FI63062C - Foerfarande foer framstaellning av de farmaceutiskt aktiva aminosockerderivaten trestatin a trestatin b och trestatin c - Google Patents

Foerfarande foer framstaellning av de farmaceutiskt aktiva aminosockerderivaten trestatin a trestatin b och trestatin c Download PDF

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Publication number
FI63062C
FI63062C FI790486A FI790486A FI63062C FI 63062 C FI63062 C FI 63062C FI 790486 A FI790486 A FI 790486A FI 790486 A FI790486 A FI 790486A FI 63062 C FI63062 C FI 63062C
Authority
FI
Finland
Prior art keywords
trestatin
höh
trestatins
isp
water
Prior art date
Application number
FI790486A
Other languages
English (en)
Finnish (fi)
Other versions
FI790486A (fi
FI63062B (fi
Inventor
Yasuji Suhara
Kiyoshi Ogawa
Kazuteru Yokose
Kimihiro Watanabe
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of FI790486A publication Critical patent/FI790486A/fi
Publication of FI63062B publication Critical patent/FI63062B/fi
Application granted granted Critical
Publication of FI63062C publication Critical patent/FI63062C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/99—Enzyme inactivation by chemical treatment
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
FI790486A 1978-02-14 1979-02-14 Foerfarande foer framstaellning av de farmaceutiskt aktiva aminosockerderivaten trestatin a trestatin b och trestatin c FI63062C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB583478 1978-02-14
GB583478 1978-02-14

Publications (3)

Publication Number Publication Date
FI790486A FI790486A (fi) 1979-08-15
FI63062B FI63062B (fi) 1982-12-31
FI63062C true FI63062C (fi) 1983-04-11

Family

ID=9803510

Family Applications (1)

Application Number Title Priority Date Filing Date
FI790486A FI63062C (fi) 1978-02-14 1979-02-14 Foerfarande foer framstaellning av de farmaceutiskt aktiva aminosockerderivaten trestatin a trestatin b och trestatin c

Country Status (26)

