FI3662910T3 - Farmakofori trail:n indusoimiseksi - Google Patents
Farmakofori trail:n indusoimiseksi Download PDFInfo
- Publication number
- FI3662910T3 FI3662910T3 FIEP19218049.5T FI19218049T FI3662910T3 FI 3662910 T3 FI3662910 T3 FI 3662910T3 FI 19218049 T FI19218049 T FI 19218049T FI 3662910 T3 FI3662910 T3 FI 3662910T3
- Authority
- FI
- Finland
- Prior art keywords
- compound
- derived
- cell
- pharmaceutical composition
- leukemias
- Prior art date
Links
- 230000006698 induction Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 6
- WQDUMFSSJAZKTM-UHFFFAOYSA-N Sodium methoxide Chemical compound [Na+].[O-]C WQDUMFSSJAZKTM-UHFFFAOYSA-N 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 229940125782 compound 2 Drugs 0.000 claims 3
- 208000032839 leukemia Diseases 0.000 claims 3
- 206010025323 Lymphomas Diseases 0.000 claims 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 210000003719 b-lymphocyte Anatomy 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 238000010992 reflux Methods 0.000 claims 2
- VLULRUCCHYVXOH-UHFFFAOYSA-N 11-benzyl-7-[(2-methylphenyl)methyl]-2,5,7,11-tetrazatricyclo[7.4.0.02,6]trideca-1(9),5-dien-8-one Chemical compound CC1=CC=CC=C1CN1C(=O)C(CN(CC=2C=CC=CC=2)CC2)=C2N2CCN=C21 VLULRUCCHYVXOH-UHFFFAOYSA-N 0.000 claims 1
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010029260 Neuroblastoma Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 230000006907 apoptotic process Effects 0.000 claims 1
- 210000000481 breast Anatomy 0.000 claims 1
- 201000007455 central nervous system cancer Diseases 0.000 claims 1
- 208000025997 central nervous system neoplasm Diseases 0.000 claims 1
- 210000003679 cervix uteri Anatomy 0.000 claims 1
- 210000001072 colon Anatomy 0.000 claims 1
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 210000003128 head Anatomy 0.000 claims 1
- 210000003630 histaminocyte Anatomy 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 210000001616 monocyte Anatomy 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
- 210000003739 neck Anatomy 0.000 claims 1
- 230000002611 ovarian Effects 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461972689P | 2014-03-31 | 2014-03-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FI3662910T3 true FI3662910T3 (fi) | 2024-10-31 |
Family
ID=54241169
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FIEP19218049.5T FI3662910T3 (fi) | 2014-03-31 | 2015-03-30 | Farmakofori trail:n indusoimiseksi |
Country Status (20)
| Country | Link |
|---|---|
| US (5) | US10239877B2 (enExample) |
| EP (3) | EP3125898B1 (enExample) |
| JP (4) | JP6756435B2 (enExample) |
| KR (2) | KR102473930B1 (enExample) |
| CN (2) | CN111499636B (enExample) |
| AU (4) | AU2015241069B2 (enExample) |
| CA (2) | CA3158795A1 (enExample) |
| CY (1) | CY1123093T1 (enExample) |
| DK (2) | DK3662910T3 (enExample) |
| ES (2) | ES2999685T3 (enExample) |
| FI (1) | FI3662910T3 (enExample) |
| HR (2) | HRP20241680T1 (enExample) |
| HU (2) | HUE069651T2 (enExample) |
| LT (2) | LT3662910T (enExample) |
| PL (2) | PL3662910T3 (enExample) |
| PT (2) | PT3662910T (enExample) |
| RS (2) | RS60163B1 (enExample) |
| SI (2) | SI3662910T1 (enExample) |
| SM (2) | SMT202400497T1 (enExample) |
| WO (1) | WO2015153468A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9376437B2 (en) | 2013-03-13 | 2016-06-28 | Oncoceutics, Inc | 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one, salts thereof and methods of using the same in combination therapy |
| HUE044238T2 (hu) | 2013-03-13 | 2019-10-28 | Oncoceutics Inc | 7-benzil-10-(2-metilbenzil)-2,6,7,8,9,10-hexahidroimidazo[l,2-a]pirido[4,3-d]pirimidin-5(3h)-on rák kezelésénél történõ alkalmazásra |
