FI58072C - Foerfarande foer framstaellning av ett torrpreparat av ett alkalimetallsalt av dehydroepiandrosteronsulfat foer parenteral administration - Google Patents
Foerfarande foer framstaellning av ett torrpreparat av ett alkalimetallsalt av dehydroepiandrosteronsulfat foer parenteral administration Download PDFInfo
- Publication number
- FI58072C FI58072C FI771525A FI771525A FI58072C FI 58072 C FI58072 C FI 58072C FI 771525 A FI771525 A FI 771525A FI 771525 A FI771525 A FI 771525A FI 58072 C FI58072 C FI 58072C
- Authority
- FI
- Finland
- Prior art keywords
- ett
- dha
- foer
- parenteral administration
- torrpreparat
- Prior art date
Links
- 238000007911 parenteral administration Methods 0.000 title description 3
- YIOCQGHBBNGBND-UHFFFAOYSA-N sodium;3-acetyl-6-methylpyran-3-ide-2,4-dione Chemical compound [Na+].CC(=O)[C-]1C(=O)C=C(C)OC1=O YIOCQGHBBNGBND-UHFFFAOYSA-N 0.000 description 26
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 14
- 159000000000 sodium salts Chemical class 0.000 description 13
- 239000004471 Glycine Substances 0.000 description 12
- 239000000243 solution Substances 0.000 description 11
- 239000003381 stabilizer Substances 0.000 description 7
- -1 alkali metal salt Chemical class 0.000 description 6
- 229940024606 amino acid Drugs 0.000 description 6
- 235000001014 amino acid Nutrition 0.000 description 6
- 150000001413 amino acids Chemical class 0.000 description 6
- 229910052783 alkali metal Inorganic materials 0.000 description 5
- QNAYBMKLOCPYGJ-UHFFFAOYSA-N Alanine Chemical group CC([NH3+])C([O-])=O QNAYBMKLOCPYGJ-UHFFFAOYSA-N 0.000 description 4
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 4
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 4
- 239000007864 aqueous solution Substances 0.000 description 4
- 229960002920 sorbitol Drugs 0.000 description 4
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 239000000600 sorbitol Substances 0.000 description 3
- 239000008223 sterile water Substances 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 229930064664 L-arginine Natural products 0.000 description 2
- 235000014852 L-arginine Nutrition 0.000 description 2
- CZWCKYRVOZZJNM-UHFFFAOYSA-N Prasterone sodium sulfate Natural products C1C(OS(O)(=O)=O)CCC2(C)C3CCC(C)(C(CC4)=O)C4C3CC=C21 CZWCKYRVOZZJNM-UHFFFAOYSA-N 0.000 description 2
- 239000003708 ampul Substances 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- CZWCKYRVOZZJNM-USOAJAOKSA-N dehydroepiandrosterone sulfate Chemical compound C1[C@@H](OS(O)(=O)=O)CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CC=C21 CZWCKYRVOZZJNM-USOAJAOKSA-N 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 229950010030 dl-alanine Drugs 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 238000004108 freeze drying Methods 0.000 description 2
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 description 2
- 239000008176 lyophilized powder Substances 0.000 description 2
- 229950009829 prasterone sulfate Drugs 0.000 description 2
- 239000004475 Arginine Substances 0.000 description 1
- FMGSKLZLMKYGDP-UHFFFAOYSA-N Dehydroepiandrosterone Natural products C1C(O)CCC2(C)C3CCC(C)(C(CC4)=O)C4C3CC=C21 FMGSKLZLMKYGDP-UHFFFAOYSA-N 0.000 description 1
- 208000034423 Delivery Diseases 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 description 1
- 125000002059 L-arginyl group Chemical group O=C([*])[C@](N([H])[H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H] 0.000 description 1
- XNOPRXBHLZRZKH-UHFFFAOYSA-N Oxytocin Natural products N1C(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CC(C)C)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C(C(C)CC)NC(=O)C1CC1=CC=C(O)C=C1 XNOPRXBHLZRZKH-UHFFFAOYSA-N 0.000 description 1
- 101800000989 Oxytocin Proteins 0.000 description 1
- 102100031951 Oxytocin-neurophysin 1 Human genes 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 235000009697 arginine Nutrition 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- FMGSKLZLMKYGDP-USOAJAOKSA-N dehydroepiandrosterone Chemical compound C1[C@@H](O)CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CC=C21 FMGSKLZLMKYGDP-USOAJAOKSA-N 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000012458 free base Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000000754 myometrium Anatomy 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- XNOPRXBHLZRZKH-DSZYJQQASA-N oxytocin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@H](N)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 XNOPRXBHLZRZKH-DSZYJQQASA-N 0.000 description 1
- 229960001723 oxytocin Drugs 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 229960002847 prasterone Drugs 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
Landscapes
- Steroid Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8061376 | 1976-07-06 | ||
| JP8061376A JPS537662A (en) | 1976-07-06 | 1976-07-06 | Preparation of injection containing stable dehydroepiandrosterone sulfate |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI771525A7 FI771525A7 (enExample) | 1978-01-07 |
| FI58072B FI58072B (fi) | 1980-08-29 |
| FI58072C true FI58072C (fi) | 1980-12-10 |
Family
ID=13723175
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI771525A FI58072C (fi) | 1976-07-06 | 1977-05-13 | Foerfarande foer framstaellning av ett torrpreparat av ett alkalimetallsalt av dehydroepiandrosteronsulfat foer parenteral administration |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JPS537662A (enExample) |
| AR (1) | AR211723A1 (enExample) |
| FI (1) | FI58072C (enExample) |
| NO (1) | NO146937C (enExample) |
| PT (1) | PT66228B (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU7011581A (en) * | 1980-08-29 | 1982-03-04 | Danly Machine Corp. | Press loading + unloading |
| JPS57187231A (en) * | 1981-05-13 | 1982-11-17 | Matsushita Electric Ind Co Ltd | Mold apparatus for compression molding of resin |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5019915A (enExample) * | 1973-06-28 | 1975-03-03 | ||
| JPS5617326B2 (enExample) * | 1973-09-27 | 1981-04-22 |
-
1976
- 1976-07-06 JP JP8061376A patent/JPS537662A/ja active Granted
-
1977
- 1977-02-24 PT PT6622877A patent/PT66228B/pt unknown
- 1977-03-03 NO NO770743A patent/NO146937C/no unknown
- 1977-03-11 AR AR26681377A patent/AR211723A1/es active
- 1977-05-13 FI FI771525A patent/FI58072C/fi not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AR211723A1 (es) | 1978-02-28 |
| JPS537662A (en) | 1978-01-24 |
| FI771525A7 (enExample) | 1978-01-07 |
| JPS5530769B2 (enExample) | 1980-08-13 |
| PT66228B (en) | 1978-07-14 |
| PT66228A (en) | 1977-03-01 |
| NO770743L (no) | 1978-01-09 |
| NO146937C (no) | 1983-01-12 |
| NO146937B (no) | 1982-09-27 |
| FI58072B (fi) | 1980-08-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MA | Patent expired | ||
| MA | Patent expired |
Owner name: KANEBO LTD. |