Country Link
US (1) US4273765A (es)
EP (1) EP0003616B1 (es)
JP (1) JPS54163511A (es)
AR (1) AR219150A1 (es)
AT (1) AT367451B (es)
AU (1) AU527318B2 (es)
CA (1) CA1121290A (es)
DE (2) DE2962165D1 (es)
DK (1) DK149599C (es)
ES (1) ES477653A1 (es)
FI (1) FI63062C (es)
FR (1) FR2416901A1 (es)
GR (1) GR72817B (es)
HU (1) HU181442B (es)
IE (1) IE47916B1 (es)
IL (1) IL56626A0 (es)
LU (1) LU80906A1 (es)
MC (1) MC1253A1 (es)
NL (1) NL7901182A (es)
NO (1) NO153011C (es)
NZ (1) NZ189625A (es)
PH (1) PH15084A (es)
PT (1) PT69218A (es)
SE (1) SE7901276L (es)
YU (1) YU41437B (es)
ZA (1) ZA79528B (es)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0056194B1 (en) 1981-01-05 1984-09-12 Takeda Chemical Industries, Ltd. N-substituted pseudo-aminosugars, their production and use
JPS57146713A (en) * 1981-03-09 1982-09-10 Akira Endo Hypoglycemic
US4595678A (en) * 1982-03-19 1986-06-17 Takeda Chemical Industries, Ltd. N-substituted pseudo-aminosugars and pharmaceutical compositions containing same
US4762857A (en) * 1986-05-30 1988-08-09 E. I. Du Pont De Nemours And Company Trehalose as stabilizer and tableting excipient
US4678812A (en) * 1986-05-30 1987-07-07 E. I. Du Pont De Nemours And Company Trehalose as stabilizer and tableting excipient
US4885361A (en) * 1987-07-31 1989-12-05 Hoffmann-La Roche Inc. Sulfated oligosaccharides
CA2097426A1 (en) * 1990-11-30 1992-05-31 Bruce M. Cameron, Sr. Method for the diagnosis of chronic lower back and cervical pain
TW381025B (en) * 1993-08-05 2000-02-01 Hoffmann La Roche Pharmaceutical composition containing a glucosidase inhibitor and a lipase inhibitor
US7022684B2 (en) * 2000-05-24 2006-04-04 Pfizer Inc. Treatment of rumen acidosis with α-amylase inhibitors
EP1745790A3 (en) * 2000-05-24 2007-03-21 Pfizer Limited Treatment of rumen acidosis with alpha-amylase inhibitors
EP2428516A1 (en) 2003-11-19 2012-03-14 Metabasis Therapeutics, Inc. Novel phosphorus-containing thyromimetics
US7262318B2 (en) * 2004-03-10 2007-08-28 Pfizer, Inc. Substituted heteroaryl- and phenylsulfamoyl compounds
US20050288340A1 (en) * 2004-06-29 2005-12-29 Pfizer Inc Substituted heteroaryl- and phenylsulfamoyl compounds
ATE439347T1 (de) * 2004-11-23 2009-08-15 Warner Lambert Co 7-(2h-pyrazol-3-yl)-3,5-dihydroxy-heptansäure- derivate als hmg-co-a-reductase-inhibitoren zur behandlung von lipidemia
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
CN101663262B (zh) 2006-12-01 2014-03-26 百时美施贵宝公司 用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物
ES2393885T7 (es) 2007-06-04 2014-01-30 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
KR20100130993A (ko) * 2008-04-11 2010-12-14 아스텔라스세이야쿠 가부시키가이샤 아미노당 화합물 및 그의 생산 방법
ES2522968T3 (es) 2008-06-04 2014-11-19 Synergy Pharmaceuticals Inc. Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
AU2009270833B2 (en) 2008-07-16 2015-02-19 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
WO2010093601A1 (en) 2009-02-10 2010-08-19 Metabasis Therapeutics, Inc. Novel sulfonic acid-containing thyromimetics, and methods for their use
WO2011145022A1 (en) 2010-05-21 2011-11-24 Pfizer Inc. 2-phenyl benzoylamides
WO2012027331A1 (en) 2010-08-27 2012-03-01 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
EP2680874A2 (en) 2011-03-04 2014-01-08 Pfizer Inc Edn3-like peptides and uses thereof
WO2013133685A1 (en) 2012-03-09 2013-09-12 Biotropics Malaysia Berhad Extract formulations of rhodamnia cinerea and uses thereof
CA2905435A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
JP2016514671A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼのアゴニストおよびその使用
WO2014170786A1 (en) 2013-04-17 2014-10-23 Pfizer Inc. N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
US10011637B2 (en) 2013-06-05 2018-07-03 Synergy Pharmaceuticals, Inc. Ultra-pure agonists of guanylate cyclase C, method of making and using same
MX2017002610A (es) 2014-08-29 2017-10-11 Tes Pharma S R L INHIBIDORES DE ACIDO A-AMINO-ß-CARBOXIMUCONICO SEMIALDEHIDO DESCARBOXILASA.
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
US20180134667A1 (en) 2016-10-14 2018-05-17 TES Pharma S.r.I. Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase
MX2021005904A (es) 2018-11-20 2021-09-08 Tes Pharma S R L Inhibidores de la ácido alfa-amino-beta-carboximucónico semialdehído descarboxilasa.
CN113574055A (zh) 2019-01-18 2021-10-29 阿斯利康(瑞典)有限公司 Pcsk9抑制剂及其使用方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2064092C2 (de) * 1970-12-28 1983-06-01 Bayer Ag, 5090 Leverkusen Inhibitoren für Glykosidhydrolasen aus Actinomyceten
US4062950A (en) * 1973-09-22 1977-12-13 Bayer Aktiengesellschaft Amino sugar derivatives
DE2347782C3 (de) * 1973-09-22 1979-10-11 Bayer Ag, 5090 Leverkusen Aminozuckerderivate, Verfahren zu ihrer Herstellung sowie diese Verbindungen enthaltende Arzneimittel
US4065557A (en) * 1974-03-21 1977-12-27 Bayer Aktiengesellschaft Amino sugars and their use in improving the meat:fat ratio in animals
USRE29903E (en) 1975-03-19 1979-02-06 American Cyanamid Company Antibacterial antibiotics AM31α, AM31β and AM31γ
DE2614393C3 (de) * 1976-04-02 1980-04-03 Bayer Ag, 5090 Leverkusen Aminozucker-Derivate und diese Verbindungen enthaltende Arzneimittel

Also Published As

Publication number Publication date
EP0003616B1 (de) 1982-02-24
FI790486A (fi) 1979-08-15
DK149599B (da) 1986-08-04
ZA79528B (en) 1980-02-27
DE2962165D1 (en) 1982-03-25
DK149599C (da) 1987-06-01
NO790469L (no) 1979-08-15
IE790274L (en) 1979-08-14
DK61179A (da) 1979-08-15
NO153011C (no) 1986-01-02
JPS54163511A (en) 1979-12-26
AU4402879A (en) 1979-08-23
IE47916B1 (en) 1984-07-25
AT367451B (de) 1982-07-12
SE7901276L (sv) 1979-08-15
YU41437B (en) 1987-06-30
AR219150A1 (es) 1980-07-31
NL7901182A (nl) 1979-08-16
YU34879A (en) 1983-01-21
EP0003616A2 (de) 1979-08-22
CA1121290A (en) 1982-04-06
FR2416901B1 (es) 1980-10-24
LU80906A1 (de) 1980-09-24
NZ189625A (en) 1981-05-01
FR2416901A1 (fr) 1979-09-07
HU181442B (en) 1983-07-28
ATA108879A (de) 1981-11-15
ES477653A1 (es) 1980-03-01
NO153011B (no) 1985-09-23
US4273765A (en) 1981-06-16
FI63062B (fi) 1982-12-31
EP0003616A3 (en) 1979-09-05
IL56626A0 (en) 1979-05-31
GR72817B (es) 1983-12-06
PT69218A (en) 1979-03-01
MC1253A1 (fr) 1980-01-14
PH15084A (en) 1982-07-02
JPS643877B2 (es) 1989-01-23
AU527318B2 (en) 1983-02-24
DE2905649A1 (de) 1979-08-16

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Owner name: F. HOFFMANN-LA ROCHE AG