FI57261C - Foerfarande foer framstaellning av pao centralnervsystemet verkande n-(heteroaryl-metyl)-6,14-endoeteno/endoetano-7alfa-hydroxylalkyltetrahydronororipavin och -tebain och deras syraadditionssalter - Google Patents

Foerfarande foer framstaellning av pao centralnervsystemet verkande n-(heteroaryl-metyl)-6,14-endoeteno/endoetano-7alfa-hydroxylalkyltetrahydronororipavin och -tebain och deras syraadditionssalter Download PDF

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Publication number
FI57261C
FI57261C FI1989/73A FI198973A FI57261C FI 57261 C FI57261 C FI 57261C FI 1989/73 A FI1989/73 A FI 1989/73A FI 198973 A FI198973 A FI 198973A FI 57261 C FI57261 C FI 57261C
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FI
Finland
Prior art keywords
formula
methyl
tetrahydro
compound
group
Prior art date
Application number
FI1989/73A
Other languages
English (en)
Finnish (fi)
Other versions
FI57261B (fi
Inventor
Adolf Langbein
Herbert Merz
Gerhard Walther
Klaus Stockhaus
Original Assignee
Boehringer Sohn Ingelheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim
Application granted granted Critical
Publication of FI57261B publication Critical patent/FI57261B/fi
Publication of FI57261C publication Critical patent/FI57261C/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
    • C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FI1989/73A 1972-06-21 1973-06-20 Foerfarande foer framstaellning av pao centralnervsystemet verkande n-(heteroaryl-metyl)-6,14-endoeteno/endoetano-7alfa-hydroxylalkyltetrahydronororipavin och -tebain och deras syraadditionssalter FI57261C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2230154A DE2230154A1 (de) 1972-06-21 1972-06-21 N-(heteroaryl-methyl)-6,14-endoaetheno7alpha-hydroxyalkyl-tetrahydro-nororipavine und -thebaine, deren hydrierungsprodukte und saeureadditionssalze sowie verfahren zu deren herstellung
DE2230154 1972-06-21

Publications (2)

Publication Number Publication Date
FI57261B FI57261B (fi) 1980-03-31
FI57261C true FI57261C (fi) 1980-07-10

Family

ID=5848276

Family Applications (1)

Application Number Title Priority Date Filing Date
FI1989/73A FI57261C (fi) 1972-06-21 1973-06-20 Foerfarande foer framstaellning av pao centralnervsystemet verkande n-(heteroaryl-metyl)-6,14-endoeteno/endoetano-7alfa-hydroxylalkyltetrahydronororipavin och -tebain och deras syraadditionssalter

Country Status (14)

Country Link
US (1) US3931189A (de)
JP (1) JPS5614673B2 (de)
AT (7) AT328100B (de)
BE (1) BE801271A (de)
CH (7) CH585753A5 (de)
DE (1) DE2230154A1 (de)
DK (1) DK141629C (de)
ES (3) ES416106A1 (de)
FI (1) FI57261C (de)
FR (1) FR2189066B1 (de)
GB (1) GB1431385A (de)
NL (1) NL7308555A (de)
NO (1) NO139050C (de)
SE (1) SE412235B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4232026A (en) * 1978-07-20 1980-11-04 Merck & Co., Inc. Diazaditwistanes, and pharmaceutical compositions for treating pain in warm blooded animals containing them
JPS60119848A (ja) * 1983-11-30 1985-06-27 三井建設株式会社 繊維補強コンクリ−ト並びにその施工法
JPS62298530A (ja) * 1986-06-16 1987-12-25 Otsuka Pharmaceut Co Ltd 坐薬用医薬組成物
CN1233645C (zh) * 2001-09-14 2005-12-28 中国人民解放军军事医学科学院毒物药物研究所 新的东罂粟碱衍生物及其医药用途
CN1939920B (zh) * 2005-09-29 2011-08-31 中国人民解放军军事医学科学院毒物药物研究所 东罂粟碱类化合物及其医药用途
US8530494B2 (en) 2008-07-30 2013-09-10 Purdue Pharma Lp Buprenophine analogs
JP2021104932A (ja) * 2018-03-30 2021-07-26 日本ケミファ株式会社 モルヒナン誘導体の製造方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3474101A (en) * 1960-09-05 1969-10-21 Reckitt & Sons Ltd Thebaine and oripavine derivatives
US3285914A (en) * 1964-06-11 1966-11-15 Smith Kline French Lab 3-n-substituted derivatives of oripavine and thebaine
GB1136764A (en) * 1965-08-13 1968-12-18 Reckitt & Sons Ltd Derivatives of thebaine and oripavine
GB1146272A (en) * 1966-01-17 1969-03-26 Reckitt & Sons Ltd Novel thebaine and oripavine derivatives
GB1223445A (en) * 1968-07-18 1971-02-24 Reckitt & Colmann Prod Ltd Improvements in or relating to derivatives of morphine, their salts, and processes for their preparation
DE2107989A1 (de) * 1971-02-19 1972-09-07 Boehringer Sohn Ingelheim N-(Furyl-methy])-morphinane, deren Säureadditionssalze sowie Verfahren zu deren Herstellung

Also Published As

Publication number Publication date
ATA461874A (de) 1975-05-15
ES416106A1 (es) 1976-02-16
JPS5614673B2 (de) 1981-04-06
NO139050C (no) 1979-01-03
AT329198B (de) 1976-04-26
NO139050B (no) 1978-09-18
AT328098B (de) 1976-03-10
ES425015A1 (es) 1976-07-01
CH594672A5 (de) 1978-01-13
ATA462174A (de) 1975-05-15
AT328101B (de) 1976-03-10
GB1431385A (en) 1976-04-07
AU5721173A (en) 1975-01-09
CH586224A5 (de) 1977-03-31
ATA462374A (de) 1975-07-15
AT325219B (de) 1975-10-10
BE801271A (fr) 1973-12-21
AT328100B (de) 1976-03-10
ATA462074A (de) 1975-05-15
CH585751A5 (de) 1977-03-15
AT327409B (de) 1976-01-26
CH594673A5 (de) 1978-01-13
ATA461974A (de) 1975-05-15
NL7308555A (de) 1973-12-27
DE2230154A1 (de) 1974-01-17
FR2189066A1 (de) 1974-01-25
AT328099B (de) 1976-03-10
DK141629B (da) 1980-05-12
DK141629C (da) 1980-09-29
CH587264A5 (de) 1977-04-29
ES425010A1 (es) 1976-06-16
FI57261B (fi) 1980-03-31
US3931189A (en) 1976-01-06
CH585753A5 (de) 1977-03-15
JPS4954390A (de) 1974-05-27
FR2189066B1 (de) 1976-12-31
CH585752A5 (de) 1977-03-15
SE412235B (sv) 1980-02-25
ATA462274A (de) 1975-04-15

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