FI3652606T3 - Jaettuihin tuumorineoantigeeneihin perustuva yleisrokote epästabiilien mikrosatelliitti (msi) -syöpien ennaltaehkäisyyn ja hoitoon - Google Patents
Jaettuihin tuumorineoantigeeneihin perustuva yleisrokote epästabiilien mikrosatelliitti (msi) -syöpien ennaltaehkäisyyn ja hoitoon Download PDFInfo
- Publication number
- FI3652606T3 FI3652606T3 FIEP18742985.7T FI18742985T FI3652606T3 FI 3652606 T3 FI3652606 T3 FI 3652606T3 FI 18742985 T FI18742985 T FI 18742985T FI 3652606 T3 FI3652606 T3 FI 3652606T3
- Authority
- FI
- Finland
- Prior art keywords
- cancer
- fsp
- collection
- fsps
- cvp
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title claims 42
- 238000011282 treatment Methods 0.000 title claims 8
- 229960005486 vaccine Drugs 0.000 title claims 6
- 230000002265 prevention Effects 0.000 title claims 4
- 108091092878 Microsatellite Proteins 0.000 title 1
- 201000011510 cancer Diseases 0.000 claims 33
- 150000001413 amino acids Chemical class 0.000 claims 27
- 230000037433 frameshift Effects 0.000 claims 24
- 231100000221 frame shift mutation induction Toxicity 0.000 claims 19
- 108090000765 processed proteins & peptides Proteins 0.000 claims 16
- 208000032818 Microsatellite Instability Diseases 0.000 claims 15
- 150000007523 nucleic acids Chemical class 0.000 claims 15
- 102000004196 processed proteins & peptides Human genes 0.000 claims 14
- 239000013598 vector Substances 0.000 claims 14
- 108020004707 nucleic acids Proteins 0.000 claims 13
- 102000039446 nucleic acids Human genes 0.000 claims 13
- 239000013604 expression vector Substances 0.000 claims 12
- 125000003275 alpha amino acid group Chemical group 0.000 claims 10
- 238000000034 method Methods 0.000 claims 8
- 239000012634 fragment Substances 0.000 claims 7
- 229940022399 cancer vaccine Drugs 0.000 claims 6
- 238000009566 cancer vaccine Methods 0.000 claims 6
- 108090000623 proteins and genes Proteins 0.000 claims 6
- 206010009944 Colon cancer Diseases 0.000 claims 5
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 5
- 206010014733 Endometrial cancer Diseases 0.000 claims 5
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 5
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 5
- 206010017758 gastric cancer Diseases 0.000 claims 5
- 201000011549 stomach cancer Diseases 0.000 claims 5
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 4
- 101150084967 EPCAM gene Proteins 0.000 claims 4
- 101150057140 TACSTD1 gene Proteins 0.000 claims 4
- 241000700605 Viruses Species 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 230000001186 cumulative effect Effects 0.000 claims 3
- 230000035772 mutation Effects 0.000 claims 3
- 208000003174 Brain Neoplasms Diseases 0.000 claims 2
- 206010008342 Cervix carcinoma Diseases 0.000 claims 2
- 102100028843 DNA mismatch repair protein Mlh1 Human genes 0.000 claims 2
- 102100021147 DNA mismatch repair protein Msh6 Human genes 0.000 claims 2
- 102000012804 EPCAM Human genes 0.000 claims 2
- 206010014611 Encephalitis venezuelan equine Diseases 0.000 claims 2
- 102100031940 Epithelial cell adhesion molecule Human genes 0.000 claims 2
- 101000577853 Homo sapiens DNA mismatch repair protein Mlh1 Proteins 0.000 claims 2
