FI118967B - 3'-substituoidut nukleosidijohdannaiset - Google Patents

3'-substituoidut nukleosidijohdannaiset Download PDF

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Publication number
FI118967B
FI118967B FI963148A FI963148A FI118967B FI 118967 B FI118967 B FI 118967B FI 963148 A FI963148 A FI 963148A FI 963148 A FI963148 A FI 963148A FI 118967 B FI118967 B FI 118967B
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FI
Finland
Prior art keywords
group
eller
compound
substituted
residue
Prior art date
Application number
FI963148A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI963148A0 (fi
FI963148A (fi
Inventor
Akira Matsuda
Takuma Sasaki
Original Assignee
Taiho Pharmaceutical Co Ltd
Akira Matsuda
Takuma Sasaki
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taiho Pharmaceutical Co Ltd, Akira Matsuda, Takuma Sasaki filed Critical Taiho Pharmaceutical Co Ltd
Publication of FI963148A0 publication Critical patent/FI963148A0/fi
Publication of FI963148A publication Critical patent/FI963148A/fi
Application granted granted Critical
Publication of FI118967B publication Critical patent/FI118967B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI963148A 1994-12-13 1996-08-12 3'-substituoidut nukleosidijohdannaiset FI118967B (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP30891294 1994-12-13
JP30891294 1994-12-13
JP20864595 1995-08-16
JP20864595 1995-08-16
PCT/JP1995/002554 WO1996018636A1 (fr) 1994-12-13 1995-12-13 Derives de nucleoside substitues en 3'
JP9502554 1995-12-13

Publications (3)

Publication Number Publication Date
FI963148A0 FI963148A0 (fi) 1996-08-12
FI963148A FI963148A (fi) 1996-08-12
FI118967B true FI118967B (fi) 2008-05-30

Family

ID=26516961

Family Applications (1)

Application Number Title Priority Date Filing Date
FI963148A FI118967B (fi) 1994-12-13 1996-08-12 3'-substituoidut nukleosidijohdannaiset

Country Status (18)

