AT328099B - Verfahren zur herstellung von neuen n-(heteroarylmethyl)-6,14-endoatheno-7alpha-hydroxyalkyl-tetrahydro-nororipavinen und -thebainen - Google Patents

Verfahren zur herstellung von neuen n-(heteroarylmethyl)-6,14-endoatheno-7alpha-hydroxyalkyl-tetrahydro-nororipavinen und -thebainen

Info

Publication number
AT328099B
AT328099B AT461974*7A AT461974A AT328099B AT 328099 B AT328099 B AT 328099B AT 461974 A AT461974 A AT 461974A AT 328099 B AT328099 B AT 328099B
Authority
AT
Austria
Prior art keywords
nororipavines
endoatheno
thebaines
7alpha
heteroarylmethyl
Prior art date
Application number
AT461974*7A
Other languages
English (en)
Other versions
ATA461974A (de
Original Assignee
Boehringer Sohn Ingelheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim
Publication of ATA461974A publication Critical patent/ATA461974A/de
Application granted granted Critical
Publication of AT328099B publication Critical patent/AT328099B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
    • C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
AT461974*7A 1972-06-21 1973-06-06 Verfahren zur herstellung von neuen n-(heteroarylmethyl)-6,14-endoatheno-7alpha-hydroxyalkyl-tetrahydro-nororipavinen und -thebainen AT328099B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2230154A DE2230154A1 (de) 1972-06-21 1972-06-21 N-(heteroaryl-methyl)-6,14-endoaetheno7alpha-hydroxyalkyl-tetrahydro-nororipavine und -thebaine, deren hydrierungsprodukte und saeureadditionssalze sowie verfahren zu deren herstellung

Publications (2)

Publication Number Publication Date
ATA461974A ATA461974A (de) 1975-05-15
AT328099B true AT328099B (de) 1976-03-10

Family

ID=5848276

Family Applications (7)

Application Number Title Priority Date Filing Date
AT462174*7A AT328101B (de) 1972-06-21 1973-06-06 Verfahren zur herstellung von neuen n-(heteroarylmethyl)-6,14-endoatheno-7alpha-hydroxyalkyl-tetrahydro-nororipavinen und -thebainen
AT462274*7A AT327409B (de) 1972-06-21 1973-06-06 Verfahren zur herstellung von neuen n-(heteroarylmethyl)-6,14-endoatheno-7alfa-hydroxyalkyltetrahydro-nororipavinen und -thebainen
AT494473A AT325219B (de) 1972-06-21 1973-06-06 Verfahren zur herstellung von neuen n-(heteroaryl-methyl)-6, 14-endoätheno-7alpha-hydroxyalkyltetrahydro-nororipavinen und -thebainen
AT462074*7A AT328100B (de) 1972-06-21 1973-06-06 Verfahren zur herstellung von neuen n-(heteroarylmethyl)-6,14-endoatheno-7alpha-hydroxyalkyl-tetrahydro-northebainen
AT461974*7A AT328099B (de) 1972-06-21 1973-06-06 Verfahren zur herstellung von neuen n-(heteroarylmethyl)-6,14-endoatheno-7alpha-hydroxyalkyl-tetrahydro-nororipavinen und -thebainen
AT462374*7A AT329198B (de) 1972-06-21 1973-06-06 Verfahren zur herstellung von neuen n-(heteroaryl-methyl)-6,14-endoatheno-7alfa-hydroxyalkyl-tetrahydro-nororipavinen und -thebainen
AT461874*7A AT328098B (de) 1972-06-21 1973-06-06 Verfahren zur herstellung von neuen n-(heteroarylmethyl)-6,14-endoatheno-7alpha-hydroxyalkyl-tetrahydro-nororipavinen und -thebainen

Family Applications Before (4)

Application Number Title Priority Date Filing Date
AT462174*7A AT328101B (de) 1972-06-21 1973-06-06 Verfahren zur herstellung von neuen n-(heteroarylmethyl)-6,14-endoatheno-7alpha-hydroxyalkyl-tetrahydro-nororipavinen und -thebainen
AT462274*7A AT327409B (de) 1972-06-21 1973-06-06 Verfahren zur herstellung von neuen n-(heteroarylmethyl)-6,14-endoatheno-7alfa-hydroxyalkyltetrahydro-nororipavinen und -thebainen
AT494473A AT325219B (de) 1972-06-21 1973-06-06 Verfahren zur herstellung von neuen n-(heteroaryl-methyl)-6, 14-endoätheno-7alpha-hydroxyalkyltetrahydro-nororipavinen und -thebainen
AT462074*7A AT328100B (de) 1972-06-21 1973-06-06 Verfahren zur herstellung von neuen n-(heteroarylmethyl)-6,14-endoatheno-7alpha-hydroxyalkyl-tetrahydro-northebainen

Family Applications After (2)