- 101000968658 Homo sapiens DNA mismatch repair protein Msh6 Proteins 0.000 claims 2
- 241000712899 Lymphocytic choriomeningitis mammarenavirus Species 0.000 claims 2
- 108010074346 Mismatch Repair Endonuclease PMS2 Proteins 0.000 claims 2
- 102100037480 Mismatch repair endonuclease PMS2 Human genes 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 241000710961 Semliki Forest virus Species 0.000 claims 2
- 208000000453 Skin Neoplasms Diseases 0.000 claims 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 2
- 208000002687 Venezuelan Equine Encephalomyelitis Diseases 0.000 claims 2
- 201000009145 Venezuelan equine encephalitis Diseases 0.000 claims 2
- 239000002671 adjuvant Substances 0.000 claims 2
- 201000010881 cervical cancer Diseases 0.000 claims 2
- 238000011161 development Methods 0.000 claims 2
- 238000003745 diagnosis Methods 0.000 claims 2
- 210000004602 germ cell Anatomy 0.000 claims 2
- 230000005847 immunogenicity Effects 0.000 claims 2
- 239000002502 liposome Substances 0.000 claims 2
- 201000007270 liver cancer Diseases 0.000 claims 2
- 208000014018 liver neoplasm Diseases 0.000 claims 2
- 201000002120 neuroendocrine carcinoma Diseases 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 238000011321 prophylaxis Methods 0.000 claims 2
- 201000000849 skin cancer Diseases 0.000 claims 2
- 230000002269 spontaneous effect Effects 0.000 claims 2
- 238000013519 translation Methods 0.000 claims 2
- 241000701161 unidentified adenovirus Species 0.000 claims 2
- 208000037965 uterine sarcoma Diseases 0.000 claims 2
- 241000710929 Alphavirus Species 0.000 claims 1
- 108020004705 Codon Proteins 0.000 claims 1
- 102000016736 Cyclin Human genes 0.000 claims 1
- 108050006400 Cyclin Proteins 0.000 claims 1
- 241000701022 Cytomegalovirus Species 0.000 claims 1
- 102100034157 DNA mismatch repair protein Msh2 Human genes 0.000 claims 1
- 238000001712 DNA sequencing Methods 0.000 claims 1
- 101000800505 Drosophila melanogaster Muscle-specific homeobox protein tinman Proteins 0.000 claims 1
- 201000003741 Gastrointestinal carcinoma Diseases 0.000 claims 1
- 241000282575 Gorilla Species 0.000 claims 1
- 101001134036 Homo sapiens DNA mismatch repair protein Msh2 Proteins 0.000 claims 1
- 241000701024 Human betaherpesvirus 5 Species 0.000 claims 1
- 102000013462 Interleukin-12 Human genes 0.000 claims 1
- 108010065805 Interleukin-12 Proteins 0.000 claims 1
- 102000003812 Interleukin-15 Human genes 0.000 claims 1
- 108090000172 Interleukin-15 Proteins 0.000 claims 1
- 102000000588 Interleukin-2 Human genes 0.000 claims 1
- 108010002350 Interleukin-2 Proteins 0.000 claims 1
- 102000015696 Interleukins Human genes 0.000 claims 1
- 108010063738 Interleukins Proteins 0.000 claims 1
- 241000713666 Lentivirus Species 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 241000282576 Pan paniscus Species 0.000 claims 1
- 241000282577 Pan troglodytes Species 0.000 claims 1
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims 1
- 241000701033 Simian cytomegalovirus Species 0.000 claims 1
- 102000003978 Tissue Plasminogen Activator Human genes 0.000 claims 1
