ES472408A1 - Procedimiento para la preparacion de nuevos 2'- hidroxi-2-(5-isoxazolimetil)-6,7-benzomorfanos. - Google Patents

Procedimiento para la preparacion de nuevos 2'- hidroxi-2-(5-isoxazolimetil)-6,7-benzomorfanos.

Info

Publication number
ES472408A1
ES472408A1 ES472408A ES472408A ES472408A1 ES 472408 A1 ES472408 A1 ES 472408A1 ES 472408 A ES472408 A ES 472408A ES 472408 A ES472408 A ES 472408A ES 472408 A1 ES472408 A1 ES 472408A1
Authority
ES
Spain
Prior art keywords
methyl
salts
benzomorphans
isoxazolyl
analgesic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES472408A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CH Boehringer Sohn AG and Co KG
Original Assignee
CH Boehringer Sohn AG and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CH Boehringer Sohn AG and Co KG filed Critical CH Boehringer Sohn AG and Co KG
Publication of ES472408A1 publication Critical patent/ES472408A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Procedimiento para la preparación de nuevos 2''-hidroxi-2-(5- isoxazolilmetil)-6,7-benzomorfanos de la fórmula general **(Fórmula)** en que R1 significa metilo, etilo o propilo, y R2 significa hidrógeno, metilo o tilo, así como sus sales por adición de ácido caracterizado porque un benzomorfano de la fórmula **(Fórmula)** en que R1 y R2 poseen los significados antes mencionados, y R4 representa un radical alcohilo, de preferencia metilo, bencilo o metoximetilo, se somete a desdoblamiento de éter con ácidos o con ácidos de Lewis, y porque eventualmente los compuestos de la fórmula general I se transforman en sus sales por adición de ácido fisiológicamene inocuas.
ES472408A 1977-04-15 1978-08-07 Procedimiento para la preparacion de nuevos 2'- hidroxi-2-(5-isoxazolimetil)-6,7-benzomorfanos. Expired ES472408A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19772716687 DE2716687A1 (de) 1977-04-15 1977-04-15 2'-hydroxy-2-(5-isoxazolylmethyl)-6,7benzomorphane, deren saeureadditionssalze und diese enthaltende arzneimittel

Publications (1)

Publication Number Publication Date
ES472408A1 true ES472408A1 (es) 1979-04-01

Family

ID=6006359

Family Applications (3)

Application Number Title Priority Date Filing Date
ES468798A Expired ES468798A1 (es) 1977-04-15 1978-04-14 Procedimiento para la preparacion de nuevos 2'-hidroxi-2-(5-isoxazolilmetil)-6,7-benzomorfanos.
ES472407A Expired ES472407A1 (es) 1977-04-15 1978-08-07 Procedimiento para la preparacion de nuevos 2'-hidroxi-2-(5-isoxazolilmetil)-6,7-benzomorfanos.
ES472408A Expired ES472408A1 (es) 1977-04-15 1978-08-07 Procedimiento para la preparacion de nuevos 2'- hidroxi-2-(5-isoxazolimetil)-6,7-benzomorfanos.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES468798A Expired ES468798A1 (es) 1977-04-15 1978-04-14 Procedimiento para la preparacion de nuevos 2'-hidroxi-2-(5-isoxazolilmetil)-6,7-benzomorfanos.
ES472407A Expired ES472407A1 (es) 1977-04-15 1978-08-07 Procedimiento para la preparacion de nuevos 2'-hidroxi-2-(5-isoxazolilmetil)-6,7-benzomorfanos.

