GB1223445A - Improvements in or relating to derivatives of morphine, their salts, and processes for their preparation - Google Patents
Improvements in or relating to derivatives of morphine, their salts, and processes for their preparationInfo
- Publication number
- GB1223445A GB1223445A GB3437268A GB3437268A GB1223445A GB 1223445 A GB1223445 A GB 1223445A GB 3437268 A GB3437268 A GB 3437268A GB 3437268 A GB3437268 A GB 3437268A GB 1223445 A GB1223445 A GB 1223445A
- Authority
- GB
- United Kingdom
- Prior art keywords
- group
- formula
- salts
- och
- july
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1,223,445. Morphine derivatives. RECKITT & COLEMAN PRODUCTS Ltd. 8 July, 1969 [18 July, 1968], No. 34372/68. Heading C2C. Novel compounds of the formula and their salts, wherein R represents H or CH 3 , R<SP>1</SP> represents a C 2-5 alkenyl group or a C 1-5 alkyl group which may be substituted on carbon atoms numbered 1 to 4 by aryl, benzoyl, pyridyl, furyl, thienyl or a C 3-6 cycloalkyl group, R<SP>2</SP> is H, -OH or -OCOCH 3 , R<SP>3</SP> is -OH, -OCH 3 , -OC 2 H 5 or -OC 3 H 7 , R<SP>4</SP> is H, -OCH 3 , -OC 2 H 5 or -OC 3 H 7 , or R<SP>3</SP> and R<SP>4</SP> together denote an oxo group ( = O ), an ethylenedioxy or a propylenedioxy group, may be obtained by dehydrogenating a compound of formula e.g. by heating in aqueous acetic acid with mercuric oxide or mercuric acetate. Pharmaceutical compositions having analgesic, sedative and antitussive actions comprise a compound of Formula I above or a pharmaceutically acceptable salt thereof and a carrier.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB3437268A GB1223445A (en) | 1968-07-18 | 1968-07-18 | Improvements in or relating to derivatives of morphine, their salts, and processes for their preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB3437268A GB1223445A (en) | 1968-07-18 | 1968-07-18 | Improvements in or relating to derivatives of morphine, their salts, and processes for their preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1223445A true GB1223445A (en) | 1971-02-24 |
Family
ID=10364834
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB3437268A Expired GB1223445A (en) | 1968-07-18 | 1968-07-18 | Improvements in or relating to derivatives of morphine, their salts, and processes for their preparation |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB1223445A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3931187A (en) * | 1972-06-19 | 1976-01-06 | Boehringer Ingelheim Gmbh | N-(heteroaryl-methyl)-7α-acyl-6,14-(endoetheno or endoethano)-tetrahydro-nororipavines or-thebaines and salts thereof |
US3931189A (en) * | 1972-06-21 | 1976-01-06 | Boehringer Ingelheim Gmbh | N-(heteroaryl-methyl)-6,14-(endoethano or endoetheno)-7α-hydroxyalkyl-tetrahydro-nororipavines or-northebaines and salts thereof |
-
1968
- 1968-07-18 GB GB3437268A patent/GB1223445A/en not_active Expired
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3931187A (en) * | 1972-06-19 | 1976-01-06 | Boehringer Ingelheim Gmbh | N-(heteroaryl-methyl)-7α-acyl-6,14-(endoetheno or endoethano)-tetrahydro-nororipavines or-thebaines and salts thereof |
US3931189A (en) * | 1972-06-21 | 1976-01-06 | Boehringer Ingelheim Gmbh | N-(heteroaryl-methyl)-6,14-(endoethano or endoetheno)-7α-hydroxyalkyl-tetrahydro-nororipavines or-northebaines and salts thereof |
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