FI3512955T3 - Muunneltuja glukosyylitransferaaseja - Google Patents
Muunneltuja glukosyylitransferaaseja Download PDFInfo
- Publication number
- FI3512955T3 FI3512955T3 FIEP17772809.4T FI17772809T FI3512955T3 FI 3512955 T3 FI3512955 T3 FI 3512955T3 FI 17772809 T FI17772809 T FI 17772809T FI 3512955 T3 FI3512955 T3 FI 3512955T3
- Authority
- FI
- Finland
- Prior art keywords
- amino acid
- seq
- seo
- residues
- residue
- Prior art date
Links
- 102000000340 Glucosyltransferases Human genes 0.000 title claims 28
- 108010055629 Glucosyltransferases Proteins 0.000 title claims 28
- 125000003275 alpha amino acid group Chemical group 0.000 claims 24
- 125000000539 amino acid group Chemical group 0.000 claims 19
- 238000006467 substitution reaction Methods 0.000 claims 19
- 229920000310 Alpha glucan Polymers 0.000 claims 9
- 230000003197 catalytic effect Effects 0.000 claims 5
- DXALOGXSFLZLLN-WTZPKTTFSA-N (3s,4s,5r)-1,3,4,6-tetrahydroxy-5-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhexan-2-one Chemical compound OCC(=O)[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O DXALOGXSFLZLLN-WTZPKTTFSA-N 0.000 claims 2
- JPFGFRMPGVDDGE-UHFFFAOYSA-N Leucrose Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)(CO)OC1 JPFGFRMPGVDDGE-UHFFFAOYSA-N 0.000 claims 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 2
- 229930006000 Sucrose Natural products 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 230000001105 regulatory effect Effects 0.000 claims 2
- 239000005720 sucrose Substances 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 238000006116 polymerization reaction Methods 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Materials Engineering (AREA)
- Polymers & Plastics (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662394354P | 2016-09-14 | 2016-09-14 | |
| PCT/US2017/051279 WO2018052942A1 (en) | 2016-09-14 | 2017-09-13 | Engineered glucosyltransferases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FI3512955T3 true FI3512955T3 (fi) | 2023-07-18 |
Family
ID=59969237
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FIEP17772809.4T FI3512955T3 (fi) | 2016-09-14 | 2017-09-13 | Muunneltuja glukosyylitransferaaseja |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US10301604B2 (OSRAM) |
| EP (1) | EP3512955B1 (OSRAM) |
| JP (1) | JP7136783B2 (OSRAM) |
| CN (1) | CN109715818A (OSRAM) |
| AU (1) | AU2017326168B2 (OSRAM) |
| BR (1) | BR112019004213A2 (OSRAM) |
| CA (1) | CA3033369A1 (OSRAM) |
| FI (1) | FI3512955T3 (OSRAM) |
| WO (1) | WO2018052942A1 (OSRAM) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2018272823B2 (en) | 2017-05-23 | 2024-05-09 | Nutrition & Biosciences USA 4, Inc. | Enzymatic production of alpha-1,3-glucan |
| EP3668970A1 (en) * | 2017-09-13 | 2020-06-24 | DuPont Industrial Biosciences USA, LLC | Engineered glucosyltransferases |
| JP7384787B2 (ja) * | 2017-09-13 | 2023-11-21 | ニュートリション・アンド・バイオサイエンシーズ・ユーエスエー・フォー，インコーポレイテッド | 遺伝子操作されたグルコシルトランスフェラーゼ |