Country Link
US (2) US5763418A (de)
EP (1) EP0747389B1 (de)
JP (1) JP3142874B2 (de)
KR (1) KR0177372B1 (de)
CN (1) CN1195768C (de)
AT (1) ATE249471T1 (de)
AU (1) AU674639B2 (de)
CA (1) CA2182707C (de)
DE (1) DE69531729T2 (de)
DK (1) DK0747389T3 (de)
ES (1) ES2206522T3 (de)
FI (1) FI118967B (de)
HU (1) HU217772B (de)
NO (1) NO305702B1 (de)
NZ (1) NZ297100A (de)
PT (1) PT747389E (de)
RU (1) RU2130029C1 (de)
WO (1) WO1996018636A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0177372B1 (ko) * 1994-12-13 1999-04-01 아키라 마츠다 3'-치환 뉴클레오시드 유도체
CA2172471C (en) * 1995-03-29 1999-01-26 Hua Qi Apparatus for and method of simulating ocular optical system
US6235782B1 (en) 1998-11-12 2001-05-22 Rifat Pamukcu Method for treating a patient with neoplasia by treatment with a platinum coordination complex
US6235776B1 (en) 1998-11-12 2001-05-22 Cell Pathways, Inc. Method for treating a patient with neoplasia by treatment with a paclitaxel derivative
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
NZ547204A (en) * 2000-05-26 2008-01-31 Idenix Cayman Ltd Methods and compositions for treating flaviviruses and pestiviruses
WO2003026589A2 (en) 2001-09-28 2003-04-03 Idenix (Cayman) Limited Methods and compositions for treating hepatitis c virus using 4'-modified nucleosides
US7012100B1 (en) 2002-06-04 2006-03-14 Avolix Pharmaceuticals, Inc. Cell migration inhibiting compositions and methods and compositions for treating cancer
CN101172993A (zh) * 2002-06-28 2008-05-07 埃迪尼克斯(开曼)有限公司 用于治疗黄病毒感染的2′－c－甲基－3′－o－l－缬氨酸酯核糖呋喃基胞苷
PL374792A1 (en) * 2002-06-28 2005-10-31 Idenix (Cayman) Limited 2' and 3'-nucleoside prodrugs for treating flaviviridae infections
US7456155B2 (en) * 2002-06-28 2008-11-25 Idenix Pharmaceuticals, Inc. 2′-C-methyl-3′-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
US7608600B2 (en) * 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
HUE033832T2 (en) 2002-11-15 2018-01-29 Idenix Pharmaceuticals Llc 2'-methyl nucleosides in combination with interferon and Flaviviridae mutation
PL377287A1 (pl) * 2002-12-12 2006-01-23 Idenix (Cayman) Limited Sposób wytwarzania 2'-rozgałęzionych nukleozydów
US7589078B2 (en) 2003-02-19 2009-09-15 Yale University Anti-viral nucleoside analogs and methods for treating viral infections, especially HIV infections
CA2571675A1 (en) * 2004-06-23 2006-01-05 Idenix (Cayman) Limited 5-aza-7-deazapurine derivatives for treating infections with flaviviridae
JP4516863B2 (ja) * 2005-03-11 2010-08-04 株式会社ケンウッド 音声合成装置、音声合成方法及びプログラム
CA2634749C (en) 2005-12-23 2014-08-19 Idenix Pharmaceuticals, Inc. Process for preparing a synthetic intermediate for preparation of branched nucleosides
US8058261B2 (en) 2006-07-24 2011-11-15 Taiho Pharmaceutical Co., Ltd. 3′-ethynylcytidine derivative
JP5066737B2 (ja) 2007-04-06 2012-11-07 大鵬薬品工業株式会社 シチジン誘導体を含有する持続静脈内投与用抗腫瘍剤
JP4954004B2 (ja) 2007-08-09 2012-06-13 株式会社バイオダイナミクス研究所 任意の化合物が導入された新規核酸誘導体、及びその製造方法
CN101980713A (zh) 2008-03-27 2011-02-23 大鹏药品工业株式会社 含有胞嘧啶核苷衍生物与卡铂的抗肿瘤剂
US9556216B2 (en) 2012-08-31 2017-01-31 Novartis Ag 2′-Ethynyl nucleoside derivatives for treatment of viral infections
US10570167B2 (en) * 2016-12-22 2020-02-25 Calithera Biosciences, Inc. Ectonucleotidase inhibitors and methods of use thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3480613A (en) * 1967-07-03 1969-11-25 Merck & Co Inc 2-c or 3-c-alkylribofuranosyl - 1-substituted compounds and the nucleosides thereof
BE739821A (de) * 1968-10-04 1970-03-16
DE3924424A1 (de) * 1989-07-24 1991-01-31 Boehringer Mannheim Gmbh Nucleosid-derivate, verfahren zu deren herstellung, deren verwendung als arzneimittel sowie deren verwendung bei der nucleinsaeure-sequenzierung
DE4204032A1 (de) * 1992-02-12 1993-08-19 Boehringer Mannheim Gmbh Neue liponucleotide, deren herstellunmg sowie deren verwendung als antivirale arzneimittel
EP0598910A1 (de) * 1992-03-11 1994-06-01 Japan Tobacco Inc. Verfahren zur herstellung von nukleosidderivaten
DE4418690A1 (de) * 1994-05-28 1996-01-11 Boehringer Mannheim Gmbh Neue Lipidester von Nucleosid-Monophosphaten und deren Verwendung als immunsuppressive Arzneimittel
US5681940A (en) * 1994-11-02 1997-10-28 Icn Pharmaceuticals Sugar modified nucleosides and oligonucleotides
KR0177372B1 (ko) * 1994-12-13 1999-04-01 아키라 마츠다 3'-치환 뉴클레오시드 유도체

Also Published As

Publication number Publication date
KR970701198A (ko) 1997-03-17
DK0747389T3 (da) 2004-01-26
CN1140453A (zh) 1997-01-15
NO963350D0 (no) 1996-08-12
RU2130029C1 (ru) 1999-05-10
AU4188496A (en) 1996-07-03
HU217772B (hu) 2000-04-28
HU9602214D0 (en) 1996-11-28
HUT75227A (en) 1997-04-28
EP0747389A4 (de) 1998-12-30
EP0747389B1 (de) 2003-09-10
ES2206522T3 (es) 2004-05-16
CA2182707C (en) 2000-05-30
NZ297100A (en) 1997-10-24
NO963350L (no) 1996-10-11
CN1195768C (zh) 2005-04-06
NO305702B1 (no) 1999-07-12
ATE249471T1 (de) 2003-09-15
US5763418A (en) 1998-06-09
DE69531729D1 (de) 2003-10-16
DE69531729T2 (de) 2004-08-05
FI963148A0 (fi) 1996-08-12
PT747389E (pt) 2003-12-31
FI963148A (fi) 1996-08-12
WO1996018636A1 (fr) 1996-06-20
JP3142874B2 (ja) 2001-03-07
AU674639B2 (en) 1997-01-02
USRE38090E1 (en) 2003-04-22
KR0177372B1 (ko) 1999-04-01
EP0747389A1 (de) 1996-12-11

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