FI3866778T3 - Influenssa viruksen replikaation estäjien yhdistelmät - Google Patents
Influenssa viruksen replikaation estäjien yhdistelmät Download PDFInfo
- Publication number
- FI3866778T3 FI3866778T3 FIEP19801437.5T FI19801437T FI3866778T3 FI 3866778 T3 FI3866778 T3 FI 3866778T3 FI 19801437 T FI19801437 T FI 19801437T FI 3866778 T3 FI3866778 T3 FI 3866778T3
- Authority
- FI
- Finland
- Prior art keywords
- combination
- pharmaceutically acceptable
- solvate
- acceptable salt
- antiviral agent
- Prior art date
Links
- 241000712461 unidentified influenza virus Species 0.000 title claims 4
- 239000003112 inhibitor Substances 0.000 title 1
- 230000029812 viral genome replication Effects 0.000 title 1
- 150000003839 salts Chemical class 0.000 claims 12
- 239000012453 solvate Substances 0.000 claims 12
- 239000003443 antiviral agent Substances 0.000 claims 9
- 229940123424 Neuraminidase inhibitor Drugs 0.000 claims 7
- 239000002911 sialidase inhibitor Substances 0.000 claims 7
- 239000002253 acid Substances 0.000 claims 4
- VSZGPKBBMSAYNT-RRFJBIMHSA-N oseltamivir Chemical group CCOC(=O)C1=C[C@@H](OC(CC)CC)[C@H](NC(C)=O)[C@@H](N)C1 VSZGPKBBMSAYNT-RRFJBIMHSA-N 0.000 claims 4
- 229960003752 oseltamivir Drugs 0.000 claims 4
- FIDLLEYNNRGVFR-CTNGQTDRSA-N (3R)-2-[(11S)-7,8-difluoro-6,11-dihydrobenzo[c][1]benzothiepin-11-yl]-11-hydroxy-5-oxa-1,2,8-triazatricyclo[8.4.0.03,8]tetradeca-10,13-diene-9,12-dione Chemical compound OC1=C2N(C=CC1=O)N([C@@H]1COCCN1C2=O)[C@@H]1C2=C(SCC3=C1C=CC(F)=C3F)C=CC=C2 FIDLLEYNNRGVFR-CTNGQTDRSA-N 0.000 claims 3
- ZTXPZSNWEBDRSK-UHFFFAOYSA-N 3-[2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrrolo[2,3-d]pyrimidin-7-yl]bicyclo[2.2.2]octane-2-carboxylic acid Chemical compound ClC=1C=C2C(=NC=1)NC=C2C=1N=CC2=C(N=1)N(C=C2F)C1C(C2CCC1CC2)C(=O)O ZTXPZSNWEBDRSK-UHFFFAOYSA-N 0.000 claims 2
- QNRRHYPPQFELSF-CNYIRLTGSA-N Laninamivir Chemical compound OC[C@@H](O)[C@@H](OC)[C@@H]1OC(C(O)=O)=C[C@H](N=C(N)N)[C@H]1NC(C)=O QNRRHYPPQFELSF-CNYIRLTGSA-N 0.000 claims 2
- PNKGHXVHKCJNBW-UHFFFAOYSA-N bicyclo[2.2.2]octane-3-carboxylic acid Chemical compound C1CC2C(C(=O)O)CC1CC2 PNKGHXVHKCJNBW-UHFFFAOYSA-N 0.000 claims 2
- ZCGNOVWYSGBHAU-UHFFFAOYSA-N favipiravir Chemical compound NC(=O)C1=NC(F)=CNC1=O ZCGNOVWYSGBHAU-UHFFFAOYSA-N 0.000 claims 2
- 229950008454 favipiravir Drugs 0.000 claims 2
- 229960003971 influenza vaccine Drugs 0.000 claims 2
- 229950004244 laninamivir Drugs 0.000 claims 2
- XRQDFNLINLXZLB-CKIKVBCHSA-N peramivir Chemical compound CCC(CC)[C@H](NC(C)=O)[C@@H]1[C@H](O)[C@@H](C(O)=O)C[C@H]1NC(N)=N XRQDFNLINLXZLB-CKIKVBCHSA-N 0.000 claims 2
- 229960001084 peramivir Drugs 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 229960001028 zanamivir Drugs 0.000 claims 2
- ARAIBEBZBOPLMB-UFGQHTETSA-N zanamivir Chemical compound CC(=O)N[C@@H]1[C@@H](N=C(N)N)C=C(C(O)=O)O[C@H]1[C@H](O)[C@H](O)CO ARAIBEBZBOPLMB-UFGQHTETSA-N 0.000 claims 2
- 229940123734 Endonuclease inhibitor Drugs 0.000 claims 1