| JP7343490B2 (ja) | 2017-10-13 | 2023-09-12 | ニュートリション・アンド・バイオサイエンシーズ・ユーエスエー・フォー，インコーポレイテッド | 流動性バルク粒状多糖 |
| JP2021507955A (ja) | 2017-12-14 | 2021-02-25 | デュポン・インダストリアル・バイオサイエンシーズ・ユーエスエイ・エルエルシー | α−１，３−グルカングラフトコポリマー |
| AU2019230061B2 (en) * | 2018-03-09 | 2025-05-15 | Nutrition & Biosciences USA 4, Inc. | Engineered glucosyltransferases |
| AU2019299002A1 (en) * | 2018-07-05 | 2021-01-28 | Dupont Nutrition Biosciences Aps | Use of glucosyl transferase to provide improved texture in fermented milk based products |
| US11859022B2 (en) | 2018-10-25 | 2024-01-02 | Nutrition & Biosciences USA 4, Inc. | Alpha-1,3-glucan graft copolymers |
| US20220033531A1 (en) | 2018-12-17 | 2022-02-03 | Dupont Industrial Biosciences Usa,Llc | Polysaccharide Derivatives and Compositions Comprising Same |
| CN115003805A (zh) * | 2019-07-09 | 2022-09-02 | 营养与生物科学美国第四公司 | 工程化的α-1,3分支酶 |
| CN115052489B (zh) | 2019-08-16 | 2024-09-13 | 营养与生物科学美国第四公司 | 包含不溶性α-1,3-葡聚糖的基于面粉和粗粉的食品产品 |
| US11608388B2 (en) | 2019-11-06 | 2023-03-21 | Nutrition & Biosciences USA 4, Inc. | Highly crystalline alpha-1,3-glucan |
| WO2021158543A1 (en) | 2020-02-04 | 2021-08-12 | Nutrition & Biosciences USA 4, Inc. | Aqueous dispersions of insoluble alpha-glucan comprising alpha-1,3 glycosidic linkages |
| WO2021247810A1 (en) | 2020-06-04 | 2021-12-09 | Nutrition & Biosciences USA 4, Inc. | Dextran-alpha-glucan graft copolymers and derivatives thereof |
| US12486338B2 (en) | 2020-06-10 | 2025-12-02 | Nutrition & Biosciences USA 4, Inc. | Poly alpha-1,6-glucan derivatives and compositions comprising same |
| US20240150497A1 (en) | 2021-02-19 | 2024-05-09 | Nutrition & Biosciences USA 4, Inc. | Polysaccharide derivatives for detergent compositions |
| CN117337308A (zh) | 2021-05-04 | 2024-01-02 | 营养与生物科学美国4公司 | 包含氧化的不溶性α-葡聚糖的组合物 |
| US20240294737A1 (en) | 2021-05-04 | 2024-09-05 | Nutrition & Biosciences USA 4, Inc. | Compositions comprising insoluble alpha-glucan |
| CN117616054A (zh) | 2021-07-13 | 2024-02-27 | 营养与生物科学美国4公司 | 阳离子葡聚糖酯衍生物 |
| MX2024004006A (es) | 2021-09-30 | 2024-04-22 | Int N&H Denmark Aps | Metodo para reducir azucar en productos alimenticios. |
| US20250002695A1 (en) | 2021-11-05 | 2025-01-02 | Nutrition & Biosciences USA 4, Inc. | Compositions comprising cationic alpha-1,6-glucan derivative and alpha-1,3-glucan |
| EP4463519A1 (en) | 2022-01-12 | 2024-11-20 | Nutrition & Biosciences USA 4, Inc. | Coating compositions comprising rubber and insoluble alpha-glucan |
| US20250188647A1 (en) | 2022-03-21 | 2025-06-12 | Nutrition & Biosciences USA 4, Inc. | Compositions comprising insoluble alpha-glucan |
| CN114717213B (zh) * | 2022-05-05 | 2023-09-22 | 广西科学院 | 一种葡聚糖蔗糖酶的n端截短突变酶及其制备方法 |
| JP2025523007A (ja) | 2022-07-11 | 2025-07-17 | ニュートリション・アンド・バイオサイエンシーズ・ユーエスエー・フォー，インコーポレイテッド | 両親媒性グルカンエステル誘導体 |
| CN120076720A (zh) | 2022-10-17 | 2025-05-30 | 国际N&H丹麦有限公司 | 用于改善基于植物的食料风味的方法 |
