CN112969457B - 流感病毒复制抑制剂的组合 - Google Patents

流感病毒复制抑制剂的组合

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Publication number
CN112969457B
CN112969457B CN201980073306.0A CN201980073306A CN112969457B CN 112969457 B CN112969457 B CN 112969457B CN 201980073306 A CN201980073306 A CN 201980073306A CN 112969457 B CN112969457 B CN 112969457B
Authority
CN
China
Prior art keywords
influenza
pharmaceutically acceptable
acceptable salt
pyrrolo
antiviral agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201980073306.0A
Other languages
English (en)
Chinese (zh)
Other versions
CN112969457A (zh
Inventor
伊里娜·C·雅各布森
林炳元
塞姆·斯科·李
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cocrystal Pharma Inc
Original Assignee
Cocrystal Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cocrystal Pharma Inc filed Critical Cocrystal Pharma Inc
Publication of CN112969457A publication Critical patent/CN112969457A/zh
Application granted granted Critical
Publication of CN112969457B publication Critical patent/CN112969457B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201980073306.0A 2018-10-17 2019-10-17 流感病毒复制抑制剂的组合 Active CN112969457B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862746884P 2018-10-17 2018-10-17
US62/746,884 2018-10-17
PCT/US2019/056632 WO2020081751A1 (en) 2018-10-17 2019-10-17 Combinations of inhibitors of influenza virus replication

Publications (2)

Publication Number Publication Date
CN112969457A CN112969457A (zh) 2021-06-15
CN112969457B true CN112969457B (zh) 2025-10-28

Family

ID=68503202

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980073306.0A Active CN112969457B (zh) 2018-10-17 2019-10-17 流感病毒复制抑制剂的组合

Country Status (17)

Country Link
US (1) US12233066B2 (https=)
EP (1) EP3866778B1 (https=)
JP (1) JP7577652B2 (https=)
KR (1) KR102890706B1 (https=)
CN (1) CN112969457B (https=)
AU (1) AU2019361038B2 (https=)
BR (1) BR112021007275A2 (https=)
CA (1) CA3115823A1 (https=)
DK (1) DK3866778T3 (https=)
ES (1) ES2939148T3 (https=)
FI (1) FI3866778T3 (https=)
IL (1) IL282018B2 (https=)
MX (1) MX2021004215A (https=)
PL (1) PL3866778T3 (https=)
PT (1) PT3866778T (https=)
TW (1) TWI829785B (https=)
WO (1) WO2020081751A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230158020A1 (en) * 2020-05-23 2023-05-25 Alexandre Vasilievich Ivaschenko Method for treating RNA viral infections, including COVID-19 (SARS-CoV-2)
WO2022074630A1 (en) * 2020-10-09 2022-04-14 Auxilla Pharmaceuticals And Research Llp Liquid oral suspension of favipiravir
CN113413365B (zh) * 2021-07-30 2022-11-22 合肥医工医药股份有限公司 一种稳定的法维拉韦口服溶液制剂及其制备方法

Citations (1)

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CN110637022A (zh) * 2017-04-24 2019-12-31 共晶制药公司 可作为流感病毒复制抑制剂的吡咯并嘧啶衍生物

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Also Published As

Publication number Publication date
AU2019361038B2 (en) 2025-07-03
KR102890706B1 (ko) 2025-11-24
FI3866778T3 (fi) 2023-03-21
EP3866778B1 (en) 2022-11-30
EP3866778A1 (en) 2021-08-25
KR20210080413A (ko) 2021-06-30
JP7577652B2 (ja) 2024-11-05
IL282018B1 (en) 2025-02-01
IL282018B2 (en) 2025-06-01
CA3115823A1 (en) 2020-04-23
US20210353629A1 (en) 2021-11-18
DK3866778T3 (da) 2023-02-20
TW202024090A (zh) 2020-07-01
AU2019361038A1 (en) 2021-05-13
US12233066B2 (en) 2025-02-25
MX2021004215A (es) 2021-07-15
WO2020081751A1 (en) 2020-04-23
IL282018A (en) 2021-05-31
TWI829785B (zh) 2024-01-21
BR112021007275A2 (pt) 2021-07-20
CN112969457A (zh) 2021-06-15
JP2022505183A (ja) 2022-01-14
PT3866778T (pt) 2023-02-28
PL3866778T3 (pl) 2023-03-27
ES2939148T3 (es) 2023-04-19

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