NO305702B1 - 3'-substituert nukleosid-derivat eller et av dets farmas°ytisk akseptable salter, anvendelse derav og medisinsk preparat - Google Patents

3'-substituert nukleosid-derivat eller et av dets farmas°ytisk akseptable salter, anvendelse derav og medisinsk preparat

Info

Publication number
NO305702B1
NO305702B1 NO963350A NO963350A NO305702B1 NO 305702 B1 NO305702 B1 NO 305702B1 NO 963350 A NO963350 A NO 963350A NO 963350 A NO963350 A NO 963350A NO 305702 B1 NO305702 B1 NO 305702B1
Authority
NO
Norway
Prior art keywords
nucleoside derivative
group
substituted nucleoside
pharmaceutically acceptable
acceptable salts
Prior art date
Application number
NO963350A
Other languages
English (en)
Other versions
NO963350L (no
NO963350D0 (no
Inventor
Akira Matsuda
Takuma Sasaki
Original Assignee
Akira Matsuda
Takuma Sasaki
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akira Matsuda, Takuma Sasaki, Taiho Pharmaceutical Co Ltd filed Critical Akira Matsuda
Publication of NO963350D0 publication Critical patent/NO963350D0/no
Publication of NO963350L publication Critical patent/NO963350L/no
Publication of NO305702B1 publication Critical patent/NO305702B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NO963350A 1994-12-13 1996-08-12 3'-substituert nukleosid-derivat eller et av dets farmas°ytisk akseptable salter, anvendelse derav og medisinsk preparat NO305702B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP30891294 1994-12-13
JP20864595 1995-08-16
PCT/JP1995/002554 WO1996018636A1 (fr) 1994-12-13 1995-12-13 Derives de nucleoside substitues en 3'

Publications (3)

Publication Number Publication Date
NO963350D0 NO963350D0 (no) 1996-08-12
NO963350L NO963350L (no) 1996-10-11
NO305702B1 true NO305702B1 (no) 1999-07-12

Family

ID=26516961

Family Applications (1)

Application Number Title Priority Date Filing Date
NO963350A NO305702B1 (no) 1994-12-13 1996-08-12 3'-substituert nukleosid-derivat eller et av dets farmas°ytisk akseptable salter, anvendelse derav og medisinsk preparat

Country Status (18)