| US20250339361A1 (en) | 2022-11-02 | 2025-11-06 | Nutrition & Biosciences USA 4, Inc. | Compositions comprising xanthan gum and crystalline alpha-1,3-glucan |
| AU2024242918A1 (en) | 2023-03-29 | 2025-09-18 | Danisco Us Inc. | Methods for modifying texture in foodstuff via preferably in situ produced alpha-glucan |
| WO2025006691A2 (en) | 2023-06-30 | 2025-01-02 | Nutrition & Biosciences USA 4, Inc. | Porous alpha-1,3-glucan compositions |
| WO2025072416A1 (en) | 2023-09-29 | 2025-04-03 | Nutrition & Biosciences USA 4, Inc. | Polysaccharide derivatives |
| WO2025072417A1 (en) | 2023-09-29 | 2025-04-03 | Nutrition & Biosciences USA 4, Inc. | Polysaccharide derivatives |
| WO2025072419A1 (en) | 2023-09-29 | 2025-04-03 | Nutrition & Biosciences Usa 1, Llc | Crosslinked alpha-glucan derivatives |
| WO2025198996A1 (en) | 2024-03-19 | 2025-09-25 | Danisco Us Inc. | Method for improving flavor in foodstuff |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998016190A1 (en) | 1996-10-11 | 1998-04-23 | Novo Nordisk A/S | STARCH BINDING DOMAINS (SBDs) FOR ORAL CARE PRODUCTS |
| US5952205A (en) | 1998-02-06 | 1999-09-14 | Neose Technologies, Inc. | Process for processing sucrose into glucose and fructose |
| JP2000175694A (ja) | 1998-12-17 | 2000-06-27 | Lion Corp | 酵素合成によるムタンの製造方法 |
| WO2000043580A1 (en) | 1999-01-25 | 2000-07-27 | E.I. Du Pont De Nemours And Company | Polysaccharide fibers |
| US6867026B2 (en) | 2000-05-25 | 2005-03-15 | Nederlandse Organisatie Voor Toegepast Natuurwetenschappelijk Onderzoek Tno | Glucosyltransferases |
| JP3709435B2 (ja) * | 2001-10-03 | 2005-10-26 | 独立行政法人食品総合研究所 | 改変デキストランスクラーゼ、その遺伝子組み換え体、グルカンの製造法 |
| EP1572149A2 (en) * | 2002-03-07 | 2005-09-14 | The Forsyth Institute | Immunogenicity of glucan binding protein |
| JP2005534315A (ja) | 2002-08-06 | 2005-11-17 | ダニスコ エイ／エス | 食品および薬学的組成物中に細胞外多糖類を産生する乳酸桿菌の使用 |
| US7524645B2 (en) | 2004-12-14 | 2009-04-28 | Centre National De La Recherche Scientifique (Cnrs) | Fully active alternansucrases partially deleted in its carboxy-terminal and amino-terminal domains and mutants thereof |
| EP1679374A1 (en) | 2005-01-10 | 2006-07-12 | Bayer CropScience GmbH | Transformed plant expressing a mutansucrase and synthesizing a modified starch |
| FR2897069B1 (fr) | 2006-02-08 | 2012-06-08 | Centre Nat Rech Scient | Construction de nouveaux variants de l'enzyme dextrane-saccharase dsr-s par ingienerie moleculaire. |
| EP2100966A1 (en) | 2008-03-12 | 2009-09-16 | Institut Pasteur | Mutants of glycoside hydrolases and uses thereof for synthesizing complex oligosaccharides and disaccharide intermediates |
| JP5680860B2 (ja) * | 2009-01-30 | 2015-03-04 | サントリーホールディングス株式会社 | フラボノイド３位ガラクトース・グルコース転移酵素、及びそれをコードするポリヌクレオチド |
| JP2011206273A (ja) | 2010-03-30 | 2011-10-20 | Terumo Corp | 注射針組立体および薬剤注射装置 |
| WO2011138316A1 (en) | 2010-05-04 | 2011-11-10 | Sanofi-Aventis Deutschland Gmbh | Tactile identification of drug filled cartridge |
| JP5015287B2 (ja) | 2010-05-11 | 2012-08-29 | シャープ株式会社 | 加熱調理器 |
