FI60868C - Foerfarande foer framstaellning av farmaceutiskt aktiva 7-acylerade cefalosporiner - Google Patents

Foerfarande foer framstaellning av farmaceutiskt aktiva 7-acylerade cefalosporiner Download PDF

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Publication number
FI60868C
FI60868C FI763044A FI763044A FI60868C FI 60868 C FI60868 C FI 60868C FI 763044 A FI763044 A FI 763044A FI 763044 A FI763044 A FI 763044A FI 60868 C FI60868 C FI 60868C
Authority
FI
Finland
Prior art keywords
compound
formula
sulfaminoethyl
cephem
salt
Prior art date
Application number
FI763044A
Other languages
English (en)
Finnish (fi)
Other versions
FI763044A (fr
FI60868B (fi
Inventor
David Alan Berges
Original Assignee
Smithkline Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/704,142 external-priority patent/US4118491A/en
Application filed by Smithkline Corp filed Critical Smithkline Corp
Publication of FI763044A publication Critical patent/FI763044A/fi
Priority to FI814133A priority Critical patent/FI64153C/fi
Application granted granted Critical
Publication of FI60868B publication Critical patent/FI60868B/fi
Publication of FI60868C publication Critical patent/FI60868C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
FI763044A 1975-10-30 1976-10-26 Foerfarande foer framstaellning av farmaceutiskt aktiva 7-acylerade cefalosporiner FI60868C (fi)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FI814133A FI64153C (fi) 1975-10-30 1981-12-22 Mellanprodukt foer framstaellning av farmaceutiskt aktiva 7-acylerade 3-acetoximetyl-cefalosporiner

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US62716475A 1975-10-30 1975-10-30
US62716475 1975-10-30
US66583776A 1976-03-11 1976-03-11
US66583776 1976-03-11
US05/704,142 US4118491A (en) 1976-03-11 1976-07-12 7-Acyl-3-(sulfaminoalkyl substituted tetrazolylthiomethyl)cephalosporins, antibacterial compositions containing them and methods of treating bacterial infections with them
US70414276 1976-07-12

Publications (3)

Publication Number Publication Date
FI763044A FI763044A (fr) 1977-05-01
FI60868B FI60868B (fi) 1981-12-31
FI60868C true FI60868C (fi) 1982-04-13

Family

ID=27417417

Family Applications (1)

Application Number Title Priority Date Filing Date
FI763044A FI60868C (fi) 1975-10-30 1976-10-26 Foerfarande foer framstaellning av farmaceutiskt aktiva 7-acylerade cefalosporiner

Country Status (17)

Country Link
JP (1) JPS6053026B2 (fr)
AT (1) AT353957B (fr)
AU (1) AU505141B2 (fr)
CA (1) CA1071188A (fr)
CH (1) CH627757A5 (fr)
DE (1) DE2649545A1 (fr)
DK (1) DK463176A (fr)
ES (1) ES452769A1 (fr)
FI (1) FI60868C (fr)
FR (3) FR2361896A1 (fr)
GB (3) GB1570093A (fr)
GR (1) GR61667B (fr)
IE (1) IE44393B1 (fr)
IL (3) IL50546A (fr)
LU (1) LU76092A1 (fr)
NL (1) NL7612010A (fr)
SE (3) SE452621B (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4117123A (en) * 1977-06-09 1978-09-26 Smithkline Corporation 7-Acylamino-3-[1-(2-sulfamidoethyl)tetrazol-5-ylthiomethyl]-3-cephem-4-carboxylic acids
AT383811B (de) * 1983-09-22 1987-08-25 Biochemie Gmbh Verfahren zur herstellung von monoalkalisalzen von 7-amino-3-cephem-4-carbonsaeurederivaten
US4717531A (en) * 1983-09-23 1988-01-05 Westinghouse Electric Corp. Fuel transfer system upender using translation drive

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR207752A1 (es) * 1973-03-30 1976-10-29 Fujisawa Pharmaceutical Co Procedimiento para obtener acidos 7-amino-sustituido-3-tiometilsustituido-3-cefem-4-carboxilicos
NL7414119A (nl) * 1973-10-31 1975-05-02 Fujisawa Pharmaceutical Co Werkwijze ter bereiding van 1h-tetrazool-5-thiol- derivaten en 1-gesubstitueerde 1h-tetrazool- -5-thiolen.
GB1449420A (en) * 1973-11-26 1976-09-15 Sankyo Co 7alpha-methoxycephalosporing derivatives
NZ176206A (en) * 1973-12-25 1978-03-06 Takeda Chemical Industries Ltd Cephalosporins
US4066762A (en) * 1976-07-12 1978-01-03 Smithkline Corporation Derivatives of 7-(2-substituted-2-hydroxyiminoacetamido)-3-(1-substituted tetrazol-5-ylthiomethyl-3-cephem-4-carboxylic acid

Also Published As

Publication number Publication date
GR61667B (en) 1978-12-05
CH627757A5 (en) 1982-01-29
SE437025B (sv) 1985-02-04
IL56758A0 (en) 1979-05-31
AT353957B (de) 1979-12-10
NL7612010A (nl) 1977-05-03
IE44393B1 (en) 1981-11-18
SE8006413L (sv) 1980-09-12
ES452769A1 (es) 1978-01-16
JPS6053026B2 (ja) 1985-11-22
AU1870276A (en) 1978-04-20
FR2361896A1 (fr) 1978-03-17
AU505141B2 (en) 1979-11-08
FR2351982B1 (fr) 1981-07-03
DK463176A (da) 1977-05-01
FR2337720A1 (fr) 1977-08-05
IE44393L (en) 1977-09-11
LU76092A1 (fr) 1977-05-17
GB1570094A (en) 1980-06-25
FI763044A (fr) 1977-05-01
SE452621B (sv) 1987-12-07
FR2337720B1 (fr) 1981-07-10
SE8006414L (sv) 1980-09-12
GB1570093A (en) 1980-06-25
IL56757A0 (en) 1979-05-31
SE435291B (sv) 1984-09-17
IL50546A (en) 1980-07-31
CA1071188A (fr) 1980-02-05
GB1570095A (en) 1980-06-25
JPS5257191A (en) 1977-05-11
ATA807276A (de) 1979-05-15
FI60868B (fi) 1981-12-31
IL50546A0 (en) 1976-11-30
FR2361896B1 (fr) 1979-02-23
SE7610722L (sv) 1977-05-01
DE2649545A1 (de) 1977-05-12
FR2351982A1 (fr) 1977-12-16

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Legal Events

Date Code Title Description
MM Patent lapsed

Owner name: SMITHKLINE CORPORATION