- 108090000373 Tissue Plasminogen Activator Proteins 0.000 claims 1
- 241000700618 Vaccinia virus Species 0.000 claims 1
- 206010046865 Vaccinia virus infection Diseases 0.000 claims 1
- 241000607479 Yersinia pestis Species 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 229940117681 interleukin-12 Drugs 0.000 claims 1
- 201000002313 intestinal cancer Diseases 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 108020004999 messenger RNA Proteins 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 230000010076 replication Effects 0.000 claims 1
- 201000002314 small intestine cancer Diseases 0.000 claims 1
- 230000002194 synthesizing effect Effects 0.000 claims 1
- 238000012360 testing method Methods 0.000 claims 1
- 230000034512 ubiquitination Effects 0.000 claims 1
- 238000010798 ubiquitination Methods 0.000 claims 1
- 241001430294 unidentified retrovirus Species 0.000 claims 1
- 238000011144 upstream manufacturing Methods 0.000 claims 1
- 208000007089 vaccinia Diseases 0.000 claims 1
- 239000013603 viral vector Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
- G16B30/10—Sequence alignment; Homology search
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5152—Tumor cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Theoretical Computer Science (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Medical Informatics (AREA)
- Evolutionary Biology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Toxicology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Plant Pathology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17181026 | 2017-07-12 | ||
| PCT/EP2018/069032 WO2019012082A1 (en) | 2017-07-12 | 2018-07-12 | UNIVERSAL VACCINE BASED ON SHARED TUMOR NEO-ANTIGENS FOR THE PREVENTION AND TREATMENT OF MICRO-SATELLITE INSTABILITY CANCER (MSI) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FI3652606T3 true FI3652606T3 (fi) | 2023-03-16 |
Family
ID=59366234
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FIEP18742985.7T FI3652606T3 (fi) | 2017-07-12 | 2018-07-12 | Jaettuihin tuumorineoantigeeneihin perustuva yleisrokote epästabiilien mikrosatelliitti (msi) -syöpien ennaltaehkäisyyn ja hoitoon |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US11578109B2 (enExample) |
| EP (1) | EP3652606B1 (enExample) |
| JP (1) | JP7274223B2 (enExample) |
| KR (1) | KR102709778B1 (enExample) |
| CN (1) | CN111328420B (enExample) |
| AU (1) | AU2018298849B2 (enExample) |
| BR (1) | BR112020000590A2 (enExample) |
| CA (1) | CA3069047A1 (enExample) |
| DK (1) | DK3652606T5 (enExample) |
| ES (1) | ES2940087T3 (enExample) |
| FI (1) | FI3652606T3 (enExample) |
| HU (1) | HUE061840T2 (enExample) |
| IL (1) | IL271966B2 (enExample) |
| MX (1) | MX2020000413A (enExample) |
| NZ (1) | NZ759940A (enExample) |
| PL (1) | PL3652606T3 (enExample) |
| PT (1) | PT3652606T (enExample) |
| SG (1) | SG11202000250PA (enExample) |
| WO (1) | WO2019012082A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3106573A1 (en) | 2018-07-26 | 2020-01-30 | Frame Pharmaceuticals B.V. | Cancer vaccines for colorectal cancer |
| WO2020022901A1 (en) | 2018-07-26 | 2020-01-30 | Frame Pharmaceuticals B.V. | Cancer vaccines for uterine cancer |
