FI63394C - Analogifoerfarande foer framstaellning av kemoterapeutiskt anvaendbara heteroarylfoereningar - Google Patents
Analogifoerfarande foer framstaellning av kemoterapeutiskt anvaendbara heteroarylfoereningar Download PDFInfo
- Publication number
- FI63394C FI63394C FI761585A FI761585A FI63394C FI 63394 C FI63394 C FI 63394C FI 761585 A FI761585 A FI 761585A FI 761585 A FI761585 A FI 761585A FI 63394 C FI63394 C FI 63394C
- Authority
- FI
- Finland
- Prior art keywords
- methyl
- alkyl
- mol
- cycloalkyl
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
- C07D271/07—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
- C07D271/113—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
- C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
- C07D285/135—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Claims (4)
1. Analogiförfarande för framställning av kemoterapeutiskt användbara heteroarylföreningar med formeln I Ar-N-R1 ' 2 <I> COR i vilken formel Ar betyder en heteroarylring, som är N-N R—r-N N N p ______—m ,ΛΛ «..A Xa och som kanvara substituerad med C, .-alkyl, C__.n-cykloalkyl eller fenyl, med acylaminogruppen -NRxCORz bunden vid en kolatom i heteroarylringen, och i vilken formel R1 är C1_10~alkyl, C2_6~ alkenyl, C3_^Q-cykloalkyl eller R^-C^g-alkyl, och R2 är C^_g-alkyl, C3_^g-cykloalkyl, R^ eller R^-C^_g-alkyl; och R2 är fenyl, som kan vara substituerad med halogen, C^_^-alkyl eller C^_^-alkoxi, förutsatt, att a) när Ar är 1,3,4-tiadiazolyl, R^ är C. --alkyl och 2 *·“·* R är C1_^-alkyl eller C3_g-cykloalkyl, kan nämnda 1,3,4-tiadiazolyl- grupp inte vara osubstituerad eller substituerad med C, --alkyl, X"*J ί b) när Ar är en fenylsubstituerad 1,2,4-oxadiazolyl, kan R 2 inte vara metyl eller bensyl, när R är metyl, känneteck-n a t därav, att man acylerar ett alkylderivat med formeln ArNHR1 (VIII) där Ar och R^ har ovan angivna betydelser.
2. Förfarande enligt patentkravet 1, kännetecknat därav, att heteroarylringen Ar eventuellt är substituerad med C^_^-alkyl, R^ är C3_g-alkenyl, C3_g-cykloalkyl eller en eventuellt halogen-, Cj^-alkyl eller C^_^-alkoxisubstituerad bensyl, och R2 är C^_g-alkyl, C3_g-cykloalkyl, bensyl eller en eventuellt halogen-eller C^^-alkoxisubstituerad fenyl.
3. Förfarande enligt patentkravet 1, kännetecknat
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB24224/75A GB1551735A (en) | 1975-06-05 | 1975-06-05 | Acylated aminothiazoles and aminooxadiazoles |
| GB2422475 | 1975-06-05 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI761585A FI761585A (sv) | 1976-12-06 |
| FI63394B FI63394B (fi) | 1983-02-28 |
| FI63394C true FI63394C (fi) | 1983-06-10 |
Family
ID=10208350
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI761585A FI63394C (fi) | 1975-06-05 | 1976-06-04 | Analogifoerfarande foer framstaellning av kemoterapeutiskt anvaendbara heteroarylfoereningar |
Country Status (34)
| Country | Link |
|---|---|
| JP (1) | JPS51146468A (sv) |
| AR (1) | AR217240A1 (sv) |
| AT (1) | AT346843B (sv) |
| AU (1) | AU503150B2 (sv) |
| BE (1) | BE842579A (sv) |
| BG (1) | BG27359A3 (sv) |
| CA (1) | CA1085860A (sv) |
| CH (2) | CH612427A5 (sv) |
| CS (1) | CS200494B2 (sv) |
| DD (1) | DD125075A5 (sv) |
| DE (1) | DE2625285A1 (sv) |
| DK (1) | DK243276A (sv) |
| EG (1) | EG12226A (sv) |
| ES (1) | ES448590A1 (sv) |
| FI (1) | FI63394C (sv) |
| FR (1) | FR2313049A1 (sv) |
| GB (1) | GB1551735A (sv) |
| GR (1) | GR60380B (sv) |
| HU (1) | HU174191B (sv) |
| IE (1) | IE43474B1 (sv) |
| IL (1) | IL49692A (sv) |
| LU (1) | LU75070A1 (sv) |
| MX (1) | MX3483E (sv) |
| NL (1) | NL7606178A (sv) |
| NO (1) | NO144346C (sv) |
| NZ (1) | NZ181011A (sv) |
| OA (1) | OA05346A (sv) |
| PH (1) | PH16077A (sv) |
| PL (1) | PL103004B1 (sv) |
| PT (1) | PT65182B (sv) |
| SE (1) | SE428561B (sv) |
| SU (1) | SU639451A3 (sv) |
| YU (1) | YU137176A (sv) |
| ZA (1) | ZA763209B (sv) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2834945A1 (de) * | 1977-08-15 | 1979-03-01 | Lilly Co Eli | Thiadiazolylbenzamide, verfahren zu ihrer herstellung und sie enthaltende insektizide mittel |