- 229940123066 Polymerase inhibitor Drugs 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 208000037797 influenza A Diseases 0.000 claims 1
- 208000037798 influenza B Diseases 0.000 claims 1
- 230000001932 seasonal effect Effects 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Pulmonology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862746884P | 2018-10-17 | 2018-10-17 | |
| PCT/US2019/056632 WO2020081751A1 (en) | 2018-10-17 | 2019-10-17 | Combinations of inhibitors of influenza virus replication |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FI3866778T3 true FI3866778T3 (fi) | 2023-03-21 |
Family
ID=68503202
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FIEP19801437.5T FI3866778T3 (fi) | 2018-10-17 | 2019-10-17 | Influenssa viruksen replikaation estäjien yhdistelmät |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US12233066B2 (https=) |
| EP (1) | EP3866778B1 (https=) |
| JP (1) | JP7577652B2 (https=) |
| KR (1) | KR102890706B1 (https=) |
| CN (1) | CN112969457B (https=) |
| AU (1) | AU2019361038B2 (https=) |
| BR (1) | BR112021007275A2 (https=) |
| CA (1) | CA3115823A1 (https=) |
| DK (1) | DK3866778T3 (https=) |
| ES (1) | ES2939148T3 (https=) |
| FI (1) | FI3866778T3 (https=) |
| IL (1) | IL282018B2 (https=) |
| MX (1) | MX2021004215A (https=) |
| PL (1) | PL3866778T3 (https=) |
| PT (1) | PT3866778T (https=) |
| TW (1) | TWI829785B (https=) |
| WO (1) | WO2020081751A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20230158020A1 (en) * | 2020-05-23 | 2023-05-25 | Alexandre Vasilievich Ivaschenko | Method for treating RNA viral infections, including COVID-19 (SARS-CoV-2) |
| WO2022074630A1 (en) * | 2020-10-09 | 2022-04-14 | Auxilla Pharmaceuticals And Research Llp | Liquid oral suspension of favipiravir |
| CN113413365B (zh) * | 2021-07-30 | 2022-11-22 | 合肥医工医药股份有限公司 | 一种稳定的法维拉韦口服溶液制剂及其制备方法 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4180646A (en) | 1975-01-28 | 1979-12-25 | Alza Corporation | Novel orthoester polymers and orthocarbonate polymers |
| US4093709A (en) | 1975-01-28 | 1978-06-06 | Alza Corporation | Drug delivery devices manufactured from poly(orthoesters) and poly(orthocarbonates) |
| US4131648A (en) | 1975-01-28 | 1978-12-26 | Alza Corporation | Structured orthoester and orthocarbonate drug delivery devices |
| US4079038A (en) | 1976-03-05 | 1978-03-14 | Alza Corporation | Poly(carbonates) |
| GB2064336B (en) | 1979-12-06 | 1984-03-14 | Glaxo Group Ltd | Device for dispensing medicaments |
| US4304767A (en) | 1980-05-15 | 1981-12-08 | Sri International | Polymers of di- (and higher functionality) ketene acetals and polyols |
| US4353656A (en) | 1980-10-14 | 1982-10-12 | Xerox Corporation | Moving coil, multiple energy print hammer system including a closed loop servo |
| DE3274065D1 (de) | 1981-07-08 | 1986-12-11 | Draco Ab | Powder inhalator |
| GB2169265B (en) | 1982-10-08 | 1987-08-12 | Glaxo Group Ltd | Pack for medicament |