Country Link
US (2) USRE38090E1 (no)
EP (1) EP0747389B1 (no)
JP (1) JP3142874B2 (no)
KR (1) KR0177372B1 (no)
CN (1) CN1195768C (no)
AT (1) ATE249471T1 (no)
AU (1) AU674639B2 (no)
CA (1) CA2182707C (no)
DE (1) DE69531729T2 (no)
DK (1) DK0747389T3 (no)
ES (1) ES2206522T3 (no)
FI (1) FI118967B (no)
HU (1) HU217772B (no)
NO (1) NO305702B1 (no)
NZ (1) NZ297100A (no)
PT (1) PT747389E (no)
RU (1) RU2130029C1 (no)
WO (1) WO1996018636A1 (no)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1195768C (zh) * 1994-12-13 2005-04-06 松田彰 3’－取代的核苷衍生物
CA2172471C (en) * 1995-03-29 1999-01-26 Hua Qi Apparatus for and method of simulating ocular optical system
US6235776B1 (en) 1998-11-12 2001-05-22 Cell Pathways, Inc. Method for treating a patient with neoplasia by treatment with a paclitaxel derivative
US6235782B1 (en) 1998-11-12 2001-05-22 Rifat Pamukcu Method for treating a patient with neoplasia by treatment with a platinum coordination complex
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
CA2410579C (en) 2000-05-26 2010-04-20 Jean-Pierre Sommadossi Methods and compositions for treating flaviviruses and pestiviruses
US7138376B2 (en) 2001-09-28 2006-11-21 Idenix Pharmaceuticals, Inc. Methods and compositions for treating hepatitis C virus using 4'-modified nucleosides
US7012100B1 (en) 2002-06-04 2006-03-14 Avolix Pharmaceuticals, Inc. Cell migration inhibiting compositions and methods and compositions for treating cancer
US7608600B2 (en) 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
CN101172993A (zh) * 2002-06-28 2008-05-07 埃迪尼克斯(开曼)有限公司 用于治疗黄病毒感染的2′－c－甲基－3′－o－l－缬氨酸酯核糖呋喃基胞苷
PL374792A1 (en) * 2002-06-28 2005-10-31 Idenix (Cayman) Limited 2' and 3'-nucleoside prodrugs for treating flaviviridae infections
JP2005533824A (ja) * 2002-06-28 2005-11-10 イデニクス（ケイマン）リミテツド フラビウイルス科感染の治療のための２’−ｃ−メチル−３’−ｏ−ｌ−バリンエステルリボフラノシルシチジン
MXPA05005192A (es) * 2002-11-15 2005-09-08 Idenix Cayman Ltd Nucleosidos ramificados en la posicion 2' y mutacion de flaviviridae.
PL377287A1 (pl) * 2002-12-12 2006-01-23 Idenix (Cayman) Limited Sposób wytwarzania 2'-rozgałęzionych nukleozydów
EP2298783B1 (en) * 2003-02-19 2017-12-06 Yale University Anti-viral nucleoside analogs and methods for treating viral infections, especially hiv infections
BRPI0512360A (pt) * 2004-06-23 2008-03-11 Idenix Cayman Ltd derivados de 5-aza-7-deazapurina para o tratamento de flaviviridae
JP4516863B2 (ja) * 2005-03-11 2010-08-04 株式会社ケンウッド 音声合成装置、音声合成方法及びプログラム
CA2634749C (en) * 2005-12-23 2014-08-19 Idenix Pharmaceuticals, Inc. Process for preparing a synthetic intermediate for preparation of branched nucleosides
JP4989649B2 (ja) * 2006-07-24 2012-08-01 大鵬薬品工業株式会社 ３’−エチニルシチジン誘導体
JP5066737B2 (ja) 2007-04-06 2012-11-07 大鵬薬品工業株式会社 シチジン誘導体を含有する持続静脈内投与用抗腫瘍剤
JP4954004B2 (ja) 2007-08-09 2012-06-13 株式会社バイオダイナミクス研究所 任意の化合物が導入された新規核酸誘導体、及びその製造方法
RU2482855C2 (ru) * 2008-03-27 2013-05-27 Тайхо Фармасьютикал Ко., Лтд. Противоопухолевое средство, включающее производное цитидина и карбоплатин
ES2671478T3 (es) 2012-08-31 2018-06-06 Novartis Ag Derivados de 2'-etinil nucleósidos para el tratamiento de infecciones virales
WO2018119284A1 (en) * 2016-12-22 2018-06-28 Calithera Biosciences, Inc. Ectonucleotidase inhibitors and methods of use thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3480613A (en) * 1967-07-03 1969-11-25 Merck & Co Inc 2-c or 3-c-alkylribofuranosyl - 1-substituted compounds and the nucleosides thereof
FR2019943A1 (no) * 1968-10-04 1970-07-10 Esco Corp
DE3924424A1 (de) * 1989-07-24 1991-01-31 Boehringer Mannheim Gmbh Nucleosid-derivate, verfahren zu deren herstellung, deren verwendung als arzneimittel sowie deren verwendung bei der nucleinsaeure-sequenzierung
DE4204032A1 (de) * 1992-02-12 1993-08-19 Boehringer Mannheim Gmbh Neue liponucleotide, deren herstellunmg sowie deren verwendung als antivirale arzneimittel
WO1993018051A1 (en) * 1992-03-11 1993-09-16 Japan Tobacco Inc. Process for producing nucleoside derivative
DE4418690A1 (de) * 1994-05-28 1996-01-11 Boehringer Mannheim Gmbh Neue Lipidester von Nucleosid-Monophosphaten und deren Verwendung als immunsuppressive Arzneimittel
US5681940A (en) * 1994-11-02 1997-10-28 Icn Pharmaceuticals Sugar modified nucleosides and oligonucleotides
CN1195768C (zh) * 1994-12-13 2005-04-06 松田彰 3’－取代的核苷衍生物

Also Published As

Publication number Publication date
FI963148A0 (fi) 1996-08-12
HU9602214D0 (en) 1996-11-28
FI118967B (fi) 2008-05-30
ES2206522T3 (es) 2004-05-16
DK0747389T3 (da) 2004-01-26
CN1140453A (zh) 1997-01-15
US5763418A (en) 1998-06-09
HUT75227A (en) 1997-04-28
NO963350L (no) 1996-10-11
DE69531729T2 (de) 2004-08-05
NZ297100A (en) 1997-10-24
KR0177372B1 (ko) 1999-04-01
EP0747389A1 (en) 1996-12-11
RU2130029C1 (ru) 1999-05-10
WO1996018636A1 (fr) 1996-06-20
CA2182707C (en) 2000-05-30
DE69531729D1 (de) 2003-10-16
AU4188496A (en) 1996-07-03
AU674639B2 (en) 1997-01-02
NO963350D0 (no) 1996-08-12
FI963148A (fi) 1996-08-12
KR970701198A (ko) 1997-03-17
CN1195768C (zh) 2005-04-06
USRE38090E1 (en) 2003-04-22
JP3142874B2 (ja) 2001-03-07
ATE249471T1 (de) 2003-09-15
EP0747389A4 (en) 1998-12-30
EP0747389B1 (en) 2003-09-10
HU217772B (hu) 2000-04-28
PT747389E (pt) 2003-12-31

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Legal Events

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MK1K Patent expired