| DE2805757A1 (de) * | 1978-02-10 | 1979-08-16 | Bayer Ag | N-azolylalkyl-halogenacetanilide, verfahren zu ihrer herstellung sowie ihre verwendung als herbizide |
| DE2805756A1 (de) * | 1978-02-10 | 1979-08-16 | Bayer Ag | N-azolylalkyl-aniline sowie verfahren zu ihrer herstellung |
| US4285959A (en) * | 1979-05-18 | 1981-08-25 | Ciba-Geigy Corporation | 3-(N-1,3,4-Thiadiazolyl-2)-aminoalkyl-alkyl-acrylates and use thereof as bactericides |
| US4264616A (en) * | 1980-08-29 | 1981-04-28 | Gulf Oil Corporation | 2-Iodoacetylimino-3-methyl-5-trifluoromethyl-1,3,4-thiadiazol-4-ine and use as a fungicide |
| MA19269A1 (fr) * | 1980-09-16 | 1982-04-01 | Lilly Co Eli | Perfectionnement relatif a des derives de n-arylbenzamides . |
| DE3120804A1 (de) | 1981-05-25 | 1982-12-16 | Basf Ag, 6700 Ludwigshafen | N-substituierte 2-methylnaphthylamide, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung von pilzen |
| US4874864A (en) * | 1988-05-24 | 1989-10-17 | Pfizer Inc. | Benzamide protease inhibitors |
| AU2010601A (en) * | 1999-12-16 | 2001-07-03 | Novartis Ag | Organic compounds |
| TW200503994A (en) * | 2003-01-24 | 2005-02-01 | Novartis Ag | Organic compounds |
| RU2448961C1 (ru) * | 2011-02-03 | 2012-04-27 | Открытое акционерное общество "Всероссийский научный центр по безопасности биологически активных веществ" (ОАО "ВНЦ БАВ") | Фармацевтическая композиция, обладающая противовоспалительной, бронхолитической, противотуберкулезной активностями |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3720684A (en) * | 1970-10-13 | 1973-03-13 | Velsicol Chemical Corp | 5-halo-1,2,4-thiadiazoles |
| IL35743A (en) * | 1970-11-27 | 1974-10-22 | Peretz B | 3-isopropyl-5-amino-1,2,4-thiadiazole compounds |
-
1975
- 1975-06-05 GB GB24224/75A patent/GB1551735A/en not_active Expired
-
1976
- 1976-05-31 IE IE1148/76A patent/IE43474B1/en unknown
- 1976-05-31 FR FR7616338A patent/FR2313049A1/fr active Granted
- 1976-05-31 CA CA253,755A patent/CA1085860A/en not_active Expired
- 1976-05-31 IL IL49692A patent/IL49692A/xx unknown
- 1976-05-31 NZ NZ181011A patent/NZ181011A/xx unknown
- 1976-06-01 GR GR50868A patent/GR60380B/el unknown
- 1976-06-01 CH CH685576A patent/CH612427A5/xx not_active IP Right Cessation
- 1976-06-01 AR AR263474A patent/AR217240A1/es active
- 1976-06-01 ZA ZA00763209A patent/ZA763209B/xx unknown
- 1976-06-02 DK DK243276A patent/DK243276A/da not_active Application Discontinuation
- 1976-06-02 LU LU75070A patent/LU75070A1/xx unknown
- 1976-06-02 SE SE7606226A patent/SE428561B/sv unknown
- 1976-06-03 CS CS763692A patent/CS200494B2/cs unknown
- 1976-06-03 AU AU14619/76A patent/AU503150B2/en not_active Expired
- 1976-06-03 HU HU76LI293A patent/HU174191B/hu unknown
- 1976-06-03 YU YU01371/76A patent/YU137176A/xx unknown
- 1976-06-03 BE BE6045539A patent/BE842579A/xx not_active IP Right Cessation
- 1976-06-03 PT PT65182A patent/PT65182B/pt unknown
- 1976-06-04 PL PL1976190132A patent/PL103004B1/pl unknown
- 1976-06-04 DE DE19762625285 patent/DE2625285A1/de not_active Ceased
- 1976-06-04 BG BG033366A patent/BG27359A3/xx unknown
- 1976-06-04 NO NO761913A patent/NO144346C/no unknown
- 1976-06-04 FI FI761585A patent/FI63394C/fi not_active IP Right Cessation
- 1976-06-04 MX MX000265U patent/MX3483E/es unknown
- 1976-06-04 SU SU762366751A patent/SU639451A3/ru active
- 1976-06-04 AT AT412276A patent/AT346843B/de not_active IP Right Cessation
- 1976-06-04 PH PH18535A patent/PH16077A/en unknown
- 1976-06-04 ES ES448590A patent/ES448590A1/es not_active Expired
- 1976-06-04 DD DD193198A patent/DD125075A5/xx unknown
- 1976-06-04 JP JP51066027A patent/JPS51146468A/ja active Pending
- 1976-06-05 OA OA55843A patent/OA05346A/xx unknown
- 1976-06-05 EG EG76334A patent/EG12226A/xx active
- 1976-06-08 NL NL7606178A patent/NL7606178A/xx not_active Application Discontinuation
-
1979
- 1979-01-10 CH CH20579A patent/CH616933A5/fr not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed |
Owner name: LILLY INDUSTRIES LTD |