FI4225297T3 - Yhdistelmälääkehoito syövän hoidossa - Google Patents
Yhdistelmälääkehoito syövän hoidossa Download PDFInfo
- Publication number
- FI4225297T3 FI4225297T3 FIEP21794474.3T FI21794474T FI4225297T3 FI 4225297 T3 FI4225297 T3 FI 4225297T3 FI 21794474 T FI21794474 T FI 21794474T FI 4225297 T3 FI4225297 T3 FI 4225297T3
- Authority
- FI
- Finland
- Prior art keywords
- pharmaceutically acceptable
- cancer
- compound
- acceptable salt
- azd5305
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title claims 7
- 201000011510 cancer Diseases 0.000 title claims 7
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 150000003839 salts Chemical class 0.000 claims 11
- 230000000973 chemotherapeutic effect Effects 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 8
- 150000003058 platinum compounds Chemical class 0.000 claims 8
- WQAVGRAETZEADU-UHFFFAOYSA-N 5-[4-[(7-ethyl-6-oxo-5H-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl]-N-methylpyridine-2-carboxamide Chemical compound C(C)C=1C(NC=2C=C(C=NC=2C=1)CN1CCN(CC1)C=1C=CC(=NC=1)C(=O)NC)=O WQAVGRAETZEADU-UHFFFAOYSA-N 0.000 claims 7
- 229940126195 AZD5305 Drugs 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- VSRXQHXAPYXROS-UHFFFAOYSA-N azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+) Chemical compound [NH2-].[NH2-].[Pt+2].OC(=O)C1(C(O)=O)CCC1 VSRXQHXAPYXROS-UHFFFAOYSA-N 0.000 claims 3
- 229960004562 carboplatin Drugs 0.000 claims 3
- 239000000825 pharmaceutical preparation Substances 0.000 claims 3
- 102000000872 ATM Human genes 0.000 claims 2
- 108010004586 Ataxia Telangiectasia Mutated Proteins Proteins 0.000 claims 2
- 108700020462 BRCA2 Proteins 0.000 claims 2
- 102000052609 BRCA2 Human genes 0.000 claims 2
- 101150008921 Brca2 gene Proteins 0.000 claims 2
- 239000002552 dosage form Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- -1 BARD11 Proteins 0.000 claims 1
- 108700020463 BRCA1 Proteins 0.000 claims 1
- 102000036365 BRCA1 Human genes 0.000 claims 1
- 101150072950 BRCA1 gene Proteins 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 102100038111 Cyclin-dependent kinase 12 Human genes 0.000 claims 1
- 102100033934 DNA repair protein RAD51 homolog 2 Human genes 0.000 claims 1
- 102100034484 DNA repair protein RAD51 homolog 3 Human genes 0.000 claims 1
- 102100034483 DNA repair protein RAD51 homolog 4 Human genes 0.000 claims 1
- 102100034546 E3 ubiquitin-protein ligase FANCL Human genes 0.000 claims 1
- 108700026162 Fanconi Anemia Complementation Group L protein Proteins 0.000 claims 1
- 108010067741 Fanconi Anemia Complementation Group N protein Proteins 0.000 claims 1
- 102000016627 Fanconi Anemia Complementation Group N protein Human genes 0.000 claims 1
- 102100034553 Fanconi anemia group J protein Human genes 0.000 claims 1
- 206010017993 Gastrointestinal neoplasms Diseases 0.000 claims 1
- 101000884345 Homo sapiens Cyclin-dependent kinase 12 Proteins 0.000 claims 1
- 101000712511 Homo sapiens DNA repair and recombination protein RAD54-like Proteins 0.000 claims 1
- 101001132271 Homo sapiens DNA repair protein RAD51 homolog 3 Proteins 0.000 claims 1
- 101001132266 Homo sapiens DNA repair protein RAD51 homolog 4 Proteins 0.000 claims 1
- 101100119754 Homo sapiens FANCL gene Proteins 0.000 claims 1
- 101000848171 Homo sapiens Fanconi anemia group J protein Proteins 0.000 claims 1
- 101000777293 Homo sapiens Serine/threonine-protein kinase Chk1 Proteins 0.000 claims 1
- 101000777277 Homo sapiens Serine/threonine-protein kinase Chk2 Proteins 0.000 claims 1
- 101000802948 Homo sapiens Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform Proteins 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 101710018890 RAD51B Proteins 0.000 claims 1
- 102100031081 Serine/threonine-protein kinase Chk1 Human genes 0.000 claims 1
- 102100031075 Serine/threonine-protein kinase Chk2 Human genes 0.000 claims 1
- 102100035728 Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform Human genes 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 102100023931 Transcriptional regulator ATRX Human genes 0.000 claims 1
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims 1
- 229960004316 cisplatin Drugs 0.000 claims 1
- 230000002950 deficient Effects 0.000 claims 1
- 239000012458 free base Substances 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 230000002489 hematologic effect Effects 0.000 claims 1
- 230000006801 homologous recombination Effects 0.000 claims 1