| US4778054A (en) | 1982-10-08 | 1988-10-18 | Glaxo Group Limited | Pack for administering medicaments to patients |
| GB2129691B (en) | 1982-10-08 | 1987-08-05 | Glaxo Group Ltd | Devices for administering medicaments to patients |
| US4501729A (en) | 1982-12-13 | 1985-02-26 | Research Corporation | Aerosolized amiloride treatment of retained pulmonary secretions |
| US4753788A (en) | 1985-01-31 | 1988-06-28 | Vestar Research Inc. | Method for preparing small vesicles using microemulsification |
| AU591152B2 (en) | 1985-07-30 | 1989-11-30 | Glaxo Group Limited | Devices for administering medicaments to patients |
| US4946931A (en) | 1989-06-14 | 1990-08-07 | Pharmaceutical Delivery Systems, Inc. | Polymers containing carboxy-ortho ester and ortho ester linkages |
| CA2070823C (en) | 1989-12-05 | 1999-01-12 | William H. Ii Frey | Neurologic agents for nasal administration to the brain |
| GB9004781D0 (en) | 1990-03-02 | 1990-04-25 | Glaxo Group Ltd | Device |
| US6413536B1 (en) | 1995-06-07 | 2002-07-02 | Southern Biosystems, Inc. | High viscosity liquid controlled delivery system and medical or surgical device |
| US5968543A (en) | 1996-01-05 | 1999-10-19 | Advanced Polymer Systems, Inc. | Polymers with controlled physical state and bioerodibility |
| US6956021B1 (en) | 1998-08-25 | 2005-10-18 | Advanced Inhalation Research, Inc. | Stable spray-dried protein formulations |
| AU6526100A (en) | 1999-08-06 | 2001-03-05 | Board Of Regents, The University Of Texas System | Drug releasing biodegradable fiber implant |
| US6749835B1 (en) | 1999-08-25 | 2004-06-15 | Advanced Inhalation Research, Inc. | Formulation for spray-drying large porous particles |
| US7678364B2 (en) | 1999-08-25 | 2010-03-16 | Alkermes, Inc. | Particles for inhalation having sustained release properties |
| US7252840B1 (en) | 1999-08-25 | 2007-08-07 | Advanced Inhalation Research, Inc. | Use of simple amino acids to form porous particles |
| US6632666B2 (en) | 2000-01-14 | 2003-10-14 | Biolife Solutions, Inc. | Normothermic, hypothermic and cryopreservation maintenance and storage of cells, tissues and organs in gel-based media |
| US6613355B2 (en) | 2000-05-11 | 2003-09-02 | A.P. Pharma, Inc. | Semi-solid delivery vehicle and pharmaceutical compositions |
| WO2002013897A2 (en) | 2000-08-14 | 2002-02-21 | Advanced Inhalation Research, Inc. | Inhalation device and method |
| JP2005504715A (ja) | 2000-12-29 | 2005-02-17 | アドバンスト インハレーション リサーチ，インコーポレイテッド | 持続放出特性を有する吸入用粒子 |
| US6766799B2 (en) | 2001-04-16 | 2004-07-27 | Advanced Inhalation Research, Inc. | Inhalation device |
| US6848197B2 (en) | 2001-04-18 | 2005-02-01 | Advanced Inhalation Research, Inc. | Control of process humidity to produce large, porous particles |
| US6524606B1 (en) | 2001-11-16 | 2003-02-25 | Ap Pharma, Inc. | Bioerodible polyorthoesters containing amine groups |