Country Status (25)

Country Link
US (1) US4133888A (es)
JP (1) JPS53130671A (es)
AT (3) AT358192B (es)
AU (1) AU514938B2 (es)
BE (1) BE866013A (es)
CA (1) CA1079726A (es)
CH (1) CH638519A5 (es)
DE (1) DE2716687A1 (es)
DK (1) DK144678C (es)
ES (3) ES468798A1 (es)
FI (1) FI63399C (es)
FR (1) FR2387228A1 (es)
GB (1) GB1575156A (es)
GR (1) GR64819B (es)
IE (1) IE46722B1 (es)
IL (1) IL54509A (es)
IT (1) IT1102595B (es)
LU (1) LU79430A1 (es)
NL (1) NL7803977A (es)
NO (1) NO148418C (es)
NZ (1) NZ186971A (es)
PH (1) PH13854A (es)
PT (1) PT67907B (es)
SE (1) SE430160B (es)
ZA (1) ZA782149B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1575009A (en) * 1976-06-21 1980-09-17 Acf Chemiefarma Nv 6,7-benzomorphan derivatives
NL7907800A (nl) 1979-10-23 1981-04-27 Acf Chemiefarma Nv Nieuwe 6,7-benzomorfanderivaten en zuuradditiezouten daarvan, farmaceutische preparaten die een dergelijke verbinding bevatten, alsmede werkwijze voor het bereiden van deze verbindingen en de farmaceutische preparaten.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3499906A (en) * 1966-05-20 1970-03-10 Merck & Co Inc 5,9-diethyl-2'-hydroxy-2-substituted-6,7-benzomorphans
CS166802B2 (es) * 1971-02-08 1976-03-29 Boehringer Sohn Ingelheim
US3853889A (en) * 1973-07-18 1974-12-10 Bristol Myers Co 3,14-substituted-8-oxamorphinans
DE2411382C3 (de) * 1974-03-09 1979-09-06 C.H. Boehringer Sohn, 6507 Ingelheim 2-Tetrahydrofurfuryl-6,7-benzomorphane, Verfahren zur Herstellung und deren Verwendung
DE2437610A1 (de) * 1974-08-05 1976-02-26 Boehringer Sohn Ingelheim Neue 5,9-beta-disubstituierte 2-tetrahydrofurfuryl-6,7-benzomorphane, deren saeureadditionssalze, ihre verwendung als arzneimittel und verfahren zu deren herstellung

Also Published As

Publication number Publication date
US4133888A (en) 1979-01-09
FR2387228B1 (es) 1981-05-29
DK144678B (da) 1982-05-10
GR64819B (en) 1980-06-03
GB1575156A (en) 1980-09-17
CA1079726A (en) 1980-06-17
ZA782149B (en) 1979-12-27
AT360667B (de) 1981-01-26
ATA241978A (de) 1980-01-15
IE46722B1 (en) 1983-09-07
NO148418C (no) 1983-10-05
AU3509878A (en) 1979-10-18
ES468798A1 (es) 1978-12-01
PH13854A (en) 1980-10-22
NL7803977A (nl) 1978-10-17
DK144678C (da) 1982-10-11
ES472407A1 (es) 1979-04-01
AT360666B (de) 1981-01-26
NO781310L (no) 1978-10-17
NO148418B (no) 1983-06-27
IL54509A0 (en) 1978-07-31
FI781025A (fi) 1978-10-16
IT7848887A0 (it) 1978-04-13
PT67907A (fr) 1978-05-01
DK163578A (da) 1978-10-16
IL54509A (en) 1982-04-30
LU79430A1 (de) 1979-05-25
DE2716687A1 (de) 1978-10-19
IE780742L (en) 1978-10-15
AT358192B (de) 1980-08-25
FI63399C (fi) 1983-06-10
ATA551979A (de) 1980-06-15
PT67907B (fr) 1980-06-16
CH638519A5 (de) 1983-09-30
FI63399B (fi) 1983-02-28
BE866013A (fr) 1978-10-16
SE7804260L (sv) 1978-10-16
IT1102595B (it) 1985-10-07
JPS53130671A (en) 1978-11-14
FR2387228A1 (fr) 1978-11-10
SE430160B (sv) 1983-10-24
ATA552079A (de) 1980-06-15
AU514938B2 (en) 1981-03-05
NZ186971A (en) 1980-10-24

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19990201