FI57409C - Foerfarande foer framstaellning av ett pao centralnervsystemet verkande racemiska och optiskt aktiva 2-(tienylmetyl)-alfa-5,9-dialkyl-6,7-bensomorfaner och deras syraadditionssalter - Google Patents

Foerfarande foer framstaellning av ett pao centralnervsystemet verkande racemiska och optiskt aktiva 2-(tienylmetyl)-alfa-5,9-dialkyl-6,7-bensomorfaner och deras syraadditionssalter Download PDF

Info

Publication number
FI57409C
FI57409C FI1142/73A FI114273A FI57409C FI 57409 C FI57409 C FI 57409C FI 1142/73 A FI1142/73 A FI 1142/73A FI 114273 A FI114273 A FI 114273A FI 57409 C FI57409 C FI 57409C
Authority
FI
Finland
Prior art keywords
formula
compound
group
methyl
alkyl
Prior art date
Application number
FI1142/73A
Other languages
English (en)
Finnish (fi)
Other versions
FI57409B (fi
Inventor
Herbert Merz
Adolf Langbein
Klaus Stockhaus
Helmut Wick
Original Assignee
Boehringer Sohn Ingelheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim
Publication of FI57409B publication Critical patent/FI57409B/fi
Application granted granted Critical
Publication of FI57409C publication Critical patent/FI57409C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/26—Benzomorphans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
FI1142/73A 1972-04-12 1973-04-11 Foerfarande foer framstaellning av ett pao centralnervsystemet verkande racemiska och optiskt aktiva 2-(tienylmetyl)-alfa-5,9-dialkyl-6,7-bensomorfaner och deras syraadditionssalter FI57409C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2217420A DE2217420C3 (de) 1972-04-12 1972-04-12 N-Thienylmethyl-Heterocyclen, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zubereitungen
DE2217420 1972-04-12

Publications (2)

Publication Number Publication Date
FI57409B FI57409B (fi) 1980-04-30
FI57409C true FI57409C (fi) 1980-08-11

Family

ID=5841625

Family Applications (1)

Application Number Title Priority Date Filing Date
FI1142/73A FI57409C (fi) 1972-04-12 1973-04-11 Foerfarande foer framstaellning av ett pao centralnervsystemet verkande racemiska och optiskt aktiva 2-(tienylmetyl)-alfa-5,9-dialkyl-6,7-bensomorfaner och deras syraadditionssalter

Country Status (7)

Country Link
US (1) US3917606A (de)
DE (1) DE2217420C3 (de)
DK (1) DK133555C (de)
FI (1) FI57409C (de)
GB (1) GB1425347A (de)
NO (1) NO137695C (de)
SE (1) SE408642B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2437610A1 (de) * 1974-08-05 1976-02-26 Boehringer Sohn Ingelheim Neue 5,9-beta-disubstituierte 2-tetrahydrofurfuryl-6,7-benzomorphane, deren saeureadditionssalze, ihre verwendung als arzneimittel und verfahren zu deren herstellung
GB1575009A (en) * 1976-06-21 1980-09-17 Acf Chemiefarma Nv 6,7-benzomorphan derivatives
CN1111900A (zh) * 1993-06-30 1995-11-15 东丽株式会社 止咳药
CA2143864C (en) * 1993-07-23 2006-01-24 Hiroshi Nagase Morphinan derivatives and pharmaceutical use thereof
US6844438B2 (en) * 2001-08-15 2005-01-18 Mclean Hospital Corporation N-substituted derivatives of morphinan and uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE582575A (de) * 1958-09-22
US3647806A (en) * 1966-04-18 1972-03-07 Syntex Corp Tetrahydropyranyl and tetrahydro-furanyl benzomorphan ethers

