FI119140B - Uusi peräpuikkojen valmistusmenetelmä - Google Patents
Uusi peräpuikkojen valmistusmenetelmä Download PDFInfo
- Publication number
- FI119140B FI119140B FI962328A FI962328A FI119140B FI 119140 B FI119140 B FI 119140B FI 962328 A FI962328 A FI 962328A FI 962328 A FI962328 A FI 962328A FI 119140 B FI119140 B FI 119140B
- Authority
- FI
- Finland
- Prior art keywords
- carbon dioxide
- pct
- suppositories
- production
- stirring
- Prior art date
Links
- 239000000829 suppository Substances 0.000 title claims abstract description 25
- 238000000034 method Methods 0.000 title claims abstract description 17
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims abstract description 43
- 229910002092 carbon dioxide Inorganic materials 0.000 claims abstract description 21
- 239000001569 carbon dioxide Substances 0.000 claims abstract description 21
- 230000008569 process Effects 0.000 claims abstract description 10
- 239000000126 substance Substances 0.000 claims abstract description 8
- 235000016337 monopotassium tartrate Nutrition 0.000 claims abstract description 4
- KYKNRZGSIGMXFH-ZVGUSBNCSA-M potassium bitartrate Chemical compound [K+].OC(=O)[C@H](O)[C@@H](O)C([O-])=O KYKNRZGSIGMXFH-ZVGUSBNCSA-M 0.000 claims abstract description 4
- 238000004519 manufacturing process Methods 0.000 claims description 11
- 239000000203 mixture Substances 0.000 claims description 9
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 6
- 239000004615 ingredient Substances 0.000 claims description 5
- -1 alkaline earth metal stearate Chemical class 0.000 claims description 4
- 238000006243 chemical reaction Methods 0.000 claims description 4
- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 claims description 3
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims description 3
- 229910052784 alkaline earth metal Inorganic materials 0.000 claims description 3
- 230000000750 progressive effect Effects 0.000 claims description 3
- 239000004408 titanium dioxide Substances 0.000 claims description 3
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 2
- 239000006194 liquid suspension Substances 0.000 claims description 2
- 239000003605 opacifier Substances 0.000 claims description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims 1
- 229910052749 magnesium Inorganic materials 0.000 claims 1
- 239000011777 magnesium Substances 0.000 claims 1
- 239000000155 melt Substances 0.000 claims 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 238000003756 stirring Methods 0.000 abstract description 9
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 abstract description 5
- 235000010445 lecithin Nutrition 0.000 abstract description 5
- 229940067606 lecithin Drugs 0.000 abstract description 5
- 239000000787 lecithin Substances 0.000 abstract description 5
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 abstract description 4
- 239000003795 chemical substances by application Substances 0.000 abstract description 3
- 230000002475 laxative effect Effects 0.000 abstract description 3
- 239000000725 suspension Substances 0.000 abstract description 3
- 235000013311 vegetables Nutrition 0.000 abstract description 3
- 238000002844 melting Methods 0.000 abstract description 2
- 230000008018 melting Effects 0.000 abstract description 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 abstract description 2
- 235000017557 sodium bicarbonate Nutrition 0.000 abstract description 2
- 239000012530 fluid Substances 0.000 abstract 2
- 239000000470 constituent Substances 0.000 abstract 1
- 238000001033 granulometry Methods 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 235000010755 mineral Nutrition 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 7
- 238000002360 preparation method Methods 0.000 description 6
- 210000000664 rectum Anatomy 0.000 description 5
- 239000004480 active ingredient Substances 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 239000002253 acid Substances 0.000 description 2
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical class [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 2
- 230000003197 catalytic effect Effects 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 235000019359 magnesium stearate Nutrition 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000008347 soybean phospholipid Substances 0.000 description 2
- 239000000454 talc Substances 0.000 description 2
- 229910052623 talc Inorganic materials 0.000 description 2
- 150000003626 triacylglycerols Chemical class 0.000 description 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- JRPBQTZRNDNNOP-UHFFFAOYSA-N barium titanate Chemical compound [Ba+2].[Ba+2].[O-][Ti]([O-])([O-])[O-] JRPBQTZRNDNNOP-UHFFFAOYSA-N 0.000 description 1
- 229910002113 barium titanate Inorganic materials 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 239000008116 calcium stearate Substances 0.000 description 1
- 235000013539 calcium stearate Nutrition 0.000 description 1
- 229940110456 cocoa butter Drugs 0.000 description 1
- 235000019868 cocoa butter Nutrition 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 235000019197 fats Nutrition 0.000 description 1
- 238000005188 flotation Methods 0.000 description 1
- 125000005456 glyceride group Chemical group 0.000 description 1
- 239000008240 homogeneous mixture Substances 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
- 239000008141 laxative Substances 0.000 description 1
