JPS5683417A - Preparation of layer laxative suppository - Google Patents
Preparation of layer laxative suppositoryInfo
- Publication number
- JPS5683417A JPS5683417A JP16099079A JP16099079A JPS5683417A JP S5683417 A JPS5683417 A JP S5683417A JP 16099079 A JP16099079 A JP 16099079A JP 16099079 A JP16099079 A JP 16099079A JP S5683417 A JPS5683417 A JP S5683417A
- Authority
- JP
- Japan
- Prior art keywords
- layer
- suppository
- drug
- reaction
- acidic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Medicinal Preparation (AREA)
Abstract
PURPOSE: A layer laxative suppository having stability of no reaction with time, by blending separately an acidic drug and an alkali drug which are to be reacted with each other with an upper and a lower layer bases respectively, followed by forming both the upper and lower layers.
CONSTITUTION: A double layer suppository consisting essentially of an upper and lower layers having the same suppository base is prepared. In the preparation, an acidic drug (e.g., sodium dihydrogenphosphate) is added to a molten base of one layer and an alkali drug (e.g., sodium hydrogencarbonate) which will produce carbon dioxide in the reaction with the acidic drug is added to the molten base of the other layer so that both the bases have the drugs separately to prepare two kinds of molten mixtures. One of the mixtures is first fed to a suppository mold, cooled to coagulated or half coagulated state, and the other mixture is fed to the mold, cooled and set, to give a layer laxative suppository comprising the acidic and alkali drugs in the upper and lower layers separately. Since divided into layer states, the reaction of the medicine with each other is prevented to increase storage stability.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP16099079A JPS5683417A (en) | 1979-12-11 | 1979-12-11 | Preparation of layer laxative suppository |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP16099079A JPS5683417A (en) | 1979-12-11 | 1979-12-11 | Preparation of layer laxative suppository |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5683417A true JPS5683417A (en) | 1981-07-08 |
JPS5749524B2 JPS5749524B2 (en) | 1982-10-22 |
Family
ID=15726470
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP16099079A Granted JPS5683417A (en) | 1979-12-11 | 1979-12-11 | Preparation of layer laxative suppository |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5683417A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6165823A (en) * | 1984-09-07 | 1986-04-04 | Kao Corp | Drug for rectal application |
US6033683A (en) * | 1994-10-05 | 2000-03-07 | Techni-Pharma | Method of the manufacture of suppositories |
-
1979
- 1979-12-11 JP JP16099079A patent/JPS5683417A/en active Granted
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6165823A (en) * | 1984-09-07 | 1986-04-04 | Kao Corp | Drug for rectal application |
US6033683A (en) * | 1994-10-05 | 2000-03-07 | Techni-Pharma | Method of the manufacture of suppositories |
Also Published As
Publication number | Publication date |
---|---|
JPS5749524B2 (en) | 1982-10-22 |
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