| AU2002352836B2 (en) | 2001-11-20 | 2005-09-29 | Alkermes, Inc. | Improved particulate compositions for pulmonary delivery |
| US7008644B2 (en) | 2002-03-20 | 2006-03-07 | Advanced Inhalation Research, Inc. | Method and apparatus for producing dry particles |
| EP1673123A2 (en) | 2003-09-05 | 2006-06-28 | Kurve Technology, Inc. | Integrated nebulizer and particle dispersing chamber for delivery of medicament |
| SG11201804348SA (en) | 2015-12-15 | 2018-06-28 | Shionogi & Co | Medicine for treating influenza characterized by comprising combination of cap-dependent endonuclease inhibitor with anti-influenza drug |
| CN108276401B (zh) * | 2017-01-05 | 2020-12-22 | 广东东阳光药业有限公司 | 流感病毒复制抑制剂及其用途 |
| WO2018157830A1 (en) * | 2017-03-02 | 2018-09-07 | Sunshine Lake Pharma Co., Ltd. | Inhibitors of influenza virus replication and uses thereof |
| TWI778052B (zh) * | 2017-04-24 | 2022-09-21 | 美商共結晶製藥公司 | 流感病毒複製之抑制劑 |
-
2019
- 2019-10-17 ES ES19801437T patent/ES2939148T3/es active Active
- 2019-10-17 CA CA3115823A patent/CA3115823A1/en active Pending
- 2019-10-17 BR BR112021007275-6A patent/BR112021007275A2/pt unknown
- 2019-10-17 FI FIEP19801437.5T patent/FI3866778T3/fi active
- 2019-10-17 AU AU2019361038A patent/AU2019361038B2/en active Active
- 2019-10-17 EP EP19801437.5A patent/EP3866778B1/en active Active
- 2019-10-17 IL IL282018A patent/IL282018B2/en unknown
- 2019-10-17 WO PCT/US2019/056632 patent/WO2020081751A1/en not_active Ceased
- 2019-10-17 CN CN201980073306.0A patent/CN112969457B/zh active Active
- 2019-10-17 KR KR1020217013515A patent/KR102890706B1/ko active Active
- 2019-10-17 JP JP2021521129A patent/JP7577652B2/ja active Active
- 2019-10-17 DK DK19801437.5T patent/DK3866778T3/da active
- 2019-10-17 PT PT198014375T patent/PT3866778T/pt unknown
- 2019-10-17 PL PL19801437.5T patent/PL3866778T3/pl unknown
- 2019-10-17 US US17/286,026 patent/US12233066B2/en active Active
- 2019-10-17 TW TW108137376A patent/TWI829785B/zh active
- 2019-10-17 MX MX2021004215A patent/MX2021004215A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2019361038B2 (en) | 2025-07-03 |
| KR102890706B1 (ko) | 2025-11-24 |
| EP3866778B1 (en) | 2022-11-30 |
| EP3866778A1 (en) | 2021-08-25 |
| KR20210080413A (ko) | 2021-06-30 |
| JP7577652B2 (ja) | 2024-11-05 |
| IL282018B1 (en) | 2025-02-01 |
| IL282018B2 (en) | 2025-06-01 |
| CA3115823A1 (en) | 2020-04-23 |
| US20210353629A1 (en) | 2021-11-18 |
| CN112969457B (zh) | 2025-10-28 |
| DK3866778T3 (da) | 2023-02-20 |
| TW202024090A (zh) | 2020-07-01 |
| AU2019361038A1 (en) | 2021-05-13 |
| US12233066B2 (en) | 2025-02-25 |
| MX2021004215A (es) | 2021-07-15 |
| WO2020081751A1 (en) | 2020-04-23 |
| IL282018A (en) | 2021-05-31 |
| TWI829785B (zh) | 2024-01-21 |
| BR112021007275A2 (pt) | 2021-07-20 |
| CN112969457A (zh) | 2021-06-15 |
| JP2022505183A (ja) | 2022-01-14 |
| PT3866778T (pt) | 2023-02-28 |
| PL3866778T3 (pl) | 2023-03-27 |
| ES2939148T3 (es) | 2023-04-19 |
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