Also Published As

Publication number Publication date
NO137695B (no) 1977-12-27
SE408642B (sv) 1979-06-25
DE2217420A1 (de) 1973-10-31
GB1425347A (en) 1976-02-18
DE2217420B2 (de) 1980-08-07
NO137695C (no) 1978-04-05
DE2217420C3 (de) 1981-03-12
DK133555B (da) 1976-06-08
FI57409B (fi) 1980-04-30
DK133555C (da) 1976-10-25
US3917606A (en) 1975-11-04

Similar Documents

Publication Publication Date Title
FI63229C (fi) Foerfarande foer framstaellning av analgetiskt verkande racemiskt eller diastereomera och optiskt aktiva 2-tetrahydrofurfuryl-5,9 beta-dimetyl-6,7-bensomorfaner och deras syraadditionssalter
FI63571B (fi) Foerfarande foer framstaellning av analgetiskt verkande racemiska eller diastereomera och optiskt aktiva 2-tetrahydrofurfuryl-(1r/s 5r/s 9r/s)-2'-hydroxi-5,9-dimetyl-6,7-bensomorfaner och deras syraadditionssalter
NO137694B (no) Analogifremgangsm}te for fremstilling av terapeutisk aktive benzomorfaner
Vejdělek et al. Synthesis Experiments in the Group of Hypotensive Alkaloids--XXI. Chemistry of 1, 2, 3, 4-Tetra-hydronorharmane-1-carboxylic Acid and Derivatives
HU176479B (en) Process for preparing new n-/methoxymethyl-furyl-methyl/-6,7-benzomorphans and -morphians further acid addition snlts thereof
FI57409C (fi) Foerfarande foer framstaellning av ett pao centralnervsystemet verkande racemiska och optiskt aktiva 2-(tienylmetyl)-alfa-5,9-dialkyl-6,7-bensomorfaner och deras syraadditionssalter
Jones et al. The synthesis of some β-aminoethyldiazines as histamine analogs
FI57758C (fi) Foerfarande foer framstaellning av terapeutiskt verksamt racematiskt eller optiskt aktivt 2-(furylmetyl)-2'-hydroxi-alfa-5,9-dialkyl-6,7-benzomorfan och dess syraadditionssalter
US3314966A (en) Substituted benzo[a]quinolizines
NO134055B (de)
Craig et al. Curariform Activity and Chemical Structure. II. Synthesis in the Benzyltetrahydroisoquinoline Series1
CN105037305B (zh) 5‑羟基‑2’‑硝基橙酮或5‑羟基‑4’‑硝基橙酮衍生物及其应用
US2619484A (en) Y-dihydro - sh-dibenz
Herz et al. Furano (3, 2-c) pyridines1
GB1590155A (en) Cis-4a-phenyl-2,3,4,4a,5,6,7,7a-octahydro-1h-2-pyrindines and pharmaceutical compositions containing them
DE3520104C2 (de) Naphthoxazine, ihre Herstellung und Verwendung
US3217006A (en) Purification of d-j-methoxy-n-methyl-ar morphinan
Gopinath et al. 805. Synthesis of dihydronitidine
US2349267A (en) Acylated derivative of vitamin b6 and process of preparing the same
CA3106620A1 (en) Substituted 3,4,12,12a-tetrahydro-1h-[1,4] oxazino[3,4-c]pyrido[2,1-f] [1,2,4]triazine-6,8-dione, pharmaceutical composition, method for the production and use thereof
US2912436A (en) Brominated alkaloids
Mosettig et al. SCISSION OF THE METHYLENEDIOXYL GROUP WITH ALUMINUM BROMIDE1
Sober et al. Selective and potent. beta. 2-adrenoceptor agents within the tetrahydroisoquinoline class: effect of methyl substitution at the benzylic carbon of the 1-(3, 4, 5-trimethoxybenzyl) group of trimetoquinol
KR900006745B1 (ko) 5-아미노-1,2-디티올-3-온 화합물 및 그의 제법
TSUDA et al. Studies on the Synthesis of Matrine. II. The Synthesis of Octadehydromatrine and Allomatridine1