| JP5851149B2 (ja) | 2011-08-08 | 2016-02-03 | 株式会社ニューフレアテクノロジー | 成膜装置および成膜方法 |
| US8642757B2 (en) | 2011-09-09 | 2014-02-04 | E I Du Pont De Nemours And Company | High titer production of highly linear poly (α 1,3 glucan) |
| US9080195B2 (en) | 2011-09-09 | 2015-07-14 | E I Du Pont De Nemours And Company | High titer production of poly (α 1,3 glucan) |
| AU2013323686B2 (en) * | 2012-09-25 | 2016-09-29 | Nutrition & Biosciences USA 4, Inc. | Glucosyltransferase enzymes for production of glucan polymers |
| CN104968781A (zh) * | 2012-12-24 | 2015-10-07 | 诺维信公司 | 具有内切葡聚糖酶活性的多肽以及对其进行编码的多核苷酸 |
| US9169506B2 (en) | 2013-09-05 | 2015-10-27 | E I Du Pont De Nemours And Company | Process for producing alpha-1,3-glucan polymer with reduced molecular weight |
| US9644190B2 (en) | 2014-02-06 | 2017-05-09 | The United States Of America, As Represented By The Secretary Of Agriculture | Modified glucansucrase and related methods |
| CN105992796A (zh) | 2014-02-14 | 2016-10-05 | 纳幕尔杜邦公司 | 用于粘度调节的聚-α-1,3-1,6-葡聚糖 |
| WO2015123327A1 (en) | 2014-02-14 | 2015-08-20 | E. I. Du Pont De Nemours And Company | Glucosyltransferase enzymes for production of glucan polymers |
| US20170204442A1 (en) | 2014-05-29 | 2017-07-20 | E I Du Pont De Nemours And Company | Enzymatic synthesis of soluble glucan fiber |
| CA2949273A1 (en) | 2014-05-29 | 2015-12-03 | E. I. Du Pont De Nemours And Company | Enzymatic synthesis of soluble glucan fiber |
| MX2016015703A (es) | 2014-05-29 | 2017-03-16 | Du Pont | Sintesis enzimatica de fibra de glucano soluble. |
| EP3149186A1 (en) | 2014-05-29 | 2017-04-05 | E. I. du Pont de Nemours and Company | Enzymatic synthesis of soluble glucan fiber |
| CA2949269A1 (en) | 2014-05-29 | 2015-12-03 | Qiong Cheng | Enzymatic synthesis of soluble glucan fiber |
| CA2949289A1 (en) | 2014-05-29 | 2015-12-03 | E. I. Du Pont De Nemours And Company | Enzymatic synthesis of soluble glucan fiber |
| JP6814737B2 (ja) | 2014-11-05 | 2021-01-20 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニーＥ．Ｉ．Ｄｕ Ｐｏｎｔ Ｄｅ Ｎｅｍｏｕｒｓ Ａｎｄ Ｃｏｍｐａｎｙ | 酵素重合ゲル化デキストラン |
| WO2016205401A1 (en) | 2015-06-17 | 2016-12-22 | E I Du Pont De Nemours And Company | Glucosyltransferase amino acid sequence motifs for producing linear poly alpha-1,3-glucan |
-
2017
- 2017-09-13 US US15/702,893 patent/US10301604B2/en active Active
- 2017-09-13 CN CN201780055064.3A patent/CN109715818A/zh active Pending
- 2017-09-13 CA CA3033369A patent/CA3033369A1/en not_active Abandoned
- 2017-09-13 JP JP2019535206A patent/JP7136783B2/ja active Active
- 2017-09-13 FI FIEP17772809.4T patent/FI3512955T3/fi active
- 2017-09-13 WO PCT/US2017/051279 patent/WO2018052942A1/en not_active Ceased
- 2017-09-13 EP EP17772809.4A patent/EP3512955B1/en active Active
- 2017-09-13 AU AU2017326168A patent/AU2017326168B2/en active Active
- 2017-09-13 BR BR112019004213A patent/BR112019004213A2/pt not_active IP Right Cessation
-
2019
- 2019-04-11 US US16/381,010 patent/US11028373B2/en active Active
-
2021