- 238000002744 homologous recombination Methods 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 claims 1
- 229960001756 oxaliplatin Drugs 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/282—Platinum compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063089195P | 2020-10-08 | 2020-10-08 | |
| PCT/EP2021/077703 WO2022074124A1 (en) | 2020-10-08 | 2021-10-07 | Combination therapy for treating cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FI4225297T3 true FI4225297T3 (fi) | 2024-12-10 |
Family
ID=78293953
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FIEP21794474.3T FI4225297T3 (fi) | 2020-10-08 | 2021-10-07 | Yhdistelmälääkehoito syövän hoidossa |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20230372333A1 (https=) |
| EP (1) | EP4225297B1 (https=) |
| JP (1) | JP7818585B2 (https=) |
| KR (1) | KR20230083291A (https=) |
| CN (1) | CN116194110B (https=) |
| AU (1) | AU2021356123B2 (https=) |
| BR (1) | BR112023005160A2 (https=) |
| CA (1) | CA3197056A1 (https=) |
| DK (1) | DK4225297T3 (https=) |
| ES (1) | ES3005507T3 (https=) |
| FI (1) | FI4225297T3 (https=) |
| HU (1) | HUE069249T2 (https=) |
| IL (1) | IL301687A (https=) |
| MX (1) | MX2023004156A (https=) |
| PL (1) | PL4225297T3 (https=) |
| PT (1) | PT4225297T (https=) |
| TW (1) | TW202228693A (https=) |
| WO (1) | WO2022074124A1 (https=) |
| ZA (1) | ZA202304965B (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115702156A (zh) * | 2021-04-23 | 2023-02-14 | 南京明德新药研发有限公司 | 吡啶酰胺类化合物 |
| CN118119618A (zh) * | 2021-09-09 | 2024-05-31 | 南京奥利墨斯医药科技有限公司 | 一种杂芳环类化合物及其应用 |
| US20230250428A1 (en) * | 2022-02-07 | 2023-08-10 | Alliance Of Cardiovascular Researchers | Method and composition for early detection of malignancies |
| IL316019A (en) * | 2022-04-07 | 2024-11-01 | Astrazeneca Ab | Combined treatment for cancer |
| CN118973572A (zh) * | 2022-04-07 | 2024-11-15 | 阿斯利康(瑞典)有限公司 | 用于治疗癌症的组合疗法 |
| CN121464135A (zh) * | 2023-07-07 | 2026-02-03 | 优领医药科技(香港)有限公司 | 含哌嗪并环类衍生物的晶型、其盐型、其制备方法及应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015184145A1 (en) * | 2014-05-28 | 2015-12-03 | Eisai R&D Management Co., Ltd. | Use of eribulin and poly (adp ribose) polymerase (parp) inhibitors as combination therapy for the treatment of cancer |
| SI3999506T1 (sl) * | 2019-07-19 | 2025-06-30 | Astrazeneca Ab | Zaviralci PARP1 |
-
2021
- 2021-10-06 TW TW110137116A patent/TW202228693A/zh unknown
- 2021-10-07 ES ES21794474T patent/ES3005507T3/es active Active
- 2021-10-07 DK DK21794474.3T patent/DK4225297T3/da active
- 2021-10-07 US US18/248,108 patent/US20230372333A1/en active Pending
- 2021-10-07 EP EP21794474.3A patent/EP4225297B1/en active Active
- 2021-10-07 KR KR1020237013320A patent/KR20230083291A/ko active Pending
- 2021-10-07 CN CN202180065599.5A patent/CN116194110B/zh active Active
- 2021-10-07 WO PCT/EP2021/077703 patent/WO2022074124A1/en not_active Ceased
- 2021-10-07 PT PT217944743T patent/PT4225297T/pt unknown
- 2021-10-07 MX MX2023004156A patent/MX2023004156A/es unknown
- 2021-10-07 CA CA3197056A patent/CA3197056A1/en active Pending
- 2021-10-07 JP JP2023521357A patent/JP7818585B2/ja active Active
- 2021-10-07 BR BR112023005160A patent/BR112023005160A2/pt unknown
- 2021-10-07 AU AU2021356123A patent/AU2021356123B2/en active Active
- 2021-10-07 IL IL301687A patent/IL301687A/en unknown
- 2021-10-07 HU HUE21794474A patent/HUE069249T2/hu unknown
- 2021-10-07 FI FIEP21794474.3T patent/FI4225297T3/fi active
- 2021-10-07 PL PL21794474.3T patent/PL4225297T3/pl unknown
-
2023
- 2023-05-04 ZA ZA2023/04965A patent/ZA202304965B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA202304965B (en) | 2024-09-25 |
| HUE069249T2 (hu) | 2025-02-28 |
| JP7818585B2 (ja) | 2026-02-20 |
| EP4225297A1 (en) | 2023-08-16 |
| CA3197056A1 (en) | 2022-04-14 |
| BR112023005160A2 (pt) | 2023-04-18 |
| MX2023004156A (es) | 2023-05-03 |
| CN116194110B (zh) | 2025-06-17 |
| DK4225297T3 (da) | 2025-01-02 |
| ES3005507T3 (en) | 2025-03-14 |
| AU2021356123A1 (en) | 2023-06-08 |
| PL4225297T3 (pl) | 2025-03-17 |
| TW202228693A (zh) | 2022-08-01 |
| KR20230083291A (ko) | 2023-06-09 |
| PT4225297T (pt) | 2024-12-30 |
| AU2021356123B2 (en) | 2025-01-09 |
| WO2022074124A1 (en) | 2022-04-14 |
| IL301687A (en) | 2023-05-01 |
| EP4225297B1 (en) | 2024-10-23 |
| JP2023546362A (ja) | 2023-11-02 |
| CN116194110A (zh) | 2023-05-30 |
| US20230372333A1 (en) | 2023-11-23 |
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