| US9688679B2 (en) | 2013-03-13 | 2017-06-27 | Oncoceutics, Inc. | 7-benzyl-4-(methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-A]pyrido[3,4-E]pyrimidin-5 (1H)-one, salts thereof and methods of using the same in combination therapy |
| KR20250006309A (ko) * | 2013-11-15 | 2025-01-10 | 온코슈틱스 인코포레이티드 | 7-벤질-4-(2-메틸벤질)-2,4,6,7,8,9-헥사하이드로이미다조[1,2-a]피리도[3,4-e]피리미딘-5(1H)-온,이의 염 및 이의 용도 |
| SMT202400497T1 (it) | 2014-03-31 | 2025-01-14 | Scripps Research Inst | Farmacoforo per induzione di trail |
| CN113149985B (zh) | 2015-01-30 | 2025-01-28 | 昂克希尔迪克斯有限公司 | 六氢咪唑并吡啶并嘧啶酮、其类似物和盐、及其治疗用途 |
| CN104860948B (zh) | 2015-05-15 | 2017-09-26 | 南京盖特医药技术有限公司 | 咪唑并嘧啶酮类化合物及其制备方法和应用 |
| RS66519B1 (sr) * | 2016-01-29 | 2025-03-31 | Oncoceutics Inc | Modulacija g protein-spregnutog receptora (gpcr) pomoću imipridona |
| US11091483B2 (en) | 2016-08-12 | 2021-08-17 | Madera Therapeutics, LLC | Protein kinase regulators |
| US10172862B2 (en) | 2017-01-30 | 2019-01-08 | Oncoceutics, Inc. | Imipridones for gliomas |
| GB2596010B (en) * | 2019-02-11 | 2023-03-01 | Madera Therapeutics Llc | Use of caseinolytic protease P function as a biomarker of drug response to imipridone-like agents |
| JP7709379B2 (ja) | 2019-02-27 | 2025-07-16 | マデラ セラピューティクス，エルエルシー | イミプリドン様薬剤に対する薬物反応のバイオマーカとしてのカゼイン分解プロテアーゼｐの機能の使用 |
| EP4192467A1 (en) | 2020-08-06 | 2023-06-14 | Eötvös Loránd Tudományegyetem | Synthesis of novel imipridone derivatives and their evaluation for their anticancer activity |
| CN115448921B (zh) * | 2021-06-08 | 2023-08-01 | 四川大学 | 一类咪唑烷并嘧啶酮化合物及在治疗HsClpP介导的疾病中的用途 |
| CN116751199B (zh) * | 2023-06-02 | 2025-03-18 | 中国科学院基础医学与肿瘤研究所(筹) | 一种线粒体蛋白酶靶向嵌合体、制备方法及用途 |
| EP4684834A1 (de) * | 2024-07-26 | 2026-01-28 | BRIU GmbH | Kristallformen onkologisch wirksamer imipridone und verfahren zu deren herstellung |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE786028A (fr) * | 1971-07-08 | 1973-01-08 | Boehringer Sohn Ingelheim | 2,3-dihydro-oxo-imidazo(1,2-a)-pyrimidines, leurs sels d'addition avec des acides et procedes pour les fabriquer |
| DE2150062A1 (de) | 1971-10-07 | 1973-04-12 | Boehringer Sohn Ingelheim | Imidazo- eckige klammer auf 1,2-a eckige klammer zu -pyrido- eckige klammer auf 4,3-d eckige klammer zu -pyrimidine, deren saeureadditionssalze und verfahren zu deren herstellung |
| JPS5374893A (en) | 1976-12-15 | 1978-07-03 | Fujitsu Ltd | Driving method for semiconductor photosensitive device |
| JPS6132833U (ja) | 1984-07-31 | 1986-02-27 | 日信工業株式会社 | デイスクブレ−キ装置 |
| JP2006506401A (ja) * | 2002-05-23 | 2006-02-23 | メルク エンド カムパニー インコーポレーテッド | 有糸分裂キネシン阻害薬 |
| PT2932968T (pt) * | 2008-06-09 | 2018-03-13 | Allergan Inc | Composto para tratar condições mediadas por alfa adrenérgicos |
| WO2011130628A1 (en) * | 2010-04-16 | 2011-10-20 | Curis, Inc. | Treatment of cancers having k-ras mutations |
| WO2012078448A1 (en) * | 2010-12-06 | 2012-06-14 | Schering Corporation | Tricyclic heterocycles useful as dipeptidyl peptidase-iv inhibitors |
| CN103391945B (zh) * | 2011-03-15 | 2016-11-09 | 奇斯药制品公司 | 异噁唑烷衍生物 |
| WO2012138789A2 (en) * | 2011-04-04 | 2012-10-11 | Netherlands Cancer Institute | Methods and compositions for predicting resistance to anticancer treatment |
| PT2701708T (pt) | 2011-04-29 | 2020-05-08 | Penn State Res Found | Indução de gene trail de moléculas pequenas através de células tumorais e normais como uma terapia anticancro |
| US9688679B2 (en) | 2013-03-13 | 2017-06-27 | Oncoceutics, Inc. | 7-benzyl-4-(methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-A]pyrido[3,4-E]pyrimidin-5 (1H)-one, salts thereof and methods of using the same in combination therapy |
| US9376437B2 (en) * | 2013-03-13 | 2016-06-28 | Oncoceutics, Inc | 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one, salts thereof and methods of using the same in combination therapy |