- 2021-06-04 US US17/338,842 patent/US11952598B2/en active Active
-
2024
- 2024-04-05 US US18/628,140 patent/US12378535B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2017326168B2 (en) | 2022-02-24 |
| US20240417702A1 (en) | 2024-12-19 |
| US11952598B2 (en) | 2024-04-09 |
| US10301604B2 (en) | 2019-05-28 |
| CA3033369A1 (en) | 2018-03-22 |
| CN109715818A (zh) | 2019-05-03 |
| US12378535B2 (en) | 2025-08-05 |
| JP2019530474A (ja) | 2019-10-24 |
| AU2017326168A1 (en) | 2019-02-21 |
| EP3512955A1 (en) | 2019-07-24 |
| US20210395705A1 (en) | 2021-12-23 |
| US20180072998A1 (en) | 2018-03-15 |
| WO2018052942A1 (en) | 2018-03-22 |
| BR112019004213A2 (pt) | 2019-06-25 |
| US11028373B2 (en) | 2021-06-08 |
| US20190292528A1 (en) | 2019-09-26 |
| EP3512955B1 (en) | 2023-04-19 |
| JP7136783B2 (ja) | 2022-09-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FI3512955T3 (fi) | Muunneltuja glukosyylitransferaaseja | |
| JP2019530474A5 (OSRAM) | ||
| MX2012015139A (es) | Polipéptido que tiene o que ayuda en la actividad de degradación del material de carbohidratos y usos del mismo. | |
| MX2020005724A (es) | Variantes de alfa-amilasa y polinucleotidos que codifican las mismas. | |
| MY176331A (en) | Carbohydrate degrading polypeptide and uses thereof | |
| AU2017248121A1 (en) | T cell receptors | |
| SA522433360B1 (ar) | L-أَسْباراجيناز مُعدل | |
| PH12018501628B1 (en) | Optimized factor viii genes | |
| AU2017248122A1 (en) | T cell receptors | |
| NZ595500A (en) | Cellulolytic enzymes, nucleic acids encoding them and methods for making and using them | |
| MX2009011179A (es) | Variantes de enzimas asparaginasas y sus usos. | |
| WO2015110473A3 (en) | Pullulanase variants and polynucleotides encoding same | |
| MX2021000328A (es) | Enzimas de variantes de galactosa oxidasa modificadas geneticamente. | |
| MY192746A (en) | Detergent compositions | |
| NZ630484A (en) | Compositions and methods for treatment of metabolic disorders and diseases | |
| NZ601950A (en) | Method for producing pyripyropene | |
| HK1198170A1 (en) | Pseudomonas exotoxin a with less immunogenic b cell epitopes | |
| NZ593893A (en) | Gene encoding human glucokinase mutant, enzyme encoded by the same, recombinant vectors and hosts, pharmaceutical compositions and uses thereof, methods for treating and preventing diseases | |
| MY159074A (en) | Polypeptide having d-lactate dehydrogenase activity, polynucleotide encoding the polypeptide, and process for production of d-lactic acid | |
| WO2009074873A1 (en) | Improved chimeric meganuclease enzymes and uses thereof | |
| WO2012093149A3 (en) | Novel cell wall deconstruction enzymes and uses thereof | |
| PH12015500771A1 (en) | Novel fc gamma receptor iib variants | |
| RU2017134724A (ru) | Химерные полипептиды | |
| NZ603990A (en) | Biotechnological production of chondroitin | |
| AU2015344324A8 (en) | Endoxylanase mutant, enzyme composition for biomass decomposition, and method for producing sugar solution |