981-05-29
FI63399B (fi) 1983-02-28
SE430160B (sv) 1983-10-24
IE780742L (en) 1978-10-15
ES472408A1 (es) 1979-04-01
SE7804260L (sv) 1978-10-16
NZ186971A (en) 1980-10-24
NO148418B (no) 1983-06-27
AU514938B2 (en) 1981-03-05
PT67907A (fr) 1978-05-01
PH13854A (en) 1980-10-22
IT1102595B (it) 1985-10-07
ATA551979A (de) 1980-06-15
BE866013A (fr) 1978-10-16
CH638519A5 (de) 1983-09-30
GB1575156A (en) 1980-09-17

Similar Documents

Publication Publication Date Title
FI63571B (fi) Foerfarande foer framstaellning av analgetiskt verkande racemiska eller diastereomera och optiskt aktiva 2-tetrahydrofurfuryl-(1r/s 5r/s 9r/s)-2'-hydroxi-5,9-dimetyl-6,7-bensomorfaner och deras syraadditionssalter
JPS6072891A (ja) ピリミド〔４，５−ｇ〕キノリンおよびその製造中間体
IE41528B1 (en) Benzomorphanes and derivatives and pharmaceutical compositions containing the same
CA1161849A (en) Derivatives of indole active on the cardiovascular system
CN116783176A (zh) 氨基吡啶类化合物及其应用
FI76336B (fi) Foerfarande foer framstaellning av farmaceutiskt aktiva pyrido/2,3-d/pyrimidin-5-oner.
US7132541B2 (en) Crystalline fluoroquinolone arginine salt form
PL165413B1 (pl) Sposób wytwarzania nowych pochodnych 6-arylo-5,6-dwuhydroimidazo [2,1-b] tiazolu PL PL
FI63399C (fi) Foerfarande foer framstaellning av farmakologiskt vaerdefulla 2'-hydroxi-2-(5-isoxazolylmetyl)-6,7-bensomorfaner och derassyraadditionssalter
US3888983A (en) Derivatives of thiazolino-pyrimidin-6-ones, in inducing analgesia
JP4292738B2 (ja) インドール誘導体およびその医薬用途
HU192501B (en) Process for producing /2-methyl-propoxy/-methyl-n-phenyl-n-/phenyl-methyl/-1-pyrrolidin-ethanamine
US5137911A (en) Isochromane derivatives
PL82037B1 (da)
US4599346A (en) Propan-2-ol derivatives, a process for their production and medicaments containing these compounds
PL140035B1 (en) Process for preparing novel derivatives of 8-carbonylamino-4-aryl-2-methyl-1,2,3,4-tetrahydroisoquinoline
US5098919A (en) Pyrrolo(2,1-b)thiazole derivatives
KR810000688B1 (ko) 2'-하이드록시-2-(5-이소옥사졸일메틸)-6,7-벤조몰판의 제조방법
JP2825643B2 (ja) 新規アリールオキシーアルキルアミン、その製法及びこれを含有する心臓循環系疾患治療用の医薬品
KR810000801B1 (ko) 2-테트라 하이드로 푸르푸릴-6,7-벤조모르판류의 제조방법
DK146129B (da) Analogifremgangsmaade til fremstilling af ergopeptidalkaloidderivater
EP0036773B1 (en) 2,3-dihydrobenzofurans, process for their preparation and pharmaceutical compositions containing them
US4318909A (en) Benzoxazocines
KR830000813B1 (ko) 2-(2-알콕시에틸)-2'-하이드록시-6, 7-벤조모르판의 제조방법
CS237331B2 (en) Processing of octahydropyrazole/3,4-g/chinoline

Legal Events

Date Code Title Description
MM Patent lapsed

Owner name: C.H. BOEHRINGER SOHN