| WO2020022897A1 (en) | 2018-07-26 | 2020-01-30 | Frame Pharmaceuticals B.V. | Method of preparing subject-specific immunogenic compositions based on a neo open-reading-frame peptide database |
| CA3106567A1 (en) | 2018-07-26 | 2020-01-30 | Frame Pharmaceuticals B.V. | Cancer vaccines for kidney cancer |
| EP3827262A1 (en) | 2018-07-26 | 2021-06-02 | Frame Pharmaceuticals B.V. | Cancer vaccines for breast cancer |
| CA3106574A1 (en) | 2018-07-26 | 2020-01-30 | Frame Pharmaceuticals B.V. | Arid1a, cdkn2a, kmt2b, kmt2d, tp53 and pten vaccines for cancer |
| TWI852977B (zh) * | 2019-01-10 | 2024-08-21 | 美商健生生物科技公司 | 前列腺新抗原及其用途 |
| WO2020163802A1 (en) * | 2019-02-07 | 2020-08-13 | Arizona Board Of Regents On Behalf Of Arizona State University | Cancer specific frameshift vaccines |
| EP4061405A1 (en) | 2019-11-18 | 2022-09-28 | Janssen Biotech, Inc. | Vaccines based on mutant calr and jak2 and their uses |
| EP4149952A1 (en) * | 2020-05-12 | 2023-03-22 | Institut Curie | Neoantigenic epitopes associated with sf3b1 mutations |
| WO2022009049A1 (en) | 2020-07-06 | 2022-01-13 | Janssen Biotech, Inc. | Prostate neoantigens and their uses |
| EP4175664A2 (en) | 2020-07-06 | 2023-05-10 | Janssen Biotech, Inc. | Prostate neoantigens and their uses |
| JP2024516542A (ja) * | 2021-04-06 | 2024-04-16 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | Ｍｈｃクラスｉペプチドを含む方法および組成物 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5922315A (en) | 1997-01-24 | 1999-07-13 | Genetic Therapy, Inc. | Adenoviruses having altered hexon proteins |
| AU2003232485A1 (en) * | 2002-04-18 | 2003-10-27 | Mtm Laboratories Ag | Neopeptides and methods useful for detection and treatment of cancer |
| WO2004092338A2 (en) * | 2003-04-11 | 2004-10-28 | Diadexus, Inc. | Compositions, splice variants and methods relating to cancer specific genes and proteins |
| CN1824325A (zh) * | 2005-12-16 | 2006-08-30 | 武汉大学 | 人乳头病毒dna嵌合疫苗及制备方法和应用 |
| CA2915560A1 (en) * | 2006-10-17 | 2008-04-24 | Tomoaki Fujioka | Peptide vaccines for cancers expressing mphosph1 or depdc1 polypeptides |
| TW201102081A (en) * | 2009-05-11 | 2011-01-16 | Oncotherapy Science Inc | TTK peptides and vaccines including the same |
| NZ596603A (en) | 2009-05-29 | 2013-07-26 | Morphosys Ag | A collection of antibodies or fragments having properties relevant to developability |
| JP2013523084A (ja) * | 2010-04-09 | 2013-06-17 | オンコセラピー・サイエンス株式会社 | Ｃｄｃａ５ペプチドおよびそれを含むワクチン |
| DK2688907T3 (en) * | 2011-03-24 | 2016-06-13 | Inst Nat De La Sante Et De La Rech Medicale (Inserm) | DOMINANT NEGATIVE HSP110 MUTANT AND ITS APPLICATION TO FORECAST AND treatment of cancers |
| US9458447B2 (en) * | 2011-08-12 | 2016-10-04 | Oncotherapy Science, Inc. | MPHOSPH1 peptides and vaccines including the same |
| JP5890769B2 (ja) * | 2012-12-13 | 2016-03-22 | ループレヒト−カルルス・ウニヴェルジテート・ハイデルベルクＲｕｐｒｅｃｈｔ−Ｋａｒｌｓ−Ｕｎｉｖｅｒｓｉｔａｅｔ Ｈｅｉｄｅｌｂｅｒｇ | がんの予防及び治療のためのｍｓｉ特異的なフレームシフトペプチド（ｆｓｐ） |
| RU2644677C2 (ru) * | 2012-12-13 | 2018-02-13 | Рупрехт-Карлс-Университэт Гейдельберг | Мсн-специфичные пептиды со смещенной рамкой считывания (псрс) для предотвращения и лечения рака |