| HUE044238T2 (hu) * | 2013-03-13 | 2019-10-28 | Oncoceutics Inc | 7-benzil-10-(2-metilbenzil)-2,6,7,8,9,10-hexahidroimidazo[l,2-a]pirido[4,3-d]pirimidin-5(3h)-on rák kezelésénél történõ alkalmazásra |
| WO2015073072A1 (en) * | 2013-11-15 | 2015-05-21 | Oncoceutics, Inc. | 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-one |
| US9181237B2 (en) * | 2013-10-04 | 2015-11-10 | Mallinckrodt Llc | Substituted berbines and their synthesis |
| SMT202400497T1 (it) | 2014-03-31 | 2025-01-14 | Scripps Research Inst | Farmacoforo per induzione di trail |
-
2015
- 2015-03-30 SM SM20240497T patent/SMT202400497T1/it unknown
- 2015-03-30 ES ES19218049T patent/ES2999685T3/es active Active
- 2015-03-30 DK DK19218049.5T patent/DK3662910T3/da active
- 2015-03-30 PL PL19218049.5T patent/PL3662910T3/pl unknown
- 2015-03-30 KR KR1020167029994A patent/KR102473930B1/ko active Active
- 2015-03-30 CN CN202010184181.3A patent/CN111499636B/zh active Active
- 2015-03-30 CA CA3158795A patent/CA3158795A1/en active Pending
- 2015-03-30 PT PT192180495T patent/PT3662910T/pt unknown
- 2015-03-30 CN CN201580021658.3A patent/CN106456643B/zh active Active
- 2015-03-30 AU AU2015241069A patent/AU2015241069B2/en active Active
- 2015-03-30 RS RS20200336A patent/RS60163B1/sr unknown
- 2015-03-30 KR KR1020227042050A patent/KR102611067B1/ko active Active
- 2015-03-30 HU HUE19218049A patent/HUE069651T2/hu unknown
- 2015-03-30 SI SI201532040T patent/SI3662910T1/sl unknown
- 2015-03-30 PL PL15772254T patent/PL3125898T3/pl unknown
- 2015-03-30 RS RS20241340A patent/RS66254B1/sr unknown
- 2015-03-30 CA CA2944452A patent/CA2944452C/en active Active
- 2015-03-30 SM SM20200219T patent/SMT202000219T1/it unknown
- 2015-03-30 EP EP15772254.7A patent/EP3125898B1/en active Active
- 2015-03-30 JP JP2016559887A patent/JP6756435B2/ja active Active
- 2015-03-30 EP EP19218049.5A patent/EP3662910B1/en active Active
- 2015-03-30 LT LTEP19218049.5T patent/LT3662910T/lt unknown
- 2015-03-30 US US15/126,192 patent/US10239877B2/en active Active
- 2015-03-30 FI FIEP19218049.5T patent/FI3662910T3/fi active
- 2015-03-30 SI SI201531141T patent/SI3125898T1/sl unknown
- 2015-03-30 HR HRP20241680TT patent/HRP20241680T1/hr unknown
- 2015-03-30 DK DK15772254.7T patent/DK3125898T3/da active
- 2015-03-30 HU HUE15772254A patent/HUE049013T2/hu unknown
- 2015-03-30 ES ES15772254T patent/ES2779979T3/es active Active
- 2015-03-30 HR HRP20200478TT patent/HRP20200478T1/hr unknown
- 2015-03-30 PT PT157722547T patent/PT3125898T/pt unknown
- 2015-03-30 LT LTEP15772254.7T patent/LT3125898T/lt unknown
- 2015-03-30 EP EP24192819.1A patent/EP4470617A3/en active Pending
- 2015-03-30 WO PCT/US2015/023362 patent/WO2015153468A1/en not_active Ceased
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2019
- 2019-03-20 US US16/359,633 patent/US10633385B2/en active Active
- 2019-09-10 JP JP2019164086A patent/JP6873201B2/ja active Active
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2020
- 2020-03-20 CY CY20201100267T patent/CY1123093T1/el unknown
- 2020-04-14 US US16/848,032 patent/US20200283440A1/en not_active Abandoned
- 2020-12-11 AU AU2020286314A patent/AU2020286314A1/en not_active Abandoned
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2021
- 2021-04-20 JP JP2021071035A patent/JP7186256B2/ja active Active
- 2021-07-12 US US17/372,894 patent/US11891392B2/en active Active
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2022
- 2022-11-28 JP JP2022188821A patent/JP7688245B2/ja active Active
- 2022-12-08 AU AU2022283729A patent/AU2022283729A1/en not_active Abandoned
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2023
- 2023-12-20 US US18/391,420 patent/US20240190877A1/en active Pending
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2024
- 2024-07-19 AU AU2024204977A patent/AU2024204977A1/en active Pending
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