Application Number Title Priority Date Filing Date
AT462374*7A AT329198B (de) 1972-06-21 1973-06-06 Verfahren zur herstellung von neuen n-(heteroaryl-methyl)-6,14-endoatheno-7alfa-hydroxyalkyl-tetrahydro-nororipavinen und -thebainen
AT461874*7A AT328098B (de) 1972-06-21 1973-06-06 Verfahren zur herstellung von neuen n-(heteroarylmethyl)-6,14-endoatheno-7alpha-hydroxyalkyl-tetrahydro-nororipavinen und -thebainen

Country Status (14)

Country Link
US (1) US3931189A (de)
JP (1) JPS5614673B2 (de)
AT (7) AT328101B (de)
BE (1) BE801271A (de)
CH (7) CH585753A5 (de)
DE (1) DE2230154A1 (de)
DK (1) DK141629C (de)
ES (3) ES416106A1 (de)
FI (1) FI57261C (de)
FR (1) FR2189066B1 (de)
GB (1) GB1431385A (de)
NL (1) NL7308555A (de)
NO (1) NO139050C (de)
SE (1) SE412235B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4232026A (en) * 1978-07-20 1980-11-04 Merck & Co., Inc. Diazaditwistanes, and pharmaceutical compositions for treating pain in warm blooded animals containing them
JPS60119848A (ja) * 1983-11-30 1985-06-27 三井建設株式会社 繊維補強コンクリ−ト並びにその施工法
JPS62298530A (ja) * 1986-06-16 1987-12-25 Otsuka Pharmaceut Co Ltd 坐薬用医薬組成物
CN1233645C (zh) * 2001-09-14 2005-12-28 中国人民解放军军事医学科学院毒物药物研究所 新的东罂粟碱衍生物及其医药用途
CN1939920B (zh) * 2005-09-29 2011-08-31 中国人民解放军军事医学科学院毒物药物研究所 东罂粟碱类化合物及其医药用途
KR101343395B1 (ko) 2008-07-30 2013-12-19 퍼듀 퍼머 엘피 부프레노르핀 유사체
JP2021104932A (ja) * 2018-03-30 2021-07-26 日本ケミファ株式会社 モルヒナン誘導体の製造方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3474101A (en) * 1960-09-05 1969-10-21 Reckitt & Sons Ltd Thebaine and oripavine derivatives
US3285914A (en) * 1964-06-11 1966-11-15 Smith Kline French Lab 3-n-substituted derivatives of oripavine and thebaine
GB1136764A (en) * 1965-08-13 1968-12-18 Reckitt & Sons Ltd Derivatives of thebaine and oripavine
GB1146272A (en) * 1966-01-17 1969-03-26 Reckitt & Sons Ltd Novel thebaine and oripavine derivatives
GB1223445A (en) * 1968-07-18 1971-02-24 Reckitt & Colmann Prod Ltd Improvements in or relating to derivatives of morphine, their salts, and processes for their preparation
DE2107989A1 (de) * 1971-02-19 1972-09-07 Boehringer Sohn Ingelheim N-(Furyl-methy])-morphinane, deren Säureadditionssalze sowie Verfahren zu deren Herstellung

Also Published As

Publication number Publication date
FI57261B (fi) 1980-03-31
ES425015A1 (es) 1976-07-01
AT327409B (de) 1976-01-26
ATA461874A (de) 1975-05-15
FR2189066B1 (de) 1976-12-31
JPS5614673B2 (de) 1981-04-06
AT325219B (de) 1975-10-10
BE801271A (fr) 1973-12-21
DE2230154A1 (de) 1974-01-17
ATA462174A (de) 1975-05-15
ATA461974A (de) 1975-05-15
CH585753A5 (de) 1977-03-15
NO139050B (no) 1978-09-18
ATA462374A (de) 1975-07-15
CH586224A5 (de) 1977-03-31
FR2189066A1 (de) 1974-01-25
ATA462274A (de) 1975-04-15
CH594672A5 (de) 1978-01-13
AT329198B (de) 1976-04-26
DK141629C (da) 1980-09-29
US3931189A (en) 1976-01-06
FI57261C (fi) 1980-07-10
AU5721173A (en) 1975-01-09
GB1431385A (en) 1976-04-07
CH585751A5 (de) 1977-03-15
ES416106A1 (es) 1976-02-16
ATA462074A (de) 1975-05-15
CH587264A5 (de) 1977-04-29
NL7308555A (de) 1973-12-27
AT328098B (de) 1976-03-10
JPS4954390A (de) 1974-05-27
DK141629B (da) 1980-05-12
NO139050C (no) 1979-01-03
CH594673A5 (de) 1978-01-13
AT328100B (de) 1976-03-10
CH585752A5 (de) 1977-03-15
SE412235B (sv) 1980-02-25
AT328101B (de) 1976-03-10
ES425010A1 (es) 1976-06-16

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Legal Events

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ELJ Ceased due to non-payment of the annual fee