| US9205140B2 (en) * | 2012-12-13 | 2015-12-08 | Ruprecht-Karls-Universität | MSI-specific frameshift peptides (FSP) for prevention and treatment of cancer |
| WO2014099979A2 (en) * | 2012-12-17 | 2014-06-26 | Virginia Tech Intellectual Properties, Inc. | Methods and compositions for identifying global microsatellite instability and for characterizing informative microsatellite loci |
| WO2015112930A1 (en) * | 2014-01-27 | 2015-07-30 | Yale University | Novel methods of identifying patients responsive to immunotherapeutic strategies |
| JP6913032B2 (ja) | 2015-05-20 | 2021-08-04 | ザ・ブロード・インスティテュート・インコーポレイテッド | 共通ネオ抗原 |
| CN106350578A (zh) * | 2015-07-13 | 2017-01-25 | 中国人民解放军第二军医大学 | Ny-eso-1在微卫星不稳定性肠癌的诊断和治疗中的应用 |
| EP3328394A4 (en) | 2015-07-30 | 2019-03-13 | ModernaTX, Inc. | CONCATEMEE peptide epitope RNAs |
-
2018
- 2018-07-12 BR BR112020000590-8A patent/BR112020000590A2/pt unknown
- 2018-07-12 FI FIEP18742985.7T patent/FI3652606T3/fi active
- 2018-07-12 CA CA3069047A patent/CA3069047A1/en active Pending
- 2018-07-12 MX MX2020000413A patent/MX2020000413A/es unknown
- 2018-07-12 EP EP18742985.7A patent/EP3652606B1/en active Active
- 2018-07-12 US US16/626,458 patent/US11578109B2/en active Active
- 2018-07-12 CN CN201880046801.8A patent/CN111328420B/zh active Active
- 2018-07-12 JP JP2020501311A patent/JP7274223B2/ja active Active
- 2018-07-12 PT PT187429857T patent/PT3652606T/pt unknown
- 2018-07-12 AU AU2018298849A patent/AU2018298849B2/en active Active
- 2018-07-12 KR KR1020207000642A patent/KR102709778B1/ko active Active
- 2018-07-12 WO PCT/EP2018/069032 patent/WO2019012082A1/en not_active Ceased
- 2018-07-12 SG SG11202000250PA patent/SG11202000250PA/en unknown
- 2018-07-12 PL PL18742985.7T patent/PL3652606T3/pl unknown
- 2018-07-12 DK DK18742985.7T patent/DK3652606T5/da active
- 2018-07-12 ES ES18742985T patent/ES2940087T3/es active Active
- 2018-07-12 IL IL271966A patent/IL271966B2/en unknown
- 2018-07-12 NZ NZ759940A patent/NZ759940A/en unknown
- 2018-07-12 HU HUE18742985A patent/HUE061840T2/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2019012082A1 (en) | 2019-01-17 |
| BR112020000590A2 (pt) | 2020-07-14 |
| AU2018298849B2 (en) | 2022-07-14 |
| US20200222519A1 (en) | 2020-07-16 |
| IL271966B2 (en) | 2025-01-01 |
| AU2018298849A1 (en) | 2020-01-02 |
| EP3652606A1 (en) | 2020-05-20 |
| IL271966A (en) | 2020-02-27 |
| PT3652606T (pt) | 2023-03-16 |
| SG11202000250PA (en) | 2020-02-27 |
| EP3652606B1 (en) | 2023-01-11 |
| CN111328420A (zh) | 2020-06-23 |
| HUE061840T2 (hu) | 2023-08-28 |
| ES2940087T3 (es) | 2023-05-03 |
| KR102709778B1 (ko) | 2024-09-26 |
| US11578109B2 (en) | 2023-02-14 |
| RU2019144505A3 (enExample) | 2021-08-12 |
| WO2019012082A9 (en) | 2019-05-02 |
| DK3652606T3 (da) | 2023-03-13 |
| IL271966B1 (en) | 2024-09-01 |
| RU2019144505A (ru) | 2021-08-12 |
| KR20200029443A (ko) | 2020-03-18 |
| PL3652606T3 (pl) | 2023-04-24 |
| DK3652606T5 (da) | 2024-08-26 |
| JP7274223B2 (ja) | 2023-05-16 |
| NZ759940A (en) | 2023-07-28 |
| CN111328420B (zh) | 2023-07-25 |
| JP2020532288A (ja) | 2020-11-12 |
| MX2020000413A (es) | 2020-09-28 |
| CA3069047A1 (en) | 2019-01-17 |
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