- HCWCAKKEBCNQJP-UHFFFAOYSA-N magnesium orthosilicate Chemical compound [Mg+2].[Mg+2].[O-][Si]([O-])([O-])[O-] HCWCAKKEBCNQJP-UHFFFAOYSA-N 0.000 description 1
- 239000000391 magnesium silicate Substances 0.000 description 1
- 229910052919 magnesium silicate Inorganic materials 0.000 description 1
- 235000019792 magnesium silicate Nutrition 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 150000004667 medium chain fatty acids Chemical class 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000005373 porous glass Substances 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000010944 pre-mature reactiony Methods 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 230000005062 synaptic transmission Effects 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 235000010215 titanium dioxide Nutrition 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Mechanical Treatment Of Semiconductor (AREA)
- Compounds Of Unknown Constitution (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Liquid Crystal Substances (AREA)
- Detergent Compositions (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9411913A FR2725371B1 (fr) | 1994-10-05 | 1994-10-05 | Nouveau procede de fabrication de suppositoires |
| FR9411913 | 1994-10-05 | ||
| PCT/FR1995/001294 WO1996010987A1 (fr) | 1994-10-05 | 1995-10-05 | Nouveau procede de fabrication de suppositoires |
| FR9501294 | 1995-10-05 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI962328L FI962328L (fi) | 1996-06-04 |
| FI962328A0 FI962328A0 (fi) | 1996-06-04 |
| FI119140B true FI119140B (fi) | 2008-08-15 |
Family
ID=9467597
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI962328A FI119140B (fi) | 1994-10-05 | 1996-06-04 | Uusi peräpuikkojen valmistusmenetelmä |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6033683A (de) |
| EP (1) | EP0741564B1 (de) |
| KR (1) | KR100384323B1 (de) |
| CN (1) | CN1303983C (de) |
| AT (1) | ATE322248T1 (de) |
| BR (1) | BR9506439A (de) |
| DE (1) | DE69534916T2 (de) |
| FI (1) | FI119140B (de) |
| FR (1) | FR2725371B1 (de) |
| MX (1) | MX9602121A (de) |
| NO (1) | NO317933B1 (de) |
| PL (1) | PL183374B1 (de) |
| WO (1) | WO1996010987A1 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000061748A1 (en) * | 1999-04-09 | 2000-10-19 | Human Genome Sciences, Inc. | 48 human secreted proteins |
| GB0818336D0 (en) | 2008-10-07 | 2008-11-12 | Cosmetic Warriors Ltd | Composition |
| CN105670003A (zh) * | 2014-11-21 | 2016-06-15 | 常州坤宇环保科技有限公司 | 高吸水树脂防结块剂 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR788198A (fr) * | 1934-12-18 | 1935-10-05 | Procédé pour la fabrication de préparations thérapeutiques dégageant de l'acide carbonique | |
| FR5391M (de) * | 1965-11-04 | 1967-10-23 | ||
| US3764668A (en) * | 1970-09-30 | 1973-10-09 | Interx Research Corp | Compositions of salts of salicylamide |
| JPS55136215A (en) * | 1979-04-10 | 1980-10-23 | Res Inst For Prod Dev | Preparation of laminar laxative suppository |
| JPS5683417A (en) * | 1979-12-11 | 1981-07-08 | Kanae:Kk | Preparation of layer laxative suppository |
| JPS58152809A (ja) * | 1982-03-05 | 1983-09-10 | Eisai Co Ltd | 安定な発泡性「膣」坐剤 |
| IT1213464B (it) * | 1986-07-25 | 1989-12-20 | Riccardo Casero | Forma farmaceutica per la somministrazione enterica di acido etodolico o di suoi sali, in miscela con eccipienti. |
| WO1993018766A1 (en) * | 1992-03-20 | 1993-09-30 | The Wellcome Foundation Limited | Further indole derivatives with antiviral activity |
-
1994
- 1994-10-05 FR FR9411913A patent/FR2725371B1/fr not_active Expired - Fee Related
-
1995
- 1995-10-05 PL PL95314835A patent/PL183374B1/pl unknown
- 1995-10-05 EP EP95934170A patent/EP0741564B1/de not_active Expired - Lifetime
- 1995-10-05 KR KR1019960702930A patent/KR100384323B1/ko not_active Expired - Lifetime
- 1995-10-05 WO PCT/FR1995/001294 patent/WO1996010987A1/fr not_active Ceased
- 1995-10-05 US US08/666,543 patent/US6033683A/en not_active Expired - Lifetime
- 1995-10-05 BR BR9506439A patent/BR9506439A/pt not_active Application Discontinuation
- 1995-10-05 DE DE69534916T patent/DE69534916T2/de not_active Expired - Lifetime
- 1995-10-05 AT AT95934170T patent/ATE322248T1/de not_active IP Right Cessation
- 1995-10-05 MX MX9602121A patent/MX9602121A/es unknown
- 1995-10-05 CN CNB951913565A patent/CN1303983C/zh not_active Expired - Fee Related
-
1996
- 1996-06-04 NO NO19962297A patent/NO317933B1/no not_active IP Right Cessation
- 1996-06-04 FI FI962328A patent/FI119140B/fi not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| BR9506439A (pt) | 1997-09-02 |
| FI962328L (fi) | 1996-06-04 |
| MX9602121A (es) | 1997-07-31 |
| ATE322248T1 (de) | 2006-04-15 |
| US6033683A (en) | 2000-03-07 |
| WO1996010987A1 (fr) | 1996-04-18 |
| NO317933B1 (no) | 2005-01-10 |
| DE69534916T2 (de) | 2007-03-08 |
| CN1139379A (zh) | 1997-01-01 |
| EP0741564B1 (de) | 2006-04-05 |
| NO962297D0 (no) | 1996-06-04 |
| NO962297L (no) | 1996-06-04 |
| CN1303983C (zh) | 2007-03-14 |
| FR2725371A1 (fr) | 1996-04-12 |
| PL183374B1 (pl) | 2002-06-28 |
| FI962328A0 (fi) | 1996-06-04 |
| EP0741564A1 (de) | 1996-11-13 |
| PL314835A1 (en) | 1996-09-30 |
| KR960706324A (ko) | 1996-12-09 |
| KR100384323B1 (ko) | 2003-11-28 |
| FR2725371B1 (fr) | 1997-08-29 |
| DE69534916D1 (de) | 2006-05-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Patent granted |
Ref document number: 119140 Country of ref document: FI |
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| MA | Patent expired |