JPS5683417A - Preparation of layer laxative suppository - Google Patents

Preparation of layer laxative suppository

Info

Publication number
JPS5683417A
JPS5683417A JP16099079A JP16099079A JPS5683417A JP S5683417 A JPS5683417 A JP S5683417A JP 16099079 A JP16099079 A JP 16099079A JP 16099079 A JP16099079 A JP 16099079A JP S5683417 A JPS5683417 A JP S5683417A
Authority
JP
Japan
Prior art keywords
layer
suppository
drug
reaction
acidic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP16099079A
Other languages
Japanese (ja)
Other versions
JPS5749524B2 (en
Inventor
Masaru Himeji
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kanae Co Ltd
Original Assignee
Kanae Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kanae Co Ltd filed Critical Kanae Co Ltd
Priority to JP16099079A priority Critical patent/JPS5683417A/en
Publication of JPS5683417A publication Critical patent/JPS5683417A/en
Publication of JPS5749524B2 publication Critical patent/JPS5749524B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicinal Preparation (AREA)

Abstract

PURPOSE: A layer laxative suppository having stability of no reaction with time, by blending separately an acidic drug and an alkali drug which are to be reacted with each other with an upper and a lower layer bases respectively, followed by forming both the upper and lower layers.
CONSTITUTION: A double layer suppository consisting essentially of an upper and lower layers having the same suppository base is prepared. In the preparation, an acidic drug (e.g., sodium dihydrogenphosphate) is added to a molten base of one layer and an alkali drug (e.g., sodium hydrogencarbonate) which will produce carbon dioxide in the reaction with the acidic drug is added to the molten base of the other layer so that both the bases have the drugs separately to prepare two kinds of molten mixtures. One of the mixtures is first fed to a suppository mold, cooled to coagulated or half coagulated state, and the other mixture is fed to the mold, cooled and set, to give a layer laxative suppository comprising the acidic and alkali drugs in the upper and lower layers separately. Since divided into layer states, the reaction of the medicine with each other is prevented to increase storage stability.
COPYRIGHT: (C)1981,JPO&Japio
JP16099079A 1979-12-11 1979-12-11 Preparation of layer laxative suppository Granted JPS5683417A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP16099079A JPS5683417A (en) 1979-12-11 1979-12-11 Preparation of layer laxative suppository

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP16099079A JPS5683417A (en) 1979-12-11 1979-12-11 Preparation of layer laxative suppository

Publications (2)

Publication Number Publication Date
JPS5683417A true JPS5683417A (en) 1981-07-08
JPS5749524B2 JPS5749524B2 (en) 1982-10-22

Family

ID=15726470

Family Applications (1)

Application Number Title Priority Date Filing Date
JP16099079A Granted JPS5683417A (en) 1979-12-11 1979-12-11 Preparation of layer laxative suppository

Country Status (1)

Country Link
JP (1) JPS5683417A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6165823A (en) * 1984-09-07 1986-04-04 Kao Corp Drug for rectal application
US6033683A (en) * 1994-10-05 2000-03-07 Techni-Pharma Method of the manufacture of suppositories

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6165823A (en) * 1984-09-07 1986-04-04 Kao Corp Drug for rectal application
US6033683A (en) * 1994-10-05 2000-03-07 Techni-Pharma Method of the manufacture of suppositories

Also Published As

Publication number Publication date
JPS5749524B2 (en) 1982-10-22

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